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EP About this file: EP1307588

EP1307588 - Method for diagnosing or determining a risk for psychosis comprising determining an heterozygous mutation of methylenetetrahydrofolate reductase (MTHFR) [Right-click to bookmark this link]
Former [2003/19]	cDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF
	[2008/18]
Status	No opposition filed within time limit Status updated on 27.11.2009 Database last updated on 18.10.2024
Most recent event Tooltip	27.11.2009	No opposition filed within time limit	published on 30.12.2009 [2009/53]
Applicant(s)	For all designated states McGill University 3550 University Street Montreal Quebec H3A 2A7 / CA
	[2009/04]
Former [2003/19]	For all designated states McGill University 3550 University Street Montreal, Quebec H3A 2A7 / CA
Inventor(s)	01 / ROZEN, Rima 9 Fairfield Crescent Montreal West, Quebec H4X 1R5 / CA
	[2003/19]
Representative(s)	Bösl, Raphael Konrad Patentanwälte Isenbruck Bösl Hörschler PartG mbB Eastsite One Seckenheimer Landstraße 4 68163 Mannheim / DE
	[N/P]
Former [2008/38]	Bösl, Raphael Konrad Patentanwälte Isenbruck Bösl Hörschler Wichmann Huhn Prinzregentenstrasse 68 81675 München / DE
Former [2003/19]	Bösl, Raphael, Dr. rer. nat., Dipl.-Chem. Patentanwälte Isenbruck Bösl Hörschler Wichmann Huhn Postfach 860 880 81635 München / DE
Application number, filing date	01944818.2	12.06.2001
	[2003/19]
	WO2001CA00867
Priority number, date	US20000592595	12.06.2000 Original published format: US 592595
	[2003/19]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO0196598
	Date:	20.12.2001
	Language:	EN
	[2001/51]
	Type:	A2 Application without search report
	No.:	EP1307588
	Date:	07.05.2003
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 20.12.2001 takes the place of the publication of the European patent application.
	[2003/19]
	Type:	B1 Patent specification
	No.:	EP1307588
	Date:	21.01.2009
	Language:	EN
	[2009/04]
Search report(s)	International search report - published on:	EP	13.03.2003
Classification	IPC:	C12Q1/68, A61K31/00, A61P25/18	[2003/19]
	CPC:	C12N9/0028 (EP,US); A61P25/00 (EP); A61P25/04 (EP); A61P25/06 (EP); A61P25/08 (EP); A61P25/14 (EP); (+) A61P25/16 (EP); A61P25/18 (EP); A61P25/22 (EP); A61P25/24 (EP); A61P25/28 (EP); A61P7/04 (EP); A61P9/10 (EP); C12N9/0026 (EP,US); C12Q1/6883 (EP,US); C12Y105/0102 (EP,US); A61K38/00 (EP,US); A61K48/00 (EP,US); C12Q2600/156 (EP,US) (-)
Designated contracting states	DE, GB [2004/21]
Former [2003/19]	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	Methode zur Diagnose von oder zur Bestimmung des Risikos für Psychose beinhaltend die Bestimmung einer heterozygoten Mutation der Methylentetrahydrolfolatreduktase (MTHFR)	[2008/18]
	English:	Method for diagnosing or determining a risk for psychosis comprising determining an heterozygous mutation of methylenetetrahydrofolate reductase (MTHFR)	[2008/18]
	French:	Méthode de diagnostic ou de prédiction d'un risque d'une psychose comprenant la détermination de mutation hétérozygote de la méthylène tetra hydrofolate réductase (MTHFR)	[2008/18]
	Former [2003/19]	CDNA FÜR HUMANE METHYLENTETRAHYDROFOLAT REDUKTASE UND VERWENDUNGEN DERSELBEN
	Former [2003/19]	cDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF
	Former [2003/19]	ADNC DE REDUCTASE DE METHYLENE TETRAHYDROFOLATE HUMAINE ET SES UTILISATIONS
Entry into regional phase	13.01.2003	National basic fee paid
	13.01.2003	Designation fee(s) paid
	13.01.2003	Examination fee paid
Examination procedure	29.12.2001	Request for preliminary examination filed International Preliminary Examining Authority: EP
	13.01.2003	Amendment by applicant (claims and/or description)
	13.01.2003	Examination requested [2003/19]
	01.12.2005	Despatch of a communication from the examining division (Time limit: M04)
	10.04.2006	Reply to a communication from the examining division
	24.05.2006	Despatch of a communication from the examining division (Time limit: M06)
	04.12.2006	Reply to a communication from the examining division
	01.06.2007	Despatch of a communication from the examining division (Time limit: M06)
	11.12.2007	Reply to a communication from the examining division
	14.07.2008	Communication of intention to grant the patent
	27.10.2008	Fee for grant paid
	27.10.2008	Fee for publishing/printing paid
Opposition(s)	22.10.2009	No opposition filed within time limit [2009/53]
Fees paid	Renewal fee
	24.09.2003	Renewal fee patent year 03
	23.06.2004	Renewal fee patent year 04
	21.06.2005	Renewal fee patent year 05
	28.06.2006	Renewal fee patent year 06
	27.06.2007	Renewal fee patent year 07
	27.03.2008	Renewal fee patent year 08
	Penalty fee
	Additional fee for renewal fee
	30.06.2003	03 M06 Fee paid on 24.09.2003
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[A]WO9533054 (UNIV MCGILL [CA], et al) [A] 1-69 * the whole document *;
		[A]WO9961014 (SEPRACOR INC [US]) [A] 52-69 * the whole document *;
		[PX]WO0071754 (UNIV NEW JERSEY MED [US], et al) [PX] 21-52 * page 67; claim 3; table 13 *;
		[X] - JOOBER R ET AL, "Association between the methyltetrahydrofolate reductase 667C.T missense mutation and schizophrenia", CHEMICAL ABSTRACTS, (20010205), vol. 134, no. 6, Database accession no. 69744y, page 514, column 1, XP002221407 [X] 1-69 * abstract *
		[ ] - JOOBER R ET AL, MOL. PSYCHIATRY, (200005), vol. 5, no. 3, pages 323 - 326
		[X] - REGLAND B ET AL, "HOMOZYGOUS THERMOLABILE METHYLENETETRAHYDROFOLATE REDUCTASE IN SCHIZOPHRENIA-LIKE PSYCHOSIS", JOURNAL OF NEURAL TRANSMISSION, SPRINGER VERLAG, VIENNA, AT, (1997), vol. 104, no. 8/9, ISSN 0300-9564, pages 931 - 941, XP001031228 [X] 21-69 * the whole document * DOI: http://dx.doi.org/10.1007/BF01285561
		[X] - KUNUGI H ET AL, "C677T POLYMORPHISM IN METHYLENETETRAHYDROFOLATE REDUCTASE GENE AND PYSCHOSES", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, (1998), vol. 3, no. 5, ISSN 1359-4184, pages 435 - 437, XP001031246 [X] 21-52 * the whole document * DOI: http://dx.doi.org/10.1038/sj.mp.4000390
		[X] - ARINAMI T ET AL, "METHYLENETETRAHYDROFOLATE REDUCTASE VARIANT AND SCHIZOPHRENIA/DEPRESSION", AMERICAN JOURNAL OF MEDICAL GENETICS, NEW YORK,NY, US, (1997), vol. 74, no. 5, pages 526 - 528, XP001031351 [X] 21-69 * the whole document * DOI: http://dx.doi.org/10.1002/(SICI)1096-8628(19970919)74:5<526::AID-AJMG14>3.0.CO;2-E
		[A] - GOYETTE P ET AL, "SEVERE AND MILD MUTATIONS IN CIS FOR THE METHYLENETETRAHYDROFOLATE RUDUCTASE (MTHFR) GENE, AND DESCRIPTION OF FIVE NOVEL MUTATIONS IN MTHFR", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, (19961201), vol. 59, no. 6, ISSN 0002-9297, pages 1268 - 1275, XP000672651 [A] 1-52 * the whole document *
		[A] - GOYETTE P ET AL, "SEVEN NOVEL MUTATIONS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE AND GENOTYPE/PHENOTYPE CORRELATIONS IN SEVERE METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, (19950501), vol. 56, no. 5, ISSN 0002-9297, pages 1052 - 1059, XP000198176 [A] 21-52 * the whole document *
		[A] - PEREIRA P ET AL, "Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, ATHENS, GR, (1999), vol. 6, no. 6, ISSN 1021-335X, pages 597 - 599, XP002121824 [A] 1-20,52-69 * the whole document *
	Examination	WO9634980
		- JOOBER ET AL., "Association between the methylene tetrahydrofolate reductase 677C->T missense mutation and schizophrenia", MOLECULAR PSYCHIATRY, (20000505), vol. 5, pages 323 - 326
		- REGLAND B. ET AL, "Homocysteinemia and schizophrenia as a case of methylation deficiency", J. NEURAL TRANSM., (1994), vol. 98, doi:doi:10.1007/BF01277017, pages 143 - 152, XP001031308 DOI: http://dx.doi.org/10.1007/BF01277017
		- FREEMAN J.M. ET AL, "Folate-responsive homocystinuria and "schizophrenia"", N. ENGL. J. MED., (1975), vol. 292, no. 10, pages 491 - 496, XP008064272
		- SAZCI A ET AL, "Methylenetetrahydrofolate reductase gene polymorphisms in pateints with schizophrenia", MOLECULAR BRAIN RESEARCH, (2003), vol. 117, pages 104 - 107

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

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