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EP About this file: EP1354064

EP1354064 - ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR ALTERING MONOMER INCORPORATION FIDELITY [Right-click to bookmark this link]
Status	The application has been withdrawn Status updated on 13.05.2011 Database last updated on 22.08.2024
Most recent event Tooltip	13.05.2011	Withdrawal of application	published on 15.06.2011 [2011/24]
Applicant(s)	For all designated states Visigen Biotechnologies, Inc. 4435 Jim West Bellaire, TX 77401 / US
	[2003/43]
Inventor(s)	01 / HARDIN, Susan, H. 4435 Jim West Bellaire, TX 77401 / US
	02 / BRIGGS, James, M. 20714 Mustang Falls Court Katy, TX 77450 / US
	03 / XIAOLIAN, Gao 2212B Bellefontaine Blvd. Houston, TX 77030 / US
	04 / WILLSON, Richard 5147 Birdwood Houston, TX 77096 / US
	05 / TU, Shiao-Chun 8203 Fawn Terrace Houston, TX 77071 / US
	[2003/43]
Representative(s)	HGF 1 City Walk Leeds LS11 9DX / GB
	[N/P]
Former [2009/08]	Harrison Goddard Foote Belgrave Hall Belgrave Street Leeds LS2 8DD / GB
Former [2003/43]	W.P. Thompson & Co. Coopers Building, Church Street Liverpool L1 3AB / GB
Application number, filing date	01996079.8	03.12.2001
	[2003/43]
	WO2001US45819
Priority number, date	US20000250764P	01.12.2000 Original published format: US 250764 P
	[2003/43]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO0244425
	Date:	06.06.2002
	Language:	EN
	[2002/23]
	Type:	A2 Application without search report
	No.:	EP1354064
	Date:	22.10.2003
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 06.06.2002 takes the place of the publication of the European patent application.
	[2003/43]
Search report(s)	International search report - published on:	EP	21.08.2003
Classification	IPC:	C12Q1/68	[2003/43]
	CPC:	C07H19/06 (EP,US); C07H19/10 (EP,US); C07H19/20 (EP,US); C12N9/1241 (EP,US); C12N9/1252 (EP,US); C12Q1/6806 (US); (+) C12Q1/6853 (EP,US); C12Q1/6869 (EP,US) (-)
	C-Set:	C12Q1/6853, C12Q2525/101 (EP,US); C12Q1/6853, C12Q2565/301, C12Q2533/101, C12Q2525/113 (US,EP)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2003/43]
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	ENZYMATISCHE NUKLEINSÄURESYNTHESE: ZUSAMMENSETZUNGEN UND VERFAHREN, UM DIE ZUVERLÄSSIGKEIT DES MONOMEREINBAUS ZU ERHÖHEN	[2003/43]
	English:	ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR ALTERING MONOMER INCORPORATION FIDELITY	[2003/43]
	French:	SYNTHESE D'ACIDES NUCLEIQUES D'ENZYMES, ET COMPOSITIONS ET METHODES MODIFIANT LA FIDELITE D'INCORPORATION DE MONOMERES	[2003/43]
Entry into regional phase	10.06.2003	National basic fee paid
	10.06.2003	Designation fee(s) paid
	10.06.2003	Examination fee paid
Examination procedure	10.06.2003	Examination requested [2003/43]
	11.08.2003	Amendment by applicant (claims and/or description)
	12.08.2004	Despatch of a communication from the examining division (Time limit: M06)
	20.12.2004	Reply to a communication from the examining division
	09.10.2006	Despatch of a communication from the examining division (Time limit: M06)
	05.04.2007	Reply to a communication from the examining division
	09.10.2009	Despatch of a communication from the examining division (Time limit: M06)
	27.05.2010	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	23.07.2010	Reply to a communication from the examining division
	09.05.2011	Application withdrawn by applicant [2011/24]
	11.05.2011	Cancellation of oral proceeding that was planned for 01.07.2011
	01.07.2011	Date of oral proceedings (cancelled)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.08.2004
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	23.07.2010	Request for further processing filed
	23.07.2010	Full payment received (date of receipt of payment)
Fees paid	Renewal fee
	12.12.2003	Renewal fee patent year 03
	14.12.2004	Renewal fee patent year 04
	15.12.2005	Renewal fee patent year 05
	13.12.2006	Renewal fee patent year 06
	12.12.2007	Renewal fee patent year 07
	15.12.2008	Renewal fee patent year 08
	28.12.2009	Renewal fee patent year 09
	27.12.2010	Renewal fee patent year 10
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[XA]WO0036151 (WILLIAMS JOHN G K ;LI COR INC (US)) [X] 1,2,4-8,10-12,15,17,18 * abstract * * page 4, line 19 - page 5, line 27 * * page 16, line 21 - page 19, line 22 * * claims 1-30 * [A] 16,19,20;
		[XA]WO0036152 (WILLIAMS JOHN G K ;LI COR INC (US)) [X] 1,2,4-8,10-12,15,17,18 * abstract * * page 2, line 28 - page 4, line 12 * * claims 1-30 * [A] 16,19,20;
		[XA]WO0070073 (CORNELL RES FOUNDATION INC) [X] 1-15,17,18 * abstract * * page 22, line 6 - page 24, line 4 * * figure 4 * * claims 1-33, in particular claims 1, 14, 16, 19 and 22-23. * [A] 16,19,20;
		[A]WO9822615 (LIFE TECHNOLOGIES INC) [A] 16 * page 3, line 2 - page 6, line 4 * * claims 1-51 *;
		[A]WO0067698 (DERRIEN VALERIE ;REISS CLAUDE (FR); CENTRE NAT RECH SCIENT (FR)) [A] 17-20 * abstract * * example 4 * * claims 1-27 *;
		[A]WO9953034 (UNIV NEBRASKA ;CHAPMAN NORA M (US); TRACY STEVEN M (US)) [A] 19,20 * the whole document *;
		[E]WO0204680 (VISIGEN BIOTECHNOLOGIES INC) [E] 1-20 * abstract * * page 19, paragraph 2 - page 20, paragraph 5 * * page 45, paragraph 4 - page 47, paragraph 3 * * claims 1,12,16-18,31,32 *
		[XA] - YARBROUGH L R, "Synthesis and properties of a new fluorescent analog of ATP: adenosine-5'-triphosphoro-gamma-1-(5-sulfonic acid) napthylamidate.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 15 MAR 1978, (19780315), vol. 81, no. 1, ISSN 0006-291X, pages 35 - 41, XP009007956 [X] 1,2,4-8,10-12,15,17,18 * abstract * * page 38 * * page 40, paragraph 2 * [A] 16,19,20 DOI: http://dx.doi.org/10.1016/0006-291X(78)91627-3
		[DXA] - WU F Y-H ET AL, "SYNTHESIS AND PROPERTIES OF ADENOSINE-5'-TRIPHOSPHORO-GAMMA-1-(5-SUL FONIC ACID)NAPHTHYL ETHYLAMIDATE: A FLUORESCENT NUCLEOTIDE SUBSTRATE FOR DNA-DEPENDENT RNA POLYMERASE FROM ESCHERICHIA COLI", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, (19860501), vol. 246, no. 2, ISSN 0003-9861, pages 564 - 571, XP009006405 [DX] 1,2,4-8,10-12,15,17,18 * the whole document * [A] 16,19,20 DOI: http://dx.doi.org/10.1016/0003-9861(86)90311-5
		[A] - WONG I ET AL, "AN INDUCED-FIT KINETIC MECHANISM FOR DNA REPLICATION FIDELITY DIRECT MEASUREMENT BY SINGLE-TURNOVER KINETICS", BIOCHEMISTRY, (1991), vol. 30, no. 2, ISSN 0006-2960, pages 526 - 537, XP002237615 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1021/bi00216a030
		[A] - YARBROUGH L R ET AL, "SYNTHESIS AND PROPERTIES OF FLUORESCENT NUCLEOTIDE SUBSTRATES FOR DNA DEPENDENT RNA POLYMERASES", JOURNAL OF BIOLOGICAL CHEMISTRY, (1979), vol. 254, no. 23, ISSN 0021-9258, pages 12069 - 12073, XP002235050 [A] 1-20 * abstract * * page 569, column R *
		[A] - SCHLAGECK J G ET AL, "SPECTROSCOPIC TECHNIQUES FOR STUDY OF PHOSPHO DI ESTER BOND FORMATION BY ESCHERICHIA-COLI RNA POLYMERASE", JOURNAL OF BIOLOGICAL CHEMISTRY, (1979), vol. 254, no. 23, ISSN 0021-9258, pages 12074 - 12077, XP002235051 [A] 1-20 * abstract *
		[A] - KUNKEL T A, "DNA REPLICATION FIDELITY", JOURNAL OF BIOLOGICAL CHEMISTRY, (1992), vol. 267, no. 26, ISSN 0021-9258, pages 18251 - 18254, XP002235052 [A] 1-20 * page 18251, column L, paragraph L * * figure 1 *
		[A] - RONAGHI M ET AL, "REAL-TIME DNA SEQUENCING USING DETECTION OF PYROSPHOSPHATE RELEASE", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, (19961101), vol. 242, ISSN 0003-2697, pages 84 - 89, XP002055379 [A] 16 * the whole document * DOI: http://dx.doi.org/10.1006/abio.1996.0432
		[A] - ARION D ET AL, "HIV RESISTANCE TO ZIDOVUDINE: THE ROLE OF PYROPHOSPHOROLYSIS", DRUG RESISTANCE UPDATES, CHURCHILL LIVINGSTONE, EDINBURGH, GB, (199904), vol. 2, no. 2, ISSN 1368-7646, pages 91 - 95, XP009008252 [A] 19,20 * the whole document * DOI: http://dx.doi.org/10.1054/drup.1999.0076
		[A] - EIGEN M, "THE FIFTH PAUL EHRLICH LECTURE* VIRUS STRAINS AS MODELS OF MOLECULAR EVOLUTION", MEDICINAL RESEARCH REVIEWS, NEW YORK, NY, US, (199307), vol. 13, no. 4, ISSN 0198-6325, pages 385 - 398, XP000430626 [A] 19,20 * the whole document *
		[A] - DROSOPOULOS W C ET AL, "Virtues of being faithful: can we limit the genetic variation in human immunodeficiency virus?", JOURNAL OF MOLECULAR MEDICINE (BERLIN, GERMANY) GERMANY AUG 1998, (199808), vol. 76, no. 9, ISSN 0946-2716, pages 604 - 612, XP002238588 [A] 19,20 * the whole document * DOI: http://dx.doi.org/10.1007/s001090050257

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