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Extract from the Register of European Patents

EP About this file: EP1309727

EP1309727 - Method for functional mapping of the gene network of Alzheimer's disease [Right-click to bookmark this link]
Former [2003/20]METHOD FOR FUNCTIONAL MAPPING OF AN ALZHEIMER'S DISEASE GENE NETWORK AND FOR IDENTIFYING THERAPEUTIC AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
[2009/32]
StatusNo opposition filed within time limit
Status updated on  12.11.2010
Database last updated on 15.06.2024
Most recent event   Tooltip19.10.2012Lapse of the patent in a contracting state
New state(s): TR		published on 21.11.2012  [2012/47]
Applicant(s)For all designated states
Neurosciences Research Foundation Inc.
10640 John Jay Hopkins Drive
San Diego, CA 92121 / US
[2003/20]
Inventor(s)01 / GREENSPAN, Ralph, J.
1020 Glorietta Boulevard
Coronado, CA 92118 / US
02 / EDELMAN, Gerald, M.
7428 High Avenue
La Jolla, CA 92037 / US
 [2003/20]
Representative(s)Uexküll & Stolberg
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstrasse 4
22607 Hamburg / DE
[N/P]
Former [2003/20]UEXKÜLL & STOLBERG
Patentanwälte Beselerstrasse 4
22607 Hamburg / DE
Application number, filing date01942677.423.01.2001
[2003/20]
WO2001US02332
Priority number, dateUS2000049024324.01.2000         Original published format: US 490243
[2003/20]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO0153538
Date:26.07.2001
Language:EN
[2001/30]
Type: A2 Application without search report 
No.:EP1309727
Date:14.05.2003
Language:EN
The application published by WIPO in one of the EPO official languages on 26.07.2001 takes the place of the publication of the European patent application.
[2003/20]
Type: B1 Patent specification 
No.:EP1309727
Date:06.01.2010
Language:EN
[2010/01]
Search report(s)International search report - published on:EP20.02.2003
ClassificationIPC:C12Q1/68, A01K67/033
[2009/32]
CPC:
A01K67/0339 (EP,US); C07K14/4711 (EP,US); C12Q1/68 (EP,US);
C12Q1/6827 (EP,US); A01K2217/075 (EP,US); A01K2227/706 (EP,US);
A01K2267/0312 (EP,US) (-)
Former IPC [2003/20]C12Q1/68, C07K14/435, C12N15/10, C07K14/47, G01N33/50
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2003/20]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:Verfahren zur funktionellen Kartierung des Gesamtnetzwerkes der Alzheimerischen Krankheit[2009/32]
English:Method for functional mapping of the gene network of Alzheimer's disease[2009/32]
French:Méthode permettant de cartographier un réseau de gènes de la maladie d'Alzheimer[2009/32]
Former [2003/20]METHODE ZUR FUNKTIONELLEN KARTIERUNG DES GENNETZWERKES DER ALZHEIMERSCHEN KRANKHMETHODE ZUR FUNKTIONELLEN KARTIERUNG DES GENNETZWERKES DER ALZHEIMERSCHEN KRANKHEIT UND ZUR IDENTIFIZIERUNG VON WIRKSTOFFEN ZUR BEHANDLUNG DER ALZHEIMERSCHEN KRANKHEIT
Former [2003/20]METHOD FOR FUNCTIONAL MAPPING OF AN ALZHEIMER'S DISEASE GENE NETWORK AND FOR IDENTIFYING THERAPEUTIC AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Former [2003/20]METHODE PERMETTANT DE CARTOGRAPHIER UN RESEAU DE GENES DE LA MALADIE D'ALZHEIMER ET D'IDENTIFIER DES AGENTS DESTINES AU TRAITEMENT DE LA MALADIE D'ALZHEIMER
Entry into regional phase16.08.2002National basic fee paid 
16.08.2002Designation fee(s) paid 
16.08.2002Examination fee paid 
Examination procedure17.08.2001Request for preliminary examination filed
International Preliminary Examining Authority: EP
16.08.2002Examination requested  [2003/20]
28.06.2006Despatch of a communication from the examining division (Time limit: M06)
12.02.2007Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
12.03.2007Reply to a communication from the examining division
28.12.2007Despatch of a communication from the examining division (Time limit: M06)
01.07.2008Reply to a communication from the examining division
25.06.2009Cancellation of oral proceeding that was planned for 10.07.2009
25.06.2009Minutes of oral proceedings despatched
10.07.2009Date of oral proceedings
10.07.2009Date of oral proceedings (cancelled)
24.07.2009Communication of intention to grant the patent
24.11.2009Fee for grant paid
24.11.2009Fee for publishing/printing paid
Opposition(s)07.10.2010No opposition filed within time limit [2010/50]
Request for further processing for:12.03.2007Request for further processing filed
12.03.2007Full payment received (date of receipt of payment)
Request granted
26.03.2007Decision despatched
Fees paidRenewal fee
28.01.2003Renewal fee patent year 03
28.01.2004Renewal fee patent year 04
26.01.2005Renewal fee patent year 05
26.01.2006Renewal fee patent year 06
24.01.2007Renewal fee patent year 07
25.01.2008Renewal fee patent year 08
30.01.2009Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT06.01.2010
BE06.01.2010
CY06.01.2010
DK06.01.2010
FI06.01.2010
IT06.01.2010
NL06.01.2010
SE06.01.2010
TR06.01.2010
IE23.01.2010
LU23.01.2010
MC31.01.2010
FR08.03.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
[2012/47]
Former [2012/43]AT06.01.2010
BE06.01.2010
CY06.01.2010
DK06.01.2010
FI06.01.2010
IT06.01.2010
NL06.01.2010
SE06.01.2010
IE23.01.2010
LU23.01.2010
MC31.01.2010
FR08.03.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2011/31]AT06.01.2010
BE06.01.2010
CY06.01.2010
DK06.01.2010
FI06.01.2010
IT06.01.2010
NL06.01.2010
SE06.01.2010
IE23.01.2010
MC31.01.2010
FR08.03.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2011/14]AT06.01.2010
BE06.01.2010
CY06.01.2010
DK06.01.2010
FI06.01.2010
IT06.01.2010
NL06.01.2010
SE06.01.2010
IE23.01.2010
MC31.01.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2011/07]AT06.01.2010
BE06.01.2010
CY06.01.2010
DK06.01.2010
FI06.01.2010
NL06.01.2010
SE06.01.2010
IE23.01.2010
MC31.01.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2010/49]AT06.01.2010
BE06.01.2010
CY06.01.2010
FI06.01.2010
NL06.01.2010
SE06.01.2010
MC31.01.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2010/47]AT06.01.2010
BE06.01.2010
CY06.01.2010
FI06.01.2010
NL06.01.2010
MC31.01.2010
GR07.04.2010
ES17.04.2010
PT06.05.2010
Former [2010/38]AT06.01.2010
FI06.01.2010
NL06.01.2010
MC31.01.2010
ES17.04.2010
PT06.05.2010
Former [2010/37]AT06.01.2010
NL06.01.2010
MC31.01.2010
ES17.04.2010
PT06.05.2010
Former [2010/35]AT06.01.2010
NL06.01.2010
ES17.04.2010
PT06.05.2010
Former [2010/32]AT06.01.2010
ES17.04.2010
Former [2010/30]AT06.01.2010
Cited inInternational search[X]WO9817782  (UNIV SOUTH FLORIDA [US], et al) [X] 1-5 * pages 9-10; claims 21-28 *;
 [A]WO9955906  (TORONTO HOSPITAL [CA], et al) [A] 1-29 * the whole document *;
 [X]  - PRICE D L ET AL, "GENETIC NEURODEGENERATIVE DISEASES: THE HUMAN ILLNESS AND TRANSGENIC MODELS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (199811), vol. 282, ISSN 0036-8075, pages 1079 - 1083, XP002929296 [X] 1-29 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.282.5391.1079
 [X]  - HOLCOMB L A ET AL, "BEHAVIORAL CHANGES IN TRANSGENIC MICE EXPRESSING BOTH AMYLOID PRECURSOR PROTEIN AND PRESENILIN-1 MUTATIONS: LACK OF ASSOCIATION WITH AMYLOID DEPOSITS", BEHAVIOR GENETICS, NEW YORK, NY, US, (199905), vol. 29, no. 3, ISSN 0001-8244, pages 177 - 185, XP000978983 [X] 1-21 * the whole document *

DOI:   http://dx.doi.org/10.1023/A:1021691918517
 [X]  - GUO YIQUAN ET AL, "Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.", JOURNAL OF NEUROSCIENCE, (19991001), vol. 19, no. 19, ISSN 0270-6474, pages 8435 - 8442, XP002196478 [X] 1-3,5,7-21 * page 8438, column R - page 8439, column L * * page 8441, column L *
 [X]  - "olfactory receptor (clone HbA1)", EMBL, (19950729), Database accession no. S76957, XP002208318 [X] 30-32 * abstract *
 [A]  - BRYANT ZEV ET AL, "Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, May 11, 1999, (19990511), vol. 96, no. 10, ISSN 0027-8424, pages 5559 - 5564, XP002214578 [A] 30-32 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.96.10.5559
ExaminationWO0055620
    - HO L. ET AL, "ALTERED EXPRESSION OF A-TYPE BUT NOT B-TYPE SYNAPSIN ISOFORM IN THE BRAIN OF PATIENTS AT HIGH RISK FOR ALZHEIMER'S DISEASE ASSESSED BY DNA MICROARRAY TECHNIQUE", NEUROSCIENCE LETTERS, LIMERICK, IE, (20010209), vol. 298, no. 3, pages 191 - 194, XP009056555

DOI:   http://dx.doi.org/10.1016/S0304-3940(00)01753-5
    - LORING J.F. ET AL, "Molecular Pathology: Gene expression microarrays used to analyze Alzheimer's disease brain", INTERNATIONAL GENOME SEQUENCING AND ANALYSIS CONFERENCE, (200009), vol. 12, page 26-27, XP002215872
    - GINSBERS S.D. ET AL, "Expression profile of individual Alzheimer's disease neurofibrillary tangle-bearing CA1 neurons using gene microarrays", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (1999), vol. 25, no. 1-2, page 833, XP001115020
    - JEE SEUNG W. ET AL, "Analysis of differentially expressed genes in early- and late-stage APPsw-transgenic and normal mice using cDNA microarray", INTERNATIONAL JOURNAL OF MOLECULAR MEDECINE, GREECE, (200703), vol. 19, no. 3, pages 461 - 468, XP009110797
    - SEUNG W. JEE ET AL, "Oligonucleotide-based Analysis of Differentially Expressed Genes in Hippocampus of Transgenci Mice Expressing NSE-controlled APPsw", NEUROCHEM. RES., (20060808), vol. 31, doi:doi:10.1007/s11064-006-9117-8, pages 1035 - 1044, XP019404674

DOI:   http://dx.doi.org/10.1007/s11064-006-9117-8
    - FRANK S. ET AL, "TREM2 is Upregulated in Amyloid Plaque-Associated Microglia in Aged APP23 Transgenic Mice", GLIA, (2008), vol. 56, doi:doi:10.1002/glia.20710, pages 1438 - 1447, XP055101917

DOI:   http://dx.doi.org/10.1002/glia.20710
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.