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Extract from the Register of European Patents

EP About this file: EP2948472

EP2948472 - MFAP4 BINDING ANTIBODIES BLOCKING THE INTERACTION BETWEEN MFAP4 AND INTEGRIN RECEPTORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.03.2020
Database last updated on 28.09.2024
FormerThe patent has been granted
Status updated on  19.04.2019
FormerGrant of patent is intended
Status updated on  04.12.2018
FormerExamination is in progress
Status updated on  11.11.2016
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Syddansk Universitet
Campusvej 55
5230 Odense M / DK
[2015/49]
Inventor(s)01 / SOERENSEN, Grith Lykke
Bjoernemosevej 116
5260 Odense S / DK
02 / SCHLOSSER, Anders
Rikkesminde Allé 12
5250 Odense SV / DK
03 / HOLMSKOV, Uffe
Bjoernemosevej 116
5260 Odense S / DK
 [2019/21]
Former [2015/49]01 / SOERENSEN, Grith Lykke
Bjoernemosevej 116
5260 Odense S / DK
02 / SCHLOSSER, Anders
Campusvej 55
5230 Odense M / DK
03 / HOLMSKOV, Uffe
Bjoernemosevej 116
5260 Odense S / DK
Representative(s)Plougmann Vingtoft a/s
Strandvejen 70
2900 Hellerup / DK
[2019/21]
Former [2015/49]Plougmann & Vingtoft A/S
Rued Langgaards Vej 8
2300 Copenhagen S / DK
Application number, filing date14743707.322.01.2014
[2015/49]
WO2014DK50011
Priority number, dateDK2013007003323.01.2013         Original published format: DK 201370033
[2016/48]
Former [2015/49]DK2013007003323.01.2013
US201361755484P23.01.2013
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014114298
Date:31.07.2014
Language:EN
[2014/31]
Type: A1 Application with search report 
No.:EP2948472
Date:02.12.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 31.07.2014 takes the place of the publication of the European patent application.
[2015/49]
Type: B1 Patent specification 
No.:EP2948472
Date:22.05.2019
Language:EN
[2019/21]
Search report(s)International search report - published on:XN31.07.2014
(Supplementary) European search report - dispatched on:EP18.10.2016
ClassificationIPC:C07K16/18, A61K39/395, A61P9/14, A61P37/08, C12N5/12, C12N5/18, C12P21/08
[2015/49]
CPC:
C07K16/28 (EP,US); C07K16/18 (US); A61P37/08 (EP);
A61P9/14 (EP); C12N5/163 (EP,US); C07K2317/56 (US);
C07K2317/73 (EP,US); C07K2317/76 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/49]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MFAP4-BINDENDE ANTIKÖRPER ZUR BLOCKIERUNG DER INTERAKTION ZWISCHEN MFAP4 UND INTEGRINREZEPTOREN[2015/49]
English:MFAP4 BINDING ANTIBODIES BLOCKING THE INTERACTION BETWEEN MFAP4 AND INTEGRIN RECEPTORS[2015/49]
French:ANTICORPS LIANT MFAP4 QUI BLOQUENT L'INTERACTION ENTRE MFAP4 ET LES RÉCEPTEURS D'INTÉGRINE[2015/49]
Entry into regional phase20.08.2015National basic fee paid 
20.08.2015Search fee paid 
20.08.2015Designation fee(s) paid 
20.08.2015Examination fee paid 
Examination procedure20.08.2015Amendment by applicant (claims and/or description)
20.08.2015Examination requested  [2015/49]
04.05.2016Loss of particular rights, legal effect: Priority
21.06.2016Despatch of communication of loss of particular rights: Priority 0002
14.11.2016Despatch of a communication from the examining division (Time limit: M04)
23.03.2017Reply to a communication from the examining division
24.07.2017Despatch of a communication from the examining division (Time limit: M04)
01.12.2017Reply to a communication from the examining division
06.11.2018Cancellation of oral proceeding that was planned for 13.11.2018
13.11.2018Date of oral proceedings (cancelled)
05.12.2018Communication of intention to grant the patent
08.04.2019Fee for grant paid
08.04.2019Fee for publishing/printing paid
08.04.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.11.2016
Opposition(s)25.02.2020No opposition filed within time limit [2020/18]
Fees paidRenewal fee
27.01.2016Renewal fee patent year 03
20.01.2017Renewal fee patent year 04
26.01.2018Renewal fee patent year 05
22.01.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.01.2014
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
MK22.05.2019
MT22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
IE22.01.2020
LU22.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
[2022/31]
Former [2022/30]HU22.01.2014
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
MT22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
IE22.01.2020
LU22.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2022/27]HU22.01.2014
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
MT22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
IE22.01.2020
LU22.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2021/08]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
IE22.01.2020
LU22.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2020/51]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
LU22.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2020/46]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
LU22.01.2020
Former [2020/39]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/25]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/17]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/14]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
SM22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/12]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/11]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/10]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/09]AL22.05.2019
CZ22.05.2019
DK22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/51]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/50]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/49]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
NL22.05.2019
SE22.05.2019
NO22.08.2019
PT22.09.2019
Former [2019/48]ES22.05.2019
FI22.05.2019
LT22.05.2019
SE22.05.2019
NO22.08.2019
PT22.09.2019
Former [2019/47]ES22.05.2019
FI22.05.2019
LT22.05.2019
NO22.08.2019
Documents cited:Search[Y]WO2009103157  (UNIV HEALTH NETWORK [CA], et al) [Y] 1-6 * paragraph [00132] - paragraph [00148] *;
 [Y]  - SCHLOSSER A ET AL, "Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, BLACKWELL SCIENCE PUBL., OXFORD, GB, vol. 64, no. 2, doi:10.1111/J.1365-3083.2006.01778.X, ISSN 0300-9475, (20060801), pages 104 - 116, (20060619), XP009112813 [Y] 1-6 * page 105, column 1, paragraph 1 - page 106, column r, paragraph 3; figures 6-8 *

DOI:   http://dx.doi.org/10.1111/j.1365-3083.2006.01778.x
 [Y]  - SHINYA KASAMATSU ET AL, "Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection", SCIENTIFIC REPORTS, (20111122), vol. 1, doi:10.1038/srep00164, XP055208308 [Y] 1-6 * the whole document *

DOI:   http://dx.doi.org/10.1038/srep00164
International search[X]US6916605  (MCCAFFERTY JOHN [GB], et al);
 [Y]US7189841  (LERNER RICHARD A [US], et al);
 [X]WO2010042562  (MINERVA BIOTECHNOLOGIES CORP [US], et al);
 [A]US2011059097  (ZHANG LI [CA], et al);
 [X]US2011076284  (CORBIN JOHN [US], et al);
 [X]US7959923  (YOU LIANG [US], et al);
 [X]  - KOKUBO T. ET AL., "Integrin avb3 as a target in the prevention of neointimal hyperplasia", J VASC SURG., (2007), vol. 45, no. A, pages 33A - 38A, XP022140592

DOI:   http://dx.doi.org/10.1016/j.jvs.2007.02.069
Examination   - RUDIKOFF S ET AL, "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19820301), vol. 79, doi:10.1073/PNAS.79.6.1979, ISSN 0027-8424, pages 1979 - 1983, XP007901436

DOI:   http://dx.doi.org/10.1073/pnas.79.6.1979
    - Jefferey R Jackson, "In Vitro Antibody Maturation Improvement of a High Affinity, Neutralizing Antibody Against IL-1 beta", The journal of Immunology, (19950101), vol. 154, pages 3310 - 3319, XP055033979
    - VAJDOS F F ET AL, "Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 320, no. 2, doi:10.1016/S0022-2836(02)00264-4, ISSN 0022-2836, (20020705), pages 415 - 428, (20020705), XP027251270

DOI:   http://dx.doi.org/10.1016/S0022-2836(02)00264-4
    - YEE WAH WONG ET AL, "Structural Requirements for a Specificity Switch and for Maintenance of Affinity Using Mutational Analysis of a Phage-Displayed Anti-Arsonate Antibody of Fab Heavy Chain First Complementarity-Determining Region", THE JOURNAL OF IMMUNO, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19980101), vol. 160, ISSN 0022-1767, pages 5990 - 5997, XP007916801
    - MCKAY BROWN ET AL, "Tolerance to single, but not multiple, amino acid replacements in antibody V-H CDR2: A means of minimizing B cell wastage from somatic hypermutation?", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19960101), vol. 156, no. 9, ISSN 0022-1767, pages 3285 - 3291, XP002649029
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.