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Extract from the Register of European Patents

EP About this file: EP0888302

EP0888302 - N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL -2(S)-ACETYLAMINO-BETA-ALANINE AS FIBRINOGEN RECEPTOR ANTAGONIST [Right-click to bookmark this link]
Former [1999/01]N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL]-2(S)-ACETYLAMINO-BETA-ALANINE AS FIBRINOGEN RECEPTOR ANTAGONIST
[2007/46]
StatusThe application is deemed to be withdrawn
Status updated on  22.11.2002
Database last updated on 25.09.2024
Most recent event   Tooltip12.10.2007Change - German titlepublished on 14.11.2007  [2007/46]
Applicant(s)For all designated states
FUJISAWA PHARMACEUTICAL CO., LTD.
4-7, Doshomachi 3-chome Chuo-ku Osaka-shi
Osaka 541-8514 / JP
[N/P]
Former [1999/01]For all designated states
FUJISAWA PHARMACEUTICAL CO., LTD.
4-7, Doshomachi 3-chome Chuo-ku
Osaka-shi Osaka 541-8514 / JP
Inventor(s)01 / OHKUBO, Mitsuru
5-1-65, Fushimidai, Inagawa-cho
Kawabe-gun, Hyogo 666-02 / JP
02 / TAKAHASHI, Fumie
3-4-29, Hishiyanishi
Higashiosaka-shi, Osaka 577 / JP
03 / YAMANAKA, Toshio
1-4-5, Akagawa, Asahi-ku
Osaka-shi, Osaka 535 / JP
04 / KATO, Masayuki
6-16-12, Goryo-oeyamacho, Nishikyo-ku
Kyoto-shi, Kyoto 610-11 / JP
[1999/01]
Representative(s)Gille Hrabal Partnerschaftsgesellschaft mbB Patentanwälte
Brucknerstraße 20
40593 Düsseldorf / DE
[N/P]
Former [1999/01]Türk, Gille, Hrabal
Brucknerstrasse 20
40593 Düsseldorf / DE
Application number, filing date97907277.412.03.1997
[1999/01]
WO1997JP00769
Priority number, dateZA1996000203313.03.1996         Original published format: ZA 9602033
[1999/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9733869
Date:18.09.1997
Language:EN
[1997/40]
Type: A1 Application with search report 
No.:EP0888302
Date:07.01.1999
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.1997 takes the place of the publication of the European patent application.
[1999/01]
Search report(s)International search report - published on:EP18.09.1997
ClassificationIPC:C07D211/42, A61K31/455
[1999/01]
CPC:
C07D211/60 (EP,KR); A61K31/445 (KR); A61P7/00 (EP);
A61P7/02 (EP)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   NL,   PT,   SE [1999/01]
TitleGerman:N-(R)-1-3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL -2(S)-ACETYLAMINO-BETA-ALANIN UND SEINE ANWENDUNG ALS FIBRINOGEN-REZEPTOR-ANTAGONIST[2007/46]
English:N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL -2(S)-ACETYLAMINO-BETA-ALANINE AS FIBRINOGEN RECEPTOR ANTAGONIST[2007/46]
French:N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL -2(S)-ACETYLAMINO-BETA-ALANINE UTILISEE COMME ANTAGONISTE DU RECEPTEUR DU FIBRINOGENE[2007/46]
Former [1999/01]N-(R)-1-3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL]-2(S)-ACETYLAMINO-BETA-ALANIN UND SEINE ANWENDUNG ALS FIBRINOGEN-REZEPTOR-ANTAGONIST
Former [1999/01]N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL]-2(S)-ACETYLAMINO-BETA-ALANINE AS FIBRINOGEN RECEPTOR ANTAGONIST
Former [1999/01]N- (R)-1- 3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL]-2(S)-ACETYLAMINO-BETA-ALANINE UTILISEE COMME ANTAGONISTE DU RECEPTEUR DU FIBRINOGENE
Entry into regional phase14.08.1998National basic fee paid 
14.08.1998Designation fee(s) paid 
14.08.1998Examination fee paid 
Examination procedure28.08.1997Request for preliminary examination filed
International Preliminary Examining Authority: EP
14.08.1998Examination requested  [1999/01]
19.02.2002Despatch of a communication from the examining division (Time limit: M04)
02.07.2002Application deemed to be withdrawn, date of legal effect  [2003/02]
05.08.2002Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2003/02]
Fees paidRenewal fee
14.04.1999Renewal fee patent year 03
13.03.2000Renewal fee patent year 04
16.03.2001Renewal fee patent year 05
13.03.2002Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
01.04.199903   M06   Fee paid on   14.04.1999
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Cited inInternational search[PX]WO9629309  (FUJISAWA PHARMACEUTICAL CO [JP], et al) [PX] 1-6 * example 146; claims 1,11-15 *;
 [X]WO9508536  (FUJISAWA PHARMACEUTICAL CO [JP], et al) [X] 1-6 * Example 26(6) *;; claims 1,13-17 *;
 [DY]EP0445796  (HOFFMANN LA ROCHE [CH]) [DY] 1-6 * entire document *;
 [DY]EP0512831  (MERCK & CO INC [US]) [DY] 1-6 * entire document *;
 [Y]WO9525091  (ORTHO PHARMA CORP [US]) [Y] 1-6 * example 8; claim 1 *;
 [Y]WO9511228  (SUMITOMO PHARMA [JP], et al) [Y] 1-6 * entire document *;
 [Y]  - W. J. HOEKSTRA ET AL., "Solid-phase parallel synthesis applied to lead optimization: discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042", BIOORG. MED. CHEM. LETT., (1996), vol. 6, no. 20, pages 2371 - 2376, XP000572765 [Y] 1-6 * compound of formula 1, 17, 18 *;; table 1 *

DOI:   http://dx.doi.org/10.1021/jm00010a002
 [Y]  - W. J. HOEKSTRA ET AL., "Design and Evaluation of Nonpeptide Fibrinogen gamma-Chain Based GPIIb/IIIa Antagonists", J. MED. CHEM., (1995), vol. 38, no. 10, pages 1582 - 1592, XP000572765 [Y] 1-6 * compound of formula 25 *;; table 2 *

DOI:   http://dx.doi.org/10.1021/jm00010a002
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