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Extract from the Register of European Patents

EP About this file: EP1254178

EP1254178 - SYNTHESIS OF A POTENT PARAMAGNETIC AGONIST (EPM-3) OF THE MELANOCYTE STIMULATING HORMONE CONTAINING AMINO ACID-TYPE STABLE FREE RADICAL [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 16.06.2006 Database last updated on 23.04.2024
Most recent event Tooltip	16.06.2006	Application deemed to be withdrawn	published on 19.07.2006 [2006/29]
Applicant(s)	For all designated states Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPQ Avenida W3 Norte Quadra 507/B, Bloco B, Edificio CNPq, SEPN CEP-70741-901 Brasilia, DF / BR
	[N/P]
Former [2002/45]	For all designated states Conselho Nacional de Desenvolvimento Cientifico e Technologico - CNPQ Avenida W3 Norte Quadra 507/B, Bloco B, Edificio CNPq, SEPN CEP-70741-901 Brasilia, DF / BR
Inventor(s)	01 / RYUICHI NAKAIE, Clovis Rua 3 de maio 100 CEP-04044-020 Sao Paulo, SP / BR
	02 / DOS REIS BARBOSA, Simone Rua 3 de maio 100 CEP-04044-020 Sao Paulo, SP / BR
	03 / MAFFUD CILLI, Eduardo Rua 3 de maio 100 CEP-04004-020 Sao Paulo, SP / BR
	04 / LAMY-FREUND, Maria, Tereza, Cidade Universitaria Dept. De Fisica CEP-66318 Sao Paulo, SP / BR
	05 / ITO SIUITI, Amando, Cidade Universitaria Dept. de Fisica CEP-66318 Sao Paulo, SP / BR
	06 / VISCONTI, Maria, Aparecida, Cidade Universitaria Dept. de Fisiologia CEP-11176 Sao Paulo, SP / BR
	07 / DE LAURO CASTRUCCI, Ana Maria, Cidade Universitaria Dept. de Fisiologia CEP-11176 Sao Paulo, SP / BR
	[2003/03]
Former [2002/45]	01 / RYUICHI NAKAIE, Clovis Rua 3 de maio 100 CEP-04044-020 Sao Paulo, SP / BR
	02 / DOS REIS BARBOSA, Simone Rua 3 de maio 100 CEP-04044-020 Sao Paulo, SP / BR
	03 / MAFFUD CILLI, Eduardo Rua 3 de maio 100 CEP-04004-020 Sao Paulo, SP / BR
	04 / LAMY-FREUND, Maria, Tereza, Cidade Universitaria Dept. De Fisica CEP-66318 Sao Paulo, SP / BR
	05 / ITO SIUITI, Amando, Cidade Universitaria Dept. de Fisica CEP-66318 Sao Paulo, SP / BR
	06 / VISCONTI, Maria, Aparecida, Cidade Universitaria Dept. de Fisiologia CEP-11176 Sao Paulo, SP / BR
	07 / DE LEME CASTRUCCI, Ana Maria, Cidade Universitaria Dept. de Fisiologia CEP-11176 Sao Paulo, SP / BR
Representative(s)	Barendregt, Frank, et al Exter Polak & Charlouis B.V. (EP&C) P.O. Box 3241 2280 GE Rijswijk / NL
	[N/P]
Former [2004/16]	Barendregt, Frank, Drs., et al Exter Polak & Charlouis B.V., P.O. Box 3241 2280 GE Rijswijk / NL
Former [2002/45]	van der Kloet-Dorleijn, G.W.F. Exter Polak & Charlouis B.V. P.O. Box 3241 2280 GE Rijswijk / NL
Application number, filing date	00989769.5	22.12.2000
	[2002/45]
	WO2000BR00161
Priority number, date	BR19999906090	22.12.1999 Original published format: BR 9906090
	[2002/45]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO0146217
	Date:	28.06.2001
	Language:	EN
	[2001/26]
	Type:	A2 Application without search report
	No.:	EP1254178
	Date:	06.11.2002
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 28.06.2001 takes the place of the publication of the European patent application.
	[2002/45]
Search report(s)	International search report - published on:	US	17.01.2002
	(Supplementary) European search report - dispatched on:	EP	29.06.2004
Classification	IPC:	C07K14/685, G01N33/532, G01N33/543	[2004/33]
	CPC:	C07K14/685 (EP,US)
	Former IPC [2002/45]	C07K16/00, C07K1/04, C07K1/06
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2002/45]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	SYNTHESE EINES POTENTEN PARAMAGNETISCHEN AGONISTEN (EPM-3) DES MELANOCYTEN STIMULIERENDEN HORMONS BEINHALTEND EINE AMINOSÄUREN-ÄHNLICHES STABILES FREIES RADIKAL	[2002/45]
	English:	SYNTHESIS OF A POTENT PARAMAGNETIC AGONIST (EPM-3) OF THE MELANOCYTE STIMULATING HORMONE CONTAINING AMINO ACID-TYPE STABLE FREE RADICAL	[2002/45]
	French:	SYNTHESE D'UN PUISSANT AGONISTE PARAMAGNETIQUE (EPM-3) DE L'HORMONE STIMULATRICE DU MELANOCYTE $g(a) CONTENANT UN RADICAL LIBRE STABLE DU TYPE ACIDE AMINE	[2002/45]
Entry into regional phase	22.07.2002	National basic fee paid
	22.07.2002	Search fee paid
	22.07.2002	Designation fee(s) paid
	22.07.2002	Examination fee paid
Examination procedure	03.07.2001	Request for preliminary examination filed International Preliminary Examining Authority: US
	22.07.2002	Examination requested [2002/45]
	11.07.2005	Despatch of a communication from the examining division (Time limit: M06)
	22.01.2006	Application deemed to be withdrawn, date of legal effect [2006/29]
	24.02.2006	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2006/29]
Fees paid	Renewal fee
	02.06.2003	Renewal fee patent year 03
	23.12.2003	Renewal fee patent year 04
	07.01.2005	Renewal fee patent year 05
	Penalty fee
	Additional fee for renewal fee
	31.12.2002	03 M06 Fee paid on 02.06.2003
	31.12.2004	05 M06 Fee paid on 28.01.2005
	31.12.2005	06 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[PX]WO0049867 (CONSELHO NACIONAL DE DESENVOLV [BR], et al) [PX] 1-8 * the whole document *;
		[A] - AHMED A R H ET AL, "ISOLATION AND PARTIAL PURIFICATION OF A MELANOCYTE-STIMULATING HORMONE RECEPTOR FROM B16 MURINE MELANOMA CELLS A NOVEL APPROACH USING A CLEAVABLE BIOTINYLATED PHOTOACTIVATED LIGAND AND STREPTAVIDIN-COATED MAGNETIC BEADS", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, (1992), vol. 286, ISSN 0264-6021, pages 377 - 382, XP001033867 [A] 1-8 * Experimental *
		[A] - BIAGGI, MARCIA H. ET AL, "Melanotropic peptides-lipid bilayer interaction. Comparison of the hormone.alpha.-MSH to a biologically more potent analog", BIOPHYSICAL CHEMISTRY (1997), 67(1-3), 139-149, (1997), XP002283017 [A] 1-8 * Abstract, whole document * DOI: http://dx.doi.org/10.1016/S0301-4622(97)00030-6
		[T] - NAKAIE, C. R. ET AL, "Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs", PEPTIDES (NEW YORK, NY, UNITED STATES) (2002), 23(1), 65-70, (2002), XP002282957 [T] 1-8 * abstract * DOI: http://dx.doi.org/10.1016/S0196-9781(01)00580-0
		[T] - NAKAIE^A C R ET AL, "Comparative EPR and fluorescence conformational studies of fully active spin-labeled melanotropic peptides", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20010525), vol. 497, no. 2-3, ISSN 0014-5793, pages 103 - 107, XP004250048 [T] 1-8 * the whole document * DOI: http://dx.doi.org/10.1016/S0014-5793(01)02449-8
	International search	[X] - BARBOSA ET AL., "First synthesis of a fully active spin-labeled peptide hormone", FEBS LETTERS, (199903), vol. 446, pages 45 - 48, XP002942689 DOI: http://dx.doi.org/10.1016/S0014-5793(99)00172-6
		[A] - MARCHETTO ET AL., "A novel spin-labeled amino acid derivative for use in peptide synthesis: (9-Fluroenylmethyloxycarbonyl)-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid", J. AM. CHEM. SOC., (1993), vol. 115, pages 11042 - 11043, XP002942688 DOI: http://dx.doi.org/10.1021/ja00076a093

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