Extract from the Register of European Patents

About this file: EP3359169

EP3359169 - DIAGNOSIS AND TREATMENT OF PARKINSON'S DISEASE BASED ON IDENTIFICATION AND AMELIORATION OF LIVER DYSFUNCTION [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  13.07.2018
Database last updated on 22.06.2019
FormerThe international publication has been made
Status updated on  18.04.2017
Most recent event   Tooltip12.02.2019Supplementary search reportpublished on 13.03.2019  [2019/11]
Applicant(s)For all designated states
ORIG3N, INC.
27 Drydock Avenue
Boston, MA 02210 / US
[2018/33]
Inventor(s)01 / GLICKSMAN, Marcie, A.
757 East 5th Street
Boston, MA 02127 / US
02 / ZAIDI, Nikhat, F.
44 Walter Street
Newton, MA 02459 / US
03 / SMITH, Robin, Y.
6 Sentry Hill Place
Boston, MA 02114 / US
 [2018/33]
Representative(s)Goodfellow, Hugh Robin
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2018/33]
Application number, filing date16854189.405.10.2016
[2018/33]
WO2016US55411
Priority number, dateUS201562237248P05.10.2015         Original published format: US 201562237248 P
[2018/33]
Filing languageEN
Procedural languageEN
PublicationType: A1  Application with search report
No.:WO2017062401
Date:13.04.2017
Language:EN
[2017/15]
Type: A1 Application with search report 
No.:EP3359169
Date:15.08.2018
Language:EN
The application has been published by WIPO in one of the EPO official languages on 13.04.2017
[2018/33]
Search report(s)International search report - published on:US13.04.2017
(Supplementary) European search report - dispatched on:EP11.02.2019
ClassificationInternational:A61K35/407, A61K35/545, C12N5/071, C12N5/074
[2018/33]
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/33]
TitleGerman:DIAGNOSE UND BEHANDLUNG VON MORBUS PARKINSON AUF DER GRUNDLAGE DER IDENTIFIZIERUNG UND LINDERUNG VON LEBERFUNKTIONSSTÖRUNGEN[2018/33]
English:DIAGNOSIS AND TREATMENT OF PARKINSON'S DISEASE BASED ON IDENTIFICATION AND AMELIORATION OF LIVER DYSFUNCTION[2018/33]
French:DIAGNOSTIC ET TRAITEMENT DE LA MALADIE DE PARKINSON BASÉS SUR L'IDENTIFICATION ET L'AMÉLIORATION D'UN DYSFONCTIONNEMENT HÉPATIQUE[2018/33]
Entry into regional phase02.05.2018National basic fee paid 
02.05.2018Search fee paid 
02.05.2018Designation fee(s) paid 
02.05.2018Examination fee paid 
Examination procedure02.05.2018Examination requested  [2018/33]
02.05.2018Date on which the examining division has become responsible
27.11.2018Amendment by applicant (claims and/or description)
Fees paidRenewal fee
29.10.2018Renewal fee patent year 03
Documents cited:Search[XY]US2010314251  (GOLDKNOPF IRA LEONARD [US]) [X] 1,4,5,9 * whole document esp. paragraph [16], claims 1,4 * [Y] 1-15;
 [Y]US2014249209  (FOX IRA JACOB [US], et al) [Y] 1-15 * whole document esp. paragraphs [4,85] *;
 [Y]WO02064748  (FURCHT LEO T [US], et al) [Y] 1-15 * whole document esp. pages 1,64-65,claims 1,24 *;
 [Y]WO2014124527  (UNIV HEALTH NETWORK [CA], et al) [Y] 1-15 * whole document esp. paragraph [2], claim 1 *
 [Y]  - LILAH TOKER ET AL, "Metaanalysis of flawed expression profiling data leading to erroneous Parkinson's biomarker identification", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, US, (20150714), vol. 112, no. 28, doi:10.1073/pnas.1507563112, ISSN 0027-8424, pages E3637 - E3637, XP055548090 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.1507563112
 [Y]  - JOSE A. SANTIAGO ET AL, "Reply to Toker and Pavlidis: Blood biomarkers for Parkinson's disease", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, US, (20150714), vol. 112, no. 28, doi:10.1073/pnas.1508415112, ISSN 0027-8424, pages E3638 - E3638, XP055548095 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.1508415112
 [Y]  - JOSE A. SANTIAGO ET AL, "Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, US, (20150217), vol. 112, no. 7, doi:10.1073/pnas.1423573112, ISSN 0027-8424, pages 2257 - 2262, XP055548100 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.1423573112
 [Y]  - BURGESS JB, BAENZIGER J U AND BROWN WR, "Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis", HEPATOLOGY, (19921231), vol. 15, no. 4, ISSN 0270-9139, pages 702 - 706, XP009510779 [Y] 1-15 * whole document esp. pages 702,705 *

DOI:   http://dx.doi.org/10.1002/hep.1840150425
 [Y]  - J.-K. LAI ET AL, "Kruppel-like factor 4 is involved in cell scattering induced by hepatocyte growth factor", JOURNAL OF CELL SCIENCE, GB, (20121015), vol. 125, no. 20, doi:10.1242/jcs.108910, ISSN 0021-9533, pages 4853 - 4864, XP055548650 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1242/jcs.108910
 [YP]  - Zhi-Xu He, "Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine", (20151116), URL: http://www.ncbi.nlm.nih.gov/pubmed/26574146, (20190129), XP055548600 [YP] 1-15 * abstract *

DOI:   http://dx.doi.org/10.3109/03602532.2015.1101131
International search[XY]US2014302068  (KHOO SOK KEAN [US], et al) [X] 1-2, 8/1-2 * ; paragraphs [0008], [0012], [0013], [0033], [0068], [0122], [0123]; claim 29 * [Y] 3/1-2, 4/3/1-2, 5/3/1-2, 6/3/1-2, 9/1-2, 16-17, 18/16-17,19/16-17, 20/19/16-17;
 [XY]WO9527512  (BAYLOR COLLEGE MEDICINE [US]) [X] 25-26 * ; page 57, lines 12.24: claims 20-21 * [Y] 27/25-26;
 [Y]US2010129440  (ZHAO YONG [US], et al) [Y] 4/3/1-2 * ; abstract; paragraphs [0009], [0011], [0085] *;
 [Y]US2014087416  (SIMEONOV KAMEN P [US], et al) [Y] 3/1-2, 4/3/1-2, 5/3/1-2, 6/3/1-2, 16-17, 18/16-17, 19/16-17, 20/19/16-1727/25-26 * ; paragraphs [0128], [0236] *;
 [Y]US2011097378  (BADYLAK STEPHEN F [US]) [Y] 9/1-2 * ; paragraph [0039] *;
 [Y]WO2014085830  (PARKINSON S INST [GB], et al) [Y] 20/19/16-17 * ; paragraph [0026] *