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EP About this file: EP1049789

EP1049789 - AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 14.04.2006 Database last updated on 23.04.2024
Most recent event Tooltip	14.04.2006	Application deemed to be withdrawn	published on 31.05.2006 [2006/22]
Applicant(s)	For all designated states Pharmacia & Upjohn Company LLC 301 Henrietta Street Kalamazoo, MI 49001 / US
	[2005/18]
Former [2000/45]	For all designated states PHARMACIA & UPJOHN COMPANY 301 Henrietta Street Kalamazoo, Michigan 49001 / US
Inventor(s)	01 / QUINN, Cheryl, L. 3010 Ridgeview Circle Kalamazoo, MI 49008 / US
	02 / FORD, Charles, W. 1306 Carriage Place Portage, MI 49024 / US
	[2000/45]
Representative(s)	Perry, Robert Edward, et al Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	[N/P]
Former [2000/45]	Perry, Robert Edward, et al GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH / GB
Application number, filing date	99903005.9	12.01.1999
	[2000/45]
	WO1999US00371
Priority number, date	US19980071640P	16.01.1998 Original published format: US 71640 P
	[2000/45]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9936554
	Date:	22.07.1999
	Language:	EN
	[1999/29]
	Type:	A1 Application with search report
	No.:	EP1049789
	Date:	08.11.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 22.07.1999 takes the place of the publication of the European patent application.
	[2000/45]
Search report(s)	International search report - published on:	EP	22.07.1999
Classification	IPC:	C12N15/63, C12N15/90, C12Q1/68, C12Q1/04	[2000/45]
	CPC:	C12N15/1034 (EP); C12N15/635 (EP); C12N15/90 (EP)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/45]
Extension states	AL	14.07.2000
	LT	14.07.2000
	LV	14.07.2000
	MK	14.07.2000
	RO	14.07.2000
	SI	14.07.2000
Title	German:	SELBSTREGULIERTES SYSTEM ZUM TESTEN VON MIKROBIELLEN GENEN, WELCHE EIN MÖGLICHES ZIEL VON ANTIMIKROBIELLEN STOFFEN SIND, UNTER VERWENDUNG VON EINEM DURCH TETRAZYKLIN-REGULIERTEM ELEMENT	[2000/45]
	English:	AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT	[2000/45]
	French:	SYSTEME AUTOREGULATEUR DE VALIDATION DE GENES MICROBIENS EN TANT QU'EVENTUELLES CIBLES ANTIMICROBIENNES UTILISANT UN ELEMENT REGULABLE PAR LA TETRACYCLINE	[2000/45]
Entry into regional phase	14.07.2000	National basic fee paid
	14.07.2000	Designation fee(s) paid
	14.07.2000	Examination fee paid
Examination procedure	21.07.1999	Request for preliminary examination filed International Preliminary Examining Authority: EP
	14.07.2000	Examination requested [2000/45]
	03.12.2003	Despatch of a communication from the examining division (Time limit: M06)
	23.09.2004	Reply to a communication from the examining division
	11.05.2005	Despatch of a communication from the examining division (Time limit: M06)
	12.11.2005	Application deemed to be withdrawn, date of legal effect [2006/22]
	29.12.2005	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2006/22]
Request for further processing for:	23.09.2004	Request for further processing filed
	22.09.2004	Full payment received (date of receipt of payment) Request granted
	05.10.2004	Decision despatched
Fees paid	Renewal fee
	05.01.2001	Renewal fee patent year 03
	10.01.2002	Renewal fee patent year 04
	09.01.2003	Renewal fee patent year 05
	05.01.2004	Renewal fee patent year 06
	07.01.2005	Renewal fee patent year 07
	Penalty fee
	Additional fee for renewal fee
	31.01.2006	08 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[YDX]US5464758 (M. GOSSEN ET AL.) [YD] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64;
		[YD]WO9640979 (MICROCIDE PHARMACEUTICALS INC.) [YD] 1-77 * the whole document *;
		[YX]US5654168 (H. BUJARD ET AL.) [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64;
		[YX]WO9429442 (BASF AKTIENGESELLSCHAFT) [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64;
		[Y]WO9601313 (DECONTI) [Y] 1-77 * the whole document *;
		[YX]WO9640946 (YALE UNIVERSITY) [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64;
		[YX] - CAMILLI, ANDREW ET AL, "Use of genetic recombination as a reporter of gene expression.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1994) VOL. 91, NO. 7, PP. 2634-2638. ISSN: 0027-8424., XP000197110 [Y] 1-58,60,62,65-77 * the whole document * [X] 59,61,64 DOI: http://dx.doi.org/10.1073/pnas.91.7.2634
		[YX] - SKERRA, ARNE, "Use of the tetracycline promoter for the tightly regulated production of a murine antibody fragment in Escherichia coli.", GENE (AMSTERDAM), (1994) VOL. 151, NO. 1-2, PP. 131-135. ISSN: 0378-1119., XP004042624 [Y] 1-58,65-77 * the whole document * [X] 59-63 DOI: http://dx.doi.org/10.1016/0378-1119(94)90643-2
		[YX] - RAMAKRISHNAN, GIRIJA ET AL, "A tetracycline -inducible gene expression system in Entamoeba histolytica.", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, (1997) VOL. 84, NO. 1, PP. 93-100 ISSN: 0166-6851., XP002105109 [Y] 1-58,60,62,65-77 * the whole document * [X] 59,61,63,64 DOI: http://dx.doi.org/10.1016/S0166-6851(96)02784-3
		[YX] - KIM, HONG-JIN ET AL, "Tetracycline repressor- regulated gene repression in recombinant human cytomegalovirus.", JOURNAL OF VIROLOGY, (1995) VOL. 69, NO. 4, PP. 2565-2573. ISSN: 0022-538X., XP002037393 [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64
		[YX] - M. GOSSEN ET AL., "Transcriptional activation by tetracycllines in mammalian cells.", SCIIENCE, (19950623), vol. 268, pages 1766 - 1769, XP002105110 [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64 DOI: http://dx.doi.org/10.1126/science.7792603
		[YX] - M. GOSSEN ET AL., "Tight control of gene expression in mammalian cells by tetracyline-responsive promoters.", PROC. NATL. ACAD. SCI. USA, (199206), vol. 89, pages 5547 - 5551, XP000564458 [Y] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64 DOI: http://dx.doi.org/10.1073/pnas.89.12.5547
		[AD] - W. HILLEN AND A. WISSMANN, Protein-Nucleic Acid Interaction; Tet repressor-tet operator interactions,, LONDON, SAEGER & HEINEMANN, EDS. MACMILLAN, (1989), XP002105116 [AD] * page 143 - page 162 *
		[A] - M. NESIN ET AL., "Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistacne determinant, tetA(M), from a Pathogenic, Methicilin-resistant strain of Staphylococcus aureus.", ANTIMICROBIAL AGNETS AND CHEMOTHERAPY, (199011), vol. 34, no. 11, pages 2273 - 2276, XP002105111 [A] * the whole document *
		[A] - T. NGUYEN ET AL., "Sequence homology between the tetracyline-resistance determinants of Tn10 and pBR322", GENE, (1983), vol. 25, pages 83 - 92, XP002105112 [A] * the whole document * DOI: http://dx.doi.org/10.1016/0378-1119(83)90170-1
		[A] - A. EAST ET AL., "Cloning and sequence determination of six Staphylococcus aureus beta-lactamases and their expression in Escherichia coli and Staphylococcus aureus.", JOURNAL OF GENERAL MICROBIOLOGY, (1989), vol. 135, pages 1001 - 1015, XP002067243 [A] * the whole document *
		[PYX] - P GHERSA ET AL., "Highly controlled gene expression using combinations of tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor.", GENE THERAPY, (199809), vol. 5, no. 9, pages 11213 - 1220, XP002105114 [PY] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64 DOI: http://dx.doi.org/10.1038/sj.gt.3300713
		[PYX] - F. YAO ET AL., "Tetracycline Repressor, tetR, rather than the tetR-Mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells.", HUMAN GENE THERAPY, (19980901), vol. 9, no. 13, pages 1939 - 1950, XP002105115 [PY] 1-58,60,62,63,65-77 * the whole document * [X] 59,61,64

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