EP1267914 - USE OF LYSOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES [Right-click to bookmark this link] | |||
Former [2003/01] | USE OF LYOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES | ||
[2009/08] | Status | Patent maintained as amended Status updated on 04.10.2013 Database last updated on 22.08.2024 | Most recent event Tooltip | 17.04.2015 | Change - lapse in a contracting state New state(s): LU | published on 20.05.2015 [2015/21] | Applicant(s) | For all designated states CHILDREN'S HOSPITAL RESEARCH FOUNDATION 3333 Burnet Avenue Cincinnati, OH 45229 / US | [2009/18] |
Former [2003/01] | For all designated states CHILDREN'S HOSPITAL MEDICAL CENTER 3333 Burnet Avenue Cincinnati, Ohio 45229-3039 / US | Inventor(s) | 01 /
GRABOWSKI, Gregory, A. 1121 Rookwood Drive Cincinnati, OH 45208 / US | 02 /
DU, Hong 1290 Winstone Court Cincinnati, OH / US | [2003/01] | Representative(s) | Goodfellow, Hugh Robin, et al Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [2013/45] |
Former [2012/43] | Goodfellow, Hugh Robin, et al Carpmaels & Ransford One Southampton Row London WC1B 5HA / GB | ||
Former [2003/01] | Turi, Michael, Dipl.-Phys. Samson & Partner Widenmayerstrasse 5 80538 München / DE | Application number, filing date | 01906927.7 | 02.02.2001 | [2003/01] | WO2001US03481 | Priority number, date | US20000180362P | 04.02.2000 Original published format: US 180362 P | US20010775517 | 02.02.2001 Original published format: US 775517 | [2003/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO0156596 | Date: | 09.08.2001 | Language: | EN | [2001/32] | Type: | A1 Application with search report | No.: | EP1267914 | Date: | 02.01.2003 | Language: | EN | The application published by WIPO in one of the EPO official languages on 09.08.2001 takes the place of the publication of the European patent application. | [2003/01] | Type: | B1 Patent specification | No.: | EP1267914 | Date: | 29.04.2009 | Language: | EN | [2009/18] | Type: | B2 New European patent specification | No.: | EP1267914 | Date: | 06.11.2013 | Language: | EN | [2013/45] | Search report(s) | International search report - published on: | EP | 09.08.2001 | Classification | IPC: | A61K38/46, A61K48/00, A61P9/10, A61P3/06 | [2003/01] | CPC: |
A61K38/465 (EP,US);
A23L33/18 (EP,US);
A61K48/005 (US);
A61K9/0019 (US);
A61P3/06 (EP);
A61P43/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
C12N7/00 (US);
C12N9/20 (EP,US);
C12Y301/01013 (EP,US);
A61K38/18 (EP,US);
A61K38/40 (EP,US);
A61K48/00 (EP,US);
C12N2799/021 (US);
C12N2799/04 (US)
(-)
| Designated contracting states | AT, BE, CH, DE, ES, FR, GB, IE, IT, LI, LU [2008/20] |
Former [2003/01] | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR | Title | German: | VERWENDUNG VON LYSOSOMAL ACID LIPASE ZUR BEHANDLUNG VON ATHEROSKLEROSE UND ÄHNLICHEN KRANKHEITEN | [2003/01] | English: | USE OF LYSOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES | [2009/08] | French: | UTILISATION DE LIPASE ACIDE LYSOSOMALE POUR TRAITER L'ATHEROSCLEROSE ET DES MALADIES ASSOCIEES | [2008/20] |
Former [2003/01] | USE OF LYOSOMAL ACID LIPASE FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES | ||
Former [2003/01] | UTILISATION DE LIPASE ACIDE LYSOSOMIALE POUR TRAITER L'ATHEROSCLEROSE ET DES MALADIES ASSOCIEES | Entry into regional phase | 02.08.2002 | National basic fee paid | 02.08.2002 | Designation fee(s) paid | 02.08.2002 | Examination fee paid | Examination procedure | 15.08.2001 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 02.08.2002 | Examination requested [2003/01] | 19.02.2004 | Despatch of a communication from the examining division (Time limit: M06) | 27.08.2004 | Reply to a communication from the examining division | 01.06.2005 | Despatch of a communication from the examining division (Time limit: M04) | 05.10.2005 | Reply to a communication from the examining division | 05.10.2007 | Despatch of a communication from the examining division (Time limit: M04) | 14.02.2008 | Reply to a communication from the examining division | 17.04.2008 | Communication of intention to grant the patent | 06.10.2008 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time | 11.12.2008 | Fee for grant paid | 11.12.2008 | Fee for publishing/printing paid | Opposition(s) | Opponent(s) | 01
28.01.2010
08.04.2013
WITHDRAWN Dehmel, Albrecht St. Cajetanstr. 9 81669 München / DE Opponent's representative Adams, Harvey Vaughan John, et al, et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB | [N/P] |
Former [2013/25] | |||
Opponent(s) | 01
28.01.2010
08.04.2013
WITHDRAWN Dehmel, Albrecht St. Cajetanstr. 9 81669 München / DE Opponent's representative Adams, Harvey Vaughan John, et al, et al Mathys & Squire LLP 120 Holborn London EC1N 2SQ / GB | ||
Former [2012/51] | |||
Opponent(s) | 01
28.01.2010
09.02.2010
ADMISSIBLE Dehmel, Albrecht St. Cajetanstr. 9 81669 München / DE Opponent's representative Adams, Harvey Vaughan John, et al, et al Mathys & Squire LLP 120 Holborn London EC1N 2SQ / GB | ||
Former [2012/26] | |||
Opponent(s) | 01
28.01.2010
09.02.2010
ADMISSIBLE Dehmel, Albrecht St. Cajetanstr. 9 81669 München / DE Opponent's representative HOFFMANN EITLE, et al, et al Patent- und Rechtsanwälte Arabellastrasse 4 81925 München / DE | ||
Former [2010/10] | |||
Opponent(s) | 01
28.01.2010
Dehmel, Albrecht St. Cajetanstr. 9 81669 München / DE Opponent's representative Dehmel, Albrecht, et al, et al Dehmel & Bettenhausen Patentanwälte Herzogspitalstrasse 11 80331 München / DE | 05.03.2010 | Invitation to proprietor to file observations on the notice of opposition | 15.09.2010 | Reply of patent proprietor to notice(s) of opposition | 23.09.2010 | Communication of observations of patent proprietor (Time limit: M06) | 04.04.2011 | Reply of parties involved to observations of patent proprietor | 23.11.2012 | Legal effect of interlocutory decision in opposition | 23.11.2012 | Date of oral proceedings | 03.01.2013 | Despatch of interlocutory decision in opposition | 03.01.2013 | Despatch of minutes of oral proceedings | 29.07.2013 | Despatch of communication that the patent will be maintained as amended | 25.09.2013 | Fee for printing new specification paid | Appeal following opposition | 21.02.2013 | Appeal received No. T0492/13 | 08.04.2013 | Result of appeal procedure: appeal of the opponent withdrawn | Request for further processing for: | The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent | 11.12.2008 | Request for further processing filed | 11.12.2008 | Full payment received (date of receipt of payment) | Fees paid | Renewal fee | 25.02.2003 | Renewal fee patent year 03 | 23.02.2004 | Renewal fee patent year 04 | 22.02.2005 | Renewal fee patent year 05 | 27.02.2006 | Renewal fee patent year 06 | 27.02.2007 | Renewal fee patent year 07 | 25.02.2008 | Renewal fee patent year 08 | 26.02.2009 | Renewal fee patent year 09 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 29.04.2009 | BE | 29.04.2009 | IE | 02.02.2010 | LU | 02.02.2010 | CH | 28.02.2010 | LI | 28.02.2010 | [2015/21] |
Former [2011/07] | AT | 29.04.2009 | |
BE | 29.04.2009 | ||
IE | 02.02.2010 | ||
CH | 28.02.2010 | ||
LI | 28.02.2010 | ||
Former [2010/47] | AT | 29.04.2009 | |
BE | 29.04.2009 | ||
CH | 28.02.2010 | ||
LI | 28.02.2010 | ||
Former [2010/10] | AT | 29.04.2009 | |
BE | 29.04.2009 | ||
Former [2009/50] | AT | 29.04.2009 | Cited in | International search | [Y] - ESCARY, JEAN-LOUIS ET AL, "Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells", ARTERIOSCLER., THROMB., VASC. BIOL. (1998), 18(6), 991-998, XP002168196 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 997 last paragraph * | [Y] - SHERIFF ET AL., "Characterization of lysosomal acid lipase by site-directed mutagenesisand heterologous expression.", J. BIOL. CHEM., (1995), vol. 270, pages 27766 - 27772, XP000986290 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 27771 left col. * DOI: http://dx.doi.org/10.1074/jbc.270.46.27766 | [Y] - DU HONG ET AL., "Two polymorphic forms of human lysosomal acid lipase have different level of activity.", AM. J. HUMAN GENET., (1995), vol. 57, page A178, XP000996468 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * abstract * | [Y] - DU HONG ET AL., "Targeted disruption of the mouse lysosomal acid lipase gene : long-term survival with massive cholesteryl ester and triglyceride storage.", HUMAN MOLECULAR GENETICS., (1998), vol. 7, pages 1347 - 1354, XP000996474 [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 * see abstract and page 1347 right col. * DOI: http://dx.doi.org/10.1093/hmg/7.9.1347 | [XY] - READER ET AL., "Expression of adenoviral vector containing the cDNA for human lysosomal acid lipase in Hela and Wolman cells.", FASEB J., (1996), vol. 10, page A233, XP000996487 [X] 51,53,54,56,58,59 * abstract * [Y] 1-6,8-24,26-39,41-51,53-56,58-62,64-68 | [X] - Sigma Chemie, product catalogue : Biochemikalien, organische Verbindungenund Diagnostika., SIGMA CHEMICAL CO., (1996), XP002168197 [X] 31-39,41,49,50 * see page 271, products C9281, C9406 and C1403 * | Opposition | - POZNANSKY ET AL., "Enzyme replacement therapy in fibriblasts from a patient", THE FASEB JOURNAL, (198902), vol. 3, pages 152 - 156 | - CHATTERJEE ET AL., "Evaluation of urinary cells in acid cholesteryl ester", CLINICAL GENETICS, (19860311), vol. 29, pages 360 - 368 | - AMEIS ET AL., "Prification, characterization and molecular cloning of human hepatic lysosomal acid lipase", EUR. J. BIOCHEM., (1994), vol. 219, pages 905 - 914 | - DU ET AL., "Enzyme therapy for lysosomal acid lipase deficiency in the mouse", HUMAN MOLECULAR GENETICS, (2001), vol. 10, no. 16, pages 1639 - 1648 | - DU ET AL., "Reduction of Artherosclerotic Plaques by Lysosomal Acid Lipase Supplementation", ARTERIOSCLER TROMB VASC BIOL., (200401), vol. 24, pages 147 - 154 | - DU ET AL., "The Role of Mannosylated Enzyme and the Mannose Receptor in Enzyme Replacement Therapy", AM. J. HUM. GENET., (2005), vol. 77, pages 1061 - 1074 | - website ncbi.nlm.nih.gov : Protein / lysosomal acid lipase; sterol esterase | - website www.sigmaaldrich.com / C9281 Cholesterol Esterase from |