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Extract from the Register of European Patents

EP About this file: EP2773199

EP2773199 - INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.02.2020
Database last updated on 23.04.2024
FormerThe patent has been granted
Status updated on  08.03.2019
FormerGrant of patent is intended
Status updated on  07.11.2018
FormerExamination is in progress
Status updated on  23.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
[2014/37]
Inventor(s)01 / WALSH, Shawn, P.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
02 / PASTERNAK, Alexander
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
03 / DEJESUS, Reynalda, K.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
04 / TANG, Haifeng
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
05 / PIO, Barbara
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
06 / SHAHRIPOUR, Aurash
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
07 / BELYK, Kevin, M.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
08 / CHOBANIAN, Harry, R.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
09 / GUO, Yan
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
10 / FRIE, Jessica, L.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
11 / SHI, Zhi-Cai
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
12 / CHEN, Helen
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
13 / BLIZZARD, Timothy, A.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
14 / CATO, Brian
209 Sandcastle Key
Secaucus, New Jersey 07094 / US
 [2014/37]
Representative(s)Hussain, Deeba, et al
Merck Sharp & Dohme Corp.
120 Moorgate
London, EC2M 6UR / GB
[N/P]
Former [2019/15]Hussain, Deeba, et al
Merck & Co., Inc.
Patent Department
Hertford Road
Hoddesdon
Hertfordshire EN11 9BU / GB
Former [2014/37]Hussain, Deeba, et al
Merck & Co., Inc. Patent Department Hertford Road Hoddesdon
Hertfordshire EN11 9BU / GB
Application number, filing date12845954.225.10.2012
[2019/15]
WO2012US61884
Priority number, dateUS201161553374P31.10.2011         Original published format: US 201161553374 P
[2014/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013066714
Date:10.05.2013
Language:EN
[2013/19]
Type: A1 Application with search report 
No.:EP2773199
Date:10.09.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 10.05.2013 takes the place of the publication of the European patent application.
[2014/37]
Type: B1 Patent specification 
No.:EP2773199
Date:10.04.2019
Language:EN
[2019/15]
Search report(s)International search report - published on:US10.05.2013
(Supplementary) European search report - dispatched on:EP16.12.2015
ClassificationIPC:C07D405/12, C07D405/14, C07D407/12, C07D409/12, C07D471/08, C07D487/08, C07D487/18, C07D498/08, A61K31/496, A61K31/499, A61K31/4995, A61P7/10, A61P9/04, A61P9/12
[2015/31]
CPC:
C07D471/08 (EP,US); A61P7/10 (EP); A61P9/04 (EP);
A61P9/12 (EP); C07D405/12 (EP,US); C07D405/14 (EP,US);
C07D407/12 (EP,US); C07D409/12 (EP,US); C07D409/14 (EP,US);
C07D487/08 (EP,US); C07D487/18 (EP,US); C07D491/08 (EP,US);
C07D498/08 (EP,US) (-)
Former IPC [2014/37]A01N29/04
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/37]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:INHIBITOREN DES RENALEN KALIUMKANALS DER ÄUSSEREN MEDULLA[2014/37]
English:INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL[2014/37]
French:INHIBITEURS DU CANAL POTASSIQUE MÉDULLAIRE EXTERNE RÉNAL[2014/37]
Entry into regional phase02.06.2014National basic fee paid 
02.06.2014Search fee paid 
02.06.2014Designation fee(s) paid 
02.06.2014Examination fee paid 
Examination procedure02.06.2014Examination requested  [2014/37]
21.07.2016Amendment by applicant (claims and/or description)
03.01.2017Despatch of a communication from the examining division (Time limit: M06)
12.07.2017Reply to a communication from the examining division
13.03.2018Despatch of a communication from the examining division (Time limit: M06)
24.09.2018Reply to a communication from the examining division
08.11.2018Communication of intention to grant the patent
27.02.2019Fee for grant paid
27.02.2019Fee for publishing/printing paid
27.02.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  03.01.2017
Opposition(s)13.01.2020No opposition filed within time limit [2020/12]
Fees paidRenewal fee
07.10.2014Renewal fee patent year 03
07.10.2015Renewal fee patent year 04
07.10.2016Renewal fee patent year 05
10.10.2017Renewal fee patent year 06
08.10.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.10.2012
AL10.04.2019
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Documents cited:Search[Y]WO2010129379  (MERCK SHARP & DOHME [US], et al) [Y] 1-3,10-12,16-24 * the whole document *;
 [YP]WO2012058134  (MERCK SHARP & DOHME [US], et al) [YP] 1-3,10-12,16-24 * the whole document; in particular, (i) claim 1,and the examples 210-212 and 217 on pages 196-197, and (ii) claim 1, in particular, the definition of R9 and R7 forming a ring *
International search[X]WO2010129379  (MERCK SHARP & DOHME [US], et al);
 [X]US2010286123  (PASTERNAK ALEXANDER [US], et al);
 [XP]WO2012058116  (MERCK SHARP & DOHME [US], et al);
 [A]US2010093634  (WELLING PAUL A [US], et al);
 [Y]  - LEE ET AL., "Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, (2008), vol. 27, pages 332 - 341, XP055066297

DOI:   http://dx.doi.org/10.1016/j.jmgm.2008.06.001
 [A]  - LEWIS ET AL., "High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1", MOLECULAR PHARMACOLOGY, (2009), vol. 76, pages 1094 - 1103, XP009135107

DOI:   http://dx.doi.org/10.1124/mol.109.059840
 [A]  - WELLING ET AL., "A comprehensive guide to the ROMK potassium channel: form and function in health and disease", AM J PHYSIOL RENAL PHYSIOL, (2009), vol. 297, pages F849 - F863, XP055068160

DOI:   http://dx.doi.org/10.1152/ajprenal.00181.2009
by applicantWO2010129379
 US5116835
 US5095119
 US5104869
 US5114937
 US5106835
 US5063208
 US4845079
 US5089471
 US5071837
 US5064965
 US5063207
 US5036054
 US5036053
 US5034512
 US4894437
 US5098924
 US5055466
 US4885292
 US5075451
 US4980283
 US5066643
 WO2011025690
    - HO, K. et al., "Cloning and expression of an inwardly rectifying A TP-regulated potassium channel", Nature, (19930000), vol. 362, no. 6415, doi:doi:10.1038/362031a0, pages 31.8.1 - 31.8.2, XP002030879

DOI:   http://dx.doi.org/10.1038/362031a0
    - SHUCK, M.E. et al., "Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel", J Biol Chem, (19940000), vol. 269, no. 39, pages 24261 - 70, XP000941647
    - HEBERT, S.C. et al., "Molecular diversity and regulation of renal potassium channels", Physiol Rev, (20050000), vol. 85, no. 1, doi:doi:10.1152/physrev.00051.2003, pages 319 - 713, XP055458873

DOI:   http://dx.doi.org/10.1152/physrev.00051.2003
    - REINALTER, S.C. et al., "Pharmacotyping ofhypokalaemic salt-losing tubular disorders", Acta Physiol Scand, (20040000), vol. 181, no. 4, doi:doi:10.1111/j.1365-201X.2004.01325.x, pages 513 - 21, XP055458892

DOI:   http://dx.doi.org/10.1111/j.1365-201X.2004.01325.x
    - WANG, W., "Renal potassium channels: recent developments", Curr Opin Nephrol Hypertens, (20040000), vol. 13, no. 5, doi:doi:10.1097/00041552-200409000-00011, pages 549 - 55, XP009504083

DOI:   http://dx.doi.org/10.1097/00041552-200409000-00011
    - LIFTON, R.P.; A.G. GHARAVI; D.S. GELLER, "Molecular mechanisms of human hypertension", Cell, (20010000), vol. 104, no. 4, doi:doi:10.1016/S0092-8674(01)00241-0, pages 545 - 56, XP055458895

DOI:   http://dx.doi.org/10.1016/S0092-8674(01)00241-0
    - JI, W. et al., "Rare independent mutations in renal salt handling genes contribute to blood pressure variation", Nat Genet, (20080000), vol. 40, no. 5, doi:doi:10.1038/ng.118, pages 592 - 9, XP055458896

DOI:   http://dx.doi.org/10.1038/ng.118
    - TOBIN, M.D. et al., "Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population", Hypertension, (20080000), vol. 51, no. 6, doi:doi:10.1161/HYPERTENSIONAHA.108.112664, pages 1658 - 64, XP055458899

DOI:   http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.112664
    - LORENZ, J.N. et al., "Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome", J Biol Chem, (20020000), vol. 277, no. 40, doi:doi:10.1074/jbc.M205627200, pages 37871 - 80, XP055458903

DOI:   http://dx.doi.org/10.1074/jbc.M205627200
    - LU, M. et al., "Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice", J Biol Chem, (20020000), vol. 277, no. 40, doi:doi:10.1074/jbc.M206644200, pages 37881 - 7, XP055458906

DOI:   http://dx.doi.org/10.1074/jbc.M206644200
    - LEWIS, L.M. et al., "High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1", Mol Pharmacol, (20090000), vol. 76, no. 5, doi:doi:10.1124/mol.109.059840, pages 1094 - 1103, XP009135107

DOI:   http://dx.doi.org/10.1124/mol.109.059840
    - HAMILL, Pfluegers Archives, (19810000), vol. 391, pages 85 - 100
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