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Extract from the Register of European Patents

EP About this file: EP2793947

EP2793947 - ENZYMATIC CONJUGATION OF POLYPEPTIDES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.12.2021
Database last updated on 23.04.2024
FormerThe patent has been granted
Status updated on  01.01.2021
FormerGrant of patent is intended
Status updated on  21.10.2020
FormerExamination is in progress
Status updated on  11.09.2020
FormerGrant of patent is intended
Status updated on  17.05.2020
FormerExamination is in progress
Status updated on  20.04.2018
Most recent event   Tooltip11.08.2023Lapse of the patent in a contracting state
New state(s): SI
published on 13.09.2023  [2023/37]
Applicant(s)For all designated states
Innate Pharma
117, Avenue de Luminy
13009 Marseille / FR
For all designated states
Paul Scherrer Institut
5232 Villigen PSI / CH
[2021/05]
Former [2014/44]For all designated states
Innate Pharma
117, Avenue de Luminy
13009 Marseille / FR
For all designated states
Paul Scherrer Institut
5232 Villigen PSI / CH
Inventor(s)01 / BREGEON, Delphine
20 Rue de Suez
13007 Marseille / FR
02 / DENNLER, Patrick
Rankstrasse 13
5430 Wettingen / CH
03 / BELMANT, Christian
36 Impasse du Hameau de la Tour
83140 Six-Fours-Les-Plages / FR
04 / GAUTHIER, Laurent
30 Chemin du Lancier
Résidence la Sarette Bât 8
13008 Marseille / FR
05 / ROMAGNÉ, François
12 Boulevard Félibrige
13009 Marseille / FR
06 / FISCHER, Eliane
Schübelbachstrasse 10
8193 Eglisau / CH
07 / SCHIBLI, Roger
Schartenrainstrasse 42
5400 Baden / CH
 [2020/25]
Former [2014/44]01 / BREGEON, Delphine
20 Rue de Suez
13007 Marseille / FR
02 / DENNLER, Patrick
Rankstrasse 13
5430 Wettingen / CH
03 / BELMANT, Christian
36 Impasse du Hameau de la Tour
83140 Six-Fours-Les-Plages / FR
04 / GAUTHIER, Laurent
30 Chemin du Lancier
Résidence la Sarette Bât 8
13008 Marseille / FR
05 / ROMAGNÈ, François
12 Boulevard Félibrige
13009 Marseille / FR
06 / FISCHER, Eliane
Schübelbachstrasse 10
8193 Eglisau / CH
07 / SCHIBLI, Roger
Schartenrainstrasse 42
5400 Baden / CH
Representative(s)Cabinet Becker et Associés
25, rue Louis le Grand
75002 Paris / FR
[N/P]
Former [2021/05]Gallois, Valérie
Cabinet BECKER & ASSOCIES 25, rue Louis Le Grand
75002 Paris / FR
Former [2014/44]Völlmy, Lukas
Innate Pharma
IP Department
117, avenue de Luminy
13009 Marseille / FR
Application number, filing date12810292.821.12.2012
[2021/05]
WO2012EP76606
Priority number, dateUS201161579908P23.12.2011         Original published format: US 201161579908 P
US201261661569P19.06.2012         Original published format: US 201261661569 P
US201261671122P13.07.2012         Original published format: US 201261671122 P
[2014/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2013092983
Date:27.06.2013
Language:EN
[2013/26]
Type: A2 Application without search report 
No.:EP2793947
Date:29.10.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 27.06.2013 takes the place of the publication of the European patent application.
[2014/44]
Type: B1 Patent specification 
No.:EP2793947
Date:03.02.2021
Language:EN
[2021/05]
Search report(s)International search report - published on:EP03.04.2014
(Supplementary) European search report - dispatched on:EP24.04.2018
ClassificationIPC:A61K47/68, A61P35/00, C07D225/08, A61K47/60, C07D257/08, C07D277/06, C12N9/10
[2020/21]
CPC:
C07D225/08 (EP,US); A61K47/6803 (EP,US); A61K47/60 (US);
A61K47/68 (US); A61K47/68031 (EP); A61K47/6807 (US);
A61K47/6813 (US); A61K47/6817 (US); A61K47/6865 (EP,US);
A61K47/6871 (EP,US); A61P35/00 (EP); C07C217/08 (US);
C07C223/02 (US); C07C229/26 (US); C07C233/62 (US);
C07C247/04 (US); C07C323/12 (US); C07C323/60 (US);
C07D257/08 (EP,US); C07D277/06 (EP,US); C07F9/5022 (US);
C07K16/00 (US); C07K19/00 (US); C12N9/1044 (EP,US);
C12P21/005 (US); G01N33/6854 (US); C07K2317/40 (US) (-)
Former IPC [2018/21]A61K47/68, A61P35/00, C07D225/08
Former IPC [2014/44]A61K47/48, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ENZYMATISCHE KONJUGATION VON POLYPEPTIDEN[2014/44]
English:ENZYMATIC CONJUGATION OF POLYPEPTIDES[2014/44]
French:CONJUGAISON ENZYMATIQUE DE POLYPEPTIDES[2014/44]
Entry into regional phase18.07.2014National basic fee paid 
18.07.2014Designation fee(s) paid 
18.07.2014Examination fee paid 
Examination procedure18.07.2014Amendment by applicant (claims and/or description)
18.07.2014Examination requested  [2014/44]
24.04.2018Despatch of a communication from the examining division to which search results under Rule 164(2) EPC are annexed (Time limit: M06) [2018/21]
24.04.2018Despatch of a communication from the examining division (Time limit: M06)
23.11.2018Reply to a communication from the examining division
06.12.2019Despatch of a communication from the examining division (Time limit: M04)
02.01.2020Reply to a communication from the examining division
18.05.2020Communication of intention to grant the patent
09.09.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
09.09.2020Fee for grant paid
09.09.2020Fee for publishing/printing paid
29.10.2020Communication of intention to grant the patent
09.12.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.04.2018
Opposition(s)04.11.2021No opposition filed within time limit [2022/02]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
23.11.2018Request for further processing filed
23.11.2018Full payment received (date of receipt of payment)
Request granted
04.12.2018Decision despatched
Fees paidRenewal fee
29.12.2014Renewal fee patent year 03
28.12.2015Renewal fee patent year 04
27.12.2016Renewal fee patent year 05
27.12.2017Renewal fee patent year 06
31.12.2018Renewal fee patent year 07
27.12.2019Renewal fee patent year 08
28.12.2020Renewal fee patent year 09
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU21.12.2012
AL03.02.2021
AT03.02.2021
CY03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
IT03.02.2021
LT03.02.2021
LV03.02.2021
MC03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SI03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
[2023/37]
Former [2023/30]HU21.12.2012
AL03.02.2021
AT03.02.2021
CY03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
IT03.02.2021
LT03.02.2021
LV03.02.2021
MC03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2023/27]HU21.12.2012
AL03.02.2021
AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
IT03.02.2021
LT03.02.2021
LV03.02.2021
MC03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2022/33]AL03.02.2021
AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
IT03.02.2021
LT03.02.2021
LV03.02.2021
MC03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2022/23]AL03.02.2021
AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
IT03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2022/10]AL03.02.2021
AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
PT04.06.2021
Former [2022/07]AL03.02.2021
AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/51]AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
ES03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/50]AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RO03.02.2021
RS03.02.2021
SE03.02.2021
SK03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/49]AT03.02.2021
CZ03.02.2021
DK03.02.2021
EE03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RS03.02.2021
SE03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/48]AT03.02.2021
CZ03.02.2021
EE03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RS03.02.2021
SE03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/46]AT03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RS03.02.2021
SE03.02.2021
SM03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/42]AT03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RS03.02.2021
SE03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
IS03.06.2021
PT04.06.2021
Former [2021/39]AT03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
PL03.02.2021
RS03.02.2021
SE03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
PT04.06.2021
Former [2021/38]AT03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
RS03.02.2021
SE03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
PT04.06.2021
Former [2021/37]AT03.02.2021
FI03.02.2021
HR03.02.2021
LT03.02.2021
LV03.02.2021
RS03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
PT04.06.2021
Former [2021/36]FI03.02.2021
HR03.02.2021
LT03.02.2021
BG03.05.2021
NO03.05.2021
GR04.05.2021
PT04.06.2021
Former [2021/35]FI03.02.2021
HR03.02.2021
LT03.02.2021
NO03.05.2021
PT04.06.2021
Former [2021/33]FI03.02.2021
LT03.02.2021
NO03.05.2021
PT04.06.2021
Cited inInternational search[AD]US2011184147  (KAMIYA NORIHO [JP], et al) [AD] 1-3,12-23,28-54,57,64,66-88* the whole document *;
    [XDYI] - JEGER S. ET AL., "Site-Specific and stoichiometric Modification of Antibodies by Bacterial Transglutaminase", ANGEW. CHEM. INT. ED., (20101217), vol. 49, pages 9995 - 9997, XP002695029 [XD] 1-3,12-17,20-22,30-32,34-40,42-47,64,66-81 * Abstract, page 9995, Figure 1; page 9996. Supportive information pages 8, 30 and 31. * [Y] 33,41,42,48,83-88 [I] 18,19,49-54,57,82

DOI:   http://dx.doi.org/10.1002/ANIE.201004243
 [XYI]  - Jeger S., PhD Thesis, Site-specific conjugation of Tumour-Targeting Antibodies Using Transglutaminase, Zürich, ETH Zürich, (20090101), XP002695030 [X] 1-3,12-17,20-22,30-32,34-40,42-47,64,66-81 * Pages 51-85 * [Y] 33,41,42,48,83-88 [I] 18,19,49-54,57,82
 [X]  - THOMAS L MINDT ET AL, "Modification of different IgG1 antibodies via glutamine and lysine using bacterial and human tissue transglutaminase", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 19, no. 1, doi:10.1021/BC700306N, ISSN 1043-1802, (20080101), pages 271 - 278, (20071108), XP002676805 [X] 64,65 * Abstract; page 272 figure 1; page 274 Scheme 1; page 275 second column paragraphs 1-3. *

DOI:   http://dx.doi.org/10.1021/bc700306n
 [Y]  - KEYANG XU ET AL, "Characterization of intact antibodydrug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatographymass spectrometry", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 412, no. 1, doi:10.1016/J.AB.2011.01.004, ISSN 0003-2697, (20110104), pages 56 - 66, (20110107), XP028173871 [Y] 83-88 * Abstract, page 58 Figure 1. *

DOI:   http://dx.doi.org/10.1016/j.ab.2011.01.004
 [Y]  - C. WÄNGLER ET AL, "Antibody-Dendrimer Conjugates: The Number, Not the Size of the Dendrimers, Determines the Immunoreactivity", BIOCONJUGATE CHEMISTRY, (20080401), vol. 19, no. 4, doi:10.1021/bc700308q, ISSN 1043-1802, pages 813 - 820, XP055020206 [Y] 33,41,42,48 * Abstract; page 815, figure 3 *

DOI:   http://dx.doi.org/10.1021/bc700308q
 [AD]  - CHI-WANG LIN ET AL, "Transglutaminase-Catalyzed Site-Specific Conjugation of Small-Molecule Probes to Proteins in Vitro and on the Surface of Living Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20060401), vol. 128, no. 14, doi:10.1021/ja0604111, ISSN 0002-7863, pages 4542 - 4543, XP055028216 [AD] 1-3,12-23,28-54,57,64,66-88 * the whole document *

DOI:   http://dx.doi.org/10.1021/ja0604111
ExaminationWO2008029281
 WO2012059882
    - F Lhospice ET AL, "Towards Homogenous ADCs : A new Site-Specific Antibody Conjugation using Bacterial Transglutaminase", (20130101), URL: https://innate-pharma.com/sites/default/files/homogenous_adcs_new_site-specific_conjugation_based_on_btg.pdf, (20180321), XP055461449
    - KYOJI TSUCHIKAMA ET AL, "Antibody-drug conjugates: recent advances in conjugation and linker chemistries", PROTEIN & CELL, Beijing, CN, (20161014), vol. 9, no. 1, doi:10.1007/s13238-016-0323-0, ISSN 1674-800X, pages 33 - 46, XP055461467

DOI:   http://dx.doi.org/10.1007/s13238-016-0323-0
    - PATRICK DENNLER ET AL, "Transglutaminase-Based Chemo-Enzymatic Conjugation Approach Yields Homogeneous Antibody-Drug Conjugates", BIOCONJUGATE CHEMISTRY, (20140319), vol. 25, no. 3, doi:10.1021/bc400574z, ISSN 1043-1802, pages 569 - 578, XP055118351

DOI:   http://dx.doi.org/10.1021/bc400574z
    - SIMONE JEGER ET AL, "Site-Specific and stoichiometric Modification of Antibodies by Bacterial Transglutaminase", vol. 49, no. 51, doi:10.1002/ANIE.201004243, ISSN 1433-7851, (20101217), pages 9995 - 9997, ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.201004243/pdf, (20101125), XP002695029

DOI:   http://dx.doi.org/10.1002/ANIE.201004243
    - SIMONE JEGER, "Site-Specific Conjugation of Tumour-Targeting Antibodies Using Transglutaminase", no. DISS. ETH 18696, (20090101), pages 51 - 85, A DISSERTATION SUBMITTED TO ETH ZURICH FOR THE DEGREE OF DOCTOR OF SCIENCES, UNIVERSITY OF BASEL, URL: http://e-collection.library.ethz.ch/eserv/eth:650/eth-650-02.pdf, XP002695030
    - CHI-WANG LIN ET AL, "Transglutaminase-Catalyzed Site-Specific Conjugation of Small-Molecule Probes to Proteins in Vitro and on the Surface of Living Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20060401), vol. 128, no. 14, doi:10.1021/ja0604111, ISSN 0002-7863, pages 4542 - 4543, XP055028216

DOI:   http://dx.doi.org/10.1021/ja0604111
    - NORIHO KAMIYA ET AL, "Site-specific cross-linking of functional proteins by transglutamination", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 33, no. 4, doi:10.1016/S0141-0229(03)00154-6, ISSN 0141-0229, (20030910), pages 492 - 496, (20030702), XP002725332

DOI:   http://dx.doi.org/10.1016/S0141-0229(03)00154-6
    - J. Grünberg ET AL, "Bacterial transglutaminase (BTG): the better way for site-specific modification of therapeutic antibodies", PSI Scientific Report 2010, (20100101), pages 48 - 49, URL: https://www.psi.ch/info/MediaBoard/PSI_ScientificReport_2010.pdf, (20180321), XP055461477
    - Laurent Ducry ET AL, "Considerations of Linker Technologies", Drug Delivery in Oncology : From Basic Research to Cancer Therapy, Weinheim, Germany, Wiley-VCH Verlag GmbH & Co. KGaA, (20111019), pages 355 - 374, doi:10.1002/9783527634057.ch12, ISBN 978-3-527-32823-9, XP055461496

DOI:   http://dx.doi.org/10.1002/9783527634057.ch12
    - DANIELLE J. VUGTS ET AL, "Synthesis of Phosphine and Antibody-Azide Probes for in Vivo Staudinger Ligation in a Pretargeted Imaging and Therapy Approach", BIOCONJUGATE CHEMISTRY, (20111019), vol. 22, no. 10, doi:10.1021/bc200298v, ISSN 1043-1802, pages 2072 - 2081, XP055461830

DOI:   http://dx.doi.org/10.1021/bc200298v
by applicantUS252028
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 US5156956
 WO9222583
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