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Extract from the Register of European Patents

EP About this file: EP1263790

EP1263790 - MONOCLONAL ANTIBODIES TO THE HUMAN LDL RECEPTOR, THEIR PRODUCTION AND USE [Right-click to bookmark this link]
StatusOpposition procedure closed
Status updated on  04.09.2009
Database last updated on 19.10.2024
Most recent event   Tooltip04.09.2009Opposition procedure terminated - date of legal effect publishedpublished on 07.10.2009  [2009/41]
Applicant(s)For all designated states
Laboratoires Serono SA
Centre Industriel
1267 Coinsins, Vaud / CH
[2007/40]
Former [2007/20]For all designated states
Applied Research Systems ARS Holding N.V.
Pietermaai 15
Curaçao / AN
Former [2002/50]For all designated states
Applied Research Systems ARS Holding N.V.
Pietermaai 15
Curacao / AN
Inventor(s)01 / YONAH, Nachum
51 Pines St.
Gedera 70700 / IL
02 / SUISSA, Dany
Moskowitz Street 28
76468 Rehovot / IL
03 / BELZER, Ilana
Harashba Street 10
75483 Rishon Le-Zion / IL
04 / SMOLARSKY, Moshe
9 Gluskin St
Rehovot 76273 / IL
05 / ANTONETTI, Francesco
Via Amadeo Cirvellucci, 35
I-00179 Roma / IT
06 / DREANO, Michel
169, Chemin de Bottereux
F-74160 Collonges-sous-Saleve / FR
 [2003/04]
Former [2002/50]01 / YONAH, Nachum
Remez Street 6
70700 Gedera / IL
02 / SUISSA, Dany
Moskowitz Street 28
76468 Rehovot / IL
03 / BELZER, Ilana
Harashba Street 10
75483 Rishon Le-Zion / IL
04 / SMOLARSKY, Moshe
9 Gluskin St
Rehovot 76273 / IL
05 / ANTONETTI, Francesco
Via Amadeo Cirvellucci, 35
I-00179 Roma / IT
06 / DREANO, Michel
169, Chemin de Bottereux
F-74160 Collonges-sous-Saleve / FR
Representative(s)Helbig, Christian
Merck Serono International S.A.
Intellectual Property
9, chemin des Mines
CH-1202 Genève / CH
[N/P]
Former [2008/45]Helbig, Christian
Merck Serono International S.A. Intellectual Property 9, chemin des Mines
CH-1202 Genève / CH
Former [2002/50]Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
Maximilianstrasse 58
80538 München / DE
Application number, filing date01912086.408.03.2001
[2002/50]
WO2001IL00216
Priority number, dateIL2000013502513.03.2000         Original published format: IL 13502500
IL2000013921723.10.2000         Original published format: IL 13921700
[2002/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0168710
Date:20.09.2001
Language:EN
[2001/38]
Type: A1 Application with search report 
No.:EP1263790
Date:11.12.2002
Language:EN
The application published by WIPO in one of the EPO official languages on 20.09.2001 takes the place of the publication of the European patent application.
[2002/50]
Type: B1 Patent specification 
No.:EP1263790
Date:16.05.2007
Language:EN
[2007/20]
Search report(s)International search report - published on:EP20.09.2001
ClassificationIPC:C07K16/28, G01N33/577, G01N33/68, C12N5/20
[2002/50]
CPC:
C07K16/28 (EP,KR,US); A61P31/00 (EP); A61P31/14 (EP);
A61P31/20 (EP); A61K2039/505 (EP,US); Y10S436/82 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2002/50]
Extension statesAL11.09.2002
LT11.09.2002
LV11.09.2002
MK11.09.2002
RO11.09.2002
SI11.09.2002
TitleGerman:MONOKLONALE ANTIKÖRPER GEGEN DEN MENSCHLICHEN LDL-REZEPTOR, DEREN HERSTELLUNG UND VERWENDUNG[2002/50]
English:MONOCLONAL ANTIBODIES TO THE HUMAN LDL RECEPTOR, THEIR PRODUCTION AND USE[2002/50]
French:ANTICORPS MONOCLONAUX ANTI-RECEPTEUR DE LDL HUMAIN, LEUR PREPARATION ET UTILISATION[2002/50]
Entry into regional phase11.09.2002National basic fee paid 
11.09.2002Designation fee(s) paid 
11.09.2002Examination fee paid 
Examination procedure07.10.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.09.2002Examination requested  [2002/50]
09.03.2004Despatch of a communication from the examining division (Time limit: M06)
20.09.2004Reply to a communication from the examining division
23.02.2005Despatch of a communication from the examining division (Time limit: M04)
28.06.2005Reply to a communication from the examining division
09.12.2005Despatch of a communication from the examining division (Time limit: M02)
20.02.2006Reply to a communication from the examining division
05.04.2006Despatch of a communication from the examining division (Time limit: M02)
12.06.2006Reply to a communication from the examining division
16.10.2006Communication of intention to grant the patent
19.02.2007Fee for grant paid
19.02.2007Fee for publishing/printing paid
Opposition(s)Opponent(s)01  14.02.2008  01.04.2009  WITHDRAWN
Laboratoire Français du Fractionnement et des Biotechnologies
3, Avenue des Tropiques
ZA de Courtaboeuf
91940 Les Ulis / FR
Opponent's representative
Guérin, Jean-Philippe
Opilex
32, rue Victor Lagrange
69007 Lyon / FR
 [N/P]
Former [2009/19]
Opponent(s)01  14.02.2008  01.04.2008  WITHDRAWN
Laboratoire Français du Fractionnement et des Biotechnologies
3, Avenue des Tropiques ZA de Courtaboeuf
91940 Les Ulis / FR
Opponent's representative
Guérin, Jean-Philippe
Opilex 324, rue Garibaldi
F-69007 Lyon / FR
Former [2008/13]
Opponent(s)01  14.02.2008   
Laboratoire Français du Fractionnement et des Biotechnologies
3, Avenue des Tropiques ZA de Courtaboeuf
91940 Les Ulis / FR
Opponent's representative
Guérin, Jean-Philippe
Opilex 324, rue Garibaldi
F-69007 Lyon / FR
07.05.2008Invitation to proprietor to file observations on the notice of opposition
10.11.2008Reply of patent proprietor to notice(s) of opposition
18.05.2009Despatch of communication that the opposition procedure will be closed
28.05.2009Legal effect of closure of opposition procedure [2009/41]
Fees paidRenewal fee
28.03.2003Renewal fee patent year 03
15.03.2004Renewal fee patent year 04
14.03.2005Renewal fee patent year 05
09.03.2006Renewal fee patent year 06
14.03.2007Renewal fee patent year 07
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Cited inInternational search[PX]JP2000279174  ;
 [A]US5945308  (TANG Y TOM [US], et al) [A] 1-25 * column 20, line 40 - column 21, line 23 * * column 36, line 33 - column 37, line 8 *;
 [X]  - C. XIE ET AL., "Preparation and properties of monoclonal antibodies against low density lipoprotein (LDL) receptors.", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, Shanghai, Peoples Republic of China, (1991), vol. 23, no. 3, pages 189 - 195, XP001015474 [X] 1,2,9,10,12,23 * English abstract *
 [X]  - I. VAN DRIEL ET AL., "Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, Baltimore, MD, USA, (19890605), vol. 264, no. 16, pages 9533 - 9538, XP002174321 [X] 1,2,9,10,12,23-25 * the whole document *
 [X]  - M. CARUSO ET AL., "Demonstration of low density lipoprotein receptor in human colonic carcinoma and surrounding mucosa by immunoenzymatic assay.", ITALIAN JOURNAL OF GASTROENTEROLOGY, Padova, Italy, (199308), vol. 25, no. 7, pages 361 - 367, XP001015472 [X] 1,2,8-10,12 * page 362, column R, line 10 - line 22 *
 [X]  - T. NISHIKAWA ET AL., "Beta-migrating very low density lipoproteins induce foam cell formation in mouse mesangial cells.", ATHEROSCLEROSIS, Amsterdam, The Netherlands, (19950407), vol. 114, no. 1, pages 123 - 132, XP001015467 [X] 1,2,9,12 * page 125, column L, line 47 - column R, line 4 * * figures 3,5 *

DOI:   http://dx.doi.org/10.1016/0021-9150(94)05476-Y
 [DA]  - V. AGNELLO ET AL., "Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., Washington, DC, USA, (19991026), vol. 96, no. 22, pages 12766 - 12771, XP002174322 [DA] 1-25 * abstract * * page 12766, column R, line 1 - line 3 *

DOI:   http://dx.doi.org/10.1073/pnas.96.22.12766
 [PX]  - DATABASE WPI, 1, Derwent World Patents Index, vol. 01, no. 02, Database accession no. 2001-011101, XP002174323 & JP2000279174 A 20001010 (BML KK) [PX] 1,2,9,10,12,23-25 * abstract *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.