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EP About this file: EP1189609

EP1189609 - CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 11.02.2005 Database last updated on 19.07.2024
Most recent event Tooltip	11.02.2005	Application deemed to be withdrawn	published on 30.03.2005 [2005/13]
Applicant(s)	For all designated states SMITHKLINE BEECHAM CORPORATION One Franklin Plaza P.O. Box 7929 Philadelphia Pennsylvania 19103 / US
	[N/P]
Former [2002/13]	For all designated states SMITHKLINE BEECHAM CORPORATION One Franklin Plaza P.O. Box 7929 Philadelphia Pennsylvania 19103 / US
Inventor(s)	01 / LUENGO, Juan I. 701 Pondview Drive Audubon, PA 19403 / US
	02 / PRICE, Alan, Thomas 2201 Eland Downe Phoenixville, PA 19460 / US
	03 / SHAW, Antony 713 Jacques Circle Chester Springs, PA 19425 / US
	04 / WIGGALL, Kenneth 910 Brookmont Circle Malvern, PA 19355 / US
	[2002/13]
Representative(s)	Waters, David Martin GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford Middlesex TW8 9GS / GB
	[N/P]
Former [2002/13]	Waters, David Martin GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
Application number, filing date	00928735.0	03.05.2000
	[2002/13]
	WO2000US11951
Priority number, date	US19990132194P	03.05.1999 Original published format: US 132194 P
	US19990132189P	03.05.1999 Original published format: US 132189 P
	US19990132185P	03.05.1999 Original published format: US 132185 P
	[2002/13]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO0066112
	Date:	09.11.2000
	Language:	EN
	[2000/45]
	Type:	A1 Application with search report
	No.:	EP1189609
	Date:	27.03.2002
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 09.11.2000 takes the place of the publication of the European patent application.
	[2002/13]
Search report(s)	International search report - published on:	US	09.11.2000
	(Supplementary) European search report - dispatched on:	EP	12.09.2002
Classification	IPC:	C07D257/02, C07D401/10, C07D401/12, C07D401/14, C07D403/10, C07D403/12, C07D403/14, C07D405/12, C07D405/14, C07D409/14, C07D413/10, C07D417/10, A61K31/33, A61K31/395, A61K31/415, A61K31/425, A61K31/44, A61K31/445, A61K31/47, A61K31/495, A61K31/50, A61K31/505, A61K31/535, A61K31/54, A61K31/55	[2002/31]
	CPC:	C07D231/12 (EP); A61P1/08 (EP); A61P1/14 (EP); A61P11/06 (EP); A61P13/02 (EP); A61P13/08 (EP); (+) A61P17/02 (EP); A61P19/10 (EP); A61P25/00 (EP); A61P25/06 (EP); A61P25/14 (EP); A61P25/16 (EP); A61P25/18 (EP); A61P25/22 (EP); A61P25/24 (EP); A61P29/00 (EP); A61P3/04 (EP); A61P3/10 (EP); A61P31/12 (EP); A61P35/00 (EP); A61P37/00 (EP); A61P43/00 (EP); A61P7/04 (EP); A61P9/02 (EP); A61P9/04 (EP); A61P9/10 (EP); A61P9/12 (EP); C07D233/56 (EP); C07D249/08 (EP); C07D257/02 (EP); C07D401/10 (EP); C07D401/12 (EP); C07D401/14 (EP); C07D403/10 (EP); C07D403/12 (EP); C07D405/12 (EP); C07D405/14 (EP); C07D413/10 (EP); C07D417/10 (EP); C07D417/12 (EP) (-)
	Former IPC [2002/13]	A61K31/33, A61K31/415, A61K31/425, A61K31/44, A61K31/445, A61K31/47, A61K31/495, A61K31/50, A61K31/535, A61K31/54, A61K31/55, A61K31/555, C07D225/00, C07D235/04, C07D257/02, C07D401/14
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/13]
Title	German:	CXCR-4 REZEPTOR ANTAGONISTEN UND THROMBOPOIETIN MIMETIKA	[2002/13]
	English:	CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS	[2002/13]
	French:	ANTAGONISTES DU RECEPTEUR CXCR-4 ET MIMETIQUES DE THROMBOPOIETINE	[2002/13]
Entry into regional phase	29.11.2001	National basic fee paid
	29.11.2001	Search fee paid
	29.11.2001	Designation fee(s) paid
	29.11.2001	Examination fee paid
Examination procedure	01.12.2000	Request for preliminary examination filed International Preliminary Examining Authority: US
	29.11.2001	Amendment by applicant (claims and/or description)
	29.11.2001	Examination requested [2002/13]
	10.02.2003	Despatch of a communication from the examining division (Time limit: M06)
	14.08.2003	Reply to a communication from the examining division
	11.05.2004	Despatch of a communication from the examining division (Time limit: M04)
	22.09.2004	Application deemed to be withdrawn, date of legal effect [2005/13]
	26.10.2004	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2005/13]
Fees paid	Renewal fee
	06.05.2002	Renewal fee patent year 03
	07.05.2003	Renewal fee patent year 04
	05.05.2004	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A]EP0427595 (AIR LIQUIDE [FR]) [A] 1 * page 3, line 36 - page 4, line 7 *;
		[X]WO9630349 (JOHNSON MATTHEY PLC [GB]) [X] 1,5,6,10 * page 13; example 1C *;
		[X]WO9216494 (JOHNSON MATTHEY PLC [GB]) [X] 1,5,6,10 * claims 1-8,10-13 *;
		[PA]WO9922734 (SMITHKLINE BEECHAM CORP [US], et al) [PA] 1,5-8 * page 13, line 16 - line 19; example - *;
		[A]US5369107 (MATSUO MASAAKI [JP], et al) [A] 1,5-8 * abstract *
		[X] - BRANDES, STEPHANE ET AL, "New facile and convenient synthesis of bispolyazamacrocycles using Boc protection. Determination of geometric parameters of dinuclear copper(II) complexes using ESR spectroscopy and molecular mechanics calculations", BULL. SOC. CHIM. FR. (1996), 133(1), 65-73, XP000196380 [X] 1,5,6,10 * page 65, paragraph L; figures 2,COMPOUNDS,2F,2G *
		[X] - SCHOLS, DOMINIQUE ET AL, "Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4", ANTIVIRAL RES. (1997), 35(3), 147-156, XP002925073 [X] 1,5,6,9,10 * page 154, paragraph 2 * DOI: http://dx.doi.org/10.1016/S0166-3542(97)00025-9
		[X] - ARAKAKI, RIEKO ET AL, "T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure", JOURNAL OF VIROLOGY (1999), 73(2), 1719-1723, XP002199036 [X] 1,5,6,9,10 * page 1719, column 2, line 4 - line 14 *
		[X] - XU, DAQIANG ET AL, "An expeditious synthesis of a biscyclam with an aromatic linker", TETRAHEDRON LETT. (1996), 37(30), 5301-5304, XP004029488 [X] 1,5,6,10 * Scheme 1; paragraph [FIRST] * DOI: http://dx.doi.org/10.1016/0040-4039(96)01097-0
		[A] - DESSOLIN, JEAN ET AL, "New Bicyclam-AZT Conjugates: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with CXCR-4 Coreceptor", JOURNAL OF MEDICINAL CHEMISTRY (1999), 42(2), 229-241, XP002199037 [A] 1,5,6,9,10 * page 236, paragraph L - page 237, paragraph 5; example 28; table 1 * DOI: http://dx.doi.org/10.1021/jm980358u
	International search	[X]US5817807 (BRIDGER GARY J [US], et al);
		[X]US5583131 (BRIDGER GARY JAMES [US], et al);
		[X] - BRIDGER ET AL., "Synthesis and structure - activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams", JOURNAL OF MEDICINAL CHEMISTRY,, (199601), vol. 39, no. 1, pages 109 - 119, XP002930503 DOI: http://dx.doi.org/10.1021/jm950584t
		[X] - JOAO ET AL., "Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors", JOURNAL OF MEDICINAL CHEMISTRY,, (199509), vol. 38, no. 19, pages 3865 - 3873, XP002930504 DOI: http://dx.doi.org/10.1021/jm00019a017
		[X] - BRIDGER ET AL., "Synthesis and structure - activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of Macrocyclic ring size and substituents on the aromatic linker", JOURNAL OF MEDICINAL CHEMISTRY,, (199501), vol. 38, no. 2, pages 366 - 378, XP002930505 DOI: http://dx.doi.org/10.1021/jm00002a019
		[X] - MALLIK ET AL., "Synthetic bis-metal ion receptors for bis-imidazole (protein analogs)", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,, (199410), vol. 116, no. 20, pages 8902 - 8911, XP002930506 DOI: http://dx.doi.org/10.1021/ja00099a007
		[X] - DE CLERCQ ET AL., "Highly protein and selective inhibitor of human immunodefiency virus by the bicyclam derivative JM3100", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,, (199404), vol. 38, no. 4, pages 668 - 674, XP002930507
		[X] - MALLIK ET AL., "Selective-recognition of bis-imidazoles by complementary bis-metal ion complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,, (199303), vol. 115, no. 6, pages 2518 - 2520, XP002930508 DOI: http://dx.doi.org/10.1021/ja00059a063
		[X] - HELPS ET AL., "General routes for the synthesis of mono, di and tri-N-substituted derivatives of cyclam", TETRAHEDRON,, (1989), vol. 45, no. 1, pages 219 - 226, XP002930509 DOI: http://dx.doi.org/10.1016/0040-4020(89)80049-3
		[X] - CIAMPOLINI ET AL., "Dinickel and dicopper couplexes with N,N-linked bis(cyclan) ligands. An ideal system to the investigation of electrostatic effects on the redox behavior of pairs of metal ions", INORGANIC CHEMISTRY,, (199710), vol. 26, no. 21, pages 3527 - 3533, XP002930510 DOI: http://dx.doi.org/10.1021/ic00268a022

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