EP1483561 - LIGHT-EMITTING FUSION PROTEINS AND DIAGNOSTIC AND THERAPEUTIC METHODS THEREFOR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 21.11.2008 Database last updated on 31.08.2024 | Most recent event Tooltip | 22.10.2010 | Lapse of the patent in a contracting state New state(s): GR | published on 24.11.2010 [2010/47] | Applicant(s) | For all designated states DANA-FARBER CANCER INSTITUTE, INC. 44 Binney Street Boston, MA 02115 / US | [2004/50] | Inventor(s) | 01 /
KAELIN, William, G. 177 Commonwealth Avenue Boston, MA 02116 / US | 02 /
LIVINGSTON, David, M. 11 Powell Street Brookline, MA 02446 / US | 03 /
KIM, Tae-You 219 West Newton Street, Apt. 1 Boston, MA 02116 / US | [2004/50] | Representative(s) | Crump, Julian Richard John, et al Mintz Levin Cohn Ferris Glovsky & Popeo Intellectual Property LLP Alder Castle 10 Noble Street London EC2V 7JX / GB | [N/P] |
Former [2004/50] | Crump, Julian Richard John, et al Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP The Rectory 9, Ironmonger Lane London EC2V 8EY / GB | Application number, filing date | 02719314.3 | 20.03.2002 | [2004/50] | WO2002US08864 | Priority number, date | US20010277425P | 20.03.2001 Original published format: US 277425 P | US20010277431P | 20.03.2001 Original published format: US 277431 P | US20010277440P | 20.03.2001 Original published format: US 277440 P | US20010332493P | 09.11.2001 Original published format: US 332493 P | US20010332334P | 09.11.2001 Original published format: US 332334 P | US20010345200P | 09.11.2001 Original published format: US 345200 P | US20010345131P | 20.12.2001 Original published format: US 345131 P | US20010342598P | 20.12.2001 Original published format: US 342598 P | US20010345132P | 20.12.2001 Original published format: US 345132 P | US20020101662 | 19.03.2002 Original published format: US 101662 | [2004/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO02075278 | Date: | 26.09.2002 | Language: | EN | [2002/39] | Type: | A2 Application without search report | No.: | EP1483561 | Date: | 08.12.2004 | Language: | EN | The application published by WIPO in one of the EPO official languages on 26.09.2002 takes the place of the publication of the European patent application. | [2004/50] | Type: | B1 Patent specification | No.: | EP1483561 | Date: | 16.01.2008 | Language: | EN | [2008/03] | Search report(s) | International search report - published on: | US | 07.10.2004 | (Supplementary) European search report - dispatched on: | EP | 24.08.2005 | Classification | IPC: | A61K49/00, A61B8/00, G01N33/50, G01N33/542 | [2007/33] | CPC: |
C12Q1/26 (EP,US);
A61K49/0045 (EP,US);
A61K49/0047 (EP,US);
G01N33/573 (EP,US);
G01N2333/90245 (EP,US);
G01N2500/02 (EP,US)
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Former IPC [2005/25] | A61K38/00, A61K49/00, A61B8/00, G01N33/50, G01N33/542, C12Q1/26 | ||
Former IPC [2004/51] | A61K38/00, A61K49/00, A61B8/00 | ||
Former IPC [2004/50] | G01N1/00 | Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2004/50] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | LICHT EMITTIERENDE FUSIONSPROTEINE SOWIE DIAGNOSE- UND THERAPIEVERFAHREN DAFÜR | [2004/50] | English: | LIGHT-EMITTING FUSION PROTEINS AND DIAGNOSTIC AND THERAPEUTIC METHODS THEREFOR | [2004/50] | French: | PROTEINES DE FUSION A EMISSION LUMINEUSE ET METHODES DIAGNOSTIQUES ET THERAPEUTIQUES ASSOCIEES | [2004/50] | Entry into regional phase | 29.09.2003 | National basic fee paid | 29.09.2003 | Search fee paid | 29.09.2003 | Designation fee(s) paid | 29.09.2003 | Examination fee paid | Examination procedure | 17.10.2002 | Request for preliminary examination filed International Preliminary Examining Authority: US | 29.09.2003 | Examination requested [2004/50] | 22.02.2006 | Despatch of a communication from the examining division (Time limit: M06) | 01.09.2006 | Reply to a communication from the examining division | 13.09.2006 | Despatch of a communication from the examining division (Time limit: M06) | 23.03.2007 | Reply to a communication from the examining division | 19.04.2007 | Despatch of a communication from the examining division (Time limit: M02) | 28.06.2007 | Reply to a communication from the examining division | 24.07.2007 | Communication of intention to grant the patent | 30.11.2007 | Fee for grant paid | 30.11.2007 | Fee for publishing/printing paid | Opposition(s) | 17.10.2008 | No opposition filed within time limit [2008/52] | Fees paid | Renewal fee | 22.03.2004 | Renewal fee patent year 03 | 22.03.2005 | Renewal fee patent year 04 | 29.03.2006 | Renewal fee patent year 05 | 28.03.2007 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 16.01.2008 | BE | 16.01.2008 | CY | 16.01.2008 | DK | 16.01.2008 | FI | 16.01.2008 | IT | 16.01.2008 | NL | 16.01.2008 | TR | 16.01.2008 | IE | 20.03.2008 | LU | 20.03.2008 | MC | 31.03.2008 | SE | 16.04.2008 | GR | 17.04.2008 | ES | 27.04.2008 | PT | 16.06.2008 | [2010/47] |
Former [2010/37] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
CY | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
IT | 16.01.2008 | ||
NL | 16.01.2008 | ||
TR | 16.01.2008 | ||
IE | 20.03.2008 | ||
LU | 20.03.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2010/32] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
CY | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
IT | 16.01.2008 | ||
NL | 16.01.2008 | ||
IE | 20.03.2008 | ||
LU | 20.03.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2009/39] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
CY | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
IT | 16.01.2008 | ||
NL | 16.01.2008 | ||
IE | 20.03.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2009/33] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
CY | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
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IE | 20.03.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2009/08] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
NL | 16.01.2008 | ||
IE | 20.03.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2008/46] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
DK | 16.01.2008 | ||
FI | 16.01.2008 | ||
NL | 16.01.2008 | ||
MC | 31.03.2008 | ||
SE | 16.04.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2008/43] | AT | 16.01.2008 | |
BE | 16.01.2008 | ||
FI | 16.01.2008 | ||
NL | 16.01.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2008/42] | AT | 16.01.2008 | |
FI | 16.01.2008 | ||
NL | 16.01.2008 | ||
ES | 27.04.2008 | ||
PT | 16.06.2008 | ||
Former [2008/39] | AT | 16.01.2008 | |
FI | 16.01.2008 | ||
NL | 16.01.2008 | ||
ES | 27.04.2008 | ||
Former [2008/35] | NL | 16.01.2008 | |
ES | 27.04.2008 | ||
Former [2008/27] | NL | 16.01.2008 | Documents cited: | Search | [A]US5925558 (TSIEN ROGER Y [US], et al) [A] 1-11,14-17,19-29,36-41,43-46 * the whole document *; | [X]WO0069908 (ISIS INNOVATION [GB], et al) [X] 36-41,43-46 * the whole document * * claims 7,11 *; | [A]WO0071565 (UNIV CALIFORNIA [US]) [A] 1-11,14-17,19-29,36-41,43-46 * the whole document * * claim 5 *; | [T]WO02059262 (UNIV MICHIGAN [US], et al) [T] 1-11,14-17,19-29,36-41,43-46 * the whole document ** claims 52,53,77-91 *; | [A] - DEO S K ET AL, "Bioluminescence Detection of Proteolytic Bond Cleavage by Using Recombinant Aequorin", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, (2000), vol. 281, no. 1, ISSN 0003-2697, pages 87 - 94, XP002903303 [A] 1-11,14-17,19-29,36-41,43-46 * the whole document * DOI: http://dx.doi.org/10.1006/abio.2000.4539 | [X] - TANIMOTO KEIJI ET AL, "Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20000815), vol. 19, no. 16, ISSN 0261-4189, pages 4298 - 4309, XP002207794 [X] 36-41,43-46 * the whole document * * figure 5B * DOI: http://dx.doi.org/10.1093/emboj/19.16.4298 | [PX] - JAAKOLA ET AL, "Targeting of HIF-alpha to the Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (20010420), vol. 292, no. 5516, ISSN 0036-8075, pages 468 - 472, XP002211146 [PX] 36-41,43-46 * the whole document * * figure 4 * DOI: http://dx.doi.org/10.1126/science.1059796 | [A] - MISTELI ET AL, "Applications of the green fluorescent protein in cell biology and biotechnology", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (1997), no. 15, ISSN 1087-0156, pages 961 - 964, XP002075695 [A] 1-11,14-17,19-29,36-41,43-46 * the whole document * DOI: http://dx.doi.org/10.1038/nbt1097-961 | International search | [A]US6436654 (BERKENSTAM ANDERS [SE], et al); | [X] - DAY R., "Visualization of Pit-1 transcription factor interaction in the living cell nucleus by fluorescence resonance energy transfer microscopy", MOLECULAR ENDOCRINOLOGY, (199809), vol. 12, no. 9, pages 1410 - 1419, XP002940052 DOI: http://dx.doi.org/10.1210/me.12.9.1410 | [X] - FUKUMURA D. ET AL, "Hypoxia and Acidosis Independently Up-Regulate Vascular Endothelial Growth Factor Transcription in Brain Tumors in Vivo", CANCER RESEARCH, (200108), vol. 61, no. 16, pages 6020 - 6024, XP002977762 | [A] - PACHECO T.R. ET AL, "Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line", GENE, (200001), vol. 242, no. 1-2, pages 249 - 256, XP004186907 DOI: http://dx.doi.org/10.1016/S0378-1119(99)00514-4 | [A] - D'ANGELO G. ET AL, "Cyclosporin A Prevents the Hypoxic Adaptation by Activating Hypoxia-inducible Factor-1 Pro-564 Hydroxylation", J. BIOL. CHEM., (200304), vol. 278, no. 17, pages 15406 - 15411, XP002977763 DOI: http://dx.doi.org/10.1074/jbc.M211293200 |