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EP Citations: EP2710124

Cited inSearch
Type:Patent literature
Publication No.:WO0183715  [Y]
 (US GOV HEALTH & HUMAN SERV [US], et al) [Y] 1-15 * figure 1 * * the whole document * * figure 2 *;
Type:Patent literature
Publication No.:WO2011130675  [YP]
 (MCLEAN HOSPITAL CORP [US], et al) [YP] 1-15 * the whole document *;
Type:Patent literature
Publication No.:WO2010096496  [Y]
 (SLOAN KETTERING INST CANCER [US], et al) [Y] 1-15 * the whole document *;
Type:Non-patent literature
Publication information:[Y]  - CHUNG S ET AL, "Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation", JOURNAL OF NEUROCHEMISTRY, WILEY INTERSCIENCE, NEW YORK, NY, US, vol. 97, no. 5, doi:10.1111/J.1471-4159.2006.03841.X, ISSN 0022-3042, (20060601), pages 1467 - 1480, (20060428), XP008143938 [Y] 1-15 * the whole document *
DOI: http://dx.doi.org/10.1111/j.1471-4159.2006.03841.x
Type:Non-patent literature
Publication information:[Y]  - YAN YIPING ET AL, "Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, (20050601), vol. 23, no. 6, ISSN 1066-5099, pages 781 - 790, XP009087442 [Y] 1-15 * the whole document * * page 784, column l, paragraph l - column r, paragraph 1 * * page 785; figure 2 *
Type:Non-patent literature
Publication information:[Y]  - GALE EMILY ET AL, "Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells", MOLECULAR BRAIN, BIOMED CENTRAL LTD, LONDON UK, (20080930), vol. 1, no. 1, doi:10.1186/1756-6606-1-8, ISSN 1756-6606, page 8, XP021045971 [Y] 1-15 * the whole document *
DOI: http://dx.doi.org/10.1186/1756-6606-1-8
Type:Non-patent literature
Publication information:[XP]  - S. CHUNG ET AL, "ES cell-derived renewable and functional midbrain dopaminergic progenitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, US, (20110607), vol. 108, no. 23, doi:10.1073/pnas.1016443108, ISSN 0027-8424, pages 9703 - 9708, XP055101591 [XP] 1-15 * the whole document *
DOI: http://dx.doi.org/10.1073/pnas.1016443108
Cited inInternational search
Type:Patent literature
Publication No.:EP1666590  [A]
 (EISAI CO LTD [JP]);
Type:Patent literature
Publication No.:US2007128168  [A]
 (JORGENSEN JESPER R [DK], et al);
Type:Patent literature
Publication No.:RU2407790  [A]
 (NOVARTIS FORSHUNGSSTIFTUNG TSVAJGNIDERLASSUNG FRIDRIKH MISHER INST FOR BIOMEDIKAL RISECH [CH])
Cited inby applicant
Type:Patent literature
Publication No.:WO0183715  
Type:Patent literature
Publication No.:WO2011130675  
Type:Patent literature
Publication No.:WO2010096496  
Type:Patent literature
Publication No.:EP1666590  
Type:Patent literature
Publication No.:EP0301777  
Type:Patent literature
Publication No.:US4353888  
Type:Patent literature
Publication No.:US4744933  
Type:Patent literature
Publication No.:US4749620  
Type:Patent literature
Publication No.:US4814274  
Type:Patent literature
Publication No.:US5084350  
Type:Patent literature
Publication No.:US5089272  
Type:Non-patent literature
Publication information:   - YAN YIPING ET AL., STEM CELLS, (2005), vol. 23, no. 6, pages 781 - 790
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Publication information:   - AGID, Y., "Parkinson's disease: pathophysiology", LANCET, (1991), vol. 337, pages 1321 - 1324
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Publication information:   - ANDERSSON, E.R.; PRAKASH, N.; CAJANEK, L.; MININA, E.; BRYJA, V.; BRYJOVA, L.; YAMAGUCHI, T.P.; HALL, A.C.; WURST, W.; ARENAS, E., "Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo", PLOS ONE, (2008), vol. 3, page E3517
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Publication information:   - BJ6RKLUND, L.; SANCHEZ-PERNAUTE, R.; CHUNG, S.; ANDERSSON, T.; CHEN, I.; MCNAUGHT, K.; BROWNELL, A.; JENKINS, B.; WAHLESTEDT, C.;, "Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model", PROC NATL ACAD SCI USA, (2002), vol. 99, pages 2344 - 2349
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Publication information:   - CASTELO-BRANCO, G.; SOUSA, K.M.; BRYJA, V.; PINTO, L.; WAGNER, J.; ARENAS, E., "Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion", MOL CELL NEUROSCI, (2006), vol. 31, pages 251 - 262
Type:Non-patent literature
Publication information:   - CASTELO-BRANCO, G.; WAGNER, J.; RODRIGUEZ, F.J.; KELE, J.; SOUSA, K.; RAWAL, N.; PASOLLI, H.A.; FUCHS, E.; KITAJEWSKI, J.; ARENAS,, "Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a", PROC NATL ACAD SCI U S A, (2003), vol. 100, pages 12747 - 12752
Type:Non-patent literature
Publication information:   - CHUNG, S.; SONNTAG, K.C.; ANDERSSON, T.; BJORKLUND, L.M.; PARK, J.J.; KIM, D.W.; KANG, U.J.; ISACSON, O.; KIM, K.S., "Genetic engineering of mouse embryonic stem cells by Nurrl enhances differentiation and maturation into dopaminergic neurons", EUR J NEUROSCI, (2002), vol. 16, pages 1829 - 1838
Type:Non-patent literature
Publication information:   - CHUNG, S.; HEDLUND, E.; HWANG, M.; KIM, D.W.; SHIN, B.S.; HWANG, D.Y.; JUNG KANG, U.; ISACSON, O.; KIM, K.S., "The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons", MOL CELL NEUROSCI, (2005), vol. 28, pages 241 - 252
Type:Non-patent literature
Publication information:   - CHUNG, S.; SHIN, B.S.; HEDLUND, E.; PRUSZAK, J.; FERREE, A.; KANG, U.J.; ISACSON, 0.; KIM, KS., "Genetic selection of soxl GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation", J NEUROCHEM, (2006), vol. 97, pages 1467 - 1480
Type:Non-patent literature
Publication information:   - CHUNG, S.; SHIN, B.S.; HWANG, M.; LARDARO, T.; KANG, U.J.; ISACSON, O.; KIM, K.S., "Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro", STEM CELLS, (2006), vol. 24, pages 1583 - 1593
Type:Non-patent literature
Publication information:   - CHUNG, S.; LEUNG, A.; HAN, B.S.; CHANG, M.Y.; MOON, J.I.; KIM, C.H.; HONG, S.; PRUSZAK, J.; ISACSON, 0.; KIM, K.S., "Wntl-lmxla forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway", CELL STEM CELL, (2009), vol. 5, pages 646 - 658
Type:Non-patent literature
Publication information:   - ELKABETZ, Y.; PANAGIOTAKOS, G.; AL SHAMY, G.; SOCCI, N.D.; TABAR, V.; STUDER, L., "Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage", GENES DEV, (2008), vol. 22, pages 152 - 165
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Publication information:   - ERIKSEN, J.; RASMUSSEN, S.G.; RASMUSSEN, T.N.; VAEGTER, C.B.; CHA, J.H.; ZOU, M.F.; NEWMAN, A.H.; GETHER, U., "Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs", J NEUROSCI, (2009), vol. 29, pages 6794 - 6808
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Publication information:   - FASANO, C.A.; CHAMBERS, S.M.; LEE, G.; TOMISHIMA, M.J.; STUDER, L., "Efficient derivation of functional floor plate tissue from human embryonic stem cells", CELL STEM CELL, (2010), vol. 6, pages 336 - 347
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Publication information:   - HEBSGAARD, J.B.; NELANDER, J.; SABELSTROM, H.; JONSSON, M.E.; STOTT, S.; PARMAR, M., "Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics", GLIA, (2009), vol. 57, pages 1648 - 1658
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Publication information:   - HEDLUND, E.; PRUSZAK, J.; LARDARO, T.; LUDWIG, W.; VINUELA, A.; KIM, K.S.; ISACSON, O., "Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease", STEM CELLS, (2008), vol. 26, pages 1526 - 1536
Type:Non-patent literature
Publication information:   - HEMRE, K.M.; KELLER-PECK, C.R.; CAMPBELL, R.M.; PETERSON, A.C.; MULLEN, R.J.; GOLDOWITZ, D., "Annexin IV is a marker of roof and floor plate development in the murine CNS", J COMP NEUROL, (1996), vol. 368, pages 527 - 537
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Publication information:   - HOCKEMEYER D; SOLDNER F; BEARD C; GAO Q; MITALIPOVA M; DEKELVER RC; KATIBAH GE; AMORA R; BOYDSTON EA; ZEITLER B, "Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases", NAT BIOTECHNOL, (2009), vol. 27, no. 9, pages 851 - 857
Type:Non-patent literature
Publication information:   - HONG, S.; HWANG, D.Y.; YOON, S.; ISACSON, O.; RAMEZANI, A.; HAWLEY, R.G; KIM, K.S., "Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells", MOL THE, (2007), vol. 15, pages 1630 - 1639
Type:Non-patent literature
Publication information:   - HONG, S.; KANG, U.J.; ISACSON, 0; KIM, K.S., "Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons", J NEUROCHEM, (2008), vol. 104, pages 316 - 324
Type:Non-patent literature
Publication information:   - HWANG, D.Y.; ARDAYFIO, P.; KANG, U.J.; SEMINA, E.V; KIM, K.S., "Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice", BRAIN RES MOL BRAIN RES, (2003), vol. 114, pages 123 - 131
Type:Non-patent literature
Publication information:   - HWANG, D.Y.; FLEMING, S.M.; ARDAYFIO, P.; MORAN-GATES, T.; KIM, H.; TARAZI, F.I.; CHESSELET, M.F; KIM, K.S., "3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease", JNEUROSCI, (2005), vol. 25, pages 2132 - 2137
Type:Non-patent literature
Publication information:   - JOHE, K.K.; HAZEL, T.G; MULLER, T; DUGICH-DJORDJEVIC, M.M.; MCKAY, R.D, "Single factors direct the differentiation of stem cells from the fetal and adult central nervous system", GENES DEV, (1996), vol. 10, pages 3129 - 3140
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Publication information:   - KAWASAKI, H.; MIZUSEKI, K.; NISHIKAWA, S.; KANEKO, S.; KUWANA, Y.; NAKANISHI, S.; NISHIKAWA, S.I.; SASAI, Y., "Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity", NEURON, (2000), vol. 28, pages 31 - 40
Type:Non-patent literature
Publication information:   - KIM, J.H.; AUERBACH, J.M.; RODRIGUEZ-GOMEZ, J.A.; VELASCO, I.; GAVIN, D.; LUMELSKY, N.; LEE, S.H.; NGUYEN, J.; SANCHEZ-PERNAUTE, R, "Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease", NATURE, (2002), vol. 418, pages 50 - 56
Type:Non-patent literature
Publication information:   - KITAJIMA, K.; KOSHIMIZU, U.; NAKAMURA, T., "Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds", DEV DYN, (1999), vol. 215, pages 206 - 214
Type:Non-patent literature
Publication information:   - KITTAPPA, R.; CHANG, W.W.; AWATRAMANI, R.B.; MCKAY, R.D., "The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age", PLOS BIOL, (2007), vol. 5, page E325
Type:Non-patent literature
Publication information:   - KORDOWER, J.H.; BRUNDIN, P., "Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another?", NEUROPSYCHOPHARMACOLOGY, (2009), vol. 34, page 254
Type:Non-patent literature
Publication information:   - KORDOWER, J.H.; CHU, Y.; HAUSER, R.A.; FREEMAN, T.B.; OLANOW, C.W., "Lewy body-like pathology in longterm embryonic nigral transplants in Parkinson's disease", NAT MED, (2008), vol. 14, pages 504 - 506
Type:Non-patent literature
Publication information:   - LEE, S.H.; LUMELSKY, N.; STUDER, L.; AUERBACH, J.M.; MCKAY, R.D., "Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells", NAT BIOTECH, (2000), vol. 18, pages 675 - 679
Type:Non-patent literature
Publication information:   - LI, J.Y.; CHRISTOPHERSEN, N.S.; HALL, V.; SOULET, D.; BRUNDIN, P., "Critical issues of clinical human embryonic stem cell therapy for brain repair", TRENDS NEUROSCI, (2008), vol. 31, pages 146 - 153
Type:Non-patent literature
Publication information:   - LI, J.Y.; ENGLUND, E.; HOLTON, J.L.; SOULET, D.; HAGELL, P.; LEES, A.J.; LASHLEY, T.; QUINN, N.P.; REHNCRONA, S.; BJORKLUND, A. ET, "Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation", NAT MED, (2008), vol. 14, pages 501 - 503
Type:Non-patent literature
Publication information:   - LINDVALL, O.; BJORKLUND, A., "Cell therapy in Parkinson's disease", NEURORX, (2004), vol. 1, pages 382 - 393
Type:Non-patent literature
Publication information:   - LINDVALL, O.; KOKAIA, Z., "Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease", TRENDS PHARMACOL SCI, (2009), vol. 30, pages 260 - 267
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Publication information:   - MENDEZ, I.; VINUELA, A.; ASTRADSSON, A.; MUKHIDA, K.; HALLETT, P.; ROBERTSON, H.; TIERNEY, T.; HOLNESS, R.; DAGHER, A.; TROJANOWSK, "Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years", NAT MED, (2008), vol. 14, pages 507 - 509
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Publication information:   - NELANDER, J.; HEBSGAARD, J.B.; PARMAR, M., "Organization of the human embryonic ventral mesencephalon", GENE EXPR PATTERNS, (2009), vol. 9, pages 555 - 561
Type:Non-patent literature
Publication information:   - OH, M.S.; HONG, S.J.; HUH, Y.; KIM, K.S., "Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter", GENE THER, (2009), vol. 16, pages 437 - 440
Type:Non-patent literature
Publication information:   - ONO, Y.; NAKATANI, T.; SAKAMOTO, Y.; MIZUHARA, E.; MINAKI, Y.; KUMAI, M.; HAMAGUCHI, A.; NISHIMURA, M.; INOUE, Y.; HAYASHI, H. ET, "Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells", DEVELOPMENT, (2007), vol. 134, pages 3213 - 3225
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Publication information:   - PANCHISION, D.M.; CHEN, H.L.; PISTOLLATO, F.; PAPINI, D.; NI, H.T.; HAWLEY, T.S., "Optimized flow cytometric analysis of central nervous system tissue reveals novel functional relationships among cells expressing CD133, CD15, and CD24", STEM CELLS, (2007), vol. 25, pages 1560 - 1570
Type:Non-patent literature
Publication information:   - PARISH, C.L.; CASTELO-BRANCO, G.; RAWAL, N.; TONNESEN, J.; SORENSEN, A.T.; SALTO, C.; KOKAIA, M.; LINDVALL, O.; ARENAS, E., "Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice", J CLIN INVEST, (2008), vol. 118, pages 149 - 160
Type:Non-patent literature
Publication information:   - PARK CH; MINN YK; LEE JY; CHOI DH; CHANG MY; SHIM JW; KO JY; KOH HC; KANG MJ; KANG JS, "In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons", J NEUROCHEM, (200503), vol. 92, no. 5, pages 1265 - 76
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Publication information:   - PERRIER, A.L.; TABAR, V.; BARBERI, T.; RUBIO, M.E.; BRUSES, J.; TOPF, N.; HARRISON, N.L.; STUDER, L., "Derivation of midbrain dopamine neurons from human embryonic stem cells", PROC NATL ACAD SCI U S A, (2004), vol. 101, pages 12543 - 12548
Type:Non-patent literature
Publication information:   - POLITIS, M.; WU, K.; LOANE, C.; QUINN, N.P.; BROOKS, D.J.; REHNCRONA, S.; BJORKLUND, A.; LINDVALL, O.; PICCINI, P., "Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants", SCI TRANSL MED, (2010), vol. 2, page 38RA46
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Publication information:   - REZGAOUI, M.; HERMEY, G.; RIEDEL, I.B.; HAMPE, W.; SCHALLER, H.C.; HERMANS-BORGMEYER, I., "Identification of SorCS2, a novel member of the VPS 10 domain containing receptor family, prominently expressed in the developing mouse brain", MECH DEV, (2001), vol. 100, pages 335 - 338
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Publication information:   - ROY, N.S.; CLEREN, C.; SINGH, S.K.; YANG, L.; BEAL, M.F.; GOLDMAN, S.A., "Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes", NAT MED, (2006), vol. 12, pages 1259 - 1268
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Publication information:   - SANCHEZ-PERNAUTE, R.; LEE, H.; PATTERSON, M.; RESKE-NIELSEN, C.; YOSHIZAKI, T.; SONNTAG, K.C.; STUDER, L.; ISACSON, O., "Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease", BRAIN, (2008), vol. 131, pages 2127 - 2139
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Publication information:   - SCHULTE, G.; BRYJA, V.; RAWAL, N.; CASTELO-BRANCO, G.; SOUSA, K.M.; ARENAS, E., "Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation", J NEUROCHEM, (2005), vol. 92, pages 1550 - 1553
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Publication information:   - SCHULZ, T.C.; NOGGLE, S.A.; PALMARINI, G.M.; WEILER, D.A.; LYONS, I.G.; PENSA, K.A.; MEEDENIYA, A.C.; DAVIDSON, B.P.; LAMBERT, N.A, "Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture", STEM CELLS, (2004), vol. 22, pages 1218 - 1238
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Publication information:   - SHEN, Q.; GODERIE, S.K.; JIN, L.; KARANTH, N.; SUN, Y.; ABRAMOVA, N.; VINCENT, P.; PUMIGLIA, K.; TEMPLE, S., "Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells", SCIENCE, (2004), vol. 304, pages 1338 - 1340
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Publication information:   - SUMMERHURST, K.; STARK, M.; SHARPE, J.; DAVIDSON, D.; MURPHY, P., "3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Tsl9", GENE EXPR PATTERNS, (2008), vol. 8, pages 331 - 348
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Publication information:   - SVENDSEN, C., "Stem cells and Parkinson's disease: toward a treatment, not a cure", CELL STEM CELL, (2008), vol. 2, pages 412 - 413
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Publication information:   - TAKAHASHI, K.; YAMANAKA, S., "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", CELL, (2006), vol. 126, pages 663 - 676
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Publication information:   - WERNIG, M.; ZHAO, J.P.; PRUSZAK, J.; HEDLUND, E.; FU, D.; SOLDNER, F.; BROCCOLI, V.; CONSTANTINE-PATON, M.; ISACSON, 0.; JAENISCH,, "Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease", PROC NATL ACAD SCI U S A, (2008), vol. 105, pages 5856 - 5861
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Publication information:   - YE, W.; SHIMAMURA, K.; RUBENSTEIN, J.L.; HYNES, M.A.; ROSENTHAL, A., "FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate", CELL, (1998), vol. 93, pages 755 - 766
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Publication information:   - ZENG, X.; CAI, J.; CHEN, J.; LUO, Y.; YOU, Z.B.; FOTTER, E.; WANG, Y.; HARVEY, B.; MIURA, T.; BACKMAN, C. ET AL., "Dopaminergic differentiation of human embryonic stem cells", STEM CELLS, (2004), vol. 22, pages 925 - 940
Type:Non-patent literature
Publication information:   - ZHU, Q.; RUNKO, E.; IMONDI, R.; MILLIGAN, T.; KAPITULA, D.; KAPRIELIAN, Z., "New cell surface marker of the rat floor plate and notochord", DEV DYN, (1998), vol. 211, pages 314 - 326
Type:Non-patent literature
Publication information:   - ZISMAN, S.; MAROM, K.; AVRAHAM, 0.; RINSKY-HALIVNI, L.; GAI, U.; KLIGUN, G.; TZARFATY-MAJAR, V.; SUZUKI, T.; KLAR, A., "Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule", J CELL BIOL, (2007), vol. 178, pages 1237 - 1249