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EP1181306
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EP About this file: EP1181306
| EP1181306 - COMPOUNDS AND METHODS FOR REGULATING APOPTOSIS, AND METHODS OF MAKING AND SCREENING FOR COMPOUNDS THAT REGULATE APOPTOSIS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 18.04.2008 Database last updated on 08.06.2024 | Most recent event Tooltip | 18.04.2008 | Application deemed to be withdrawn | published on 21.05.2008 [2008/21] | Applicant(s) | For all designated states Apoptosis Technology, Inc. 128 Sidney Street Cambridge, MA 02139-4239 / US | [2002/09] | Inventor(s) | 01 /
ZHOU, Xiao-Mai 55 Thatcher Street, 2 Brookline, MA 02446 / US | [2002/09] | Representative(s) | Daniels, Jeffrey Nicholas, et al Page White & Farrer Limited Bedford House 21A John Street London WC1N 2BF / GB | [N/P] |
| Former [2002/09] | Daniels, Jeffrey Nicholas, et al Page White & Farrer 54 Doughty Street London WC1N 2LS / GB | Application number, filing date | 00935853.2 | 30.05.2000 | [2002/09] | WO2000US11864 | Priority number, date | US19990136783P | 28.05.1999 Original published format: US 136783 P | [2002/09] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO0110888 | Date: | 15.02.2001 | Language: | EN | [2001/07] | Type: | A1 Application with search report | No.: | EP1181306 | Date: | 27.02.2002 | Language: | EN | The application published by WIPO in one of the EPO official languages on 15.02.2001 takes the place of the publication of the European patent application. | [2002/09] | Search report(s) | International search report - published on: | US | 15.02.2001 | (Supplementary) European search report - dispatched on: | EP | 06.05.2003 | Classification | IPC: | C07K1/00, C07K1/13, C07K1/14, C07K14/00, C12P21/00, C12P21/02, C07K14/47, G01N33/50, G01N33/53 | [2003/23] | CPC: |
C07K14/4703 (EP);
C07K14/4702 (EP);
C07K14/4747 (EP);
C07K2319/00 (EP)
|
| Former IPC [2002/09] | C07K1/00, C07K1/13, C07K1/14, C07K14/00, C12P21/00, C12P21/02 | Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/09] | Title | German: | VERBINDUNGEN UND METHODEN ZUR REGULIERUNG VON APOPTOSE UND METHODEN ZUR HERSTELLUNG UND ZUM SCREENING VON ENTSPRECHENDEN VERBINDUNGEN | [2002/09] | English: | COMPOUNDS AND METHODS FOR REGULATING APOPTOSIS, AND METHODS OF MAKING AND SCREENING FOR COMPOUNDS THAT REGULATE APOPTOSIS | [2002/09] | French: | COMPOSES ET METHODES DE REGULATION DE L'APOPTOSE, ET METHODES D'ELABORATION ET DE CRIBLAGE DE COMPOSES REGULATEURS DE L'APOPTOSE | [2002/09] | Entry into regional phase | 27.11.2001 | National basic fee paid | 27.11.2001 | Search fee paid | 27.11.2001 | Designation fee(s) paid | 27.11.2001 | Examination fee paid | Examination procedure | 04.12.2000 | Request for preliminary examination filed International Preliminary Examining Authority: US | 27.11.2001 | Examination requested [2002/09] | 08.12.2004 | Amendment by applicant (claims and/or description) | 03.02.2005 | Despatch of a communication from the examining division (Time limit: M06) | 16.06.2005 | Reply to a communication from the examining division | 11.07.2007 | Despatch of a communication from the examining division (Time limit: M04) | 22.11.2007 | Application deemed to be withdrawn, date of legal effect [2008/21] | 02.01.2008 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2008/21] | Fees paid | Renewal fee | 23.05.2002 | Renewal fee patent year 03 | 23.05.2003 | Renewal fee patent year 04 | 17.05.2004 | Renewal fee patent year 05 | 13.05.2005 | Renewal fee patent year 06 | 30.03.2006 | Renewal fee patent year 07 | Penalty fee | Additional fee for renewal fee | 31.05.2007 | 08 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X] - OTTILIE S ET AL, "Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 DEC 1997, (19971205), vol. 272, no. 49, ISSN 0021-9258, pages 30866 - 30872, XP002238393 [X] 1-3,10,11,13,14,18,21,23 * page 30869, column R, paragraph L - page 30870, column R, paragraph 1; figures 4,5 * DOI: http://dx.doi.org/10.1074/jbc.272.49.30866 | [X] - HARADA HISASHI ET AL, "Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A.", MOLECULAR CELL, (199904), vol. 3, no. 4, ISSN 1097-2765, pages 413 - 422, XP002238394 [X] 25-30,35-40,52-55 * page 416 - page 417 * DOI: http://dx.doi.org/10.1016/S1097-2765(00)80469-4 | [X] - DATTA SANDEEP ROBERT ET AL, "Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.", CELL, (1997), vol. 91, no. 2, ISSN 0092-8674, pages 231 - 241, XP002238395 [X] 25-27,30,35-37,40,52-55 * page 233 - page 237 * DOI: http://dx.doi.org/10.1016/S0092-8674(00)80405-5 | [X] - ZHA JIPING ET AL, "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X-L.", CELL, (1996), vol. 87, no. 4, ISSN 0092-8674, pages 619 - 628, XP002238396 [X] 52-55 * page 626, column R, paragraph 3 * DOI: http://dx.doi.org/10.1016/S0092-8674(00)81382-3 | [T] - DATTA SANDEEP ROBERT ET AL, "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.", MOLECULAR CELL, (200007), vol. 6, no. 1, ISSN 1097-2765, pages 41 - 51, XP002238397 [T] 1-56 * the whole document * DOI: http://dx.doi.org/10.1016/S1097-2765(00)00006-X | [T] - ZHOU XIAO-MAI ET AL, "Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.", JOURNAL OF BIOLOGICAL CHEMISTRY, (20000811), vol. 275, no. 32, ISSN 0021-9258, pages 25046 - 25051, XP002238398 [T] 1-56 * the whole document * DOI: http://dx.doi.org/10.1074/jbc.M002526200 | International search | [XP]US5965703 ; | [X] - O'CONNOR, PROTEIN, (19980601), Database accession no. O54920, XP002954942 | [X] - O'CONNER ET AL., "Bim: a novel member of the Bcl-2 family that promotes apoptosis", EMBO J.,, (19980115), vol. 17, no. 2, pages 384 - 395, XP002931336 DOI: http://dx.doi.org/10.1093/emboj/17.2.384 | [X] - PROTEIN, (19971101), Database accession no. P55472, XP002954943 | Examination | - BOWIE J.U. ET AL, "Deciphering the message in protein sequences: tolerance to amino acid substitutions.", SCIENCE, NEW YORK, NY, US, (19900316), vol. 247, no. 4948, pages 1306 - 1310 | - BURGESS W.H. ET AL, "POSSIBLE DISSOCIATION OF THE HEPARIN-BINDING AND MITOGENIC ACTIVITIES OF HEPARIN-BINDING (ACIDIC FIBROBLAST) GROWTH FACTOR-1 FROM ITS RECEPTOR-BINDING ACTIVITIES BY SITE-DIRECTED MUTAGENESIS OF A SINGLE LYSINE RESIDUE.", JOURNAL OF CELL BIOLOGY, NEW YORK, NY, US, (199011), XP002074068 DOI: http://dx.doi.org/10.1083/jcb.111.5.2129 | - LAZAR E. ET AL, "TRANSFORMING GROWTH FACTOR ALPHA MUTATION OF ASPARTIC ACID 47 AND LEUCINE 48 RESULTS IN DIFFERENT BIOLOGICAL ACTIVITIES", MOLECULAR AND CELLULAR BIOLOGY, (1988), vol. 8, no. 3, pages 1247 - 1252 | - TAO M.-H.; MORRISON S.L., "STUDIES OF AGLYCOSYLATED CHIMERIC MOUSE-HUMAN IGG", JOURNAL OF IMMUNOLOGY, BALTIMORE, MD, US, (19891015), vol. 143, no. 8, pages 2595 - 2601, XP000984625 | - GILLIES S.D.; WESOLOWSKI J.S., "ANTIGEN BINDING AND BIOLOGICAL ACTIVITIES OF ENGINEERED MUTANT CHIMERIC ANTIBODIES WITH HUMAN TUMOR SPECIFICITIES.", HUMAN ANTIBODIES AND HYBRIDOMAS, (1990), vol. 1, no. 1, pages 47 - 54, XP002050448 |