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Extract from the Register of European Patents

EP About this file: EP1019432

EP1019432 - THE OB RECEPTOR AND METHODS OF DIAGNOSING AND TREATING WEIGHT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.11.2012
Database last updated on 23.04.2024
Most recent event   Tooltip11.10.2013Lapse of the patent in a contracting state
New state(s): ES		published on 13.11.2013  [2013/46]
Applicant(s)For all designated states
MILLENNIUM PHARMACEUTICALS, INC.
73 Sidney Street
Cambridge, MA 02139 / US
[N/P]
Former [2000/29]For all designated states
Millennium Pharmaceuticals, Inc.
Fifth floor, 640 Memorial Drive
Cambridge, MA 02139 / US
Inventor(s)01 / TARTAGLIA, Louis A.
Apartment 6
104 Coolidge Hill Road
Watertown, MA 02172 / US
02 / TEPPER, Robert, I.
53 Laurel Road
Weston, MA 02193 / US
03 / CULPEPPER, Janice, A.
1734 Beacon Street
Brookline, MA 02146 / US
04 / WHITE, David, W.
393 Pine Street
Holbrook, MA 02343 / US
 [2012/02]
Former [2000/29]01 / TARTAGLIA, Louis A.
Apartment 6, 104 Coolidge Hill Road
Watertown, MA 02172 / US
02 / TEPPER, Robert, I.
53 Laurel Road
Weston, MA 02193 / US
03 / CULPEPPER, Janice, A.
1734 Beacon Street
Brookline, MA 02146 / US
04 / WHITE, David, W.
393 Pine Street
Holbrook, MA 02343 / US
Representative(s)Price, Vincent Andrew, et al
Fry Heath & Spence LLP The Gables
Massetts Road
Horley
Surrey RH6 7DQ / GB
[N/P]
Former [2000/29]Price, Vincent Andrew, et al
FRY HEATH & SPENCE The Old College 53 High Street
Horley Surrey RH6 7BN / GB
Application number, filing date96942110.627.11.1996
[2000/29]
WO1996US19128
Priority number, dateUS1995056266327.11.1995         Original published format: US 562663
US1995056662204.12.1995         Original published format: US 566622
US1995056948508.12.1995         Original published format: US 569485
US1995057014211.12.1995         Original published format: US 570142
US1995058315328.12.1995         Original published format: US 583153
US1996059945522.01.1996         Original published format: US 599455
US1996063852426.04.1996         Original published format: US 638524
US1996070812303.09.1996         Original published format: US 708123
[2000/29]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9719952
Date:05.06.1997
Language:EN
[1997/24]
Type: A1 Application with search report 
No.:EP1019432
Date:19.07.2000
Language:EN
The application published by WIPO in one of the EPO official languages on 05.06.1997 takes the place of the publication of the European patent application.
[2000/29]
Type: B1 Patent specification 
No.:EP1019432
Date:11.01.2012
Language:EN
[2012/02]
Search report(s)International search report - published on:US05.06.1997
(Supplementary) European search report - dispatched on:EP16.09.2002
ClassificationIPC:C07H21/04, C07K14/705, C07K14/71, C07K14/715, C07K16/28, C07K16/46, C12Q1/68, C12Q1/00, C12Q1/02, G01N33/53, C12P21/00
[2000/29]
CPC:
C07K14/715 (EP,US); A61K38/00 (EP,US); C07K2319/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2000/29]
TitleGerman:OB-REZEPTOR UND VERFAHREN ZUR DIAGNOSE UND BEHANDLUNG VON GEWICHT[2000/29]
English:THE OB RECEPTOR AND METHODS OF DIAGNOSING AND TREATING WEIGHT[2000/29]
French:RECEPTEUR OB ET PROCEDES DE DIAGNOSTIC ET DE TRAITEMENT DES DEREGLEMENTS DE LA MASSE CORPORELLE[2000/29]
Entry into regional phase17.06.1998National basic fee paid 
17.06.1998Search fee paid 
03.06.1998Designation fee(s) paid 
17.06.1998Examination fee paid 
Examination procedure26.06.1997Request for preliminary examination filed
International Preliminary Examining Authority: US
17.06.1998Examination requested  [2000/29]
08.12.2003Despatch of a communication from the examining division (Time limit: M06)
14.05.2004Reply to a communication from the examining division
12.01.2005Despatch of a communication from the examining division (Time limit: M06)
19.07.2005Reply to a communication from the examining division
04.10.2005Despatch of a communication from the examining division (Time limit: M06)
18.04.2006Reply to a communication from the examining division
12.10.2006Despatch of a communication from the examining division (Time limit: M06)
19.03.2007Reply to a communication from the examining division
31.08.2007Despatch of a communication from the examining division (Time limit: M04)
07.01.2008Reply to a communication from the examining division
16.01.2009Despatch of a communication from the examining division (Time limit: M06)
21.07.2009Reply to a communication from the examining division
10.02.2010Despatch of a communication from the examining division (Time limit: M06)
11.06.2010Reply to a communication from the examining division
08.04.2011Communication of intention to grant the patent
09.08.2011Fee for grant paid
09.08.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.12.2003
Opposition(s)12.10.2012No opposition filed within time limit [2012/51]
Fees paidRenewal fee
20.11.1998Renewal fee patent year 03
19.11.1999Renewal fee patent year 04
03.11.2000Renewal fee patent year 05
22.11.2001Renewal fee patent year 06
18.11.2002Renewal fee patent year 07
14.11.2003Renewal fee patent year 08
22.11.2004Renewal fee patent year 09
29.11.2005Renewal fee patent year 10
27.11.2006Renewal fee patent year 11
27.11.2007Renewal fee patent year 12
27.03.2008Renewal fee patent year 13
25.11.2009Renewal fee patent year 14
24.11.2010Renewal fee patent year 15
23.11.2011Renewal fee patent year 16
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.01.2012
BE11.01.2012
DK11.01.2012
FI11.01.2012
IT11.01.2012
NL11.01.2012
SE11.01.2012
GR12.04.2012
ES22.04.2012
PT11.05.2012
[2013/46]
Former [2013/07]AT11.01.2012
BE11.01.2012
DK11.01.2012
FI11.01.2012
IT11.01.2012
NL11.01.2012
SE11.01.2012
GR12.04.2012
PT11.05.2012
Former [2012/50]BE11.01.2012
DK11.01.2012
FI11.01.2012
IT11.01.2012
NL11.01.2012
SE11.01.2012
GR12.04.2012
PT11.05.2012
Former [2012/49]BE11.01.2012
DK11.01.2012
FI11.01.2012
NL11.01.2012
SE11.01.2012
GR12.04.2012
PT11.05.2012
Former [2012/48]BE11.01.2012
FI11.01.2012
NL11.01.2012
SE11.01.2012
GR12.04.2012
PT11.05.2012
Former [2012/37]BE11.01.2012
FI11.01.2012
NL11.01.2012
GR12.04.2012
PT11.05.2012
Former [2012/36]BE11.01.2012
NL11.01.2012
GR12.04.2012
Former [2012/35]BE11.01.2012
NL11.01.2012
Former [2012/33]BE11.01.2012
Documents cited:Search[E]WO9725425  (GENENTECH INC [US]) [E] 1-10 * figure 1 *;
 [E]WO9725424  (AMGEN INC [US], et al) [E] 1-10 * page 64 - page 79 *;
 [E]WO9712037  (AMRAD OPERATIONS PTY LTD [AU], et al) [E] 1-10 * figure 2; example 9 *
 [X]  - STEPHENS T W ET AL, "THE ROLE OF NEUROPEPTIDE Y IN THE ANTIOBESITY ACTION OF THE OBESE GENE PRODUCT", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, (19951012), vol. 377, ISSN 0028-0836, pages 530 - 532, XP000999194 [X] 1-10 * page 531, column R, paragraph 1; figure 3 *

DOI:   http://dx.doi.org/10.1038/377530a0
 [X]  - MAFFEI MARGHERITA ET AL, "Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, 1995, (1995), vol. 92, no. 15, ISSN 0027-8424, pages 6957 - 6960, XP002209604 [X] 1-10 * page 6959, column L; figure 4 *

DOI:   http://dx.doi.org/10.1073/pnas.92.15.6957
 [PX]  - TARTAGLIA L A ET AL, "IDENTIFICATION AND EXPRESSION CLONING OF A LEPTIN RECEPTOR, OB-R", CELL, CELL PRESS, CAMBRIDGE, NA, US, (19951229), vol. 83, no. 7, ISSN 0092-8674, pages 1263 - 1271, XP000602068 [PX] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1016/0092-8674(95)90151-5
International search[Y]WO9307294  (US HEALTH [US]);
 [XP]WO9608510  (PROGENITOR INC [US])
 [XP]  - NATURE MEDICINE, May 1996, Vol. 2, No. 5, COIFFI et al., "Novel B219/OB Receptor Isoforms: Possible Role of Leptin in Hematopoiesis and Reproduction", pages 585-589.
 [XP]  - SCIENCE, 16 February 1996, Vol. 271, CHUA et al., "Phenotypes of Mouse Diabetes and Rat Fatty Due to Mutations in the OB (Leptin) Receptor", pages 994-996.
 [XP]  - CELL, February 1996, Vol. 84, CHEN et al., "Evidence that the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice", pages 491-495.
 [XP]  - FEBS, August 1996, Vol. 392, WANG et al., "A Novel Leptin Receptor Isoform in Rat", pages 87-90.
 [XP]  - NATURE, 15 February 1996, Vol. 395, LEE et al., "Abnormal Splicing of the Leptin Receptor in Diabetic Mice", pages 632-635.
 [XP]  - DIABETES, July 1996, Vol. 19, CONSIDINE et al., "The Hypothalamic Leptin Receptor in Humans: Identification of Incidential Sequence Polymorphisms and Absence of the db/db and fa/fa Rat Mutations", pages 992-994.
 [Y]  - CURRENT PROTOCOLS IN IMMUNOLOGY, New York, 1992, HOLLENBAUGH et al., pages 10.19.1-10.19.11.
 [Y]  - CURRENT OPINION IN BIOTECHNOLOGY, 1995, Vol. 6, SEED et al., "Developments in Expression Cloning", pages 567-573.
 [Y]  - SEALFON, STUART, "Receptor Molecular Biology: Methods in Neuroscience", SAN DIEGO: ACADEMIC PRESS, 1995, Vol. 25, pages 278-301 and 470-509.
 [Y]  - MOLECULAR AND CELLULAR BIOLOGY, February 1992, Vol. 12, No. 2, REDEMANN et al., "Anti-Oncogenic Activity of Signalling-Defective Epidermal Growth Factor Receptor Mutants", pages 491-498.
 [Y]  - PHARMACEUTICAL TECHNOLOGY, October 1994, WU-PONG S., "Oligonucleotides: Opportunities for Drug Therapy and Research", pages 102-114.
 [Y]  - SCIENCE, 20 August 1993, Vol. 261, STEIN et al., "Antisense Oligonucleotides as Therapeutic Agents-Is the Bullet Really Magical?", pages 1004-112.
 [Y]  - ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1991, Vol. 2, No. 4, JAMES W., "Towards Gene-Inhibition Therapy: A Review of Progress and Prospects in the Field of Antiviral Antisense Nucleic Acids and Ribozymes", pages 191-214.
 [Y]  - PHARMACEUTICAL RESEARCH, 1995, Vol. 12, No. 4, STULL et al., "Antigene, Ribozymes and Aptamer Nucleic Acid Drugs: Progress and Prospects", pages 465-483.
 [Y]  - PARASITOLOGY TODAY, 1994, Vol. 10, No. 3, MILLER et al., "Gene Transfer and Antisense Nucleic Acid Techniques", pages 92-97.
 [Y]  - SCIENCE, 1993, Vol. 260, MULLIGAN R., "The Basic Science of Gene Therapy", pages 926-931.
 [Y]  - HUMAN GENE THERAPY, September 1995, Vol. 6, LEDLEY F., "Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products", pages 1120-1144.
 [Y]  - SCIENCE, 27 October 1995, Vol. 270, GURA T., "Antisense Has Growing Pains", pages 575-577.
 [A]  - BIOCHEM. BIOPHYS. RES. COMM., 26 April 1995, Vol. 209, No. 3, MURAKAMI et al., "Cloning of Rat Obese cDNA and Its Expression in Obese Rats", pages 944-952.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.