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Extract from the Register of European Patents

EP About this file: EP1169038

EP1169038 - CYCLIC PROTEIN TYROSINE KINASE INHIBITORS [Right-click to bookmark this link]
Status	Patent revoked Status updated on 04.08.2017 Database last updated on 11.04.2026
Most recent event Tooltip	15.06.2018	Petition for review: decision	published on 18.07.2018 [2018/29]
Applicant(s)	For all designated states Bristol-Myers Squibb Holdings Ireland Hinterbergstrasse 16 6312 Steinhausen / CH
	[2015/23]
Former [2012/32]	For all designated states Bristol-Myers Squibb Company P.O. Box 4000 Princeton NJ 08543-4000 / US
Former [2002/02]	For all designated states BRISTOL-MYERS SQUIBB COMPANY P.O. Box 4000 Princeton, NJ 08543-4000 / US
Inventor(s)	01 / DAS, Jagabandhu 38 Martin Lane Mercerville, NJ 08619 / US
	02 / PADMANABHA, Ramesh 80 Carmel Street Hamden, CT 06518 / US
	03 / CHEN, Ping 21 Derby Chase Court Belle Mead, NJ 08502 / US
	04 / NORRIS, Derek, J. 52 Manley Road Pennington, NJ 08534-5135 / US
	05 / DOWEYKO, Arthur, M., P. 9 Highland Avenue Long Valley, NJ 07853 / US
	06 / BARRISH, Joel, C. 38 Dorchester Lane Richboro, PA 18954 / US
	07 / WITYAK, John 25 Jared Drive Robbinsville, NJ 08691 / US
	[2002/30]
Former [2002/02]	01 / DAS, Jagabandhu 38 Martin Lane Mercerville, NJ 08619 / US
	02 / PADMANABHA, Ramesh 80 Carmel Street Hamden, CT 06518 / US
	03 / CHEN, Ping 21 Derby Chase Court Belle Mead, NJ 08502 / US
	04 / NORRIS, Derek, J. 52 Manley Road Trenton, NJ 08638 / US
	05 / DOWEYKO, Arthur, M., P. 9 Highland Avenue Long Valley, NJ 07853 / US
	06 / BARRISH, Joel, C. 46 Heather Valley Road Holland, PA 18966 / US
	07 / WITYAK, John 25 Jared Drive Robbinsville, NJ 08691 / US
Representative(s)	Reitstötter Kinzebach Patentanwälte Postfach 86 06 49 81633 München / DE
	[N/P]
Former [2013/36]	Reitstötter - Kinzebach Patentanwälte Postfach 86 06 49 81633 München / DE
Former [2012/32]	Vossius & Partner Siebertstrasse 4 81675 München / DE
Former [2008/35]	Vossius & Partner Siebertstrasse 3 81675 München / DE
Former [2002/02]	VOSSIUS & PARTNER Siebertstrasse 4 81675 München / DE
Application number, filing date	00922102.9	12.04.2000
	[2002/02]
	WO2000US09753
Priority number, date	US19990129510P	15.04.1999 Original published format: US 129510 P
	[2002/02]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO0062778
	Date:	26.10.2000
	Language:	EN
	[2000/43]
	Type:	A1 Application with search report
	No.:	EP1169038
	Date:	09.01.2002
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.10.2000 takes the place of the publication of the European patent application.
	[2002/02]
	Type:	B1 Patent specification
	No.:	EP1169038
	Date:	08.08.2012
	Language:	EN
	[2012/32]
	Type:	B9 Corrected patent specification
	No.:	EP1169038
	Date:	10.07.2013
	[2013/28]
Search report(s)	International search report - published on:	US	26.10.2000
	(Supplementary) European search report - dispatched on:	EP	31.08.2004
Classification	IPC:	A61K31/426, C07C237/40, C07D213/81, C07D213/82, C07D231/38, C07D233/90, C07D239/42, C07D263/48, C07D277/56, C07D409/12, C07D417/12	[2004/41]
	CPC:	C07D277/56 (EP,KR,US); A61P1/00 (EP); A61P11/00 (EP); A61P11/02 (EP); A61P11/06 (EP); A61P17/00 (EP); (+) A61P17/06 (EP); A61P19/02 (EP); A61P21/00 (EP); A61P25/00 (EP); A61P27/02 (EP); A61P29/00 (EP); A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP); A61P5/14 (EP); A61P9/10 (EP); C07C233/65 (US); C07C237/40 (EP,US); C07D213/81 (EP,KR,US); C07D213/82 (EP,KR,US); C07D231/38 (EP,KR,US); C07D233/90 (EP,KR,US); C07D239/42 (EP,KR,US); C07D263/48 (EP,KR,US); C07D409/12 (EP,KR,US); C07D417/06 (EP,KR,US); C07D417/12 (EP,KR,US); C07D417/14 (EP,US); C07D471/04 (EP,KR,US); C07D491/113 (EP,US) (-)
	Former IPC [2002/02]	A61K31/426
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/02]
Title	German:	CYCLISCHE PROTEIN-TYROSINKINASEHEMMER	[2012/31]
	English:	CYCLIC PROTEIN TYROSINE KINASE INHIBITORS	[2002/02]
	French:	INHIBITEURS CYCLIQUES DE PROTEINE TYROSINE KINASE	[2002/02]
	Former [2002/02]	CYCLISCHE PROTEIN TYROSINKINASEHEMMER
Entry into regional phase	26.09.2001	National basic fee paid
	26.09.2001	Search fee paid
	26.09.2001	Designation fee(s) paid
	26.09.2001	Examination fee paid
Examination procedure	26.10.2000	Request for preliminary examination filed International Preliminary Examining Authority: US
	03.09.2001	Amendment by applicant (claims and/or description)
	26.09.2001	Examination requested [2002/02]
	14.10.2004	Despatch of a communication from the examining division (Time limit: M07)
	24.05.2005	Reply to a communication from the examining division
	06.04.2006	Despatch of a communication from the examining division (Time limit: M06)
	16.10.2006	Reply to a communication from the examining division
	17.01.2008	Despatch of a communication from the examining division (Time limit: M06)
	24.07.2008	Reply to a communication from the examining division
	21.06.2010	Despatch of a communication from the examining division (Time limit: M03)
	27.09.2010	Reply to a communication from the examining division
	07.12.2010	Observations by third parties
	14.01.2011	Despatch of a communication from the examining division (Time limit: M06)
	19.07.2011	Reply to a communication from the examining division
	25.08.2011	Despatch of a communication from the examining division (Time limit: M04)
	13.10.2011	Reply to a communication from the examining division
	27.02.2012	Communication of intention to grant the patent
	31.05.2012	Fee for grant paid
	31.05.2012	Fee for publishing/printing paid
Divisional application(s)	EP10013204.2 / EP2308833
	EP17167936.8 / EP3222619
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 14.10.2004
Opposition(s)	Opponent(s)	01 06.05.2013 10.06.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Patentanwälte Isenbruck Bösl Hörschler PartG mbB Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 10.06.2013 ADMISSIBLE APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative Uexküll & Stolberg Partnerschaft von Patent- und Rechtsanwälten mbB Beselerstraße 4 22607 Hamburg / DE
		03 08.05.2013 10.06.2013 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 10.06.2013 ADMISSIBLE Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
		[N/P]
	Former [2016/29]
	Opponent(s)	01 06.05.2013 10.06.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 10.06.2013 ADMISSIBLE APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative Uexküll & Stolberg Partnerschaft von Patent- und Rechtsanwälten mbB Beselerstraße 4 22607 Hamburg / DE
		03 08.05.2013 10.06.2013 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 10.06.2013 ADMISSIBLE Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	Former [2016/24]
	Opponent(s)	01 06.05.2013 10.06.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 10.06.2013 ADMISSIBLE APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative Uexküll & Stolberg Partnerschaft von Patent- und Rechtsanwälten mbB Beselerstraße 4 DE-22607 Hamburg / DE
		03 08.05.2013 10.06.2013 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 10.06.2013 ADMISSIBLE Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Clarke, Lionel Paul Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	Former [2016/19]
	Opponent(s)	01 06.05.2013 10.06.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 10.06.2013 ADMISSIBLE APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative Uexküll & Stolberg Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		03 08.05.2013 10.06.2013 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 10.06.2013 ADMISSIBLE Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Clarke, Lionel Paul Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	Former [2016/14]
	Opponent(s)	01 06.05.2013 10.06.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 10.06.2013 ADMISSIBLE APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative UEXKÜLL & STOLBERG Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		03 08.05.2013 10.06.2013 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 10.06.2013 ADMISSIBLE Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Clarke, Lionel Paul Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	Former [2013/25]
	Opponent(s)	01 06.05.2013 ADMISSIBLE Isenbruck Bösl Hörschler LLP Seckenheimer Landstrasse 4 68163 Mannheim / DE Opponent's representative Jacobi, Markus Alexander Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim / DE
		02 08.05.2013 APOTEX INC. 150 Signet Drive Toronto, Ontario M9L 1T9 / CA Opponent's representative UEXKÜLL & STOLBERG Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		03 08.05.2013 ADMISSIBLE Actavis group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponent's representative Gillard, Richard Edward Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
		04 08.05.2013 Generics [UK] Limited (trading as Mylan) Albany Gate Darkes Lane Potters Bar Hertfordshire EN6 1AG / GB Opponent's representative Gallafent, Alison Alison Gallafent Ltd 4 George Street Llandeilo, South Wales SA19 6AS / GB
	14.06.2013	Invitation to proprietor to file observations on the notice of opposition
	23.12.2013	Reply of patent proprietor to notice(s) of opposition
	20.01.2016	Date of oral proceedings
	09.02.2016	Despatch of minutes of oral proceedings
	09.02.2016	Despatch of communication that the patent will be revoked
	01.02.2017	Legal effect of revocation of patent [2017/36]
Appeal following opposition	24.02.2016	Appeal received No. T0488/16
	20.05.2016	Statement of grounds filed
	01.02.2017	Result of appeal procedure: appeal of the proprietor was rejected
	01.02.2017	Date of oral proceedings
	13.02.2017	Minutes of the oral proceedings despatched
Petition(s) for review:	02.10.2017	Petition for review received
		Number: R0009/17
		for appeal No. T0488/16-3301
		Petitioner: APPR
	04.06.2018	Decision: Petition for review obviously unsubstantiated only.
	04.06.2018	Date of oral proceedings
Fees paid	Renewal fee
	12.04.2002	Renewal fee patent year 03
	14.04.2003	Renewal fee patent year 04
	15.04.2004	Renewal fee patent year 05
	13.04.2005	Renewal fee patent year 06
	17.03.2006	Renewal fee patent year 07
	12.04.2007	Renewal fee patent year 08
	28.03.2008	Renewal fee patent year 09
	16.04.2009	Renewal fee patent year 10
	25.03.2010	Renewal fee patent year 11
	12.04.2011	Renewal fee patent year 12
	30.03.2012	Renewal fee patent year 13
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	CH	08.08.2012
	LI	08.08.2012
	[2017/51]
Documents cited:	Search	[PX] EP0928790 (HOFFMANN LA ROCHE et al.) [PX] 1,32 * pages 12-19; example -; claim 15 *
		[X] EP0275312 (OTSUKA PHARMA CO LTD et al.) [X] 1,32 * page 48; examples 20-22 * * page 49; example 23 *
		[X] WO9857937 (DU PONT MERCK PHARMA et al.) [X] 1,32 * page 87; example 22 * * page 93; example 31 * * page 104; example 51 * * page 106; example 53 * * page 107; example 54 * * page 108; example 55 * * pages 164-170; examples 131-140 *
		[X] DE3220118 (BAYER AG et al.) [X] 1,32 * page 15, formula (Ia) and (Ib) ; page 18; example 17; table I
		[X] GB1437137 (UNIROYAL INC et al.) [X] 1,32 * page 6; examples 3-5; table . *
		[X] EP0276177 (SUMITOMO CHEM IND et al.) [X] 1,32 * page 13; examples 1,4; table 1 *
		[X] EP0315502 (SUMITOMO CHEMICAL CO et al.) [X] 1,32 * claim 11 * * page 13; example 27; table 1 *
		[X] JP1210949
		[X] JP1199955
		[E] WO0156567 (NOVO NORDISK AS et al.) [E] 32 * pages 57-58; examples 45,48 * * page 65; table . *
		[E] WO0024724 (HOFFMANN LA ROCHE et al.) [E] 1,32 * pages 11-12; example - * * pages 37-42; examples 1-19 * * claim - *
		[X] PATENT ABSTRACTS OF JAPAN vol. 0135, no. 17 (P - 962) 20 November 1989 (1989-11-20) [X] 1,32 * abstract * * page 4, column 2; example 3 * * page 5, column 1; example 17 *
		[X] PATENT ABSTRACTS OF JAPAN vol. 0135, no. 01 (C - 652) 10 November 1989 (1989-11-10) [X] 1,32 * abstract * * page 5; examples 11-13,17,19; table . *
		[X] DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1998, KASSAB, RAFIKA RAMADAN: "Some reactions with 2-imino 4-thiazolidone", XP002292173, retrieved from STN Database accession no. 1998:726008 [X] 1,32 * abstract *
		[X] AL-AZHAR BULLETIN OF SCIENCE , 8(1), 1-6 CODEN: ABSCE7; ISSN: 1110-2535, 1997
		[X] PHILLIPS W G ET AL: "THIAZOLE CARBOXANILIDE FUNGICIDES: A NEW STRUCTURE-ACTIVITY RELATIONSHIP FOR SUCCINATE DEHYDROGENASE INHIBITORS", PESTICIDE SCIENCE, ELSEVIER APPLIED SCIENCE PUBLISHER. BARKING, GB, vol. 38, no. 1, 1993, pages 1 - 7, XP000654631, ISSN: 0031-613X [X] 1,32 * page 5; example LXX; table 3 *
		[X] ODA, M. ET AL.: "Structure-activity relationships of N-(1,1,3-trimethylindan-4-yl)carboxamide fungicides", J. PESTICIDE SCI., vol. 18, no. 3, 1993, pages 245 - 251, XP009034823 [X] 1,32 * page 249; example 43; table 3 *
		[X] WOBIG, D.: "Darstellung von Thiazolo[4,5-d]-v-triazin-7(6H)-onen", LIEBIGS ANNALEN DER CHEMIE, vol. 12, 1984, pages 1994 - 1997, XP001183045 [X] 1,32 * page 1994; examples b,c,d,f,h,i,j; table . *
		[X] ABDEL-LATEEF M F-A ET AL: "SYSTEMIC AND CHEMOTHERAPEUTIC FUNGICIDAL ACTIVITY-CHEMICAL STRUCTURE RELATIONSHIP OF SOME 4-METHYL-5-THIAZOLECARBOXYLIC ACID DERIVATIVES. - LABORATORY SCREENING TESTS", ACTA PHYTOPATHOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE, vol. 8, no. 3/4, 1973, pages 269 - 282, XP000614059 [X] 1,32 * page 276; examples 107,108; table 1 *
	International search	[X] US3547917 (KULKA MARSHALL et al.) [X]
		[X] WO9828282 (DU PONT MERCK PHARMA et al.) [X]
		[X] "ALDRICH CHEMICAL COMPANY", CATALOGUE ALDRICH CHEMIE, XX, XX, 1 January 1992 (1992-01-01), XX, pages 50/51 + 98, XP002930612 [X]
		[X] CHUPP J.P.: "A novel synthesis of 2,4-thiophenediamines and their behavior as stable reactive enamines", J. HETEROCYCLIC CHEM.,, vol. 7, no. 2, 1970, pages 285 - 289, XP002930613 [X] DOI: http://dx.doi.org/10.1002/jhet.5570070206
		[X] EREMEEV A.V. ET AL.: "Addition of isocyanates and isothiocyanates to 2-amino-3-phenylcarbamoylazirine", KHIM. GETEROTSIKL. SOEDIN.,, no. 2, 1986, pages 277 - 278, XP002930614 [X]
		[X] ALI M.I. ET AL.: "Reactions with naphthoylacetanilides", EGYPT J. CHEM.,, vol. 22, no. 3, 1979, pages 179 - 188, XP002930615 [X]
		[A] FRY D.W.: "Recent advances in tyrosine kinase inhibitors", ANNUAL REPORTS IN MEDICINAL CHEMISTRY,, vol. 31, 1996, pages 151 - 160, XP002930616 [A]

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