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Extract from the Register of European Patents

EP About this file: EP1958956

EP1958956 - Peptidomimetic protease inhibitors [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.10.2014
Database last updated on 23.04.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
Vertex Pharmaceuticals Incorporated
50 Northern Avenue
Boston, MA 02210 / US
[2014/35]
Former [2014/09]For all designated states
Vertex Pharmaceuticals Inc.
50 Northern Avenue
Boston, MA 02210 / US
Former [2008/34]For all designated states
VERTEX PHARMACEUTICALS INCORPORATED
130 Waverly Street
Cambridge, MA 02139 / US
Inventor(s)01 / Babine, Robert Edward
7919 Estancia St.
Carlsbad, CA 92009-8322 / US
02 / Chen, Shu-Hui
3807 Steeplechase Drive
Carmel, IN 46032 / US
03 / Lamar, Jason Eric
1240 North Broadway, Apt. 19
Indianapolis, IN 46202 / US
04 / Snyder, Nancy June
3830 West 850 North
Lizton, IN 46149 / US
05 / Sun, Xicheng David
923 Grays Peak Drive
Superior, CO 80027 / US
06 / Tebbe, Mark Joseph
Volksdorfer Weg 32
22391 Hamburg / DE
07 / Victor, Frantz
4855 North Tuxedo Street
Indianapolis, IN 46205 / US
08 / Wang, Q. May
12345 Moon River Court
Indianapolis, IN 46236 / US
09 / Yip, Yvonne Mai Yee
1441 Bagder Drive
Indianapolis, IN 46260 / US
10 / Collado, Ivan
C/Santa Barbara 21, 2c
28220 Madrid / ES
11 / Garcia-Paredes, Cristina
C/Arroyo de la Elipa 1, 4 Drcha
28017 Madrid / ES
12 / Parker, Samuel Raymond, III
361 Union Street
Doylestown, PA 18901 / US
13 / Jin, Ling
3750 Power Drive
Carmel, IN 46033 / US
14 / Guo, Deqi
5747 Aqua Marine Drive
Carmel, IN 46033 / US
15 / Glass, John Irvin
625 Bryn Mawr Drive
Indianapolis, IN 46260 / US
 [2014/17]
Former [2011/35]01 / Babine, Robert Edward
7919 Estancia St.
Carlsbad, CA 92009-8322 / US
02 / Chen, Shu-Hui
3807 Steeplechase Drive
Carmel, IN 46032 / US
03 / Lamar, Jason Eric
1240 North Broadway, Apt. 19
Indianapolis, IN 46202 / US
04 / Snyder, Nancy June
3830 West 850 North
Lizton, IN 46149 / US
05 / Sun, Xicheng
923 Grays Peak Drive
Superior, CO 80027 / US
06 / Tebbe, Mark Joseph
Volksdorfer Weg 32
22391 Hamburg / DE
07 / Victor, Frantz
4855 North Tuxedo Street
Indianapolis, IN 46205 / US
08 / Wang, May Q.
12345 Moon River Court
Indianapolis, IN 46236 / US
09 / Yip, Mai Yee Yvonne
1441 Bagder Drive
Indianapolis, IN 46260 / US
10 / Collado, Ivan
C/Santa Barbara 21, 2c
28220 Madrid / ES
11 / Garcia-Paredes, Cristina
C/Arroyo de la Elipa 1, 4 Drcha
28017 Madrid / ES
12 / Parker, Samuel Raymond, III
361 Union Street
Doylestown, PA 18901 / US
13 / Jin, Ling
3750 Power Drive
Carmel, IN 46033 / US
14 / Guo, Deqi
5747 Aqua Marine Drive
Carmel, IN 46033 / US
15 / Glass, John Irvin
625 Bryn Mawr Drive
Indianapolis, IN 46260 / US
Former [2009/10]01 / Babine, Robert Edward
7919 Estancia St.
Carlsbad, CA 92009-8322 / US
02 / Chen, Shu-Hui
3807 Steeplechase Drive
Carmel, IN 46032 / US
03 / Lamar, Jason Eric
1240 North Broadway, Apt. 19
Indianapolis, IN 46202 / US
04 / Snyder, Nancy June
3830 West 850 North
Lizton, IN 46149 / US
05 / Sun, Xicheng
923 Grays Peak Drive
Superior, CO 80027 / US
06 / Tebbe, Mark Joseph
Volksdorfer Weg 32
22391 Hamburg / DE
07 / Victor, Frantz
4855 North Tuxedo Street
Indianapolis, IN 46205 / US
08 / Wang, May Q.
12345 Moon River Court
Indianapolis, IN 46236 / US
09 / Yip, Mai Yee Yvonne
1441 Bagder Drive
Indianapolis, IN 46260 / US
10 / Collado, Ivan
C/Santa Barbara 21, 2c
28220 Madrid / ES
11 / Garcia-Paredes, Cristina
C/Arroyo de la Elipa 1, 4 Drcha
28017 Madrid / ES
12 / Parker, Samuel Raymond, III
361 Union Street
Doylestown, PA 18901 / US
13 / Jin, Ling
3750 Power Drive
Carmel, IN 46033 / US
14 / Duo, Deqi
5747 Aqua Marine Drive
Carmel, IN 46033 / US
15 / Glass, John Irvin
625 Bryn Mawr Drive
Indianapolis, IN 46260 / US
Former [2008/34]01 / Babine, Robert Edward
19 Concetta Way
Franklin, MA 02038 / US
02 / Chen, Shu-Hui
3807 Steeplechase Drive
Carmel, IN 46032 / US
03 / Lamar, Jason Eric
1240 North Broadway, Apt. 19
Indianapolis, IN 46202 / US
04 / Snyder, Nancy June
3830 West 850 North
Lizton, IN 46149 / US
05 / Sun, Xicheng
923 Grays Peak Drive
Superior, CO 80027 / US
06 / Tebbe, Mark Joseph
Volksdorfer Weg 32
22391 Hamburg / DE
07 / Victor, Frantz
4855 North Tuxedo Street
Indianapolis, IN 46205 / US
08 / Wang, May Q.
12345 Moon River Court
Indianapolis, IN 46236 / US
09 / Yip, Mai Yee Yvonne
1441 Bagder Drive
Indianapolis, IN 46260 / US
10 / Collado, Ivan
C/Santa Barbara 21, 2c
28220 Madrid / ES
11 / Garcia-Paredes, Cristina
C/Arroyo de la Elipa 1, 4 Drcha
28017 Madrid / ES
12 / Parker, Samuel Raymond, III
511 Hayfield Court
Doylestown, PA 18901 / US
13 / Jin, Ling
3750 Power Drive
Carmel, IN 46033 / US
14 / Duo, Deqi
5747 Aqua Marine Drive
Carmel, IN 46033 / US
15 / Glass, John Irvin
625 Bryn Mawr Drive
Indianapolis, IN 46260 / US
Representative(s)Cohausz & Florack
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
[N/P]
Former [2013/50]Cohausz & Florack
Patent- und Rechtsanwälte Partnerschaftsgesellschaft Bleichstraße 14
40211 Düsseldorf / DE
Former [2008/34]Cohausz & Florack
Patent- und Rechtsanwälte Bleichstrasse 14
40211 Düsseldorf / DE
Application number, filing date07012483.931.08.2001
[2008/34]
Priority number, dateUS20000229398P31.08.2000         Original published format: US 229398 P
US20010277641P21.03.2001         Original published format: US 277641 P
[2008/34]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1958956
Date:20.08.2008
Language:EN
[2008/34]
Type: A3 Search report 
No.:EP1958956
Date:24.09.2008
[2008/39]
Type: B1 Patent specification 
No.:EP1958956
Date:11.12.2013
Language:EN
[2013/50]
Search report(s)(Supplementary) European search report - dispatched on:EP26.08.2008
ClassificationIPC:C07K7/06, A61K38/08, A61P31/12
[2008/34]
CPC:
C07K7/02 (EP,US); C07D401/12 (KR); A61K38/07 (EP,US);
A61K38/08 (EP,US); A61K38/21 (EP,US); A61K38/212 (EP,US);
A61K38/215 (EP,US); A61K45/06 (US); A61P1/16 (EP);
A61P31/12 (EP); A61P31/14 (EP); A61P31/18 (EP);
A61P43/00 (EP); C07D209/02 (EP,US); C07D209/52 (EP,US);
C07K14/005 (EP,US); C07K5/0202 (EP,US); C07K5/0205 (EP,US);
C07K5/06052 (EP,US); C07K5/0808 (EP,US); C07K5/101 (EP,US);
C07K5/1016 (EP,US); C07K7/06 (EP,US); A61K38/095 (EP,US);
C12N2770/24222 (EP,US); Y02P20/55 (EP,US) (-)
C-Set:
A61K38/21, A61K2300/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2008/34]
Extension statesAL19.07.2007
LT19.07.2007
LV19.07.2007
MK19.07.2007
RO19.07.2007
SI19.07.2007
TitleGerman:Inhibitoren der peptidomimetischen Protease[2008/34]
English:Peptidomimetic protease inhibitors[2008/34]
French:Inhibiteurs de prothèse peptidominétique[2008/34]
Examination procedure19.07.2007Examination requested  [2008/34]
18.02.2008Despatch of communication that the application is refused, reason: Examination on filing A.90(5) {1}
11.02.2009Despatch of a communication from the examining division (Time limit: M06)
09.12.2009Reply to a communication from the examining division
25.08.2010Despatch of a communication from the examining division (Time limit: M04)
31.08.2010Despatch of a communication from the examining division (Time limit: M04)
18.02.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
28.04.2011Reply to a communication from the examining division
08.03.2012Despatch of a communication from the examining division (Time limit: M06)
18.09.2012Reply to a communication from the examining division
20.06.2013Communication of intention to grant the patent
30.10.2013Fee for grant paid
30.10.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP01968040.4  / EP1320540
Divisional application(s)EP10185722.5  / EP2371839
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20010968040) is  08.12.2005
Opposition(s)12.09.2014No opposition filed within time limit [2014/47]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
09.12.2009Request for further processing filed
09.12.2009Full payment received (date of receipt of payment)
Request granted
21.12.2009Decision despatched
The application was refused due to failure to file the sequence listing
06.03.2008Request for further processing filed
06.03.2008Full payment received (date of receipt of payment)
Request granted
16.04.2008Decision despatched
Fees paidRenewal fee
19.07.2007Renewal fee patent year 03
19.07.2007Renewal fee patent year 04
19.07.2007Renewal fee patent year 05
19.07.2007Renewal fee patent year 06
19.07.2007Renewal fee patent year 07
25.08.2008Renewal fee patent year 08
25.08.2009Renewal fee patent year 09
25.08.2010Renewal fee patent year 10
25.08.2011Renewal fee patent year 11
27.08.2012Renewal fee patent year 12
27.08.2013Renewal fee patent year 13
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
MC11.12.2013
SE11.12.2013
TR11.12.2013
GR12.03.2014
PT11.04.2014
LU31.08.2014
[2016/33]
Former [2016/32]AT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
MC11.12.2013
SE11.12.2013
GR12.03.2014
PT11.04.2014
LU31.08.2014
Former [2016/28]AT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
MC11.12.2013
SE11.12.2013
GR12.03.2014
PT11.04.2014
BE31.08.2014
LU31.08.2014
Former [2015/19]AT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
MC11.12.2013
SE11.12.2013
PT11.04.2014
BE31.08.2014
LU31.08.2014
Former [2015/18]AT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
MC11.12.2013
SE11.12.2013
PT11.04.2014
Former [2014/48]AT11.12.2013
CY11.12.2013
DK11.12.2013
FI11.12.2013
SE11.12.2013
PT11.04.2014
Former [2014/37]AT11.12.2013
CY11.12.2013
FI11.12.2013
SE11.12.2013
PT11.04.2014
Former [2014/26]AT11.12.2013
CY11.12.2013
FI11.12.2013
SE11.12.2013
Former [2014/24]AT11.12.2013
FI11.12.2013
SE11.12.2013
Former [2014/22]FI11.12.2013
SE11.12.2013
Documents cited:Search[Y]JPH09124691  ;
 [Y]US4880780  (TRAINOR DIANE A [US], et al) [Y] 1-125 * claim 1 *;
 [Y]US5371072  (WEBB THOMAS R [US], et al) [Y] 1-125 * claim 1 *;
 [Y]US5656600  (ABELMAN MATTHEW M [US], et al) [Y] 1-125 * claim 1 *;
 [DX]WO9817679  (VERTEX PHARMA [US], et al) [DX] 1-125 * claim 1 *;
 [DX]WO9907733  (BOEHRINGER INGELHEIM CA LTD [CA], et al) [DX] 1-125 * claim 1 *;
 [DX]WO9907734  (BOEHRINGER INGELHEIM CA LTD [CA], et al) [DX] 1-125* claim 1 *;
 [A]WO0009543  (BOEHRINGER INGELHEIM CA LTD [CA], et al) [A] 1-125 * claim 1 *;
 [DX]WO0009558  (BOEHRINGER INGELHEIM CA LTD [CA], et al) [DX] 1-125 * claim 1 *
 [Y]  - PATENT ABSTRACTS OF JAPAN, (19970930), vol. 1997, no. 09, & JP09124691 A 19970513 (GREEN CROSS CORP:THE) [Y] 1-125 * abstract *
by applicant   - A. ALBERTI ET AL., "Natural History of Hepatitis C", J. HEPATOLOGY, (1999), vol. 31, no. 1, pages 17 - 24
    - M.J. ALTER, "Hepatitis C Virus Infection in the United States", J. HEPATOLOGY, (1999), vol. 31, no. 1, pages 88 - 91
    - D. LAVANCHY, "Global Surveillance and Control of Hepatitis C", J. VIRAL HEPATITIS, (1999), vol. 6, pages 35 - 47
    - Q.-L. CHOO ET AL., "Genetic Organization and Diversity of the Hepatitis C Virus", PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 2451 - 2455
    - LIPINSKI, "Annual Reports in Medicinal Chemistry", BIOISOSTERISM IN DRUG DESIGN, (1986), vol. 21, page 283
    - YUN; HWAHAK SEKYE, APPLICATION OF BIOISOSTERISM TO NEW DRUG DESIGN, (1993), vol. 33, pages 576 - 579
    - ZHAO, "Huaxue Tongbao", BIOISOSTERIC REPLACEMENT AND DEVELOPMENT OF LEAD COMPOUNDS IN DRUG DESIGN, (1995), pages 34 - 38
    - GRAHAM, "Theochem", THEORETICAL STUDIES APPLIED TO DRUG DESIGN:AB INITIO ELECTRONIC DISTRIBUTIONS IN BIOISOSTERES, (1995), vol. 343, pages 105 - 109
    - Encyclopedia of Pharmaceutical Technology, vol. 10, page 33
    - GIBSON, F.G.; BERMEIER, S.C.; RAPOPORT, H., J. ORG CHEM., (1994), vol. 59, pages 3216 - 3218
    - The organic Chemistry of ?-Lactams, VCH PUBLISHERS, INC., (1993), pages 240 - 241,303-
    - TETRAHEDRON, (1999), vol. 55, pages 6785 - 6796
    - BLIGHT ET AL., "Efficient Initiation of HCV RNA Replication in Cell Culture", SCIENCE, (2000), vol. 290, pages 1972 - 1974
    - CHUNG ET AL., "Hepatitis C virus replication is directly inhibited by IFN-? in a full-length binary expression system", PROC. NAT. ACAD. SCI. U.S.A., (2001), vol. 98, no. 17, pages 9847 - 52
    - CHUTAPUTTI A., "Adverse effects and other safety aspects of the hepatitis C antivirals", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, (2000), pages E156 - 63
    - SHIFFMAN M. L.; VERBEKE S. B.; KIMBALL P. M., "Alpha interferon combined with ribavirin potentiates proliferative suppression but not cytokine production in mitogenically stimulated human lymphocytes", ANTIVIRAL RESEARCH., (2000), vol. 48, no. 2, pages 91 - 9
    - ROEHM N.W.; RODGERS G. H.; HATFIELD S. M.; GLASEBROOK A. L., "An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT", JOURNAL OF IMMUNOL. METHODS, (1991), vol. 142, no. 2, pages 257 - 65
    - BRINK N.; SZAMEL M.; YOUNG A.R.; WITTEM K.P.; BERGEMANN J., "Comparative quantification of IL-lbeta, IL-10, IL-10r, TNFalpha and IL-7 mRNA levels in UV-irradiated human skin in vivo", INFLAMATION RESEARCH, (2000), vol. 49, no. 6, pages 290 - 6
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.