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EP About this file: EP1558648

EP1558648 - HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 [Right-click to bookmark this link]
Status	Patent revoked by proprietor Status updated on 03.04.2021 Database last updated on 28.09.2024
Former	Opposition rejected Status updated on 30.03.2021
Most recent event Tooltip	14.04.2021	New entry: Proprietor files request for revocation
Applicant(s)	For all designated states Genmab A/S Bredgade 34 E 1260 Copenhagen K / DK
	[2013/15]
Former [2009/19]	For all designated states Genmab A/S Bredgade 34 P.O. Box 9068 1260 Copenhagen K / DK
Former [2005/31]	For all designated states Genmab A/S Toldbodgade 33 1253 Copenhagen K / DK
Inventor(s)	01 / TEELING, Jessica@Woodmill Cottage 299 Woodmill Lane Swaithling Southampton SO18 2JR / GB
	02 / RUULS, Sigrid Hessenweg 121B NL-3731 JG De Bilt / NL
	03 / GLENNIE, Martin 1 Thornhill Road Southampton SO16 7AU / GB
	04 / VAN DE WINKEL, Jan, G., J. Werlengde Slotlaan 80 NL-3707 CK Zeist / NL
	05 / PARREN, Paul Werdorperwaard 17 NL-3984 PR Odijk / NL
	06 / PETERSEN, Jorgen Solkrogen 6 DK-2960 Rungsted Kyst / DK
	07 / BAADSGAARD, Ole, D., M., Sc. Tuborg Sundpark 10 2900 Hellerup / DK
	08 / HUANG, Haichun 4329 Crestwood Street Fremont, CA 94538 / US
	[2012/02]
Former [2007/02]	01 / TEELING, Jessica Woodmill Cottage 299 Woodmill Lane Swaithling Southampton SO18 2JR / GB
	02 / RUULS, Sigrid Hessenweg 121B NL-3731 JG De Bilt / NL
	03 / GLENNIE, Martin 1 Thornhill Road Southampton SO16 7AU / GB
	04 / VAN DE WINKEL, Jan, G., J. Werlengde Slotlaan 80 NL-3707 CK Zeist / NL
	05 / PARREN, Paul Werdorperwaard 17 NL-3984 PR Odijk / NL
	06 / PETERSEN, Jorgen Solkrogen 6 DK-2960 Rungsted Kyst / DK
	07 / BAADSGAARD, Ole, D., M., Sc. Tuborg Sundpark 10 2900 Hellerup / DK
	08 / HUANG, Haichun 4329 Crestwood Street Fremont, CA 94538 / US
Former [2005/31]	01 / TEELING, Jessica Lisdoddelaan 70 NL-1562 SN Krommenie / NL
	02 / RUULS, Sigrid Hessenweg 121B NL-3731 JG De Bilt / NL
	03 / GLENNIE, Martin 1 Thornhill Road Southampton SO16 7AU / GB
	04 / VAN DE WINKEL, Jan, G., J. Werlengde Slotlaan 80 NL-3707 CK Zeist / NL
	05 / PARREN, Paul Werdorperwaard 17 NL-3984 PR Odijk / NL
	06 / PETERSEN, Jorgen Solkrogen 6 DK-2960 Rungsted Kyst / DK
	07 / BAADSGAARD, Ole, D., M., Sc. Kyrkogatan 3 S-211 22 Malmo / SE
	08 / HUANG, Haichun 2425 Sueno Way Fremont, CA 94539 / US
Representative(s)	Woods, Geoffrey Corlett J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
	[N/P]
Former [2012/02]	Woods, Geoffrey Corlett J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ / GB
Former [2008/29]	Woods, Geoffrey Corlett J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ / GB
Former [2005/31]	Woods, Geoffrey Corlett J.A. Kemp & Co 14 South Square Gray's Inn London WC1R 5LX / GB
Application number, filing date	03809145.0	17.10.2003
	[2005/31]
	WO2003US33057
Priority number, date	US20020419163P	17.10.2002 Original published format: US 419163 P
	US20030460028P	02.04.2003 Original published format: US 460028 P
	[2005/31]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2004035607
	Date:	29.04.2004
	Language:	EN
	[2004/18]
	Type:	A2 Application without search report
	No.:	EP1558648
	Date:	03.08.2005
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 29.04.2004 takes the place of the publication of the European patent application.
	[2005/31]
	Type:	B1 Patent specification
	No.:	EP1558648
	Date:	11.01.2012
	Language:	EN
	[2012/02]
Search report(s)	International search report - published on:	US	12.08.2004
	(Supplementary) European search report - dispatched on:	EP	02.01.2006
Classification	IPC:	C07K16/28, C07K16/30, C12N5/22, C12N5/24, C12N15/63	[2005/31]
	CPC:	C07K16/2887 (EP,US); C07K16/28 (KR); A61K39/3955 (US); A61K45/06 (US); A61P1/00 (EP); A61P1/04 (EP); (+) A61P11/00 (EP); A61P11/06 (EP); A61P13/12 (EP); A61P17/00 (EP); A61P17/06 (EP); A61P17/08 (EP); A61P19/02 (EP); A61P21/04 (EP); A61P25/00 (EP); A61P25/28 (EP); A61P27/02 (EP); A61P29/00 (EP); A61P3/10 (EP); A61P31/18 (EP); A61P31/20 (EP); A61P31/22 (EP); A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP); A61P5/14 (EP); A61P7/00 (EP); A61P7/04 (EP); A61P7/06 (EP); A61P9/08 (EP); A61P9/10 (EP); A61P9/14 (EP); C07K16/30 (KR); C07K16/4258 (EP,US); C12N5/16 (KR); G01N33/686 (US); A61K2039/505 (EP,US); C07K2317/21 (EP,US); C07K2317/54 (EP,US); C07K2317/56 (EP,US); C07K2317/72 (EP,US); C07K2317/732 (EP,US); C07K2317/734 (EP,US); C07K2317/92 (EP,US) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2005/31]
Extension states	AL	06.05.2005
	LT	06.05.2005
	LV	06.05.2005
	MK	06.05.2005
Title	German:	HUMANE MONOKLONALE ANTIKÖRPER GEGEN CD20	[2005/31]
	English:	HUMAN MONOCLONAL ANTIBODIES AGAINST CD20	[2005/31]
	French:	ANTICORPS MONOCLONAUX HUMAINS ANTI-CD20	[2005/31]
Entry into regional phase	06.05.2005	National basic fee paid
	06.05.2005	Search fee paid
	06.05.2005	Designation fee(s) paid
	06.05.2005	Examination fee paid
Examination procedure	13.05.2004	Request for preliminary examination filed International Preliminary Examining Authority: US
	06.05.2005	Examination requested [2005/31]
	06.07.2005	Amendment by applicant (claims and/or description)
	28.04.2006	Despatch of a communication from the examining division (Time limit: M06)
	23.02.2007	Reply to a communication from the examining division
	15.02.2008	Despatch of a communication from the examining division (Time limit: M06)
	16.12.2008	Reply to a communication from the examining division
	09.12.2009	Despatch of a communication from the examining division (Time limit: M06)
	23.07.2010	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	30.09.2010	Reply to a communication from the examining division
	31.03.2011	Communication of intention to grant the patent
	27.07.2011	Fee for grant paid
	27.07.2011	Fee for publishing/printing paid
	14.09.2011	Despatch of a communication from the examining division (Time limit: M02)
	31.10.2011	Observations by third parties
	07.11.2011	Reply to a communication from the examining division
Divisional application(s)	EP10013084.8 / EP2330130
	EP10013085.5 / EP2316856
	EP17179855.6 / EP3284753
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 28.04.2006
Opposition(s)	Opponent(s)	01 11.10.2012 ADMISSIBLE Actavis Group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponents representative Neuefeind, Regina Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE
		[N/P]
	Former [2012/47]
	Opponent(s)	01 11.10.2012 ADMISSIBLE Actavis group PTC ehf Reykjavikurvegi 76-78 220 Hafnarfjördur / IS Opponents representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE
	19.11.2012	Invitation to proprietor to file observations on the notice of opposition
	22.03.2013	Reply of patent proprietor to notice(s) of opposition
	30.10.2013	Legal effect of rejection of opposition [2014/18]
	30.10.2013	Date of oral proceedings
	10.12.2013	Despatch of minutes of oral proceedings
	10.12.2013	Date of despatch of rejection of opposition
Revocation procedure	26.03.2021	Request for revocation under Article 105a
		ADMISSIBLE
	15.04.2021	Despatch of communication that patent will be revoked
	05.05.2021	Date of legal effect of revocation of patent
	26.03.2021	Fee for revocation paid
Former [2021/18]	26.03.2021	Request for revocation under Article 105a
		ADMISSIBLE
	05.05.2021	Date of legal effect of revocation of patent
	26.03.2021	Fee for revocation paid
Former [N/P]	26.03.2021	Request for revocation under Article 105a
	[2021/18]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	16.12.2008	Request for further processing filed
	16.12.2008	Full payment received (date of receipt of payment) Request granted
	09.01.2009	Decision despatched
	23.02.2007	Request for further processing filed
	23.02.2007	Full payment received (date of receipt of payment) Request granted
	07.03.2007	Decision despatched
Fees paid	Renewal fee
	12.10.2005	Renewal fee patent year 03
	12.10.2006	Renewal fee patent year 04
	12.10.2007	Renewal fee patent year 05
	31.03.2008	Renewal fee patent year 06
	13.10.2009	Renewal fee patent year 07
	12.10.2010	Renewal fee patent year 08
	11.10.2011	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	deleted
	[2013/15]
Former [2012/24]	SI	11.01.2012
Documents cited:	Search	[Y]WO9411026 (IDEC PHARMA CORP [US]) [Y] 1-40,44 * the whole document *;
		[YD]US5770429 (LONBERG NILS [US], et al) [YD] 1-44 * the whole document *;
		[Y]WO0009160 (IDEC PHARMA CORP [US], et al) [Y] 1-40,44 * the whole document *;
		[Y]US6120767 (ROBINSON RANDY R [US], et al) [Y] 1-40,44 * the whole document *;
		[XY]US2002009427 (WOLIN MAURICE J [US], et al) [X] 1-40,44 * paragraph [0050] - paragraph [0063] * * claims 1-9 * [Y] 41-43;
		[XY]WO0222212 (IDEC PHARMA CORP [US]) [X] 1-37,41-44 * the whole document * [Y] 38-40;
		[X] - GAZZANO-SANTORO H ET AL, "A non-radioactive complement-dependent cytotoxicity assay for anti-CD20 monoclonal antibody", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (19970328), vol. 202, no. 2, ISSN 0022-1759, pages 163 - 171, XP004126276 [X] 45-47 * the whole document * DOI: http://dx.doi.org/10.1016/S0022-1759(97)00002-1
		[Y] - EDWARDS J C W ET AL, "Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, (200102), vol. 40, no. 2, ISSN 1462-0324, pages 205 - 211, XP002348931 [Y] 41-43 * the whole document * DOI: http://dx.doi.org/10.1093/rheumatology/40.2.205
		[A] - VAN SPRIEL A B ET AL, "Immunotherapeutic perspective for bispecific antibodies", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (20000801), vol. 21, no. 8, ISSN 0167-5699, pages 391 - 397, XP004215167 [A] 36 * the whole document * DOI: http://dx.doi.org/10.1016/S0167-5699(00)01659-5
	International search	[Y]WO0212437 (SCHOOTEN WIM VAN [US], et al);
		[Y]US2002064823 (WELCHER ANDREW A [US], et al)
	Examination	- TEELING JESSICA L ET AL, "The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 JUL 2006, (20060701), vol. 177, no. 1, ISSN 0022-1767, pages 362 - 371
		- KLIMKA A ET AL, "Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning.", BRITISH JOURNAL OF CANCER JUL 2000, (200007), vol. 83, no. 2, ISSN 0007-0920, pages 252 - 260
		- BARBAS S M ET AL, "Human autoantibody recognition of DNA.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 28 MAR 1995, (19950328), vol. 92, no. 7, ISSN 0027-8424, pages 2529 - 2533
		- BEIBOER S H ET AL, "Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.", JOURNAL OF MOLECULAR BIOLOGY 25 FEB 2000, (20000225), vol. 296, no. 3, ISSN 0022-2836, pages 833 - 849
		- POLYMENIS M ET AL, "Critical binding site amino acids of anti-Z-DNA single chain Fv molecules. Role of heavy and light chain CDR3 and relationship to autoantibody activity.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 JUN 1994, (19940601), vol. 152, no. 11, ISSN 0022-1767, pages 5318 - 5329
		- DITZEL H J ET AL, "Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUL 1996, (19960715), vol. 157, no. 2, ISSN 0022-1767, pages 739 - 749
		- RADER C ET AL, "A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 21 JUL 1998, (19980721), vol. 95, no. 15, ISSN 0027-8424, pages 8910 - 8915
		- BARBAS SHANA M ET AL, "Recognition of DNA by synthetic antibodies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1994), vol. 116, no. 5, ISSN 0002-7863, pages 2161 - 2162
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		US2003133939
		- GRAZIANO, R.F. ET AL., J. IMMUNOL, (1995), vol. 155, no. 10, pages 4996 - 5002
		- MORTON, H.C. ET AL., CRITICAL REVIEWS IN IMMUNOLOGY, (1996), vol. 16, pages 423 - 440
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