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EP1188437
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EP About this file: EP1188437
| EP1188437 - Beta-hydroxybutyric acid or acetoacetic acid or salts or esters therof for use in improving cerebral function [Right-click to bookmark this link] | Status | The application has been refused Status updated on 18.06.2010 Database last updated on 14.05.2024 | Most recent event Tooltip | 18.06.2010 | Change - refusal | published on 21.07.2010 [2010/29] | Applicant(s) | For all designated states BTG INTERNATIONAL LIMITED 10 Fleet Place, Limeburner Lane London EC4M 7SB / GB | [N/P] |
| Former [2002/12] | For all designated states BTG INTERNATIONAL LIMITED 10 Fleet Place, Limeburner Lane London EC4M 7SB / GB | Inventor(s) | 01 /
Hiraide, Atsushi, M.D. 3-1-35, Miyayama-cho Toyonaka-shi / JP | 02 /
Dohi, Sekiko, Ph. D. Shimizu Pharmaceutical Co., Ltd., 235, Miyakami Shimizu-shi, Shizuoka 424 / JP | 03 /
Suzuki, Motohisa Shimizu Pharmaceutical Co., Ltd., 235, Miyakami Shimizu-shi, Shizuoka 424 / JP | 04 /
Shiba, Yoshihiro Shimizu Pharmaceutical Co., Ltd., 235, Miyakami Shimizu-shi, Shizuoka 424 / JP | [2002/12] | Representative(s) | Hiebl, Inge Elisabeth, et al Kraus & Weisert Patentanwälte PartGmbB Thomas-Wimmer-Ring 15 80539 München / DE | [N/P] |
| Former [2003/44] | Hiebl, Inge Elisabeth, et al Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München / DE | ||
| Former [2002/12] | Weisert, Annekäte, Dipl.-Ing. Dr.-Ing., et al Patentanwälte Kraus & Weisert Thomas-Wimmer-Ring 15 80539 München / DE | Application number, filing date | 01122563.8 | 22.11.1996 | [2002/12] | Priority number, date | JP19950337750 | 01.12.1995 Original published format: JP 33775095 | JP19960202671 | 31.07.1996 Original published format: JP 20267196 | JP19960202676 | 01.08.1996 Original published format: JP 20267696 | JP19960299247 | 24.10.1996 Original published format: JP 29924796 | [2002/12] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP1188437 | Date: | 20.03.2002 | Language: | EN | [2002/12] | Type: | A3 Search report | No.: | EP1188437 | Date: | 27.03.2002 | [2002/13] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 13.02.2002 | Classification | IPC: | A61K31/19, A61K31/22, A61P25/00 | [2002/12] | CPC: |
A61K31/19 (EP,US);
A61K31/22 (EP,US);
A61P25/00 (EP);
A61P25/28 (EP);
A61P3/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP)
(-)
| Designated contracting states | DE, FR, GB [2002/12] | Title | German: | Betahydroxybuttersäure oder Acetoessigsäure oder deren Salze oder Ester zur Verwendung zur Verbesserung der Gehirnfunktion | [2002/12] | English: | Beta-hydroxybutyric acid or acetoacetic acid or salts or esters therof for use in improving cerebral function | [2002/12] | French: | L'acide bêta-hydroxybutyrique ou l'acide acétoacétique ou leurs sels ou esters pour l'utilisation dans l'amélioration du fonctionnement cérébral | [2002/12] | Examination procedure | 04.03.2002 | Examination requested [2002/20] | 03.06.2002 | Observations by third parties | 11.09.2002 | Despatch of a communication from the examining division (Time limit: M06) | 17.03.2003 | Reply to a communication from the examining division | 04.07.2003 | Despatch of a communication from the examining division (Time limit: M08) | 19.04.2004 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 25.06.2004 | Reply to a communication from the examining division | 07.04.2005 | Application refused, date of legal effect [2010/28] | 07.04.2005 | Date of oral proceedings | 15.04.2005 | Minutes of oral proceedings despatched | 20.04.2005 | Despatch of communication that the application is refused, reason: substantive examination [2010/28] | 20.04.2005 | Despatch of communication that the application is refused, reason: substantive examination [2010/29] | 19.01.2010 | Application refused, date of legal effect [2010/29] | Appeal following examination | 17.06.2005 | Appeal received No. T1151/05 | 19.08.2005 | Statement of grounds filed | 18.01.2010 | Result of appeal procedure: appeal of the applicant was rejected | 18.01.2010 | Date of oral proceedings | 22.01.2010 | Minutes of oral proceedings despatched | Parent application(s) Tooltip | EP96118764.8 / EP0780123 | Request for further processing for: | 25.06.2004 | Request for further processing filed | 25.06.2004 | Full payment received (date of receipt of payment) Request granted | 09.07.2004 | Decision despatched | Fees paid | Renewal fee | 25.09.2001 | Renewal fee patent year 03 | 25.09.2001 | Renewal fee patent year 04 | 25.09.2001 | Renewal fee patent year 05 | 25.09.2001 | Renewal fee patent year 06 | 05.11.2002 | Renewal fee patent year 07 | 12.11.2003 | Renewal fee patent year 08 | 12.11.2004 | Renewal fee patent year 09 | 14.11.2005 | Renewal fee patent year 10 | 14.11.2006 | Renewal fee patent year 11 | 15.11.2007 | Renewal fee patent year 12 | 12.11.2008 | Renewal fee patent year 13 | 10.11.2009 | Renewal fee patent year 14 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X] - ALBERT S.Y.CHANG ET AL., "Hypoxia and beta-hydroxybutyrate acutely reduce glucose extraction by the brain in anesthetized dogs", CAN.J.PHYSIOL.PHARMACOL., (1993), vol. 71, no. 7, pages 465 - 472, XP000652713 [X] 1-6 * abstract * * page 465, column L * * page 470, column R, paragraph 4 * | [X] - MEDLINE, KNIGHT RIDDER, XP002188201 [X] 1-6 * abstract * | [X] - ROBERTSON C ET AL, "DIETARY NONPROTEIN CALORIES AND CEREBRAL INFARCTION SIZE IN RATS", STROKE, AMERICAN HEART ASSOCIATION, DALLAS TX, US, (19920401), vol. 23, no. 4, ISSN 0039-2499, pages 564 - 568, XP000652742 [X] 1-6 * abstract * * page 564, right hand column * * page 568, left hand column, paragraph 1 * | [ ] - BENDIKOV E A ET AL, "Effect of sodium hydroxybutyrate on cerebral circulation and regional vasomotor reflexes", BIULLETEN EKSPERIMENTALNOI BIOLOGII I MEDITSINY, (197911), vol. 88, no. 11, pages 555 - 557 | other | EP0355453 | - TILDON J. ET AL, "Transport of 3-Hydroxybutyrate by Cultured Rat Brain Astrocytes", NEUROCHEMICAL RESEARCH, (1994), vol. 19, no. 10, pages 1237 - 1242 | - NEHLIG A., "Respective roles of glucose and ketone bodies as substrates for cerebral energy metabolism in the suckling rat", DEVELOPMENTAL NEUROSCIENCE, (1996), vol. 18, no. 5-6, pages 426 - 433 | - LAMANNA J.C.; LUST W.D., "Nutrient consumption and metabolic perturbations", NEUROSURGERY CLINICS OF NORTH AMERICA, (1997), vol. 8, pages 145 - 163 | - BIRKHAHN R.H. ET AL, "POTENTIAL OF THE MONOGLYCERIDE AND TRIGLYCERIDE OF DL-3-HYDROXYBUTYRATE FOR PARENTERAL NUTRITION: SYNTHESIS AND PRELIMINARY BIOLOGICAL TESTING IN THE RAT", NUTRITION, (199703), vol. 13, no. 3, pages 213 - 219, XP000869660 DOI: http://dx.doi.org/10.1016/S0899-9007(96)00404-2 | - BROOKS K.J. ET AL, "3-Hydroxybutrate aids the recovery of the energy state from aglycaemic hypoxia of adult but not neonatal rat brain slices", JOURNAL OF NEUROCHEMISTRY, (199805), vol. 70, no. 5, pages 1986 - 1990 | - ISALES C.M. ET AL, "Acetoacetate and Beta-Hydroxybutyrate Differentially Regulate Endothelin-1 and Vascular Endothelial Growth Factor in Mouse Brain Microvascular Endothelial Cells", JOURNAL OF DIABETES AND ITS COMPLICATIONS, (199903), vol. 13, no. 2, pages 91 - 97, XP002950053 DOI: http://dx.doi.org/10.1016/S1056-8727(99)00030-6 | - NEHLIG A., "Age-dependent pathways of brain energy metabolism: the suckling rat, a natural model of the ketogenic diet", EPILEPSY RESEARCH, (199912), vol. 37, no. 3, pages 211 - 221, XP002950052 DOI: http://dx.doi.org/10.1016/S0920-1211(99)00073-X | - TRIFIRO G., "Beta-hydroxybutyrate in neonatal hypoglycemia", NEW TECHNOLOGIES IN REPRODUCTIVE MEDICIN, (1999), pages 125 - 330 | - TASAKI O. ET AL, "THE DIMER AND TRIMER OF 3-HYDROXYBUTYRATE OLIGOMER AS A PRECURSOR OF KETONE BODIES FOR NUTRITIONAL CARE", JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, (1999), vol. 23, no. 6, pages 321 - 325, XP000869678 | - TODOROVA M.T. ET AL, "THE KETOGENIC DIET INHIBITS EPILEPTOGENESIS IN EL MICE: A GENETIC MODEL FOR IDIOPATHIC EPILEPSY", EPILEPSIA, (200008), vol. 41, no. 8, pages 933 - 940, XP001053439 DOI: http://dx.doi.org/10.1111/j.1528-1157.2000.tb00275.x | - DARDZINSKI B.J. ET AL, "Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment", PEDIATRIC RESEARCH, (200008), vol. 48, no. 2, pages 248 - 255, XP002225771 | - PAN J.W. ET AL, "Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, (200010), vol. 20, no. 10, pages 1502 - 1507 | - SUZUKI M. ET AL, "Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats", JAPANESE JOURNAL OF PHARMACOLOGY, (200110), vol. 87, no. 2, doi:doi:10.1254/jjp.87.143, pages 143 - 150, XP008166028 DOI: http://dx.doi.org/10.1254/jjp.87.143 |