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Extract from the Register of European Patents

EP About this file: EP1177185

EP1177185 - 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.02.2006
Database last updated on 07.10.2024
Most recent event   Tooltip31.07.2009Change - representativepublished on 02.09.2009  [2009/36]
Applicant(s)For all designated states
Pharmacia Italia S.p.A.
Via Robert Koch 1.2
20152 Milano / IT
[2002/15]
Former [2002/06]For all designated states
PHARMACIA & UPJOHN S.p.A.
Via Robert Koch, 1.2
20152 Milano / IT
Inventor(s)01 / PEVARELLO, Paolo
Piazza San Pietro in Ciel d'Oro, 7/A
I-27100 Pavia / IT
02 / VILLA, Manuela
Via San Bernardino, 12
I-22040 Lurago d'Erba / IT
03 / VARASI, Mario
Via Giambellino, 80
I-20146 Milan / IT
04 / ISACCHI, Antonella
Via Montecatini, 14
I-20144 Milan / IT
 [2002/06]
Representative(s)Modiano, Micaela Nadia
Modiano Josif Pisanty & Staub Ltd
Thierschstrasse 11
80538 München / DE
[N/P]
Former [2009/36]Modiano, Micaela Nadia
Modiano Josif Pisanty & Staub Ltd Thierschstrasse 11
80538 München / DE
Former [2004/34]Modiano, Micaela Nadia
Modiano, Josif, Pisanty & Staub, Baaderstrasse 3
80469 München / DE
Application number, filing date00927184.204.05.2000
[2002/06]
WO2000EP04208
Priority number, dateGB1999001105312.05.1999         Original published format: GB 9911053
[2002/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0069846
Date:23.11.2000
Language:EN
[2000/47]
Type: A1 Application with search report 
No.:EP1177185
Date:06.02.2002
Language:EN
The application published by WIPO in one of the EPO official languages on 23.11.2000 takes the place of the publication of the European patent application.
[2002/06]
Type: B1 Patent specification 
No.:EP1177185
Date:20.04.2005
Language:EN
[2005/16]
Search report(s)International search report - published on:EP23.11.2000
ClassificationIPC:C07D401/04, C07D231/56, A61K31/416, A61P35/00
[2002/06]
CPC:
C07D401/04 (EP,KR,US); C07D231/56 (EP,KR,US); A61K31/416 (KR);
A61P17/06 (EP); A61P17/14 (EP); A61P25/28 (EP);
A61P35/00 (EP); A61P43/00 (EP); A61P9/10 (EP);
C07D213/38 (KR) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2005/16]
Former [2002/06]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
Extension statesAL21.11.2001
LT21.11.2001
LV21.11.2001
MK21.11.2001
RO21.11.2001
SI21.11.2001
TitleGerman:4, 5, 6, 7-TETRAHYDROINDAZOLDERIVATE ALS ANTITUMORMITTEL[2002/06]
English:4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS[2002/06]
French:DERIVES DE 4,5,6,7-TETRAHYDROINDAZOLE UTILES COMME AGENTS ANTITUMORAUX[2002/06]
Entry into regional phase21.11.2001National basic fee paid 
21.11.2001Designation fee(s) paid 
21.11.2001Examination fee paid 
Examination procedure23.11.2000Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.11.2001Examination requested  [2002/06]
14.02.2002Despatch of a communication from the examining division (Time limit: M08)
14.10.2002Reply to a communication from the examining division
22.01.2003Despatch of a communication from the examining division (Time limit: M06)
25.07.2003Reply to a communication from the examining division
04.12.2003Despatch of a communication from the examining division (Time limit: M02)
03.02.2004Reply to a communication from the examining division
12.08.2004Communication of intention to grant the patent
08.02.2005Fee for grant paid
08.02.2005Fee for publishing/printing paid
Opposition(s)23.01.2006No opposition filed within time limit [2006/15]
Fees paidRenewal fee
06.05.2002Renewal fee patent year 03
07.05.2003Renewal fee patent year 04
05.05.2004Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]US4734430  (LE TOURNEAU MICHAEL E [US], et al) [X] 7 * example 2 *;
 [A]WO9915500  (GLAXO GROUP LTD [GB], et al) [A] 1,13,14 * abstract *;
 [A]WO9917769  (BASF AG [DE], et al) [A] 1,13,14* claim 1 *;
 [X]  - SCHENONE, PIETRO ET AL, "Reaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. I. Synthesis of 1,5-disubstituted 4-acylpyrazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 98:160635, URL: STN, XP002144430 [X] 7 * compound with RN=85302-12-1 *
    [ ] - J. HETEROCYCL. CHEM. (1982), 19(6), 1355-61
 [X]  - BIANCHI, GIORGIO ET AL, "Regioselectivity in the reactions of benzonitrile N-phenylimide and some benzonitrile N-oxides with.alpha.,.beta.-unsaturated ketones", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 95:97308, URL: STN, XP002144431 [X] 7,12 * compound with RN=77987-78-1 *
    [ ] - J. CHEM. RES., SYNOP. (1981), (1), 6-7
 [X]  - SLIEDE, J. ET AL, "Bromination of 1-phenyl-3,5,5-trimethyl-4-oxocyclopentapyrazole", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 87:23141, URL: STN, XP002144432 [X] 7,12 * compounds with RN=61330-33-4; 63077-20-3 *
    [ ] - LATV. PSR ZINAT. AKAD. VESTIS, KIM. SER. (1977), (1), 112-13
 [X]  - STRAKOV, A. YA. ET AL, "1-Phenyl-5,5-dimethyl- and 1-phenyl-3,5,5-trimethyl-4- hydroxycyclopentapyrazole-4-carboxylic acids and some of their reactions", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 86:29709, URL: STN, XP002144433 [X] 7 * compounds with RN=61330-32-3; 61330-33-4 *
    [ ] - LATV. PSR ZINAT. AKAD. VESTIS, KIM. SER. (1976), (4), 469-70
 [X]  - STRAKOV, A. YA. ET AL, "1-(1-Phthalazinyl)- and 1-(4-methoxyphenyl)-6,6-dimethyl-4-oxo- 4,5,6,7-tetrahydroindazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 125:300882, URL: STN, XP002144434 [X] 7,8,12 * compounds with RN=51300-52-8; 182744-31-6 *
    [ ] - KHIM. GETEROTSIKL. SOEDIN. (1996), (5), 708-710
 [X]  - STRAKOV, A. YA. ET AL, "Reaction of 2-amino- and 2-hydrazinobenzimidazoles with 2-acyldimedones", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 125:167869, URL: STN, XP002144435 [X] 7,8,12 * compounds with RN=180141-39-3; 180141-40-6 *
    [ ] - KHIM. GETEROTSIKL. SOEDIN. (1996), (2), 247-252
 [X]  - RUBINOV, D. B. ET AL, "Reaction of 2-acylcylohexane-1,3-diones with 6- hydrazinophenanthridine", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 119:117172, URL: STN, XP002144436 [X] 7,8,12 * compounds with RN=149430-94-4; 149430-95-5 *
    [ ] - KHIM. GETEROTSIKL. SOEDIN. (1992), (12), 1617-20
 [X]  - GUDRINIECE, E. ET AL, "1-Aryl-4-carboxy-5-(.beta.-methyl-.beta.-carboxypropyl)pyrazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 81:91415, URL: STN, XP002144437 [X] 7,8,12 * compounds with RN=16315-26-7; 21269-61-4 *
    [ ] - DOKL. AKAD. NAUK SSSR (1974), 216(6), 1293-5 [(CHEM)]
 [X]  - NUNN, ARTHUR J. ET AL, "Semmler-Wolff aromatization and abnormal Beckmann and Schmidt reactions of 3-alkyl-4-oxo-1-phenyl-4,5,6,7-tetrahydroindazoles and their oximes in polyphosphoric acid", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 80:82796, URL: STN, XP002144438 [X] 7,8,12 * compounds with RN=51300-55-1; 21269-61-4; 51300-51-7;51300-54-0;51300-56-2; 51376-27-3; 51300-52-8 *
    [ ] - J. CHEM. SOC., PERKIN TRANS. 1 (1973), (22), 2697-703
 [X]  - SUCROW, WOLFGANG ET AL, "Enehydrazines. 4. Reaction of dimedone with hydrazones", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 77:100891, URL: STN, XP002144439 [X] 7,8,12 * compounds with RN=38126-75-9; 38126-75-9; 38327-04-7; 38341-19-4 *
    [ ] - CHEM. BER. (1972), 105(7), 2143-55
 [X]  - STRAKOVA, I. A. ET AL, "Alkylation of 3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 73:87837, URL: STN, XP002144440 [X] 7,8,12 * compounds with RN=16315-22-3; 28714-62-7; 28714-64-9;28714-70-7; 28714-63-8 *
    [ ] - KHIM. GETEROTSIKL. SOEDIN. (1970), (4), 520-4
 [X]  - STRAKOVA, I. A. ET AL, "Reduction of 1-phenyl-3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 73:77133, URL: STN, XP002144441 [X] 7,9 * compound with RN=28795-07-5 *
    [ ] - LATV. PSR ZINAT. AKAD. VESTIS, KIM. SER. (1969), (5), 574-8
 [X]  - STRAKOVA, I. A. ET AL, "6-Substituted 3-methyl-4-hydroxy-4,5,6,7-tetrahydroindazoles", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 70:77862, URL: STN, XP002144442 [X] 7,8,12 * compounds with RN=21444-51-9; 21444-57-5 *
    [ ] - LATV. PSR ZINAT. AKAD. VESTIS, KIM. SER. (1968), (6), 718-21
 [X]  - STRAKOVA, I. A. ET AL, "3,6,6-Trimethyl-4,5,6,7-tetrahydro-4-indazoline derivatives", CHEMABS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 67:116848, URL: STN, XP002144443 [X] 7,8,12 * compounds with RN=163-16-5; 16315-17-6; 16315-18-7; 16315-19-8; 16315-22-3; 16315-26-7; 16342-78-2 *
    [ ] - LATV. PSR ZINAT. AKAD. VESTIS, KIM. SER. (1966), (6), 680-3
ExaminationUS3657270
 US3657438
 US3691180
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.