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Extract from the Register of European Patents

About this file: EP1524321

EP1524321 - Non-invasive detection of fetal genetic traits [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  20.06.2014
Database last updated on 21.09.2019
Most recent event   Tooltip17.04.2015Change - lapse in a contracting state
New state(s): CY, TR		published on 20.05.2015  [2015/21]
Applicant(s)For all designated states
SEQUENOM, INC.
3595 John Hopkins Court San Diego
California 92121 / US
[2008/30]
Former [2005/16]For all designated states
Hahn, Sinuhe, Dr.
Weidweg 39
4410 Liestal / CH
For all designated states
Zimmermann, Bernhard
Vogesenstrasse 87
4056 Basel / CH
For all designated states
Holzgreve, Wolfgang, Prof.
Münsterplatz 2
4051 Basel / CH
For all designated states
Li, Ying
Appenzellerstrasse 21
4055 Basel / CH
Inventor(s)01 / Hahn, Sinuhe, Dr.
Weidweg 39
4410 Liestal / CH
02 / Zimmermann, Bernhard
1662 Lodi Ave
San Mateo, CA 94401 / US
03 / Holzgreve, Wolfgang, Prof.
Münsterplatz 2
4051 Basel / CH
04 / Li, Ying
Brühlstrasse 127
4500 Solothurn / CH
 [2009/11]
Former [2009/04]01 / Hahn, Sinuhe, Dr.
Weidweg 39
4410 Liestal / CH
02 / Zimmermann, Bernhard
Vogesenstrasse 87
4056 Basel / CH
03 / Holzgreve, Wolfgang, Prof.
Münsterplatz 2
4051 Basel / CH
04 / Li, Ying
Appenzellerstrasse 21
4055 Basel / CH
Former [2005/16]01 / see applicant
...
Representative(s)Jaenichen, Hans-Rainer , et al
Vossius & Partner
Postfach 86 07 67
81634 München / DE
[2014/30]
Former [2010/43]Jaenichen, Hans-Rainer , et al
Vossius & Partner Postfach 86 07 67
81634 München / DE
Former [2005/16]Eder, Carl E.
Braunpat Braun Eder AG Patent - Marken - Rechtsanwälte Reussstrasse 22 Postfach
4015 Basel / CH
Application number, filing date03405742.216.10.2003
[2005/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1524321
Date:20.04.2005
Language:EN
[2005/16]
Type: B1 Patent specification 
No.:EP1524321
Date:01.07.2009
Language:EN
[2009/27]
Type: B2 New European patent specification 
No.:EP1524321
Date:23.07.2014
Language:EN
[2014/30]
Search report(s)(Supplementary) European search report - dispatched on:EP15.03.2004
ClassificationInternational:C12Q1/68
[2005/16]
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2006/03]
Former [2006/02]
Former [2005/16]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Nicht invasiver Nachweis fötaler genetischer Merkmale[2009/02]
English:Non-invasive detection of fetal genetic traits[2005/16]
French:Détection non invasive de traits génétiques létaux[2005/16]
Former [2005/16]Nicht invasiver Nachweis fötales genetischer Merkmale
Examination procedure17.10.2005Examination requested  [2006/03]
19.10.2005Amendment by applicant (claims and/or description)
27.12.2005Despatch of a communication from the examining division (Time limit: M06)
27.05.2006Reply to a communication from the examining division
19.01.2009Communication of intention to grant the patent
20.05.2009Fee for grant paid
20.05.2009Fee for publishing/printing paid
Divisional application(s)EP09011315.0   Application deemed to be withdrawn  : 02.09.2009
Opposition(s)Opponent(s)01  01.04.2010  20.04.2010  ADMISSIBLE
Fluidigm Corporation
7000 Shoreline Court, Suite 100
South San Francisco, CA 94080 / US
Opponent's representative
Wilkinson, Marc George
Avidity IP
Broers Building
Hauser Forum
21 JJ Thomson Ave
Cambridge CB3 0FA / GB
 [N/P]
Former [2013/15]
Opponent(s)01  01.04.2010  20.04.2010  ADMISSIBLE
Fluidigm Corporation
7000 Shoreline Court, Suite 100
South San Francisco, CA 94080 / US
Opponent's representative
Wilkinson, Marc George
Avidity IP
Kestrel House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Former [2010/19]
Opponent(s)01  01.04.2010   
Fluidigm Corporation
7000 Shoreline Court, Suite 100
South San Francisco, CA 94080 / US
Opponent's representative
Broughton, Jon Philip
HLBBshaw Ltd Merlin House Falconry Court Baker's Lane Epping
Essex CM16 5DQ / GB
10.05.2010Invitation to proprietor to file observations on the notice of opposition
22.11.2010Reply of patent proprietor to notice(s) of opposition
06.06.2013Legal effect of interlocutory decision in opposition
06.06.2013Date of oral proceedings
02.10.2013Despatch of interlocutory decision in opposition
02.10.2013Despatch of minutes of oral proceedings
25.02.2014Despatch of communication that the patent will be maintained as amended
08.05.2014Fee for printing new specification paid
Fees paidRenewal fee
26.10.2005Renewal fee patent year 03
24.01.2007Renewal fee patent year 04
08.04.2008Renewal fee patent year 05
14.10.2008Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.10.200604   M06   Fee paid on   24.01.2007
31.10.200705   M06   Fee paid on   08.04.2008
Lapses during opposition  TooltipAT01.07.2009
BE01.07.2009
CY01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
IT01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
TR01.07.2009
BG01.10.2009
GR02.10.2009
ES12.10.2009
LU16.10.2009
MC31.10.2009
PT02.11.2009
HU02.01.2010
[2015/21]
Former [2011/31]AT01.07.2009
BE01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
IT01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
GR02.10.2009
ES12.10.2009
LU16.10.2009
MC31.10.2009
PT02.11.2009
HU02.01.2010
Former [2011/21]AT01.07.2009
BE01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
IT01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
GR02.10.2009
ES12.10.2009
LU16.10.2009
MC31.10.2009
PT02.11.2009
Former [2011/14]AT01.07.2009
BE01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
IT01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
GR02.10.2009
ES12.10.2009
MC31.10.2009
PT02.11.2009
Former [2010/48]AT01.07.2009
BE01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
GR02.10.2009
ES12.10.2009
MC31.10.2009
PT02.11.2009
Former [2010/25]AT01.07.2009
BE01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
ES12.10.2009
MC31.10.2009
PT02.11.2009
Former [2010/23]AT01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
RO01.07.2009
SI01.07.2009
SK01.07.2009
BG01.10.2009
ES12.10.2009
PT02.11.2009
Former [2010/22]AT01.07.2009
CZ01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
RO01.07.2009
SI01.07.2009
BG01.10.2009
ES12.10.2009
PT02.11.2009
Former [2010/20]AT01.07.2009
DK01.07.2009
EE01.07.2009
FI01.07.2009
SI01.07.2009
BG01.10.2009
ES12.10.2009
PT02.11.2009
Former [2010/18]AT01.07.2009
EE01.07.2009
FI01.07.2009
SI01.07.2009
BG01.10.2009
ES12.10.2009
PT02.11.2009
Former [2010/16]AT01.07.2009
EE01.07.2009
FI01.07.2009
SI01.07.2009
ES12.10.2009
PT02.11.2009
Former [2010/09]AT01.07.2009
EE01.07.2009
FI01.07.2009
SI01.07.2009
ES12.10.2009
Former [2010/08]AT01.07.2009
EE01.07.2009
SI01.07.2009
ES12.10.2009
Former [2009/51]SI01.07.2009
Documents cited:Search[X]  - SIVA SASHI C ET AL, "Evaluation of the clinical usefulness of isolation of fetal DNA from the maternal circulation.", THE AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY. AUSTRALIA FEB 2003, (200302), vol. 43, no. 1, ISSN 0004-8666, pages 10 - 15, XP009024979 [X] 1-7 * page 11 - page 13; figures 1,2 *

DOI:   http://dx.doi.org/10.1046/j.0004-8666.2003.00011.x
 [X]  - LO Y M D ET AL, "PRESENCE OF FETAL DNA IN MATERNAL PLASMA AND SERUM", LANCET, XX, XX, (19970816), vol. 350, ISSN 0140-6736, pages 485 - 487, XP001037118 [X] 1-7 * page 486 *

DOI:   http://dx.doi.org/10.1016/S0140-6736(97)02174-0
 [X]  - SMID MADDALENA ET AL, "Evaluation of different approaches for fetal DNA analysis from maternal plasma and nucleated blood cells", CLINICAL CHEMISTRY, (199909), vol. 45, no. 9, ISSN 0009-9147, pages 1570 - 1572, XP002268967 [X] 1-7 * page 1570 - page 1571 *
 [X]  - PERTL BARBARA ET AL, "Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amplification of short tandem repeats", HUMAN GENETICS, (200001), vol. 106, no. 1, ISSN 0340-6717, pages 45 - 49, XP002268968 [X] 1-7 * the whole document *
 [A]  - LO Y M DENNIS, "Fetal DNA in maternal plasma: Biology and diagnostic applications", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, US, (200012), vol. 46, no. 12, ISSN 0009-9147, pages 1903 - 1906, XP002247511 [A] 1-15 * the whole document *
 [A]  - PERTL BARBARA ET AL, "Fetal DNA in maternal plasma: Emerging clinical applications", OBSTETRICS AND GYNECOLOGY, (200109), vol. 98, no. 3, ISSN 0029-7844, pages 483 - 490, XP001179125 [A] 1-15 * abstract * * page 486 - page 487 *

DOI:   http://dx.doi.org/10.1016/S0029-7844(01)01195-4
 [A]  - HOUFFLIN-DEBARGE VERONIQUE ET AL, "High sensitivity of fetal DNA in plasma compared to serum and nucleated cells using unnested PCR in maternal blood", FETAL DIAGNOSIS AND THERAPY, (200003), vol. 15, no. 2, ISSN 1015-3837, pages 102 - 107, XP009025236 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1159/000020985
 [A]  - HAHN S ET AL, "MULTIPLEX AND REAL-TIME QUANTITATIVE PCR ON FETAL DNA IN MATERNAL PLASMA A COMPARISON WITH FETAL CELLS ISOLATED FROM MATERNAL BLOOD", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, (2000), vol. 906, ISSN 0077-8923, pages 148 - 152, XP008007707 [A] 1-15 * the whole document *