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Extract from the Register of European Patents

EP About this file: EP1267914

EP1267914 - USE OF LYSOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES [Right-click to bookmark this link]
Former [2003/01]USE OF LYOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES
[2009/08]
StatusPatent maintained as amended
Status updated on  04.10.2013
Database last updated on 22.08.2024
Most recent event   Tooltip17.04.2015Change - lapse in a contracting state
New state(s): LU		published on 20.05.2015  [2015/21]
Applicant(s)For all designated states
CHILDREN'S HOSPITAL RESEARCH FOUNDATION
3333 Burnet Avenue
Cincinnati, OH 45229 / US
[2009/18]
Former [2003/01]For all designated states
CHILDREN'S HOSPITAL MEDICAL CENTER
3333 Burnet Avenue
Cincinnati, Ohio 45229-3039 / US
Inventor(s)01 / GRABOWSKI, Gregory, A.
1121 Rookwood Drive
Cincinnati, OH 45208 / US
02 / DU, Hong
1290 Winstone Court
Cincinnati, OH / US
 [2003/01]
Representative(s)Goodfellow, Hugh Robin, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2013/45]
Former [2012/43]Goodfellow, Hugh Robin, et al
Carpmaels & Ransford One Southampton Row London
WC1B 5HA / GB
Former [2003/01]Turi, Michael, Dipl.-Phys.
Samson & Partner Widenmayerstrasse 5
80538 München / DE
Application number, filing date01906927.702.02.2001
[2003/01]
WO2001US03481
Priority number, dateUS20000180362P04.02.2000         Original published format: US 180362 P
US2001077551702.02.2001         Original published format: US 775517
[2003/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0156596
Date:09.08.2001
Language:EN
[2001/32]
Type: A1 Application with search report 
No.:EP1267914
Date:02.01.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 09.08.2001 takes the place of the publication of the European patent application.
[2003/01]
Type: B1 Patent specification 
No.:EP1267914
Date:29.04.2009
Language:EN
[2009/18]
Type: B2 New European patent specification 
No.:EP1267914
Date:06.11.2013
Language:EN
[2013/45]
Search report(s)International search report - published on:EP09.08.2001
ClassificationIPC:A61K38/46, A61K48/00, A61P9/10, A61P3/06
[2003/01]
CPC:
A61K38/465 (EP,US); A23L33/18 (EP,US); A61K48/005 (US);
A61K9/0019 (US); A61P3/06 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/10 (EP); C12N7/00 (US);
C12N9/20 (EP,US); C12Y301/01013 (EP,US); A61K38/18 (EP,US);
A61K38/40 (EP,US); A61K48/00 (EP,US); C12N2799/021 (US);
C12N2799/04 (US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   ES,   FR,   GB,   IE,   IT,   LI,   LU [2008/20]
Former [2003/01]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE,  TR 
TitleGerman:VERWENDUNG VON LYSOSOMAL ACID LIPASE ZUR BEHANDLUNG VON ATHEROSKLEROSE UND ÄHNLICHEN KRANKHEITEN[2003/01]
English:USE OF LYSOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES[2009/08]
French:UTILISATION DE LIPASE ACIDE LYSOSOMALE POUR TRAITER L'ATHEROSCLEROSE ET DES MALADIES ASSOCIEES[2008/20]
Former [2003/01]USE OF LYOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES
Former [2003/01]UTILISATION DE LIPASE ACIDE LYSOSOMIALE POUR TRAITER L'ATHEROSCLEROSE ET DES MALADIES ASSOCIEES
Entry into regional phase02.08.2002National basic fee paid 
02.08.2002Designation fee(s) paid 
02.08.2002Examination fee paid 
Examination procedure15.08.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
02.08.2002Examination requested  [2003/01]
19.02.2004Despatch of a communication from the examining division (Time limit: M06)
27.08.2004Reply to a communication from the examining division
01.06.2005Despatch of a communication from the examining division (Time limit: M04)
05.10.2005Reply to a communication from the examining division
05.10.2007Despatch of a communication from the examining division (Time limit: M04)
14.02.2008Reply to a communication from the examining division
17.04.2008Communication of intention to grant the patent
06.10.2008Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
11.12.2008Fee for grant paid
11.12.2008Fee for publishing/printing paid
Opposition(s)Opponent(s)01  28.01.2010  08.04.2013  WITHDRAWN
Dehmel, Albrecht
St. Cajetanstr. 9
81669 München / DE
Opponent's representative
Adams, Harvey Vaughan John, et al, et al
Mathys & Squire LLP The Shard
32 London Bridge Street
London SE1 9SG / GB
 [N/P]
Former [2013/25]
Opponent(s)01  28.01.2010  08.04.2013  WITHDRAWN
Dehmel, Albrecht
St. Cajetanstr. 9
81669 München / DE
Opponent's representative
Adams, Harvey Vaughan John, et al, et al
Mathys & Squire LLP 120 Holborn London
EC1N 2SQ / GB
Former [2012/51]
Opponent(s)01  28.01.2010  09.02.2010  ADMISSIBLE
Dehmel, Albrecht
St. Cajetanstr. 9
81669 München / DE
Opponent's representative
Adams, Harvey Vaughan John, et al, et al
Mathys & Squire LLP 120 Holborn London
EC1N 2SQ / GB
Former [2012/26]
Opponent(s)01  28.01.2010  09.02.2010  ADMISSIBLE
Dehmel, Albrecht
St. Cajetanstr. 9
81669 München / DE
Opponent's representative
HOFFMANN EITLE, et al, et al
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2010/10]
Opponent(s)01  28.01.2010   
Dehmel, Albrecht
St. Cajetanstr. 9
81669 München / DE
Opponent's representative
Dehmel, Albrecht, et al, et al
Dehmel & Bettenhausen Patentanwälte Herzogspitalstrasse 11
80331 München / DE
05.03.2010Invitation to proprietor to file observations on the notice of opposition
15.09.2010Reply of patent proprietor to notice(s) of opposition
23.09.2010Communication of observations of patent proprietor (Time limit: M06)
04.04.2011Reply of parties involved to observations of patent proprietor
23.11.2012Legal effect of interlocutory decision in opposition
23.11.2012Date of oral proceedings
03.01.2013Despatch of interlocutory decision in opposition
03.01.2013Despatch of minutes of oral proceedings
29.07.2013Despatch of communication that the patent will be maintained as amended
25.09.2013Fee for printing new specification paid
Appeal following opposition21.02.2013Appeal received No.  T0492/13
08.04.2013Result of appeal procedure: appeal of the opponent withdrawn
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
11.12.2008Request for further processing filed
11.12.2008Full payment received (date of receipt of payment)
Fees paidRenewal fee
25.02.2003Renewal fee patent year 03
23.02.2004Renewal fee patent year 04
22.02.2005Renewal fee patent year 05
27.02.2006Renewal fee patent year 06
27.02.2007Renewal fee patent year 07
25.02.2008Renewal fee patent year 08
26.02.2009Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT29.04.2009
BE29.04.2009
IE02.02.2010
LU02.02.2010
CH28.02.2010
LI28.02.2010
[2015/21]
Former [2011/07]AT29.04.2009
BE29.04.2009
IE02.02.2010
CH28.02.2010
LI28.02.2010
Former [2010/47]AT29.04.2009
BE29.04.2009
CH28.02.2010
LI28.02.2010
Former [2010/10]AT29.04.2009
BE29.04.2009
Former [2009/50]AT29.04.2009
Cited inInternational search[Y]  - ESCARY, JEAN-LOUIS ET AL, "Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells", ARTERIOSCLER., THROMB., VASC. BIOL. (1998), 18(6), 991-998, XP002168196 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 997 last paragraph *
 [Y]  - SHERIFF ET AL., "Characterization of lysosomal acid lipase by site-directed mutagenesisand heterologous expression.", J. BIOL. CHEM., (1995), vol. 270, pages 27766 - 27772, XP000986290 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 27771 left col. *

DOI:   http://dx.doi.org/10.1074/jbc.270.46.27766
 [Y]  - DU HONG ET AL., "Two polymorphic forms of human lysosomal acid lipase have different level of activity.", AM. J. HUMAN GENET., (1995), vol. 57, page A178, XP000996468 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * abstract *
 [Y]  - DU HONG ET AL., "Targeted disruption of the mouse lysosomal acid lipase gene : long-term survival with massive cholesteryl ester and triglyceride storage.", HUMAN MOLECULAR GENETICS., (1998), vol. 7, pages 1347 - 1354, XP000996474 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 1347 right col. *

DOI:   http://dx.doi.org/10.1093/hmg/7.9.1347
 [XY]  - READER ET AL., "Expression of adenoviral vector containing the cDNA for human lysosomal acid lipase in Hela and Wolman cells.", FASEB J., (1996), vol. 10, page A233, XP000996487 [X] 51,53,54,56,58,59 * abstract * [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68
 [X]  - Sigma Chemie, product catalogue : Biochemikalien, organische Verbindungenund Diagnostika., SIGMA CHEMICAL CO., (1996), XP002168197 [X] 31-39,41,49,50 * see page 271, products C9281, C9406 and C1403 *
Opposition   - POZNANSKY ET AL., "Enzyme replacement therapy in fibriblasts from a patient", THE FASEB JOURNAL, (198902), vol. 3, pages 152 - 156
    - CHATTERJEE ET AL., "Evaluation of urinary cells in acid cholesteryl ester", CLINICAL GENETICS, (19860311), vol. 29, pages 360 - 368
    - AMEIS ET AL., "Prification, characterization and molecular cloning of human hepatic lysosomal acid lipase", EUR. J. BIOCHEM., (1994), vol. 219, pages 905 - 914
    - DU ET AL., "Enzyme therapy for lysosomal acid lipase deficiency in the mouse", HUMAN MOLECULAR GENETICS, (2001), vol. 10, no. 16, pages 1639 - 1648
    - DU ET AL., "Reduction of Artherosclerotic Plaques by Lysosomal Acid Lipase Supplementation", ARTERIOSCLER TROMB VASC BIOL., (200401), vol. 24, pages 147 - 154
    - DU ET AL., "The Role of Mannosylated Enzyme and the Mannose Receptor in Enzyme Replacement Therapy", AM. J. HUM. GENET., (2005), vol. 77, pages 1061 - 1074
    - website ncbi.nlm.nih.gov : Protein / lysosomal acid lipase; sterol esterase
    - website www.sigmaaldrich.com / C9281 Cholesterol Esterase from
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.