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Extract from the Register of European Patents

EP About this file: EP3018144

EP3018144 - PRLR-SPECIFIC ANTIBODY AND USES THEREOF [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  13.04.2018
Database last updated on 28.09.2024
FormerExamination is in progress
Status updated on  04.11.2016
Most recent event   Tooltip13.04.2018New entry: Date of cancellation oral proceedings 
13.04.2018Change - divisional application(s)published on 16.05.2018  [2018/20]
13.04.2018Withdrawal of applicationpublished on 16.05.2018  [2018/20]
Applicant(s)For all designated states
XOMA Technology Ltd.
2910 Seventh Street
Berkeley CA 94701 / US
For all designated states
Novartis AG
Lichtstrasse 35
4056 Basel / CH
[2016/19]
Inventor(s)01 / BEDINGER, Daniel
451 Robin Circle
Vacaville, CA 95687 / US
02 / DAMIANO, Jason
Novartis AG Intellectual Property R-338
P.O. Box 8097
Emeryville, CA 94662-8097 / US
03 / LUQMAN, Mohammad
Novartis AG Intellectual Property R-338
P.O. Box 8097
Emeryville, CA 94662-8097 / US
04 / MASAT, Linda
2728 San Antonio Drive
Walnut Creek, CA 94598 / US
05 / MIRZA, Amer
271 6th Avenue, Apt. 13
San Francisco, CA 94118 / US
06 / NONET, Genevieve
739 Grizzley Peak Blvd.
Berkeley, CA 94708 / US
 [2016/19]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2016/19]
Application number, filing date15186855.117.08.2007
[2016/19]
Priority number, dateUS20060838648P18.08.2006         Original published format: US 838648 P
US20070946360P26.06.2007         Original published format: US 946360 P
[2016/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3018144
Date:11.05.2016
Language:EN
[2016/19]
Search report(s)(Supplementary) European search report - dispatched on:EP30.03.2016
ClassificationIPC:C07K16/28, A61K39/395, A61P35/00, C12N5/18, C12N15/13, A61K31/00
[2016/19]
CPC:
C07K16/2869 (EP,US); C07K16/28 (KR); A61K39/395 (KR);
A61K39/3955 (EP,US); A61K39/39558 (US); A61K45/06 (EP,US);
A61K47/6851 (EP,US); A61P31/00 (EP); A61P35/00 (EP);
C07K16/30 (US); G01N33/53 (KR); G01N33/5308 (US);
G01N33/57492 (US); A61K2039/505 (EP,US); C07K2317/21 (EP,US);
C07K2317/24 (EP,US); C07K2317/34 (EP,US); C07K2317/52 (EP,US);
C07K2317/56 (EP,US); C07K2317/565 (EP,US); C07K2317/622 (EP,US);
C07K2317/73 (EP,US); C07K2317/732 (EP,US); C07K2317/76 (EP,US);
C07K2317/92 (EP,US); C07K2319/00 (EP,US); G01N2333/72 (US) (-)
C-Set:
A61K39/3955, A61K2300/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/51]
Former [2016/19]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL09.11.2016
BA09.11.2016
HR09.11.2016
MK09.11.2016
RS09.11.2016
TitleGerman:PRLR-SPEZIFISCHER ANTIKÖRPER UND VERWENDUNGEN DAVON[2016/19]
English:PRLR-SPECIFIC ANTIBODY AND USES THEREOF[2016/19]
French:ANTICORPS PRLR SPÉCIFIQUE ET SES UTILISATIONS[2016/19]
Examination procedure25.09.2015Examination requested  [2016/19]
26.04.2016Despatch of a communication from the examining division (Time limit: M04)
06.09.2016Reply to a communication from the examining division
25.10.2016Despatch of a communication from the examining division (Time limit: M04)
06.03.2017Reply to a communication from the examining division
10.04.2018Application withdrawn by applicant  [2018/20]
12.04.2018Cancellation of oral proceeding that was planned for 16.04.2018
16.04.2018Date of oral proceedings (cancelled)
Parent application(s)   TooltipEP07814191.8  / EP2059535
EP11190591.5  / EP2423231
Divisional application(s)EP18166185.1
Fees paidRenewal fee
25.09.2015Renewal fee patent year 03
25.09.2015Renewal fee patent year 04
25.09.2015Renewal fee patent year 05
25.09.2015Renewal fee patent year 06
25.09.2015Renewal fee patent year 07
25.09.2015Renewal fee patent year 08
25.09.2015Renewal fee patent year 09
29.08.2016Renewal fee patent year 10
28.08.2017Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO2005068503  (CHIRON CORP [US], et al)[A] 1-17;
 [XI]  - "Monoclonal Anti-human Prolactin R Antibody", (20050606), INTERNET CITATION, URL: http://www.rndsystems.com/pdf/MAB1167.pdf, (20080505), XP002479170 [X] 1-5,9-13 * the whole document * [I] 6-8,14-17
 [XI]  - HU ZHANG-ZHI ET AL, "Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11", JOURNAL OF BIOLOGICAL CHEMISTRY, (20011102), vol. 276, no. 44, ISSN 0021-9258, pages 41086 - 41094, XP002479171 [X] 1-5,9-13 * page 41087, column R, paragraph 1 * * figures 3,8,9,11 * [I] 6-8,14-17

DOI:   http://dx.doi.org/10.1074/jbc.M102109200
 [T]  - "Prolactin Receptor", INTERNET CITATION, URL: http://www.bioreagents.com/products/productDetails/productDetails.cfm?catnbr=MA1-610, (20080505), XP002479172
 [XDI]  - SISSOM J F ET AL, "ANTI-GROWTH ACTION ON MOUSE MAMMARY AND PROSTATE GLANDS OF A MONOCLONAL ANTIBODY TO PROLACTIN RECEPTOR", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, (19881201), vol. 133, no. 3, ISSN 0002-9440, pages 589 - 595, XP008068076 [XD] 1-6,9-14 * the whole document * [I] 7,8,15-17
 [XI]  - OKAMURA H ET AL, "CHARACTERIZATION AND APPLICATIONS OF MONOCLONAL ANTIBODIES TO THE PROLACTIN RECEPTOR", ENDOCRINOLOGY, ENDOCRINE SOCIETY, US, (19890101), vol. 124, no. 4, ISSN 0013-7227, pages 2499 - 2508, XP009099845 [X] 1-5,9-13 * the whole document * [I] 6-8,14-17
 [A]  - DAVIES J ET AL, "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, (19960901), vol. 2, no. 3, ISSN 1380-2933, pages 169 - 179, XP004070292 [A] 1-17 * the whole document *

DOI:   http://dx.doi.org/10.1016/S1380-2933(96)00045-0
 [A]  - HOLT L J ET AL, "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (20031101), vol. 21, no. 11, ISSN 0167-7799, pages 484 - 490, XP004467495 [A] 1-17 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tibtech.2003.08.007
 [A]  - MCKAY BROWN ET AL, "Tolerance to single, but not multiple, amino acid replacements in antibody V-H CDR2: A means of minimizing B cell wastage from somatic hypermutation?", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19960101), vol. 156, no. 9, ISSN 0022-1767, pages 3285 - 3291, XP002649029 [A] 1-17 * the whole document *
by applicantUS30985
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 US4301144
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 US4560655
 EP0171496
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 US2005136049
 US2006121604
    - BOUTIN, J.- M. ET AL., MOLEC. ENDOCR., (1989), vol. 3, pages 1455 - 1461
    - ARDEN, K. C. ET AL., CYTOGENET. CELL GENE, (1990), vol. 53, pages 161 - 165
    - ARDEN, K.C. ET AL., AM. J. HUM. GENET., (1989), vol. 45, no. A129
    - HU, Z.-Z. ET AL., J. CLIN. ENDOCR. METAB., (1999), vol. 84, pages 1153 - 1156
    - LING, C. ET AL., J. CLIN. ENDOCR. METAB., (2003), vol. 88, pages 1804 - 1808
    - PERROT-APPLANAT, M. ET AL., MOLEC. ENDOCR., (1997), vol. 11, pages 1020 - 1032
    - LI ET AL., CANCER RES., (2004), vol. 64, pages 4774 - 4782
    - GILL ET AL., J CLIN PATHOL., (2001), vol. 54, pages 956 - 960
    - TOURAINE ET AL., J CLIN ENDOCRINOL METAB., (1998), vol. 83, pages 667 - 674
    - TWOROGER ET AL., CANCER RES., (2004), vol. 64, pages 6814 - 6819
    - TWOROGER ET AL., CANCER RES., (2006), vol. 66, pages 2476 - 2482
    - WENNBO ET AL., J CLIN INVEST., (1997), vol. 100, pages 2744 - 2751
    - WENNBO ET AL., ENDOCRINOLOGY, (1997), vol. 138, pages 4410 - 4415
    - SISSOM ET AL., AM. J. PATHOL., (1988), vol. 133, pages 589 - 595
    - XU ET AL., CANCER RES., (2001), vol. 61, pages 6098 - 6104
    - SCATCHARD ET AL., ANN N.Y. ACAD. SCI., (1949), vol. 51, page 660
    - KOHLER ET AL., NATURE, (1975), vol. 256, page 495
    - ROTH, D.B.; CRAIG, N.L., CELL, (1998), vol. 94, pages 411 - 414
    - ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, no. 10, pages 1057 - 1062
    - PLUCKTHUN, The Pharmacology of Monoclonal Antibodies, SPRINGER-VERLAG, (1994), vol. 1 13, pages 269 - 315
    - CHOTHIA ET AL., J. MOL.BIOL., (1987), vol. 196, pages 901 - 917
    - GODING, Monoclonal Antibodies: Principles and Practice, ACADEMIC PRESS, (1986), pages 59 - 103
    - KOZBOR, J. IMMUNOL., (1984), vol. 133, page 3001
    - BRODEUR ET AL., Monoclonal Antibody Production Techniques and Applications, MARCEL DEKKER, INC., (1987), pages 51 - 63
    - MUNSON ET AL., ANAL. BIOCHEM., (1980), vol. 107, page 220
    - SAMBROOK ET AL., Molecular Cloning: A Laboratory Guide, COLD SPRING HARBOR PRESS, (1989), vol. 1-3
    - CATON; KOPROWSKI, PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, pages 6450 - 6454
    - SANGER, F. ET AL., PROC. NATL. ACAD. SCI. USA, (1977), vol. 74, pages 5463 - 5467
    - National Center for Biotechnology Information, National Library of Medicine, ATIONAL INSTITUTES OF HEALTH
    - 30 HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
    - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
    - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546
    - ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, pages 1057 - 62
    - OLAFSEN ET AL., PROTEIN ENG DES SEL., (200404), vol. 17, no. 4, pages 315 - 23
    - GREENBERG ET AL., NATURE, (1995), vol. 374, pages 168 - 73
    - NUTTALL ET AL., MOL IMMUNOL., (2001), vol. 38, pages 313 - 26
    - HAMERS-CASTERMAN ET AL., NATURE, (1993), vol. 363, pages 446 - 8
    - NGUYEN ET AL., J. MOL. BIOL., (1998), vol. 275, page 413
    - REICHMAN ET AL., J IMMUNOL METHODS, (1999), vol. 231, pages 25 - 38
    - DESMYTER ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 26285 - 90
    - EWERT ET AL., BIOCHEMISTRY, (2002), vol. 41, pages 3628 - 36
    - CORTEZ-RETAMOZO ET AL., CANCER RESEARCH, (2004), vol. 64, pages 2853 - 57
    - CONRATH ET AL., ANTIMICROB AGENTS CHEMOTHER, (2001), vol. 45, pages 2807 - 12
    - BIOCCA ET AL., EMBO J., (1990), vol. 9, pages 101 - 108
    - COLBY ET AL., PROC NATL ACAD SCI USA., (2004), vol. 101, pages 17616 - 21
    - MHASHILKAR ET AL., EMBO J, (1995), vol. 14, pages 1542 - 51
    - WHEELER ET AL., FASEB J., (2003), vol. 17, pages 1733 - 5
    - HENG ET AL., MED HYPOTHESES., (2005), vol. 64, pages 1105 - 8
    - BRENNAN ET AL., SCIENCE, (1985), vol. 229, page 81
    - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043
    - SKERRA ET AL., SCIENCE, (1988), vol. 240, pages 1038 - 1041
    - CARTER ET AL., BIO/TECHNOLOGY, (1992), vol. 10, pages 163 - 167
    - SHALABY ET AL., J. EXP. MED., (1992), vol. 175, pages 217 - 225
    - KOSTELNY ET AL., J. IMMUNOL., (1992), vol. 148, no. 5, pages 1547 - 1553
    - HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - GRUBER ET AL., J. IMMUNOL., (1994), vol. 152, page 5368
    - TUTT ET AL., J. IMMUNOL., (1991), vol. 147, page 60
    - NERI ET AL., J MOL BIOL., (1995), vol. 246, pages 367 - 73
    - SCHOONJANS ET AL., J IMMUNOL., (2000), vol. 165, pages 7050 - 57
    - WILLEMS ET AL., J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., (2003), vol. 786, pages 161 - 76
    - MORIMOTO ET AL., JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, (1992), vol. 24, pages 107 - 117
    - STINCHCOMB ET AL., NATURE, (1979), vol. 282, page 39
    - JONES, GENETICS, (1977), vol. 85, page 12
    - K. LACTIS; VAN DEN BERG, BIO/TECHNOLOGY, (1990), vol. 8, page 135
    - FLEER ET AL., BIO/TECHNOLOGY, (1991), vol. 9, pages 968 - 975
    - REYES ET AL., NATURE, (1982), vol. 297, pages 598 - 601
    - YANIV, NATURE, (1982), vol. 297, pages 17 - 18
    - URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, page 4216
    - GRAHAM ET AL., J. GEN VIROL., (1977), vol. 36, page 59
    - MATHER, BIOL. REPROD., (1980), vol. 23, pages 243 - 251
    - MATHER ET AL., Annals N.Y Acad. Sci., (1982), vol. 383, pages 44 - 68
    - HAM ET AL., METH. ENZ., (1979), vol. 58, page 44
    - BARNES ET AL., ANAL. BIOCHEM., (1980), vol. 102, page 255
    - ICSU SHORT REPORTS, (1990), vol. 10, page 105
    - PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 457 - 461
    - CARTER ET AL., BIOLTECHNOLOGY, (1992), vol. 10, pages 163 - 167
    - LINDMARK ET AL., J. IMMUNOL. METH, (1983), vol. 62, pages 1 - 13
    - GUSS ET AL., EMBO J., (1986), vol. 5, pages 1567 - 1575
    - MORRISON, S. L. ET AL., "Chimeric Human Antibody Molecules; Mouse Antigen Binding Domains with Human Constant Region Domains", PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 6841 - 6855
    - BOULIANNE, G. L. ET AL., NATURE, (1984), vol. 312, pages 643 - 646
    - JONES ET AL., NATURE, (1986), vol. 321, pages 522 - 525
    - MORRISON ET AL., PROC. NATL. ACAD. SCI., U.S.A., (1984), vol. 81, pages 6851 - 6855
    - MORRISON; OI, ADV. IMMUNOL., (1988), vol. 44, pages 65 - 92
    - VERHOEYER ET AL., SCIENCE, (1988), vol. 239, pages 1534 - 1536
    - PADLAN, MOLEC. IMMUN., (1991), vol. 28, pages 489 - 498
    - PADLAN, MOLEC. IMMUNOL., (1994), vol. 31, no. 3, pages 169 - 217
    - KETTLEBOROUGH, C.A. ET AL., PROTEIN ENG., (1991), vol. 4, no. 7, pages 773 - 83
    - RIECHMANN, L. ET AL., NATURE, (1988), vol. 332, page 323
    - CO, M. S. ET AL., J. IMMUNOL., (1994), vol. 152, pages 2968 - 2976
    - STUDNICKA ET AL., PROTEIN ENGINEERING, (1994), vol. 7, pages 805 - 814
    - JAKOBOVITS ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, page 2551
    - JAKOBOVITS ET AL., NATURE, (1993), vol. 362, pages 255 - 258
    - BRUGGERMANN ET AL., YEAR IN IMMUNO., (1993), vol. 7, page 33
    - FISHWILD ET AL., NAT. BIOTECHNOL., (1996), vol. 14, pages 845 - 851
    - ISHIDA ET AL., CLONING STEM CELLS., (2002), vol. 4, pages 91 - 102
    - JESPERS, L. S. ET AL., BIO/TECHNOLOGY, (1994), vol. 12, pages 899 - 903
    - HOOGENBOOM ET AL., J. MOL. BIOL., (1991), vol. 227, page 381
    - MARKS ET AL., J. MOL. BIOL, (1991), vol. 222, pages 581 - 597
    - CLACKSON, T.; WELLS, J. A., TIBTECH, (1994), vol. 12, pages 173 - 184
    - BURTON, D. R.; BARBAS III, C. F., ADV. IMMUNOL., (1994), vol. 57, pages 191 - 280
    - WINTER, G. ET AL., ANNU. REV. IMMUNOL., (1994), vol. 12, pages 433 - 455
    - WATKINS, "Screening of Phage-Expressed Antibody Libraries by Capture Lift", METHODS IN MOLECULAR BIOLOGY, ANTIBODY PHAGE DISPLAY: METHODS AND PROTOCOLS, vol. 178, pages 187 - 193
    - DAYHOFF ET AL., Atlas of Protein Sequence and Structure, (1978), vol. 5
    - FIELD ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 2159 - 2165
    - EVAN ET AL., MOL. CELL. BIOL., (1985), vol. 5, no. 12, pages 3610 - 3616
    - PABORSKY ET AL., PROTEIN ENGINEERING, (1990), vol. 3, no. 6, pages 547 - 553
    - LOW ET AL., J. MOL. BIOL., (1996), vol. 260, pages 359 - 68
    - NISHIMIYA ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 12813 - 20
    - CHOWDHURY, P. S., METHODS MOL. BIOL., (2002), vol. 178, pages 269 - 85
    - RAJPAL ET AL., PROC NATL ACAD SCI U S A., (2005), vol. 102, pages 8466 - 71
    - HULS ET AL., CANCER IMMUNOL IMMUNOTHER., (2001), vol. 50, pages 163 - 71
    - DAUGHERTY ET AL., PROC NATL ACAD SCI USA., (2000), vol. 97, pages 2029 - 34
    - RAJPAL ET AL., PROC NATL ACAD SCI USA., (2005), vol. 102, pages 8466 - 71
    - ZACCOLO ET AL., J. MOL. BIOL., (1999), vol. 285, pages 775 - 783
    - HAWKINS ET AL., J MOL BIOL., (1992), vol. 226, pages 889 - 96
    - STEMMER, PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 10747 - 51
    - CUNNINGHAM; WELLS, SCIENCE, (1989), vol. 244, pages 1081 - 1085
    - CARON ET AL., J. EXP MED., (1992), vol. 176, pages 1191 - 1195
    - SHOPES, B., J. IMMUNOL., (1992), vol. 148, pages 2918 - 2922
    - WOLFF ET AL., CANCER RESEARCH, (1993), vol. 53, pages 2560 - 2565
    - STEVENSON ET AL., ANTI-CANCER DRUG DESIGN, (1989), vol. 3, pages 219 - 230
    - STEPLEWSKI ET AL., PROC NATL ACAD SCI USA., (1988), vol. 85, no. 13, pages 4852 - 6
    - MOLEC. IMMUNOL., (1992), vol. 29, no. 5, pages 633 - 9
    - SHIELDS ET AL., J. BIOL. CHEM., (2001), vol. 276, no. 9, pages 6591 - 6604
    - PRESTA ET AL., BIOCHEM. SOC. TRANS., (2001), vol. 30, pages 487 - 490
    - CHAPPEL ET AL., PROC NATL ACAD SCI USA., (1991), vol. 88, no. 20, pages 9036 - 40
    - ISAACS ET AL., J IMMUNOL., (1998), vol. 161, no. 8, pages 3862 - 9
    - ARMOUR ET AL., MOL IMMUNOL., (2003), vol. 40, no. 9, pages 585 - 93
    - XU ET AL., J BIOL CHEM., (1994), vol. 269, no. 5, pages 3469 - 74
    - SCHUURMAN ET AL., MOL IMMUNOL., (2001), vol. 38, no. 1, pages 1 - 8
    - ANGAL ET AL., MOL IMMUNOL., (1993), vol. 30, no. 1, pages 105 - 8
    - YAMANE-OHNUKI ET AL., BIOTECHNOL BIOENG., (20040905), vol. 87, no. 5, pages 614 - 22
    - ROTHMAN ET AL., MOL IMMUNOL., (198912), vol. 26, no. 12, pages 1113 - 23
    - SHIELDS ET AL., J BIOL CHEM., (20020726), vol. 277, no. 30, pages 26733 - 40
    - SHINKAWA ET AL., J BIOL CHEM., (20030131), vol. 278, no. 5, pages 3466 - 73
    - UMANA ET AL., NAT BIOTECHNOL., (199902), vol. 17, no. 2, pages 176 - 80
    - T. E. CREIGHTON, Proteins: Structure and Molecular Properties, W.H. FREEMAN & CO., (1983), pages 79 - 86
    - APLIN; WRISTON, CRC CRIT. REV. BIOCHEM., (1981), pages 259 - 306
    - HAKIMUDDIN ET AL., ARCH. BIOCHEM. BIOPHYS., (1987), vol. 259, page 52
    - EDGE ET AL., ANAL. BIOCHEM., (1981), vol. 118, page 131
    - THOTAKURA ET AL., METH. ENZYMOL., (1987), vol. 138, page 350
    - FELGNER ET AL., PROC. NATL. ACAD. SCI. USA, (1987), vol. 84, pages 7413 - 7417
    - MALONE ET AL., PROC. NATL ACAD. SCI. USA, (1989), vol. 86, pages 6077 - 6081
    - ITO ET AL., BIOCHEM. BIOPHYS. ACTA, (1990), vol. 1023, pages 124 - 132
    - J. P. BEHR, TETRAHEDRON LETT., (1986), vol. 27, pages 5861 - 5864
    - J. P. BEHR ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 6982 - 6986
    - LEVENTIS ET AL., BIOCHIM. INTER., (1990), vol. 22, pages 235 - 241
    - GAO ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 1065, pages 8 - 14
    - BEHR ET AL., BIOCONJUGATE CHEM, (1994), vol. 5, pages 382 - 389
    - ZHOU ET AL., BIOCHIM. BIOPHYS. ACTA, (1991), vol. 939, pages 8 - 18
    - BALLAS ET AL., BIOCHIM. BIOPHYS. ACTA, (1988), vol. 939, pages 8 - 18
    - PINNADUWAGE ET AL., BIOCHIM. BIOPHYS. ACTA, (1989), vol. 985, pages 33 - 37
    - ROSE ET AL., BIOTECHNIQUE, (1991), vol. 10, pages 520 - 525
    - OHMORI N I ET AL., BIOCHEM BIOPHYS RES COMMUN, (19970627), vol. 235, no. 3, pages 726 - 9
    - POLLARD H ET AL., J BIOL CHEM, (1998), vol. 273, no. 13, pages 7507 - 11
    - LETSINGER, R. L., PROC NATL ACAD SCI USA, (1989), vol. 86, no. 17, pages 6553 - 6
    - FRIEDMANN, SCIENCE, (1989), vol. 244, pages 1275 - 1281
    - ANDERSON, NATURE, (1998), vol. 392, no. 6679, pages 25 - 30
    - VERMA, SCIENTIFIC AMERICAN, (1990), pages 68 - 84
    - MILLER, NATURE, (1992), vol. 357, pages 455 - 460
    - CHAMPE ET AL., J. BIOL. CHEM., (1995), vol. 270, pages 1388 - 1394
    - WILMAN, "Prodrugs in Cancer Chemotherapy", BIOCHEMICAL SOCIETY TRANSACTIONS, (1986), vol. 14, pages 375 - 382
    - "Prodrugs: A Chemical Approach to Targeted Drug Delivery", STELLA ET AL., Directed Drug Delivery, HUMANA PRESS, (1985), pages 247 - 267
    - EPSTEIN ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, page 3688
    - HWANG ET AL., PROC. NATL ACAD. SCI. USA, (1980), vol. 77, page 4030
    - MARTIN ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 286 - 288
    - GABIZON ET AL., J. NATIONAL CANCER INST., (1989), vol. 81, no. 19, page 1484
    - STERNBERGER, L.A. ET AL., J. HISTOCHEM. CYTOCHEM., (1970), vol. 18, page 315
    - BAYER, E.A. ET AL., METH. ENZYM., (1979), vol. 62, page 308
    - ENGVAL, E. ET AL., IMMUNOL., (1972), vol. 109, page 129
    - GODING, J.W., J. IMMUNOL. METH., (1976), vol. 13, page 215
    - SHIH ET AL., INT. J. CANCER, (1988), vol. 41, pages 832 - 839
    - SHIH ET AL., INT. J. CANCER, (1990), vol. 46, pages 1101 - 1106
    - YU ET AL., INT. J. CANCER, (1994), vol. 56, page 244
    - "Modification of Antibodies by Chemical Methods", UPESLACIS ET AL., Monoclonal Antibodies: Principles and Applications, WILEY-LISS, INC., (1995), pages 187 - 230
    - "Production and Characterization of Synthetic Peptide-Derived Antibodies", PRICE ET AL., Monoclonal Antibodies: Production, Enineering and Clinical Application, CAMBRIDGE UNIVERSITY PRESS, (1995), pages 60 - 84
    - BOLETI ET AL., ANN. ONCOL., (1995), vol. 6, page 945
    - NICOLET ET AL., CANCER GENE THER., (1995), vol. 2, page 161
    - BECKER ET AL., PROC. NAT'L ACAD. SCI. USA, (1996), vol. 93, page 7826
    - HANK ET AL., CLIN. CANCER RES., (1996), vol. 2, page 1951
    - HU ET AL., CANCER RES., (1996), vol. 56, page 4998
    - VITETTA ET AL., SCIENCE, (1987), vol. 238, page 1098
    - LEUNG ET AL., J. IMMUNOL., (1995), vol. 154, page 5919
    - YANG ET AL., HUM. ANTIBODIES HYBRIDOMAS, (1995), vol. 6, page 129
    - CHAUDHARY ET AL., NATURE, (1989), vol. 339, page 394
    - BRINKMANN ET AL., PROC. NAT'L ACAD. SCI. USA, (1991), vol. 88, page 8616
    - BATRA ET AL., PROC. NAT'L ACAD. SCI. USA, (1992), vol. 89, page 5867
    - FRIEDMAN ET AL., J. IMMUNOL., (1993), vol. 150, page 3054
    - WELS ET AL., INT. J. CAN., (1995), vol. 60, page 137
    - FOMINAYA ET AL., J. BIOL. CHEM., (1996), vol. 271, page 10560
    - KUAN ET AL., BIOCHEMISTRY, (1996), vol. 35, page 2872
    - SCHMIDT ET AL., INT. J. CAN., (1996), vol. 65, page 538
    - KREITMAN ET AL., LEUKEMIA, (1993), vol. 7, page 553
    - NICHOLLS ET AL., J. BIOL. CHEM., (1993), vol. 268, page 5302
    - THOMPSON ET AL., J. BIOL. CHEM., (1995), vol. 270, page 28037
    - VALLERA ET AL., BLOOD, (1996), vol. 88, page 2342
    - DEONARAIN ET AL., TUMOR TARGETING, (1995), vol. 1, page 177
    - LINARDOU ET AL., CELL BIOPHYS., (1994), vol. 24-25, page 243
    - DOHLSTEN ET AL., PROC. NAT'L ACAD. SCI. USA, (1994), vol. 91, page 8945
    - PASTAN ET AL., CELL, (1986), vol. 47, page 641
    - GOLDENBERG, CA, A CANCER JOURNAL FOR CLINICIANS, (1994), vol. 44, page 43
    - MASSEY, NATURE, (1987), vol. 328, pages 457 - 458
    - NEUBERGER ET AL., NATURE, (1984), vol. 312, pages 604 - 608
    - ZOLA, Monoclonal Antibodies: A Manual of Techniques, CRC PRESS, INC., (1987), pages 147 - 158
    - MARKS ET AL., METHODS MOL BIOL., (2004), vol. 248, pages 161 - 76
    - METHODS MOL BIOL., (2004), vol. 248, pages 161 - 76
    - SWARTZMAN ET AL., ANAL BIOCHEM., (1999), vol. 271, pages 143 - 51
    - FREDERICKS ET AL., PROTEIN ENG DES SEL., (200401), vol. 1 7, no. 1, pages 95 - 106
    - POWERS ET AL., J IMMUNOL METHODS, (20010501), vol. 251, no. 1-2, pages 123 - 35
    - SHU ET AL., PROC. NAT. ACAD. SCI. USA, (1993), vol. 90, pages 7995 - 7998
    - KABAT, J. IMMUNOL., (1980), vol. 125, pages 961 - 969
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