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Extract from the Register of European Patents

EP About this file: EP1224469

EP1224469 - METHOD OF SCREENING FOR INHIBITORS OF ASP2 [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 10.02.2006 Database last updated on 13.07.2024
Most recent event Tooltip	13.04.2007	Lapse of the patent in a contracting state New state(s): CY	published on 16.05.2007 [2007/20]
Applicant(s)	For all designated states SMITHKLINE BEECHAM PLC 980 Great West Road Brentford Middlesex TW8 9GS / GB
	For all designated states SMITHKLINE BEECHAM CORPORATION One Franklin Plaza P.O. Box 7929 Philadelphia, PA 19101 / US
	[N/P]
Former [2005/10]	For all designated states SmithKline Beecham plc 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	For all designated states SmithKline Beecham Corporation One Franklin Plaza P.O. Box 7929 Philadelphia, PA 19101 / US
Former [2002/36]	For all designated states SmithKline Beecham plc 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	For all designated states SMITHKLINE BEECHAM CORPORATION One Franklin Plaza P.O. Box 7929 Philadelphia Pennsylvania 19103 / US
Former [2002/30]	For all designated states SMITHKLINE BEECHAM PLC New Horizons Court Brentford, Middlesex TW8 9EP / GB
	For all designated states SMITHKLINE BEECHAM CORPORATION One Franklin Plaza P.O. Box 7929 Philadelphia Pennsylvania 19103 / US
Inventor(s)	01 / CHRISTIE, Gary SmithKline Beecham Pharmaceuticals New Frontiers Science Park South Third Avenue Harlow Essex CM19 5AW / GB
	02 / HUSSAIN, Ishrut SmithKline Beecham Pharmaceuticals New Frontiers Science Park South Third Avenue Harlow Essex CM19 5AW / GB
	03 / POWELL, David SmithKline Beecham Pharmaceuticals New Frontiers Science Park South Third Avenue Harlow Essex CM19 5AW / GB
	[2002/30]
Representative(s)	Valentine, Jill Barbara GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	[N/P]
Former [2002/30]	Valentine, Jill Barbara GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
Application number, filing date	00969693.1	19.10.2000
	[2002/30]
	WO2000GB04039
Priority number, date	GB19990024957	21.10.1999 Original published format: GB 9924957
	[2002/30]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO0129563
	Date:	26.04.2001
	Language:	EN
	[2001/17]
	Type:	A1 Application with search report
	No.:	EP1224469
	Date:	24.07.2002
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.04.2001 takes the place of the publication of the European patent application.
	[2002/30]
	Type:	B1 Patent specification
	No.:	EP1224469
	Date:	06.04.2005
	Language:	EN
	[2005/14]
Search report(s)	International search report - published on:	EP	26.04.2001
Classification	IPC:	G01N33/68, C12Q1/37, C07K7/02, C07K7/04	[2002/30]
	CPC:	C07K14/4711 (EP,US); A61P25/16 (EP); A61P25/28 (EP); C07K7/02 (EP,US); C12Q1/37 (EP,US); G01N33/6896 (EP,US); (+) A61K38/00 (EP,US); G01N2333/4709 (EP,US); G01N2333/96472 (EP,US); G01N2500/00 (EP,US); G01N2500/02 (EP,US) (-)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2002/30]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	VERFAHREN ZUM SCREENING VON INHIBITOREN VON ASP2	[2002/30]
	English:	METHOD OF SCREENING FOR INHIBITORS OF ASP2	[2002/30]
	French:	PROCEDE DE DEPISTAGE DES INHIBITEURS DE ASP2	[2002/30]
Entry into regional phase	16.05.2002	National basic fee paid
	16.05.2002	Designation fee(s) paid
	16.05.2002	Examination fee paid
Examination procedure	17.05.2001	Request for preliminary examination filed International Preliminary Examining Authority: EP
	16.05.2002	Examination requested [2002/30]
	11.09.2003	Despatch of a communication from the examining division (Time limit: M06)
	28.04.2004	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	28.06.2004	Reply to a communication from the examining division
	20.10.2004	Communication of intention to grant the patent
	17.12.2004	Fee for grant paid
	17.12.2004	Fee for publishing/printing paid
Opposition(s)	10.01.2006	No opposition filed within time limit [2006/13]
Request for further processing for:	28.06.2004	Request for further processing filed
	28.06.2004	Full payment received (date of receipt of payment) Request granted
	13.07.2004	Decision despatched
Fees paid	Renewal fee
	07.10.2002	Renewal fee patent year 03
	06.10.2003	Renewal fee patent year 04
	06.10.2004	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	AT	06.04.2005
	CH	06.04.2005
	FI	06.04.2005
	LI	06.04.2005
	NL	06.04.2005
	DK	06.07.2005
	GR	06.07.2005
	SE	06.07.2005
	PT	08.09.2005
	CY	19.10.2005
	IE	19.10.2005
	LU	31.10.2005
	MC	31.10.2005
	[2007/20]
Former [2007/08]	AT	06.04.2005
	CH	06.04.2005
	FI	06.04.2005
	LI	06.04.2005
	NL	06.04.2005
	DK	06.07.2005
	GR	06.07.2005
	SE	06.07.2005
	PT	08.09.2005
	IE	19.10.2005
	LU	31.10.2005
	MC	31.10.2005
Former [2006/48]	AT	06.04.2005
	CH	06.04.2005
	FI	06.04.2005
	LI	06.04.2005
	NL	06.04.2005
	DK	06.07.2005
	GR	06.07.2005
	SE	06.07.2005
	PT	08.09.2005
	IE	19.10.2005
	MC	31.10.2005
Former [2006/30]	AT	06.04.2005
	CH	06.04.2005
	FI	06.04.2005
	LI	06.04.2005
	NL	06.04.2005
	DK	06.07.2005
	GR	06.07.2005
	SE	06.07.2005
	PT	08.09.2005
	MC	31.10.2005
Former [2006/14]	AT	06.04.2005
	CH	06.04.2005
	FI	06.04.2005
	LI	06.04.2005
	NL	06.04.2005
	DK	06.07.2005
	GR	06.07.2005
	SE	06.07.2005
	PT	08.09.2005
Former [2006/13]	AT	06.04.2005
	FI	06.04.2005
	DK	06.07.2005
	SE	06.07.2005
Former [2005/52]	FI	06.04.2005
	SE	06.07.2005
Former [2005/50]	SE	06.07.2005
Cited in	International search	[Y]WO9513084 (MILES INC [US], et al) [Y] 1-9 * page 28, paragraph 3 - page 29, line 3 * * page 87, paragraph 2 - page 102 *;
		[DA]WO9640885 (ATHENA NEUROSCIENCES INC [US], et al) [DA] 1-9 * page 41, line 17 - page 48, line 34; claims 23-39 *;
		[A]WO9815828 (SCIOS INC [US], et al) [A] 1-9 * figure 1; claim 1 *;
		[DY]EP0855444 (SMITHKLINE BEECHAM PLC [GB], et al) [DY] 1-9 * claim 16 *;
		[E]WO0100663 (OKLAHOMA MED RES FOUND [US]) [E] 1-19 * examples 7,8 *;
		[A] - SAHASRABUDHE, SUDHIR R. ET AL, "Enzymic generation of the amino terminus of the.beta.-amyloid peptide", J. BIOL. CHEM. (1993), 268(22), 16699-705, XP000573976 [A] 1-9 * the whole document *
		[PX] - ERMOLIEFF, JACQUES ET AL, "Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-.beta.-secretase) Studied with New Fluorogenic Substrates", BIOCHEMISTRY (2000), 39(40), 12450-12456, XP002162928 [PX] 1-9 * the whole document * DOI: http://dx.doi.org/10.1021/bi001494f
		[DPA] - A K GHOSH, D SHIN, D DOWNS, G KOELSCH, X LIN, J ERMOLIEFF, J TANG, "Design of Potent Inhibitors for Human Brain Memapsin 2 (beta-Secretase)", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (200003), vol. 122, pages 3522 - 3523, XP002162929 [DPA] 10-19 * the whole document * DOI: http://dx.doi.org/10.1021/ja000300g
		[PX] - HONG, LIN ET AL, "Structure of the protease domain of memapsin 2 (.beta.-secretase) complexed with inhibitor", SCIENCE (WASHINGTON, D. C.) (2000), 290(5489), 150-153, XP002162930 [PX] 10-19 * the whole document * DOI: http://dx.doi.org/10.1126/science.290.5489.150
		[DPA] - SINHA SUKANTO ET AL, "Purification and cloning of amyloid precursor protein beta-secretase from human brain.", NATURE (LONDON), (19991202), vol. 402, no. 6761, ISSN 0028-0836, pages 537 - 540, XP002162931 DOI: http://dx.doi.org/10.1038/990114
		[DPA] - HUSSAIN ISHRUT ET AL, "Identification of a novel aspartic protease (Asp 2) as beta-secretase.", MOLECULAR AND CELLULAR NEUROSCIENCE, (199912), vol. 14, no. 6, ISSN 1044-7431, pages 419 - 427, XP000908710 [DPA] * the whole document * DOI: http://dx.doi.org/10.1006/mcne.1999.0811

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