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Extract from the Register of European Patents

EP About this file: EP2768980

EP2768980 - COMPOSITE BIOMARKERS FOR NON-INVASIVE SCREENING, DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.04.2019
Database last updated on 28.09.2024
FormerThe patent has been granted
Status updated on  27.04.2018
FormerGrant of patent is intended
Status updated on  17.01.2018
FormerExamination is in progress
Status updated on  03.02.2017
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): IS		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
King Abdullah University of Science and Technology
4700 King Abdullah University of
Science and Technology
Thuwal 23955-6900 / SA
[2018/22]
Former [2014/35]For all designated states
King Abdullah University of Science and Technology
4700 King Abdullah University of
Science and Technology
Thuwal 23955-6900 / SA
Inventor(s)01 / MANSOUR, Hicham
3 bis Rue Khan Younes
Cite Quods
Oujda 60000 / MA
02 / INCITTI, Roberto
4700 King Abdullah University
of Science and Technology
Thuwal 23955-6900 / SA
03 / BAJIC, Vladimir
4700 King Abdullah University
of Science and Technology
Thuwal 23955-6900 / SA
 [2018/22]
Former [2014/35]01 / MANSOUR, Hicham
4700 King Abdullah University
of Science and Technology
Thuwal 23955-6900 / SA
02 / INCITTI, Roberto
4700 King Abdullah University
of Science and Technology
Thuwal 23955-6900 / SA
03 / BAJIC, Vladimir
4700 King Abdullah University
of Science and Technology
Thuwal 23955-6900 / SA
Representative(s)Feray, Valérie
Ipsilon
Le Centralis
63, avenue du Général Leclerc
92340 Bourg-la-Reine / FR
[2018/22]
Former [2014/35]Bentham, Andrew
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date12813096.016.10.2012
[2018/22]
WO2012IB02515
Priority number, dateUS201161548202P17.10.2011         Original published format: US 201161548202 P
[2014/35]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2013057581
Date:25.04.2013
Language:EN
[2013/17]
Type: A2 Application without search report 
No.:EP2768980
Date:27.08.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 25.04.2013 takes the place of the publication of the European patent application.
[2014/35]
Type: B1 Patent specification 
No.:EP2768980
Date:30.05.2018
Language:EN
[2018/22]
Search report(s)International search report - published on:EP18.07.2013
(Supplementary) European search report - dispatched on:EP27.01.2016
ClassificationIPC:C12Q1/6886
[2018/07]
CPC:
C12Q1/6886 (EP,US); C12Q1/6883 (US); C12Q2600/154 (EP,US)
Former IPC [2014/35]C12Q1/68
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/35]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERBUNDBIOMARKER FÜR NICHTINVASIVES SCREENING, DIAGNOSE UND PROGNOSE VON KOLOREKTALKARZINOM[2014/35]
English:COMPOSITE BIOMARKERS FOR NON-INVASIVE SCREENING, DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER[2014/35]
French:BIOMARQUEURS COMPOSITES POUR CRIBLAGE, DIAGNOSTIC ET PRONOSTIC NON INVASIFS DE CANCER COLORECTAL[2014/35]
Entry into regional phase16.05.2014National basic fee paid 
16.05.2014Designation fee(s) paid 
16.05.2014Examination fee paid 
Examination procedure16.05.2014Amendment by applicant (claims and/or description)
16.05.2014Examination requested  [2014/35]
27.01.2016Despatch of a communication from the examining division to which search results under Rule 164(2) EPC are annexed (Time limit: M06) [2016/09]
27.01.2016Despatch of a communication from the examining division (Time limit: M06)
27.07.2016Reply to a communication from the examining division
25.01.2017Despatch of a communication from the examining division (Time limit: M04)
23.05.2017Reply to a communication from the examining division
08.09.2017Despatch of a communication from the examining division (Time limit: M02)
07.11.2017Reply to a communication from the examining division
18.01.2018Communication of intention to grant the patent
17.04.2018Fee for grant paid
17.04.2018Fee for publishing/printing paid
17.04.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.01.2016
Opposition(s)01.03.2019No opposition filed within time limit [2019/19]
Fees paidRenewal fee
14.10.2014Renewal fee patent year 03
12.10.2015Renewal fee patent year 04
11.10.2016Renewal fee patent year 05
27.10.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.10.2012
AL30.05.2018
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
MK30.05.2018
NL30.05.2018
PL30.05.2018
PT30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IS30.09.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
[2020/33]
Former [2020/31]HU16.10.2012
AL30.05.2018
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
MK30.05.2018
NL30.05.2018
PL30.05.2018
PT30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2020/30]HU16.10.2012
AL30.05.2018
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CZ30.05.2018
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MC30.05.2018
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PT30.05.2018
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SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2020/28]AL30.05.2018
AT30.05.2018
CY30.05.2018
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DK30.05.2018
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IT30.05.2018
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LV30.05.2018
MC30.05.2018
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PL30.05.2018
PT30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2020/16]AL30.05.2018
AT30.05.2018
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CZ30.05.2018
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IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2020/08]AL30.05.2018
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
MT16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2019/51]AL30.05.2018
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2019/48]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IE16.10.2018
LU16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2019/40]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
LU16.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
Former [2019/38]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
LU16.10.2018
BE31.10.2018
Former [2019/30]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
LU16.10.2018
Former [2019/28]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/26]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/11]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SK30.05.2018
SM30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/10]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
RS30.05.2018
SE30.05.2018
SK30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/09]CY30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
RS30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/08]CY30.05.2018
DK30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
RS30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/03]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
RS30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2018/52]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
RS30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2018/51]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
RS30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
Former [2018/50]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
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Cited inInternational search[Y]WO03072821  (EPIGENOMICS AG [DE], et al) [Y] 1-31,36-43 * page 7, paragraph 2; figures 1-3; claims 1-31 * * page 20, paragraph 3; figure 4; table 6 *;
 [Y]WO2005001140  (EPIGENOMICS AG [DE], et al) [Y] 1-31,36-43 * claim 5 * * the whole document *;
 [Y]  - MUHAMMAD G KIBRIYA ET AL, "A genome-wide DNA methylation study in colorectal carcinoma", BMC MEDICAL GENOMICS, BIOMED CENTRAL LTD, LONDON UK, (20110623), vol. 4, no. 1, doi:10.1186/1755-8794-4-50, ISSN 1755-8794, page 50, XP021104259 [Y] 1-31,36-43 * the whole document * * page 10, column 2, paragraph 2 - page 11; table 1 *

DOI:   http://dx.doi.org/10.1186/1755-8794-4-50
 [Y]  - XIAO-LI XU ET AL, "Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis", WORLD J GASTROENTEROL, (20040101), vol. 10, no. 23, pages 3441 - 3454, XP055056012 [Y] 1-31,36-43 * the whole document * * page 3447, column 2 * * page 3453, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.3748/wjg.v10.i23.3441
 [Y]  - CHENG YU-WEI ET AL, "Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, (20060201), vol. 16, no. 2, doi:10.1101/GR.4181406, ISSN 1088-9051, pages 282 - 289, XP002522613 [Y] 1-31,36-43 * the whole document * * page 286 - page 287 *

DOI:   http://dx.doi.org/10.1101/gr.4181406
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DOI:   http://dx.doi.org/10.1111/j.1440-1746.2006.04137.x
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ExaminationWO2007140319
 WO2008102002
    - YOUNG-HO KIM ET AL, "Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer Identifies Genes Commonly Affected by Epigenetic Alterations", ANNALS OF SURGICAL ONCOLOGY, SPRINGER-VERLAG, NE, (20110205), vol. 18, no. 8, doi:10.1245/S10434-011-1573-Y, ISSN 1534-4681, pages 2338 - 2347, XP019926925

DOI:   http://dx.doi.org/10.1245/s10434-011-1573-y
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DOI:   http://dx.doi.org/10.1002/ijc.25951
    - GURO E LIND ET AL, "Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas", MOLECULAR CANCER, GB, (20110101), vol. 10, no. 1, doi:10.1186/gb-2008-9-9-r139, ISSN 1476-4598, page 85, XP055230547

DOI:   http://dx.doi.org/10.1186/1476-4598-10-85
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