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Extract from the Register of European Patents

EP About this file: EP3077397

EP3077397 - 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 24.07.2020 Database last updated on 23.04.2024
Former	The patent has been granted Status updated on 16.08.2019
Former	Grant of patent is intended Status updated on 05.04.2019
Former	Examination is in progress Status updated on 31.03.2017
Most recent event Tooltip	28.05.2021	Lapse of the patent in a contracting state New state(s): CY	published on 30.06.2021 [2021/26]
Applicant(s)	For all designated states Vertex Pharmaceuticals Inc. 50 Northern Avenue 15th Floor Boston, MA 02210 / US
	[2019/38]
Former [2016/41]	For all designated states Vertex Pharmaceuticals Inc. 50 Northern Avenue 15th Floor Boston, MA 02210 / US
Inventor(s)	01 / CHARRIER, Jean-Damien 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	02 / DAVIS, Christopher, John 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	03 / FRAYSSE, Damien 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	04 / ETXEBARRIA I JARDI, Gorka 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	05 / PEGG, Simon 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	06 / PIERARD, Francoise 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	07 / PINDER, Joanne 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	08 / STUDLEY, John 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	09 / ZWICKER, Carl 1662 Commonwealth Avenue Apt. 45 Brighton, MA 02135 / US
	10 / SANGHVI, Tapan 157 Summer Stgreet 2 Watertown, MA 02472 / US
	11 / WALDO, Michael 4 Patricia Drive Grafton, MA 01519 / US
	12 / MEDEK, Ales 14 Lockland Road Winchester, MA 01890 / US
	13 / SHAW, David, Matthew 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	14 / PANESAR, Maninder 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	15 / ZHANG, Yuegang 15 Fairfield Road Wayland, MA 01778 / US
	16 / ALEM, Naziha 86-88 Jubilee Avenue Milton Park Abingdon Oxfordshire OX14 4RW / GB
	[2016/41]
Representative(s)	Tostmann, Holger Carl Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
	[2019/38]
Former [2016/41]	Coles, Andrea Birgit, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB
Application number, filing date	14815187.1	05.12.2014
	[2016/41]
	WO2014US68713
Priority number, date	US201361912636P	06.12.2013 Original published format: US 201361912636 P
	US201462008220P	05.06.2014 Original published format: US 201462008220 P
	US201462058819P	02.10.2014 Original published format: US 201462058819 P
	[2016/41]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2015085132
	Date:	11.06.2015
	Language:	EN
	[2015/23]
	Type:	A1 Application with search report
	No.:	EP3077397
	Date:	12.10.2016
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 11.06.2015 takes the place of the publication of the European patent application.
	[2016/41]
	Type:	B1 Patent specification
	No.:	EP3077397
	Date:	18.09.2019
	Language:	EN
	[2019/38]
Search report(s)	International search report - published on:	EP	11.06.2015
Classification	IPC:	C07D487/04, C07B59/00, A61K31/519, A61P35/00	[2016/41]
	CPC:	C07D487/04 (EP,KR,RU,US); C07B59/002 (EP,IL,KR,US); A61K31/519 (KR,RU,US); A61P35/00 (EP,RU); A61P43/00 (EP); C07B59/00 (RU); (+) C07C45/00 (US); C07C45/63 (KR,US); C07B2200/05 (US); C07B2200/13 (EP,KR,US) (-)
	C-Set:	C07D487/04, C07B2200/05 (US,EP); C07D487/04, C07B2200/13 (EP,US); C07D487/04, C07B59/002 (US,EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/41]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	2-AMINO-6-FLUOR-N-5-[FLUOR-PYRIDIN-3-YL]PYRAZOL[1,5-A] PYRIMIDIN-3-CARBOXAMID-VERBINDUNG ALS ATR-KINASEINHIBITOR, DEREN HERSTELLUNG, UNTERSCHIEDLICHE FESTE FORMEN UND RADIOAKTIV MARKIERTE DERIVATE DAVON	[2016/41]
	English:	2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF	[2016/41]
	French:	COMPOSE 2-AMINO -6-FLUORO-N- [5-FLUORO-PYRIDIN -3-YL]PYRAZOLO [1,5-A]PYRIMIDINE-3-CARBOXAMIDE UTILE COMME INHIBITEUR DE LA KINASE ATR, SA PRÉPARATION, DIFFÉRENTES FORMES SOLIDES ET DÉRIVÉS RADIOMARQUÉS DE CELUI-CI	[2016/41]
Entry into regional phase	21.06.2016	National basic fee paid
	21.06.2016	Designation fee(s) paid
	21.06.2016	Examination fee paid
Examination procedure	21.06.2016	Examination requested [2016/41]
	15.02.2017	Amendment by applicant (claims and/or description)
	31.03.2017	Despatch of a communication from the examining division (Time limit: M06)
	10.10.2017	Reply to a communication from the examining division
	06.02.2018	Despatch of a communication from the examining division (Time limit: M04)
	15.06.2018	Reply to a communication from the examining division
	17.07.2018	Despatch of a communication from the examining division (Time limit: M04)
	30.10.2018	Reply to a communication from the examining division
	14.12.2018	Despatch of a communication from the examining division (Time limit: M02)
	13.02.2019	Reply to a communication from the examining division
	05.04.2019	Communication of intention to grant the patent
	09.08.2019	Fee for grant paid
	09.08.2019	Fee for publishing/printing paid
	09.08.2019	Receipt of the translation of the claim(s)
Opposition(s)	19.06.2020	No opposition filed within time limit [2020/35]
Fees paid	Renewal fee
	27.12.2016	Renewal fee patent year 03
	27.12.2017	Renewal fee patent year 04
	31.12.2018	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	AL	18.09.2019
	CY	18.09.2019
	MC	18.09.2019
	SM	18.09.2019
	BG	18.12.2019
	GR	19.12.2019
	[2021/26]
Former [2020/39]	AL	18.09.2019
	MC	18.09.2019
	SM	18.09.2019
	BG	18.12.2019
	GR	19.12.2019
Former [2020/28]	AL	18.09.2019
	SM	18.09.2019
	BG	18.12.2019
	GR	19.12.2019
Former [2020/15]	AL	18.09.2019
	BG	18.12.2019
	GR	19.12.2019
Former [2020/12]	BG	18.12.2019
	GR	19.12.2019
Former [2020/10]	SE	18.09.2019
	BG	18.12.2019
Cited in	International search	[A]WO2011003065 (GENENTECH INC [US], et al) [A] 1-141 * reaction scheme 13, p.44;; claims 1,17 *;
		[A]WO2012178124 (VERTEX PHARMA [US], et al) [A] 25-141 * claims 1,39,83,86 *;
		[XPA]WO2014089379 (VERTEX PHARMA [US]) [XP] 26-141 * paragraphs [00153] , [ 00221]; example 3f; claims 223-228,285; compounds I-G-32 *[A] 1-25

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