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Extract from the Register of European Patents

EP About this file: EP2893061

EP2893061 - METHODS FOR DISCOVERING THERAPEUTIC TARGETS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.03.2020
Database last updated on 23.04.2024
FormerThe patent has been granted
Status updated on  19.04.2019
FormerGrant of patent is intended
Status updated on  05.12.2018
FormerExamination is in progress
Status updated on  03.02.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University
1475 North Scottsdale Road
Skysong Suite 200
Scottsdale, AZ 85257-9908 / US
[2018/51]
Former [2015/29]For all designated states
Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University
1475 North Scottsdale Road
Sky Song Suite 200
Scottsdale, US 85257 / US
Inventor(s)01 / JOHNSTON, Stephen, Albert
8606 South Dorsey Lane
Tempe, AZ 85284 / US
02 / LEGUTKI, Joseph, Barten
1475 North Scottsdale Road
Skysong Suite 200
Scottsdale, AZ 85257-9908 / US
03 / KUKREJA, Muskan
445 Ribbon Beach Way
Apt. 278
Oceanside, CA 92058 / US
 [2015/43]
Former [2015/29]01 / JOHNSTON, Stephen, Albert
8606 South Dorsey Lane
Tempe, AZ 85284 / US
02 / LEGUTKI, Joseph, Barten
1475 North Scottsdale Road
Skysong Suite 200
Scottsdale, AZ 85257-9908 / US
03 / KUKREJA, Muskan
1475 North Scottsdale Road
Skysong Suite 200
Scottsdale, AZ 85257-9908 / US
Representative(s)Avidity IP
Broers Building
Hauser Forum
21 JJ Thomson Avenue
Cambridge CB3 0FA / GB
[2019/21]
Former [2015/29]Cole, William Gwyn, et al
Avidity IP
Broers Building
Hauser Forum
21 J J Thomson Ave
Cambridge CB3 0FA / GB
Application number, filing date13834985.705.09.2013
[2019/21]
WO2013US58325
Priority number, dateUS201261696873P05.09.2012         Original published format: US 201261696873 P
US20131401416829.08.2013         Original published format: US201314014168
[2015/29]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014039718
Date:13.03.2014
Language:EN
[2014/11]
Type: A1 Application with search report 
No.:EP2893061
Date:15.07.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 13.03.2014 takes the place of the publication of the European patent application.
[2015/29]
Type: B1 Patent specification 
No.:EP2893061
Date:22.05.2019
Language:EN
[2019/21]
Search report(s)International search report - published on:US13.03.2014
(Supplementary) European search report - dispatched on:EP13.04.2016
ClassificationIPC:C40B30/04
[2015/29]
CPC:
G01N33/6854 (EP,CN,GB); G01N33/6845 (EP,CN,GB,US); C40B30/04 (GB);
C07K1/047 (EP,US); G01N2500/00 (EP,US); G01N2800/60 (EP,US);
G01N33/564 (EP,US); G01N33/574 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/29]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR ENTDECKUNG THERAPEUTISCHER ZIELMOLEKÜLE[2015/29]
English:METHODS FOR DISCOVERING THERAPEUTIC TARGETS[2015/29]
French:PROCÉDÉS DE DÉCOUVERTE DE CIBLES THÉRAPEUTIQUES[2015/29]
Entry into regional phase30.03.2015National basic fee paid 
30.03.2015Search fee paid 
30.03.2015Designation fee(s) paid 
30.03.2015Examination fee paid 
Examination procedure30.03.2015Examination requested  [2015/29]
10.11.2016Amendment by applicant (claims and/or description)
02.02.2017Despatch of a communication from the examining division (Time limit: M06)
11.08.2017Reply to a communication from the examining division
16.10.2018Cancellation of oral proceeding that was planned for 19.10.2018
19.10.2018Date of oral proceedings (cancelled)
06.12.2018Communication of intention to grant the patent
15.04.2019Fee for grant paid
15.04.2019Fee for publishing/printing paid
15.04.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19175462.1  / EP3604634
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.02.2017
Opposition(s)25.02.2020No opposition filed within time limit [2020/18]
Fees paidRenewal fee
28.09.2015Renewal fee patent year 03
27.09.2016Renewal fee patent year 04
27.09.2017Renewal fee patent year 05
27.09.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.09.2013
AL22.05.2019
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Documents cited:Search[X]WO2008151146  (DIGITAB INC [US], et al) [X] 1-15 * par.29, 373; claims 6, 13 *;
 [X]  - R. F. HALPERIN ET AL, "Exploring Antibody Recognition of Sequence Space through Random-Sequence Peptide Microarrays", MOLECULAR & CELLULAR PROTEOMICS, (20110301), vol. 10, no. 3, doi:10.1074/mcp.M110.000786, ISSN 1535-9476, XP055261904 [X] 1-15 * p.1 last par. - p.2; figure 1; discussion last column *

DOI:   http://dx.doi.org/10.1074/mcp.M110.000786
 [X]  - CHEN GUOAN ET AL, "Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20070401), vol. 67, no. 7, doi:10.1158/0008-5472.CAN-06-4475, ISSN 0008-5472, pages 3461 - 3467, XP002613601 [X] 1-15 * abstract; discussion last paragraph *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-06-4475
 [X]  - MICHAEL HECKER ET AL, "Computational analysis of high-density peptide microarray data with application from systemic sclerosis to multiple sclerosis", AUTOIMMUNITY REVIEWS, vol. 11, no. 3, doi:10.1016/J.AUTREV.2011.05.010, ISSN 1568-9972, (20120101), pages 180 - 190, (20110518), XP028445112 [X] 1-15 * abstract; p.9 col.1 par.1 *

DOI:   http://dx.doi.org/10.1016/j.autrev.2011.05.010
International search[A]US2009176664  (CHU KETING [US]);
 [A]US2011143953  (JOHNSTON STEPHEN A [US], et al);
 [X]US2012190574  (JOHNSTON STEPHEN ALBERT [US], et al)
by applicantUS2012190574
    - HANASH, S., "Disease proteomics", Nature, (20030000), vol. 422, doi:doi:10.1038/nature01514, pages 226 - 232, XP002337600

DOI:   http://dx.doi.org/10.1038/nature01514
    - REDDY, M.M. et al., "Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening", Cell, vol. 144, doi:doi:10.1016/j.cell.2010.11.054, pages 132 - 142, XP028151095

DOI:   http://dx.doi.org/10.1016/j.cell.2010.11.054
    - PANICKER, R.C. et al., "Recent advances in peptide-based microarray technologies", Comb Chem High Throughput Screen, (20040000), vol. 7, pages 547 - 556
    - FU, J. et al., "Exploring peptide space for enzyme modulators", J Am Chem Soc, (20100000), vol. 132, pages 6419 - 6424
    - FU, J. et al., "Peptide-modified surfaces for enzyme immobilization", PLoS One, (20110000), vol. 6, page e18692
    - DIEHNELT, C.W. et al., "Discovery of high-affinity protein binding ligands-backwards", PLoS One, vol. 5, doi:doi:10.1371/journal.pone.0010728, page e10728, XP055052323

DOI:   http://dx.doi.org/10.1371/journal.pone.0010728
    - GREVING, M.P. et al., "High-throughput screening in two dimensions: binding intensity and off-rate on a peptide microarray", Anal Biochem, vol. 402, pages 93 - 95
    - GREVING, M.P. et al., "Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information", PLoS One, vol. 5, page e15432
    - GUPTA, N. et al., "Engineering a synthetic ligand for tumor necrosis factor-alpha", Bioconjug Chem, vol. 22, doi:doi:10.1021/bc200091c, pages 1473 - 1478, XP055052318

DOI:   http://dx.doi.org/10.1021/bc200091c
    - BOLTZ, K.W. et al., "Peptide microarrays for carbohydrate recognition", Analyst, (20090000), vol. 134, doi:doi:10.1039/b823156g, pages 650 - 652, XP009120846

DOI:   http://dx.doi.org/10.1039/b823156g
    - FOONG, Y.M. et al., "Current advances in peptide and small molecule microarray technologies", Curr Opin Chem Biol, (20120000), vol. 16, pages 234 - 242
    - MORALES BETANZOS, C. et al., "Bacterial glycoprofiling by using random sequence peptide microarrays", Chembiochem, (20090000), vol. 10, doi:doi:10.1002/cbic.200800716, pages 877 - 888, XP055051159

DOI:   http://dx.doi.org/10.1002/cbic.200800716
    - FALSEY, J.R. et al., "Peptide and small molecule microarray for high throughput cell adhesion and functional assays", Bioconjug Chem, (20010000), vol. 12, doi:doi:10.1021/bc000141q, pages 346 - 353, XP001145929

DOI:   http://dx.doi.org/10.1021/bc000141q
    - CERECEDO, I. et al., "Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay", J Allergy Clin Immunol, (20080000), vol. 122, doi:doi:10.1016/j.jaci.2008.06.040, pages 589 - 594, XP024519626

DOI:   http://dx.doi.org/10.1016/j.jaci.2008.06.040
    - CRETICH, M. et al., "Epitope mapping of human chromogranin A by peptide microarrays", Methods Mol Biol, (20090000), vol. 570, pages 221 - 232
    - LIN, J. et al., "Development of a novel peptide microarray for large-scale epitope mapping of food allergens", J Allergy Clin Immunol, (20090000), vol. 124, pages 315 - 322,322 e311-313
    - LORENZ, P. et al., "Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease", Methods Mol Biol, (20090000), vol. 524, doi:doi:10.1007/978-1-59745-450-6_18, pages 247 - 258, XP009138991

DOI:   http://dx.doi.org/10.1007/978-1-59745-450-6_18
    - PEREZ-GORDO, M. et al., "Epitope mapping of Atlantic salmon major allergen by peptide microarray immunoassay", Int. Arch Allergy Immunol, (20120000), vol. 157, pages 31 - 40
    - SHREFFLER, W.G. et al., "IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2", J Allergy Clin Immunol, (20050000), vol. 116, doi:doi:10.1016/j.jaci.2005.06.033, pages 893 - 899, XP005094484

DOI:   http://dx.doi.org/10.1016/j.jaci.2005.06.033
    - MOHAN, S. et al., "Association energetics of cross-reactive and specific antibodies", Biochemistry, (20090000), vol. 48, doi:doi:10.1021/BI801901D, pages 1390 - 1398, XP002556431

DOI:   http://dx.doi.org/10.1021/BI801901D
    - THORPE, I.F.; BROOKS, C.L., 3RD, "Molecular evolution of affinity and flexibility in the immune system", Proceedings of the National Academy of Sciences of the United States of America, (20070000), vol. 104, doi:doi:10.1073/pnas.0610064104, pages 8821 - 8826, XP055069476

DOI:   http://dx.doi.org/10.1073/pnas.0610064104
    - ZHOU, Z.H. et al., "Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells", J Autoimmun, (20070000), vol. 29, doi:doi:10.1016/j.jaut.2007.07.015, pages 219 - 228, XP022317186

DOI:   http://dx.doi.org/10.1016/j.jaut.2007.07.015
    - FOLGORI, A. et al., "A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera", Embo J, (19940000), vol. 13, pages 2236 - 2243, XP000441903
    - CHRISTIAN, R.B. et al., "Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage", Journal of Molecular Biology, (19920000), vol. 227, doi:doi:10.1016/0022-2836(92)90219-A, pages 711 - 718, XP024020603

DOI:   http://dx.doi.org/10.1016/0022-2836(92)90219-A
    - LIU, R. et al., "Combinatorial peptide library methods for immunobiology research", Experimental Hematology, (20030000), vol. 31, pages 11 - 30
    - WANG, Y. et al., "Detection of Mammary Tumor Virus ENV Gene-like Sequences in Human Breast Cancer", Cancer Research, (19950000), vol. 55, pages 5173 - 5179, XP001008892
    - DERDA, R. et al., "Diversity of phage-displayed libraries of peptides during panning and amplification", Molecules, (20110000), vol. 16, doi:doi:10.3390/molecules16021776, pages 1776 - 1803, XP009157587

DOI:   http://dx.doi.org/10.3390/molecules16021776
    - SZARDENINGS, M., "Phage display of random peptide libraries: applications, limits, and potential", J Recept Signal Transduct Res, (20030000), vol. 23, pages 307 - 34953
    - NOBREGA, A. et al., "Functional diversity and clonal frequencies of reactivity in the available antibody repertoire", European Journal of Immunology, (19980000), vol. 28, pages 1204 - 1215
    - BROWN, J.R. et al., "Statistical methods for analyzing immunosignatures", BMC Bioinformatics, (20110000), vol. 12, doi:doi:10.1186/1471-2105-12-349, page 349, XP021108665

DOI:   http://dx.doi.org/10.1186/1471-2105-12-349
    - HUGHES, A.K. et al., "Immunosignaturing can detect products from molecular markers in brain cancer", PLoS One, (20120000), vol. 7, doi:doi:10.1371/journal.pone.0040201, page e40201, XP055261866

DOI:   http://dx.doi.org/10.1371/journal.pone.0040201
    - KROENING, K. et al., "Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays. Are autoantibodies really autoantibodies?", Exp Mol Pathol, (20120000), vol. 92, doi:doi:10.1016/j.yexmp.2012.03.002, pages 304 - 311, XP028423893

DOI:   http://dx.doi.org/10.1016/j.yexmp.2012.03.002
    - KUKREJA, M. et al., "Comparative study of classification algorithms for immunosignaturing data", BMC Bioinformatics, (20120000), vol. 13, doi:doi:10.1186/1471-2105-13-139, page 139, XP021132325

DOI:   http://dx.doi.org/10.1186/1471-2105-13-139
    - LEGUTKI, J.B. et al., "A general method for characterization of humoral immunity induced by a vaccine or infection", Vaccine, (20100000), vol. 28, doi:doi:10.1016/j.vaccine.2010.04.061, pages 4529 - 4537, XP027078073

DOI:   http://dx.doi.org/10.1016/j.vaccine.2010.04.061
    - STAFFORD, P.; JOHNSTON, S., "Microarray technology displays the complexities of the humoral immune response", Expert Rev Mol Diagn, (20110000), vol. 11, pages 5 - 8
    - HALPERIN, R.F. et al., "Exploring Antibody Recognition of Sequence Space through Random-Sequence Peptide Microarrays", Molecular & Cellular Proteomics, (20110000), vol. 10, doi:doi:10.1074/mcp.M110.000786, XP055261904

DOI:   http://dx.doi.org/10.1074/mcp.M110.000786
    - STAFFORD, P.; JOHNSTON, S., "Microarray technology displays the complexities of the humoral immune response", Expert Rev Mol Diagn, (20110000), vol. 11
    - STAFFORD, P. et al., "Physical characterization of the ''immunosignaturing effect", Mol Cell Proteomics, (20120000), vol. 11, page Ml 11 011593
    - CHASE, B.A. et al., "Evaluation of biological sample preparation for immunosignature-based diagnostics", Clin Vaccine Immunol, (20120000), vol. 19, doi:doi:10.1128/CVI.05667-11, pages 352 - 358, XP055261902

DOI:   http://dx.doi.org/10.1128/CVI.05667-11
    - RESTREPO, L. et al., "Application of immunosignatures to the assessment of Alzheimer's disease", Annals of Neurology, (20110000), vol. 70, doi:doi:10.1002/ana.22405, pages 286 - 295, XP055261912

DOI:   http://dx.doi.org/10.1002/ana.22405
    - UHLEN, M.; HOBER, S., "Generation and validation of affinity reagents on a proteome-wide level", J Mol Recognit, (20090000), vol. 22, pages 57 - 64
    - YANG, Y. et al., "Segmentation and intensity estimation for microarray images with saturated pixels", BMC Bioinformatics, (20110000), vol. 12, doi:doi:10.1186/1471-2105-12-462, page 462, XP021130391

DOI:   http://dx.doi.org/10.1186/1471-2105-12-462
    - HUGHES, A.K. et al., "Immunosignaturing can detect products from molecular markers in brain cancer", PLoS One, vol. 7, doi:doi:10.1371/journal.pone.0040201, page e40201, XP055261866

DOI:   http://dx.doi.org/10.1371/journal.pone.0040201
    - B. W. JAGGER et al., Science, (20120713), vol. 337, page 199 9
    - J. B. LEGUTKI; D. M. MAGEE; P. STAFFORD; S. A. JOHNSTON, Vaccine, (20100505), vol. 28, page 4529
    - R. F. HALPERIN; P. STAFFORD; J. S. EMERY; K. A. NAVALKAR; S. A. JOHNSTON, BMC Bioinformatics, (20120000), vol. 13, page 1
    - B. A. CHASE; S. A. JOHNSTON; J. B. LEGUTKI, Clin Vaccine Immunol, (20120300), vol. 19, page 352
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