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Following a clean-up exercise of event information regarding (previously) revoked patents, that were later reinstated, some existing revocation events ("Despatch of communication that patent is revoked") were duplicated on 15.04.2019.

2019.04.15

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Extract from the Register of European Patents

Citations: EP2215124

Cited inInternational search
Type:Patent literature
Publication No.:WO2008063382  [PX]
 (MERCK & CO INC [US], et al) [PX] 1-38 * figure 4; example 6; table 3 *;
Type:Patent literature
Publication No.:WO2008057458  [PX]
 (MERCK & CO INC [US], et al) [PX] 1-38 * figure 4; example 6; table 3 *;
Type:Patent literature
Publication No.:WO2008133647  [E]
 (MERCK & CO INC [US], et al) [E] 1-38 * figure 4; example 6; table 3 *;
Type:Patent literature
Publication No.:WO2008057457  [PX]
 (MERCK & CO INC [US], et al) [PX] 1-38 * figure 4; example 6; table 3 *;
Type:Patent literature
Publication No.:WO2008125623  [E]
 (NOVARTIS AG [CH], et al) [E] 1-38 * page 72; examples 5,6 *;
Type:Patent literature
Publication No.:WO2008057459  [PX]
 (MERCK & CO INC [US], et al) [PX] 1-38 * figure 4; example 6; table 3 *
Type:Non-patent literature
Publication information:[X]  - GROZDANOV PETAR N ET AL, "Expression and localization of PCSK9 in rat hepatic cells", BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE, XX, XX, (20060201), vol. 84, no. 1, ISSN 0829-8211, pages 80 - 92, XP008095646 [X] 1-28,30,31 * see "antibodies" page 81 *
DOI: http://dx.doi.org/10.1139/O05-155
Type:Non-patent literature
Publication information:[X]  - MAXWELL KARA N ET AL, "Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, (20040504), vol. 101, no. 18, ISSN 0027-8424, pages 7100 - 7105, XP002493244 [X] 1-28,30,31 * see "Materials" on pages 7100 and 7101 *
DOI: http://dx.doi.org/10.1073/pnas.0402133101
Type:Non-patent literature
Publication information:[X]  - RASHID S ET AL, "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, (20050412), vol. 102, no. 15, ISSN 0027-8424, pages 5374 - 5379, XP002478031 [X] 1-28,30,31 * See "Antibodies and immunoblot analysis", page 5375 *
DOI: http://dx.doi.org/10.1073/pnas.0501652102
Type:Non-patent literature
Publication information:[X]  - BENJANNET SUZANNE ET AL, The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications., THE JOURNAL OF BIOLOGICAL CHEMISTRY 13 OCT 2006, VOL. 281, NR. 41, PAGE(S) 30561 - 30572, (20061013), ISSN 0021-9258, XP002506016 [X] 1-28,30,31 * see "experimental procedures - anti PCSK9 antibodies" page 30562 *
DOI: http://dx.doi.org/10.1074/jbc.m606495200
Type:Non-patent literature
Publication information:[X]  - LAGACE THOMAS A ET AL, "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, (20061101), vol. 116, no. 11, ISSN 0021-9738, pages 2995 - 3005, XP002493243 [X] 1-28,30,31 * see "methods - antibodies" page 3003 *
DOI: http://dx.doi.org/10.1172/JCI29383
Cited inExamination
Type:Patent literature
Publication No.:EP2615114  
Type:Non-patent literature
Publication information:   - LAGACE THOMAS A ET AL, "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, (20061101), vol. 116, no. 11, doi:10.1172/JCI29383, ISSN 0021-9738, pages 2995 - 3005, XP002493243
DOI: http://dx.doi.org/10.1172/JCI29383
Type:Non-patent literature
Publication information:   - HYOCK JOO KWON ET AL, "Molecular basis for LDL receptor recognition by PCSK9", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (20080212), vol. 105, no. 6, doi:10.1073 PNAS.0712064105, ISSN 0027-8424, pages 1820 - 1825, XP007912351
DOI: http://dx.doi.org/10.1073/pnas.0712064105
Type:Non-patent literature
Publication information:   - DA-WEI ZHANG ET AL, "Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation*", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 282, no. 25, doi:10.1074/JBC.M702027200, ISSN 0021-9258, (20070622), pages 18602 - 18612, (20070423), XP007912352
DOI: http://dx.doi.org/10.1074/jbc.M702027200
Type:Non-patent literature
Publication information:   - NI YAN G ET AL, "A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, BETHESDA, MD, USA, vol. 285, no. 17, doi:10.1074/JBC.M110.113035, ISSN 1083-351X, (20100423), pages 12882 - 12891, (20100219), XP002619048
DOI: http://dx.doi.org/10.1074/JBC.M110.113035
Type:Non-patent literature
Publication information:   - Third Report of tho National Choiesterol Education Progiam (NCEP) Ecpert Panelon Detection. Evaluation, and Treatment cf High Blood Cholesterol in Mults (AdultTreatment Panel IH) Final Report, (20020901), pages 3161 - 3167,
Type:Non-patent literature
Publication information:   - Saurabh Saha ET AL, "Solution Structure of the LDL Receptor EGF-AB Pair", STRUCTURE, US, (20010601), vol. 9, no. 6, doi:10.1016/S0969-2126(01)00606-2, ISSN 0969-2126, pages 451 - 456, XP055229481
DOI: http://dx.doi.org/10.1016/S0969-2126(01)00606-2
Type:Non-patent literature
Publication information:   - Steven Malby ET AL, "The First Epidermal Growth Factor-like Domain of the Low-Density Lipoprotein Receptor Contains a Noncanonical Calcium Binding Site +", Biochemistry, US, (20010201), vol. 40, no. 8, doi:10.1021/bi002322l, ISSN 0006-2960, pages 2555 - 2563, XP055229482
DOI: http://dx.doi.org/10.1021/bi002322l
Cited inOpposition
Type:Patent literature
Publication No.:WO2009026558  
Type:Patent literature
Publication No.:WO2008125623  
Type:Patent literature
Publication No.:WO2009100297  
Type:Patent literature
Publication No.:WO2008057457  
Type:Patent literature
Publication No.:WO2006081171  
Type:Patent literature
Publication No.:EP2215124  
Type:Non-patent literature
Publication information:   - SEIDAH, N.G. et al., "the secretory proprotein convertase neutral apoptosis-regulated convertase 1 (narc-1): liver regeneration and nenronal differentiation", PNAS, (20030000), vol. 100, no. 3, pages 928 - 933, XP002495458
DOI: http://dx.doi.org/10.1073/pnas.0335507100
Type:Non-patent literature
Publication information:   - ABIFADEL M. et al., "mutations in pcsk9 cause autosomal dominant hypercholesterolemia", Nat. Genet., (20030000), vol. 34, no. 2, page 154, XP002253513
DOI: http://dx.doi.org/10.1038/ng1161
Type:Non-patent literature
Publication information:   - BENJANNET, S. et al., "narc-1/pcsk9 and its natural mutants", JBC, (20040000), vol. 279, no. 47, pages 48865 - 48875, XP002495460
DOI: http://dx.doi.org/10.1074/jbc.M409699200
Type:Non-patent literature
Publication information:   - TIMMS K.M. et al., "a mutation in pck9 causing autosomal-dominant hypercholesterolemia in utah pedigree", Hum. Genet., (20040000), vol. 114, no. 4, pages 349 - 353, XP055264602
DOI: http://dx.doi.org/10.1007/s00439-003-1071-9
Type:Non-patent literature
Publication information:   - MAXWELL K.N et al., "adenoviral mediated expression of pck9 in mice results in a low density lipoprotein receptor knockout phenotype", PNAS, (20040000), vol. 101, no. 18, pages 7100 - 7105, XP002493244
DOI: http://dx.doi.org/10.1073/pnas.0402133101
Type:Non-patent literature
Publication information:   - QIAN Y.-W. et al., "secreted pck9 downregulates low density lipoprotein receptor throuth receptor mediated endocytosis", J . Lipid Res., (20070000), vol. 48, no. 7, pages 1488 - 1498, XP055265230
DOI: http://dx.doi.org/10.1194/jlr.M700071-JLR200
Type:Non-patent literature
Publication information:   - COHEN J. et al., "low ldl cholesterol in individuals of african descent resulting from frequent nonsense mutations in pcsk9", Nat. Genet., (20050000), vol. 37, no. 2, pages 161 - 165, XP008102949
DOI: http://dx.doi.org/10.1038/ng1509
Type:Non-patent literature
Publication information:   - ZHAO Z. et al., "molecular characterization of loss of function mutations in pcsk9 and identification of a compound heterozygote", Am. J. Hum. Genet., (20060000), vol. 79, pages 514 - 523, XP055265231
DOI: http://dx.doi.org/10.1086/507488
Type:Non-patent literature
Publication information:   - LAGACE T.A. et al., "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", J. Clin. Invest., (20060000), vol. 116, no. 11, pages 2995 - 3005, XP002493243
DOI: http://dx.doi.org/10.1172/JCI29383
Type:Non-patent literature
Publication information:   - FISHER T.S. et al., "Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation", J. Biol. Chem., (20070510), vol. 282, no. 28, pages 20502 - 20512, XP055265234
DOI: http://dx.doi.org/10.1074/jbc.M701634200
Type:Non-patent literature
Publication information:   - ZHANG D.-W. et al., "Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation*", J. Biol. Chem., (20070000), vol. 282, no. 25, pages 18602 - 18612, XP007912352
DOI: http://dx.doi.org/10.1074/jbc.M702027200
Type:Non-patent literature
Publication information:   - CUNNINGHAM D. et al., "Structural and biophysical studies of PCSK9 and its mutants linked to familialhypercholesterolemia", Nat. Struct. Mol. Biol., vol. 14, no. 5, pages 413 - 419, XP002507497
DOI: http://dx.doi.org/10.1038/NSMB1235
Type:Non-patent literature
Publication information:   - NI, Y.G. et al., "A PCSK9-binding antibody that structurally mimics theEGF(A) domain of LDL-receptor reduces LDL cholesterolin vivo 1", J. Lipid Res., (20110000), vol. 52, pages 78 - 86, XP002686538
DOI: http://dx.doi.org/10.1194/jlr.m011445
Type:Non-patent literature
Publication information:   - KWON, H.J. et al., "Molecular basis for LDL receptor recognition by PCSK9", PNAS, vol. 105, no. 6, page 1820, XP007912351
DOI: http://dx.doi.org/10.1073/pnas.0712064105
Type:Non-patent literature
Publication information:   - davis et al, "Antibody Engineering, Methods and Protocols", Methods in Molecular Biology, Totowa, New Jersey, U.S., (20040000), vol. 248, XP055265232
Type:Non-patent literature
Publication information:   - HOOGENBOOM, H.R., TIBTECH, (19970000), vol. 15, page 62, XP004034115
DOI: http://dx.doi.org/10.1016/S0167-7799(97)84205-9
Type:Non-patent literature
Publication information:   - YANG W.P. et al., J. Mol. Biol., (19950000), vol. 254, page 392, XP000199739
DOI: http://dx.doi.org/10.1006/jmbi.1995.0626
Type:Non-patent literature
Publication information:   - HARLOW, E. et al., Antibodies, A Laboratory Manual, New York, (19880000), XP055288200
Type:Non-patent literature
Publication information:   - RASHID, S. et al., "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9", PNAS, (20050000), vol. 102, no. 15, page 5374, XP002478031
DOI: http://dx.doi.org/10.1073/pnas.0501652102
Type:Non-patent literature
Publication information:   - PEREZ DE LA LASTRA et al., Immunology, (19990000), vol. 96, pages 663 - 670, XP055217740
DOI: http://dx.doi.org/10.1046/j.1365-2567.1999.00732.x
Type:Non-patent literature
Publication information:   - Request for correction of inventorship, (20090211),
Type:Non-patent literature
Publication information:   - SEIDAH, N.G. et al., "the secretory proprotein convertase neural apoptosis regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation", PNAS, (20030000), vol. 100, no. 3, page 928, XP002495458
DOI: http://dx.doi.org/10.1073/pnas.0335507100
Type:Non-patent literature
Publication information:   - ABIFADEL M. et al., "mutations in PCKSK9 cause autosomal dominant hypercholesterolemia", Nat. Genet., (20030000), vol. 34, no. 2, page 154, XP002253513
DOI: http://dx.doi.org/10.1038/ng1161
Type:Non-patent literature
Publication information:   - BENJANNET, S. et al., "NARC-1/PCSK9 and its natural mutants", JBC, (20040000), vol. 279, no. 47, page 48875, XP002495460
DOI: http://dx.doi.org/10.1074/jbc.M409699200
Type:Non-patent literature
Publication information:   - TIMMS K.M. et al., "a mutation in PCK9 causing autosomal dominant hypercholesterolemia in a Utah pedigree", Hum. Genet., (20040000), vol. 114, no. 4, page 349, XP055264602
DOI: http://dx.doi.org/10.1007/s00439-003-1071-9
Type:Non-patent literature
Publication information:   - MAXWELL K.N et al., "adenoviral mediated expression of PCSK9 in mice results in a low density lipoprotein receptor knockout phenotype", PNAS, (20040000), vol. 101, no. 18, page 7100, XP002493244
DOI: http://dx.doi.org/10.1073/pnas.0402133101
Type:Non-patent literature
Publication information:   - QIAN Y.-W. et al., "secreted PCSK9 downregulated low density lipoprotein receptor through receptor mediated endocytosis", J. Lipid Res., (20070000), vol. 48, no. 7, page 1488, XP055265230
DOI: http://dx.doi.org/10.1194/jlr.M700071-JLR200
Type:Non-patent literature
Publication information:   - COHEN J. et al., "low LDL cholesterol in individuals of African descent resulting fro frequent nonsense mutations in PCSK9", Nat. Genet., (20050000), vol. 37, no. 2, pages 161 - 65, XP008102949
DOI: http://dx.doi.org/10.1038/ng1509
Type:Non-patent literature
Publication information:   - ZHAO Z. et al., "molecular characterization of loss of function mutations in PCSK9 and identification of a compound heterozygote", Am. J. Hum. Genet., (20060000), vol. 79, pages 514 - 23, XP055265231
DOI: http://dx.doi.org/10.1086/507488
Type:Non-patent literature
Publication information:   - LAGACE T.A. et al., "secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in the livers of parabiotic mice", J. Clin. Invest., (20060000), vol. 116, no. 11, page 2995, XP002493243
DOI: http://dx.doi.org/10.1172/JCI29383
Type:Non-patent literature
Publication information:   - FISHER T.S. et al., "effects of PH and LDL on PCSK9 dependent LDL receptor regulation", J. Biol. Chem., (20070510), vol. 282, no. 28, page 20502, XP055265234
DOI: http://dx.doi.org/10.1074/jbc.M701634200
Type:Non-patent literature
Publication information:   - ZHANG D.-W. et al., "Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation*", J. Biol. Chem., vol. 282, no. 25, page 18602, XP007912352
DOI: http://dx.doi.org/10.1074/jbc.M702027200
Type:Non-patent literature
Publication information:   - CUNNINGHAM D. et al., "Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia", Nat. Struct. Mol. Biol., (20070415), vol. 14, no. 5, page 413, XP002507497
DOI: http://dx.doi.org/10.1038/NSMB1235
Type:Non-patent literature
Publication information:   - Analysis of the features of claim 1,
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 1 depicting the non-linear epitope comprising amino acids 187- 202 , 231-246 , and 368-383 of PCSK9 bound by preferred PCSK9-specific antibodies disclosed in Novartis (D14,
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 2 depicting the overlap between the amino acid residues that are bound by preferred PCSK9-specific antibodies disclosed in Novartis (D14,
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 3 depicting the overlap between the amino acid residues that are bound by antibodies disclosed in Novartis (D14) and the residues positioned within 8 Angstroms of 31H4,
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 4 depicting the amino acid residues taught in PB to be bound by the EGFa domain of the LDL Receptor,
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 5 depicting the overlap between the amino acid residues that are bound by preferred PCSK9-specific antibodies disclosed in Novartis (D14,
Type:Non-patent literature
Publication information:   - Calculation of IC50 of the antibodies of D14 to PCSK9,
Type:Non-patent literature
Publication information:   - NI, Y.G. et al., "a PCSK9 binding antibody that structurally mimics the EGF domain of LDL receptor reduces LDL cholesterol in vivo", J. Lipid Res., (20110000), vol. 52, page 78, XP002686538
DOI: http://dx.doi.org/10.1194/jlr.m011445
Type:Non-patent literature
Publication information:   - Atomic coordinates and structure factors deposited with the Protein Data Bank under the accession code: ''2xtj'' and amino acid sequences of the proteins in fasta format,
Type:Non-patent literature
Publication information:   - Declaration of Chadwick King submitted by Patentee at the Oral Proceeding, (20151127),
Type:Non-patent literature
Publication information:   - KWON, H.J. et al., "molecular basis of LDL receptor recognition by PCSK9", PNAS, (20080204), vol. 105, no. 6, page 1820, XP007912351
DOI: http://dx.doi.org/10.1073/pnas.0712064105
Type:Non-patent literature
Publication information:   - "Antibody Engineering, Methods and Protocols", Methods in Molecular Biology, Totowa, New Jersey, U.S., (20040000), vol. 248, XP055265232
Type:Non-patent literature
Publication information:   - HOOGENBOOM, H.R., "designing and optimizing library selection strategies for generating high affinity antibodies", TIBTECH, (19970000), vol. 15, page 62, XP004034115
DOI: http://dx.doi.org/10.1016/S0167-7799(97)84205-9
Type:Non-patent literature
Publication information:   - YANG W.P. et al., "CDR walking mutagenesis for the affinity maturation of a potent human anti HIV1 antibody into the picomolar range", J. Mol. Biol., (19950000), vol. 254, page 392, XP000199739
DOI: http://dx.doi.org/10.1006/jmbi.1995.0626
Type:Non-patent literature
Publication information:   - Antibodies, A Laboratory Manual, (19880000), XP055265233
Type:Non-patent literature
Publication information:   - RASHID, S. et al., "decreased plasma cholesterol and hypersensitivity tot statins in mice lacking PCSK9", PNAS, (20050000), vol. 102, no. 15, page 5374, XP002478031
DOI: http://dx.doi.org/10.1073/pnas.0501652102
Type:Non-patent literature
Publication information:   - PEREZ DE LA LASTRA et al., "epitope mapping of 10 monoclonal antibodies against the pig analogue of human membrane cofactor protein (MCP)", Immunology, (19990000), vol. 96, pages 663 - 670, XP055217740
DOI: http://dx.doi.org/10.1046/j.1365-2567.1999.00732.x
Type:Non-patent literature
Publication information:   - SEIDAH, N.G. et al., "the secretory proprotein convertase neural apoptosis regulated convertase 1", PNAS, (20030000), vol. 100, no. 3, page 928, XP002495458
DOI: http://dx.doi.org/10.1073/pnas.0335507100
Type:Non-patent literature
Publication information:   - ABIFADEL M. et al., "mutations in PCSK9 cause autosomal dominant hypercholesterolemia", Nat. Genet., (20030000), vol. 34, no. 2, page 154, XP002253513
DOI: http://dx.doi.org/10.1038/ng1161
Type:Non-patent literature
Publication information:   - BENJANNET, S. et al., "narc PCSK9 and its natural mutants", JBC, (20040000), vol. 279, no. 47, page 48875, XP002495460
DOI: http://dx.doi.org/10.1074/jbc.M409699200
Type:Non-patent literature
Publication information:   - TIMMS K.M. et al., "a mutation in PCSK9 causing autosomal dominant hypercholesterolemia in a Utah pedigree", Hum. Genet., (20040000), vol. 114, no. 4, page 349, XP055264602
DOI: http://dx.doi.org/10.1007/s00439-003-1071-9
Type:Non-patent literature
Publication information:   - QIAN Y.-W. et al., "secreted PCSK9 downregulates low density lipoprotein receptor through receptor mediated endocytosis", J. Lipid Res., (20070000), vol. 48, no. 7, page 1488, XP055265230
DOI: http://dx.doi.org/10.1194/jlr.M700071-JLR200
Type:Non-patent literature
Publication information:   - COHEN J. et al., "low LDL cholesterol in individuals of African descent resulting fro frequent nonsense mutations", Nat. Genet., (20050000), vol. 37, no. 2, pages 161 - 65, XP008102949
DOI: http://dx.doi.org/10.1038/ng1509
Type:Non-patent literature
Publication information:   - ZHAO Z. et al., "molecular characterization of loss of function mutations in PCSK9 and identifcation", Am. J. Hum. Genet., (20060000), vol. 79, pages 514 - 23, XP055265231
DOI: http://dx.doi.org/10.1086/507488
Type:Non-patent literature
Publication information:   - LAGACE T.A. et al., "secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", J. Clin. Invest., (20060000), vol. 116, no. 11, page 2995, XP002493243
DOI: http://dx.doi.org/10.1172/JCI29383
Type:Non-patent literature
Publication information:   - FISHER T.S. et al., "effects of PH and low density lipoprotein on PCSK9 dependent LDL receptor regulation", J. Biol. Chem., (20070510), vol. 282, no. 28, page 20502, XP055265234
DOI: http://dx.doi.org/10.1074/jbc.M701634200
Type:Non-patent literature
Publication information:   - ZHANG D.-W. et al., "binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor like repeat", J. Biol. Chem., vol. 282, no. 25, page 18602, XP007912352
DOI: http://dx.doi.org/10.1074/jbc.M702027200
Type:Non-patent literature
Publication information:   - CUNNINGHAM D. et al., "structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia", Nat. Struct. Mol. Biol., (20070415), vol. 14, no. 5, page 413, XP002507497
DOI: http://dx.doi.org/10.1038/NSMB1235
Type:Non-patent literature
Publication information:   - Enlarged version of Fig. 1 depicting the non-linear epitope comprising amino acids, pages 187 - 202, 231-246 , and 368-383,
Type:Non-patent literature
Publication information:   - NI, Y.G. et al., "A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo", J. Lipid Res., (20110000), vol. 52, page 78, XP002686538
DOI: http://dx.doi.org/10.1194/jlr.m011445
Type:Non-patent literature
Publication information:   - Atomic coordinates and structure factors deposited with the Protein Data Bank under the accession code ''2xtj'' and amino acid sequences of the proteins in fasta format,
Type:Non-patent literature
Publication information:   - Declaration of Chadwick King submitted by Patentee, (20151127),
Type:Non-patent literature
Publication information:   - KWON, H.J. et al., "molecular basis for LDL receptor recognition by PCSK9", PNAS, vol. 105, no. 6, page 1820, XP007912351
DOI: http://dx.doi.org/10.1073/pnas.0712064105
Type:Non-patent literature
Publication information:   - Antibody Engineering, Methods and Protocols, Methods in Molecular Biology, Totowa, New Jersey, U.S., (20040000), vol. 248,
Type:Non-patent literature
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