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Extract from the Register of European Patents

EP About this file: EP2633325

EP2633325 - LC-MS SEPARATION AND DETECTION OF VITAMIN D METABOLITES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.11.2017
Database last updated on 23.04.2024
FormerThe patent has been granted
Status updated on  25.11.2016
FormerGrant of patent is intended
Status updated on  15.11.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Cohesive Technologies Inc.
101 Constitution Boulevard
Franklin, MA 02038 / US
[2013/36]
Inventor(s)01 / HERMAN, Joseph, L.
1051 Squires Drive
West Chester, PA 19382 / US
02 / ARGOTI, Dayana
42 8th Street
Suite 5413
Charlestown, MA 02129 / US
 [2013/36]
Representative(s)Browne, Robin Forsythe, et al
Hepworth Browne
15 St Paul's Street
Leeds LS1 2JG / GB
[2016/52]
Former [2013/36]Browne, Robin Forsythe, et al
Hepworth Browne Pearl Chambers 22 East Parade Leeds
LS1 5BY / GB
Application number, filing date11782327.828.10.2011
[2016/52]
WO2011US58423
Priority number, dateUS20100408385P29.10.2010         Original published format: US 408385 P
[2013/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012058614
Date:03.05.2012
Language:EN
[2012/18]
Type: A1 Application with search report 
No.:EP2633325
Date:04.09.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 03.05.2012 takes the place of the publication of the European patent application.
[2013/36]
Type: B1 Patent specification 
No.:EP2633325
Date:28.12.2016
Language:EN
[2016/52]
Search report(s)International search report - published on:EP03.05.2012
ClassificationIPC:G01N33/82
[2013/36]
CPC:
G01N33/82 (EP,US); G01N2560/00 (EP,US); Y10T436/203332 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/36]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:LC-MS-TRENNUNG UND DETEKTION VON VITAMIN-D-METABOLITEN[2013/36]
English:LC-MS SEPARATION AND DETECTION OF VITAMIN D METABOLITES[2013/36]
French:SÉPARATION PAR LC-MS ET DÉTECTION DES MÉTABOLITES DE LA VITAMINE D[2013/36]
Entry into regional phase24.05.2013National basic fee paid 
24.05.2013Designation fee(s) paid 
24.05.2013Examination fee paid 
Examination procedure24.05.2013Examination requested  [2013/36]
17.01.2014Amendment by applicant (claims and/or description)
20.05.2014Despatch of a communication from the examining division (Time limit: M06)
16.10.2014Reply to a communication from the examining division
21.01.2015Despatch of a communication from the examining division (Time limit: M06)
23.07.2015Reply to a communication from the examining division
15.09.2015Despatch of a communication from the examining division (Time limit: M04)
14.01.2016Reply to a communication from the examining division
11.02.2016Despatch of a communication from the examining division (Time limit: M02)
18.04.2016Reply to a communication from the examining division
11.07.2016Communication of intention to grant the patent
11.11.2016Fee for grant paid
11.11.2016Fee for publishing/printing paid
11.11.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.05.2014
Opposition(s)29.09.2017No opposition filed within time limit [2017/49]
Fees paidRenewal fee
24.10.2013Renewal fee patent year 03
23.10.2014Renewal fee patent year 04
12.10.2015Renewal fee patent year 05
11.10.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.10.2011
AL28.12.2016
AT28.12.2016
BE28.12.2016
CY28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
MK28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
TR28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
[2020/34]
Former [2020/15]HU28.10.2011
AT28.12.2016
BE28.12.2016
CY28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
MK28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
TR28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2019/51]HU28.10.2011
AT28.12.2016
BE28.12.2016
CY28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
MK28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2019/46]HU28.10.2011
AT28.12.2016
BE28.12.2016
CY28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2019/31]HU28.10.2011
AT28.12.2016
BE28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2018/29]AT28.12.2016
BE28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
MC28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2018/14]AT28.12.2016
BE28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SI28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2018/01]AT28.12.2016
BE28.12.2016
CZ28.12.2016
DK28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2017/41]AT28.12.2016
BE28.12.2016
CZ28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
IT28.12.2016
LT28.12.2016
LV28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SK28.12.2016
SM28.12.2016
BG28.03.2017
NO28.03.2017
GR29.03.2017
IS28.04.2017
PT28.04.2017
Former [2017/36]BE28.12.2016
CZ28.12.2016
EE28.12.2016
ES28.12.2016
FI28.12.2016
HR28.12.2016
LT28.12.2016
LV28.12.2016
NL28.12.2016
PL28.12.2016
RO28.12.2016
RS28.12.2016
SE28.12.2016
SK28.12.2016
NO28.03.2017
GR29.03.2017
IS28.04.2017
Former [2017/31]FI28.12.2016
HR28.12.2016
LT28.12.2016
LV28.12.2016
NL28.12.2016
RS28.12.2016
SE28.12.2016
NO28.03.2017
GR29.03.2017
Former [2017/28]FI28.12.2016
HR28.12.2016
LT28.12.2016
LV28.12.2016
RS28.12.2016
SE28.12.2016
NO28.03.2017
GR29.03.2017
Former [2017/12]LV28.12.2016
Cited inInternational search[X]  - TRENERRY V C ET AL, "The determination of vitamin D3 in bovine milk by liquid chromatography mass spectrometry", FOOD CHEMISTRY, ELSEVIER LTD, NL, vol. 125, no. 4, doi:10.1016/J.FOODCHEM.2010.09.097, ISSN 0308-8146, (20101010), pages 1314 - 1319, (20101028), XP027504503 [X] 1-11 * abstract * * page 1317 *

DOI:   http://dx.doi.org/10.1016/j.foodchem.2010.09.097
 [X]  - MAUNSELL Z ET AL, "Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25 hydroxy metabolites of vitamins D2 and D3", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, (20050901), vol. 51, no. 9, doi:10.1373/CLINCHEM.2005.052936, ISSN 0009-9147, pages 1683 - 1690, XP003005459 [X] 1-11 * abstract * * page 1684; figure 1a; table 1 *

DOI:   http://dx.doi.org/10.1373/clinchem.2005.052936
 [X]  - VOGESER M ET AL, "Candidate reference method for the quantification of circulating 25-hydroxyvitamin D3 by liquid chromatography-tandem mass spectrometry", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, (20040801), vol. 50, no. 8, doi:10.1373/CLINCHEM.2004.031831, ISSN 0009-9147, pages 1415 - 1417, XP003005458 [X] 1-11 * page 1415 - page 1416 *

DOI:   http://dx.doi.org/10.1373/clinchem.2004.031831
 [I]  - YING YU ET AL, "Identification and Structural Elucidation of Vitamin D3 Metabolites in Human Urine Using LC-MS-MS", CHROMATOGRAPHIA ; AN INTERNATIONAL JOURNAL FOR RAPID COMMUNICATION IN CHROMATOGRAPHY, ELECTROPHORESIS AND ASSOCIATED TECHNIQUES, VIEWEG VERLAG, WI, (20081126), vol. 69, no. 1-2, ISSN 1612-1112, pages 103 - 109, XP019666676 [I] 1-11 * abstract * * page 104; figures 2,4 *
Examination   - KNOX S ET AL, "A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography- tandem mass spectrometry", ANNALS OF CLINICAL BIOCHEMISTRY, BRITISH MEDICAL ASSOCIATION, LONDON, GB, (20090101), vol. 46, no. 3, ISSN 0004-5632, pages 226 - 230, XP008138348
by applicantUS7700365
 US7745226
 US2011195513
 US5968367
 US5919368
 US5795469
 US5772874
    - SAENGER ET AL., AM J CLIN PATHOL, (2006), vol. 125, pages 914 - 920
    - CAPOTE ET AL., RAPID COMMUN.. MASS SPECTROM., (2007), vol. 21, pages 1745 - 1754
    - TAYLOR ET AL., THERAPEUTIC DRUG MONITORING, (2000), vol. 22, pages 608 - 12
    - ZIMMER ET AL., J. CHROMATOGR. A, (1999), vol. 854, pages 23 - 35
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.