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Extract from the Register of European Patents

EP About this file: EP0946221

EP0946221 - USE OF TAUROLIDINE OR TAURULTAM FOR THE PREVENTION AND THE TREATMENT OF INFECTIONS IN DELIVERY SYSTEMS [Right-click to bookmark this link]
Former [1999/40]	COMBATTING INFECTION IN DELIVERY SYSTEMS
	[2006/24]
Status	Patent revoked Status updated on 13.05.2011 Database last updated on 23.04.2024
Most recent event Tooltip	19.08.2011	Lapse of the patent in a contracting state	published on 21.09.2011 [2011/38]
Applicant(s)	For all designated states Ed. Geistlich Söhne AG für Chemische Industrie Bahnhofstrasse 40 6110 Wolhusen / CH
	[N/P]
Former [2000/41]	For all designated states Ed Geistlich Söhne AG Für Chemische Industrie Bahnhofstrasse 40 6110 Wolhusen / CH
Former [1999/40]	For all designated states Ed Geistlich Söhne AG Für Chemische Industrie Bahnhofstrasse 40 6110 Wolhusen / CH
	For:GB Pett, Christopher Frank B. Dehn & Co., 179 Queen Victoria Street London EC4V 4EL / GB
Inventor(s)	01 / LEHNER, Joachim, Hermann Scherrweg 5 D-44309 Dortmund / DE
	[1999/40]
Representative(s)	Barry, Robert Stewart Wilson Central Court 25 Southampton Buildings London WC2A 1AL / GB
	[N/P]
Former [2010/07]	Barry, Robert Stewart Wilson 25 Southampton Buildings London WC2A 1AL / GB
Former [2009/01]	Barry, Robert Stewart Wilson Barrys IP Lawyers Bracton House 34-36 High Holborn London WC1V 6AE / GB
Former [2003/10]	Marsden, John Christopher, et al Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL / GB
Former [1999/40]	Pett, Christopher Phineas, et al Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL / GB
Application number, filing date	97950310.9	23.12.1997
	[1999/40]
	WO1997GB03524
Priority number, date	GB19960026795	23.12.1996 Original published format: GB 9626795
	[1999/40]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9828027
	Date:	02.07.1998
	Language:	EN
	[1998/26]
	Type:	A1 Application with search report
	No.:	EP0946221
	Date:	06.10.1999
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 02.07.1998 takes the place of the publication of the European patent application.
	[1999/40]
	Type:	B1 Patent specification
	No.:	EP0946221
	Date:	30.08.2006
	Language:	EN
	[2006/35]
Search report(s)	International search report - published on:	EP	02.07.1998
Classification	IPC:	A61K31/495, A61L29/00, A61P31/04	[2006/24]
	CPC:	A61L29/16 (EP,US); A61L2/16 (EP,US); A61P31/00 (EP); A61P31/02 (EP); A61P31/04 (EP); A61L2300/204 (EP,US); (+) A61L2300/404 (EP,US) (-)
	Former IPC [1999/40]	A61L29/00
Designated contracting states	AT, CH, DE, ES, FR, GB, IT, LI, NL, SE [1999/40]
Title	German:	VERWENDUNG VON TAUROLIDINE ODER TAURULTAM ZUR BEHANDLUNG UND PRÄVENTION VON INFEKTIONEN IN MEDIZINISCHEN FREISETZUNGSSYSTEMEN	[2006/24]
	English:	USE OF TAUROLIDINE OR TAURULTAM FOR THE PREVENTION AND THE TREATMENT OF INFECTIONS IN DELIVERY SYSTEMS	[2006/24]
	French:	UTILISATION DE TAUROLIDINE OU DE TAURULTAM POUR LE TRAITEMENT ET LA PREVENTION DES INFECTIONS DANS DES DISPOSITIFS D'ADMINISTRATION	[2006/24]
	Former [1999/40]	BEKÄMPFUNG VON INFEKTIONEN IN MEDIZINISCHEN FREISETZUNGSSYSTEMEN
	Former [1999/40]	COMBATTING INFECTION IN DELIVERY SYSTEMS
	Former [1999/40]	COMBATTRE LE DEVELOPPEMENT DE GERMES INFECTIEUX DANS DES DISPOSITIFS D'ADMINISTRATION
Entry into regional phase	25.05.1999	National basic fee paid
	25.05.1999	Designation fee(s) paid
	25.05.1999	Examination fee paid
Examination procedure	09.07.1998	Request for preliminary examination filed International Preliminary Examining Authority: EP
	25.05.1999	Examination requested [1999/40]
	18.04.2001	Despatch of a communication from the examining division (Time limit: M06)
	29.10.2001	Reply to a communication from the examining division
	19.03.2002	Observations by third parties
	04.06.2002	Despatch of a communication from the examining division (Time limit: M08)
	14.02.2003	Reply to a communication from the examining division
	27.02.2003	Observations by third parties
	28.08.2003	Despatch of a communication from the examining division (Time limit: M06)
	13.04.2004	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	23.06.2004	Reply to a communication from the examining division
	24.10.2005	Observations by third parties
	26.10.2005	Minutes of oral proceedings despatched
	28.10.2005	Date of oral proceedings
	31.10.2005	Despatch of a communication from the examining division (Time limit: M03)
	09.02.2006	Reply to a communication from the examining division
	01.06.2006	Communication of intention to grant the patent
	14.07.2006	Fee for grant paid
	14.07.2006	Fee for publishing/printing paid
Opposition(s)	Opponent(s)	01 18.01.2007 29.01.2007 ADMISSIBLE TauroPharm GmbH Jägerstr. 5a 97297 Waldbüttelbrunn / DE Opponent's representative Andrae, Steffen, et al, et al Andrae l Westendorp Patentanwälte Partnerschaft Balanstrasse 55 81541 München / DE
		[N/P]
	Former [2008/40]
	Opponent(s)	01 18.01.2007 29.01.2007 ADMISSIBLE TauroPharm GmbH Mit Sitz in Würzburg Jägerstr. 5a 97297 Waldbüttelbrunn / DE Opponent's representative Andrae, Steffen, et al, et al Andrae Flach Haug Balanstrasse 55 81541 München / DE
	Former [2007/08]
	Opponent(s)	01 18.01.2007 TauroPharm GmbH Mit Sitz in Würzburg Jägerstr. 5a 97297 Waldbüttelbrunn / DE Opponent's representative Andrae, Steffen, et al, et al Andrae Flach Haug Balanstrasse 55 81541 München / DE
	deleted	Deletion: Legal effect of rejection of opposition [ N /P ]
	05.07.2007	Invitation to proprietor to file observations on the notice of opposition
	14.11.2007	Reply of patent proprietor to notice(s) of opposition
	20.01.2009	Date of oral proceedings
	02.04.2009	Despatch of minutes of oral proceedings
	02.04.2009	Date of despatch of rejection of opposition
	23.06.2010	Legal effect of revocation of patent [2011/24]
	23.06.2010	Despatch of communication that the patent will be revoked
Appeal following opposition	24.04.2009	Appeal received No. T0945/09
	18.06.2009	Statement of grounds filed
	23.06.2010	Result of appeal procedure: revocation of the patent
	23.06.2010	Date of oral proceedings
	01.07.2010	Minutes of the oral proceedings despatched
Petition(s) for review:	29.11.2010	Petition for review received
		Number: R0019/10
		for appeal No. T0945/09-3302
		Petitioner: APPR
	16.03.2011	Decision: Petition for review obviously unsubstantiated only.
	16.03.2011	Date of oral proceedings
Request for further processing for:	23.06.2004	Request for further processing filed
	23.06.2004	Full payment received (date of receipt of payment) Request granted
	07.07.2004	Decision despatched
Fees paid	Renewal fee
	24.12.1999	Renewal fee patent year 03
	21.12.2000	Renewal fee patent year 04
	27.12.2001	Renewal fee patent year 05
	27.12.2002	Renewal fee patent year 06
	19.12.2003	Renewal fee patent year 07
	27.12.2004	Renewal fee patent year 08
	21.12.2005	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	CH	30.08.2006
	LI	30.08.2006
	[2011/38]
Cited in	International search	[X] - MUGHAL M. ET AL., "INFECTED FEEDING LINES", CARE OF THE CRITICALLY ILL, (1990), vol. 6, no. 6, pages 228 - 231, XP002062743 [X] 1,2,5 * page 230, column R, paragraph 4 - page 231, column L, paragraph 2 *
		[X] - JOHNSTON D.A. ET AL, "TAUROLIN FOR THE PREVENTION OF PARENTERAL NUTRITION RELATED INFECTION: ANTIMICROBIAL ACTIVITY AND LONG-TERM USE", CLINICAL NUTRITION, (1993), vol. 12, no. 6, pages 365 - 368, XP002062744 [X] 1,2,4,5 * abstract * DOI: http://dx.doi.org/10.1016/0261-5614(93)90034-2
		[X] - BLENKHARN J. I., "THE ANTIMICROBIAL ACTIVITY OF TAUROLIN - A POSSIBLE ADDITIVE FOR PARENTERAL NUTRITION SOLUTIONS", CLINICAL NUTRITION, (1987), vol. 6, no. 1, pages 35 - 38, XP002062745 [X] 1,2,5 * abstract * * page 37, column L, paragraph 4 - column R, paragraph 1 * DOI: http://dx.doi.org/10.1016/0261-5614(87)90066-5
	Examination	US5210083
		US5352204
		US5433705
		- Br.J.Surg. (1986) 76(1) pp. 15-21
		- Clinical Infectious Diseases (1995) 21 pp. 1286-1288
		- J. Paren. and Enter. Nutrit. (1988) 12(2) pp. 185-189
	other	US3423408
		US4587268
		US4960415
		US5077281
		US5210083
		US5263930
		US5352204
		US5433705
		US6146363
		US6174537
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		- REEVES D.S. AND SCHWEITZER F.A.W., "Experimental Studies with an Antibacterial Substance, Taurolin", PROCEEDINGS OF THE 8TH INTERNATIONAL CONGRESS OF CHEMOTHERAPY, (1974), vol. 2, pages 583 - 586, XP002907597
		- BENOIT J-L. ET AL, "Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at Home", CLINICAL INFECTTIONS DISEASES, (1995), vol. 21, pages 1286 - 1288, XP002907598
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		- ELIAN J.C. ET AL, "Etude de la cinetique serique de la vancomycine au decours de la technique de << blocage in situ >>", ARCH. FR. PEDIATR., (1992), vol. 49, pages 357 - 360, XP002909101
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		- COWAN C.E., "Antibiotic Lock Technique", J. INTRAVENOUS NURS., (199209), vol. 15, no. 5, pages 283 - 287, XP002909103
		- PALM Ü. ET AL, "Verhinderung katheterbedingter Infektionen, eine experimentelle Langzeituntersuchung", DER ANESTHESIST, (1989), vol. 38, no. 1, page 129, XP002909104
		- PALM Ü. ET AL, "Prevention of vatheter-related infections by a new, catheter-restricted antibiotic filling technique", LABORATORY ANIMALS, (1991), vol. 25, pages 142 - 152, XP002909105
		- GAUDRY C. ET KOURILSKY O., "Est-il possible de conserver un catheter infecte ?", NEPHROLOGIE, (1994), vol. 15, no. 2, pages 171 - 172, XP002909106
		- GAUNDRY C. AND KOURILSKY C., "Is it possible to salvage an infected catheter ?", NEPHROLOGIE (ENGLISH TRANSLATION), (1994), vol. 15, XP002909107
		- JOHNSON D.C. ET AL, "Preliminary Results Treating Persistant Central Venous Catheter Infections with the Antibiotic Lock Technique in Pediatric Patients", PEDIATRIC INFECTIOUS DISEASE JOURNAL, (199410), vol. 13, no. 10, pages 930 - 931, XP002909108 DOI: http://dx.doi.org/10.1097/00006454-199410000-00015
		- YAZBECK F. ET AL, "THE ANTIBIOTIC LOCK TECHNIQUE USED IN AN INFECTED CATHETER: PREVENTIVE THERAPY", ANGIOACCESS FOR HEMODIALYSIS - AN INTERNATIONAL MULTIDISCIPLINARY SYMPOSIUM, (19960603), pages 189 - 190, XP002909109
		- GAILLARD J-L. ET AL, "Conventional and Nonconventional Modes of Vancomycin Administration to Decontaminate the Internal Surface of Catheters Colonized with Coagulase-Negative Staphylococci", JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, (1990), vol. 14, no. 6, pages 593 - 597, XP002909110
		- KRZYWDA E.A. ET AL, "Treatment of Hickman Catheter Sepsis Using Antibiotic Lock Technique", INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, (199510), vol. 16, pages 596 - 598, XP002909111
		- BREGENZER T., "Bloodstream Infection From a Port-A-Cath: With the Antibiotic Lock Technique", INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, (1996), vol. 17, page 772, XP002909112
		- HENRICKSON K.J. AND DUNNE W.M. JR., "Modification of Central Venous Catheter Flush Solution Improves In Vitro Antimicrobial Activity", THE JOURNAL OF INFECTIOUS DISEASES, (1992), vol. 166, pages 944 - 946, XP002909113
		- ROOT J.L. ET AL, "Inhibitory Effect of Disodium EDTA upon the Growth of Staphylococcus epidermidis In Vitro: Relation to Infection Prophylaxis of Hickman Catheters", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1988), vol. 32, no. 11, pages 1627 - 1631, XP002909114
		- SCHWARTZ C. ET AL, "Prevention of Bacteremia Attributed to Luminal Colonization of Tunneled Central Venous Catheters With Vancomycin-Susceptible Organisms", JOURNAL OF CLINICAL OONCOLOGY, (199009), vol. 8, no. 9, pages 1591 - 1596, XP002909115
		- WINTERS V. ET AL, "A Trial With a New Peripheral Implanted Vascular Access Device", ONC. NURS. FOR., (1990), vol. 17, no. 6, pages 891 - 896, XP002909116
		- WORTHLEY L.I.G., "Treatment of Central Venous Silastic Catheter Infections Using Hydrochloric Acid", ANAESTHESIA AND INTENSIVE CARE, (198211), vol. 10, no. 4, pages 314 - 318, XP002909117
		- ELLIOTT T.S.J. AND CURRAN A., "Effects of heparin and chlorbutol on bacterial colonisation of intravascular cannulae in an in vitro model", JOURNAL OF HOSPITAL INFECTION, (1989), vol. 14, pages 193 - 200, XP002909118 DOI: http://dx.doi.org/10.1016/0195-6701(89)90035-2
		- JOHNSTON D.A. ET AL, "Antimicrobial activity and long-term use of Taurolin as an additive to parenteral nutrition", PROCEEDINGS NUTRITION SOC. (MEETING OF 2/3 DECEMBER 1992), (1993), vol. 52, page 245A, XP002909119
		- BLENKHARN J.I., "Prevention of Septic Complications Associated with TPN", J. PAREN. & ENTER. NUTRITION, (1986), vol. 10, no. 4, pages 436 - 437, XP002909120
		- KNIGHT B.I. ET AL, "NMR Studies and GC Analysis of the Antibacterial Agent Taurolidine", JOURNAL OF PHARMACEUTICAL SCIENCES, (198306), vol. 72, no. 6, pages 705 - 707, XP002909121 DOI: http://dx.doi.org/10.1002/jps.2600720630
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		- BROWNE M.K. ET AL, "Taurolin, a New Chemotherapeutic Agent", JOURNAL OF APPLIED BACTERIOLOGY, (1976), vol. 41, pages 363 - 368, XP002909123
		- BREARLEY S. AND GEORGE R.H., "The rate of antimicrobial action of noxythiolin and taurolin", JOURNAL OF HOSPITAL INFECTION, (1980), vol. 1, pages 201 - 209, XP002909124 DOI: http://dx.doi.org/10.1016/0195-6701(80)90057-2
		- BROWNE M.K. ET AL, "THE IN VITRO AND IN VIVO ACTIVITY OF TAUROLIN AGAINST ANAEROBIC PATHOGENIC ORGANISMS", SURGERY, GYNECOLOGY & OBSTETRICS, (197712), vol. 145, pages 842 - 846, XP002909125
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		- BUDAVARI S. ET AL, THE MERCK INDEX, WHITEHOUSE STATION, NJ, MERCK & CO.,INC., (1996), vol. 12, XP002909128
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		- GORMAN S.P. ET AL, "A COMPARATIVE STUDY OF THE MICROBIAL ANTI-ADHERENCE CAPACITIES OF THREE ANTIMICROBIAL AGENTS", JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, (1987), vol. 12, pages 393 - 399, XP002909130
		- FARBER B.F. ET AL, "Staphylococcus epidermidis Extracted Slime Inhibits the Antimicrobial Action of Glycopeptide Antibiotics", JOURNAL OF INFECTIOUS DISEASES, (199001), vol. 161, pages 37 - 40, XP002909131
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