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Extract from the Register of European Patents

EP About this file: EP1483561

EP1483561 - LIGHT-EMITTING FUSION PROTEINS AND DIAGNOSTIC AND THERAPEUTIC METHODS THEREFOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.11.2008
Database last updated on 31.08.2024
Most recent event   Tooltip22.10.2010Lapse of the patent in a contracting state
New state(s): GR		published on 24.11.2010  [2010/47]
Applicant(s)For all designated states
DANA-FARBER CANCER INSTITUTE, INC.
44 Binney Street
Boston, MA 02115 / US
[2004/50]
Inventor(s)01 / KAELIN, William, G.
177 Commonwealth Avenue
Boston, MA 02116 / US
02 / LIVINGSTON, David, M.
11 Powell Street
Brookline, MA 02446 / US
03 / KIM, Tae-You
219 West Newton Street, Apt. 1
Boston, MA 02116 / US
 [2004/50]
Representative(s)Crump, Julian Richard John, et al
Mintz Levin Cohn Ferris Glovsky & Popeo
Intellectual Property LLP
Alder Castle
10 Noble Street
London EC2V 7JX / GB
[N/P]
Former [2004/50]Crump, Julian Richard John, et al
Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP The Rectory 9, Ironmonger Lane
London EC2V 8EY / GB
Application number, filing date02719314.320.03.2002
[2004/50]
WO2002US08864
Priority number, dateUS20010277425P20.03.2001         Original published format: US 277425 P
US20010277431P20.03.2001         Original published format: US 277431 P
US20010277440P20.03.2001         Original published format: US 277440 P
US20010332493P09.11.2001         Original published format: US 332493 P
US20010332334P09.11.2001         Original published format: US 332334 P
US20010345200P09.11.2001         Original published format: US 345200 P
US20010345131P20.12.2001         Original published format: US 345131 P
US20010342598P20.12.2001         Original published format: US 342598 P
US20010345132P20.12.2001         Original published format: US 345132 P
US2002010166219.03.2002         Original published format: US 101662
[2004/50]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO02075278
Date:26.09.2002
Language:EN
[2002/39]
Type: A2 Application without search report 
No.:EP1483561
Date:08.12.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 26.09.2002 takes the place of the publication of the European patent application.
[2004/50]
Type: B1 Patent specification 
No.:EP1483561
Date:16.01.2008
Language:EN
[2008/03]
Search report(s)International search report - published on:US07.10.2004
(Supplementary) European search report - dispatched on:EP24.08.2005
ClassificationIPC:A61K49/00, A61B8/00, G01N33/50, G01N33/542
[2007/33]
CPC:
C12Q1/26 (EP,US); A61K49/0045 (EP,US); A61K49/0047 (EP,US);
G01N33/573 (EP,US); G01N2333/90245 (EP,US); G01N2500/02 (EP,US)
Former IPC [2005/25]A61K38/00, A61K49/00, A61B8/00, G01N33/50, G01N33/542, C12Q1/26
Former IPC [2004/51]A61K38/00, A61K49/00, A61B8/00
Former IPC [2004/50]G01N1/00
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2004/50]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:LICHT EMITTIERENDE FUSIONSPROTEINE SOWIE DIAGNOSE- UND THERAPIEVERFAHREN DAFÜR[2004/50]
English:LIGHT-EMITTING FUSION PROTEINS AND DIAGNOSTIC AND THERAPEUTIC METHODS THEREFOR[2004/50]
French:PROTEINES DE FUSION A EMISSION LUMINEUSE ET METHODES DIAGNOSTIQUES ET THERAPEUTIQUES ASSOCIEES[2004/50]
Entry into regional phase29.09.2003National basic fee paid 
29.09.2003Search fee paid 
29.09.2003Designation fee(s) paid 
29.09.2003Examination fee paid 
Examination procedure17.10.2002Request for preliminary examination filed
International Preliminary Examining Authority: US
29.09.2003Examination requested  [2004/50]
22.02.2006Despatch of a communication from the examining division (Time limit: M06)
01.09.2006Reply to a communication from the examining division
13.09.2006Despatch of a communication from the examining division (Time limit: M06)
23.03.2007Reply to a communication from the examining division
19.04.2007Despatch of a communication from the examining division (Time limit: M02)
28.06.2007Reply to a communication from the examining division
24.07.2007Communication of intention to grant the patent
30.11.2007Fee for grant paid
30.11.2007Fee for publishing/printing paid
Opposition(s)17.10.2008No opposition filed within time limit [2008/52]
Fees paidRenewal fee
22.03.2004Renewal fee patent year 03
22.03.2005Renewal fee patent year 04
29.03.2006Renewal fee patent year 05
28.03.2007Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT16.01.2008
BE16.01.2008
CY16.01.2008
DK16.01.2008
FI16.01.2008
IT16.01.2008
NL16.01.2008
TR16.01.2008
IE20.03.2008
LU20.03.2008
MC31.03.2008
SE16.04.2008
GR17.04.2008
ES27.04.2008
PT16.06.2008
[2010/47]
Former [2010/37]AT16.01.2008
BE16.01.2008
CY16.01.2008
DK16.01.2008
FI16.01.2008
IT16.01.2008
NL16.01.2008
TR16.01.2008
IE20.03.2008
LU20.03.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2010/32]AT16.01.2008
BE16.01.2008
CY16.01.2008
DK16.01.2008
FI16.01.2008
IT16.01.2008
NL16.01.2008
IE20.03.2008
LU20.03.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2009/39]AT16.01.2008
BE16.01.2008
CY16.01.2008
DK16.01.2008
FI16.01.2008
IT16.01.2008
NL16.01.2008
IE20.03.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2009/33]AT16.01.2008
BE16.01.2008
CY16.01.2008
DK16.01.2008
FI16.01.2008
NL16.01.2008
IE20.03.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2009/08]AT16.01.2008
BE16.01.2008
DK16.01.2008
FI16.01.2008
NL16.01.2008
IE20.03.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2008/46]AT16.01.2008
BE16.01.2008
DK16.01.2008
FI16.01.2008
NL16.01.2008
MC31.03.2008
SE16.04.2008
ES27.04.2008
PT16.06.2008
Former [2008/43]AT16.01.2008
BE16.01.2008
FI16.01.2008
NL16.01.2008
ES27.04.2008
PT16.06.2008
Former [2008/42]AT16.01.2008
FI16.01.2008
NL16.01.2008
ES27.04.2008
PT16.06.2008
Former [2008/39]AT16.01.2008
FI16.01.2008
NL16.01.2008
ES27.04.2008
Former [2008/35]NL16.01.2008
ES27.04.2008
Former [2008/27]NL16.01.2008
Documents cited:Search[A]US5925558  (TSIEN ROGER Y [US], et al) [A] 1-11,14-17,19-29,36-41,43-46 * the whole document *;
 [X]WO0069908  (ISIS INNOVATION [GB], et al) [X] 36-41,43-46 * the whole document * * claims 7,11 *;
 [A]WO0071565  (UNIV CALIFORNIA [US]) [A] 1-11,14-17,19-29,36-41,43-46 * the whole document * * claim 5 *;
 [T]WO02059262  (UNIV MICHIGAN [US], et al) [T] 1-11,14-17,19-29,36-41,43-46 * the whole document ** claims 52,53,77-91 *;
 [A]  - DEO S K ET AL, "Bioluminescence Detection of Proteolytic Bond Cleavage by Using Recombinant Aequorin", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, (2000), vol. 281, no. 1, ISSN 0003-2697, pages 87 - 94, XP002903303 [A] 1-11,14-17,19-29,36-41,43-46 * the whole document *

DOI:   http://dx.doi.org/10.1006/abio.2000.4539
 [X]  - TANIMOTO KEIJI ET AL, "Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20000815), vol. 19, no. 16, ISSN 0261-4189, pages 4298 - 4309, XP002207794 [X] 36-41,43-46 * the whole document * * figure 5B *

DOI:   http://dx.doi.org/10.1093/emboj/19.16.4298
 [PX]  - JAAKOLA ET AL, "Targeting of HIF-alpha to the Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (20010420), vol. 292, no. 5516, ISSN 0036-8075, pages 468 - 472, XP002211146 [PX] 36-41,43-46 * the whole document * * figure 4 *

DOI:   http://dx.doi.org/10.1126/science.1059796
 [A]  - MISTELI ET AL, "Applications of the green fluorescent protein in cell biology and biotechnology", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (1997), no. 15, ISSN 1087-0156, pages 961 - 964, XP002075695 [A] 1-11,14-17,19-29,36-41,43-46 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt1097-961
International search[A]US6436654  (BERKENSTAM ANDERS [SE], et al);
 [X]  - DAY R., "Visualization of Pit-1 transcription factor interaction in the living cell nucleus by fluorescence resonance energy transfer microscopy", MOLECULAR ENDOCRINOLOGY, (199809), vol. 12, no. 9, pages 1410 - 1419, XP002940052

DOI:   http://dx.doi.org/10.1210/me.12.9.1410
 [X]  - FUKUMURA D. ET AL, "Hypoxia and Acidosis Independently Up-Regulate Vascular Endothelial Growth Factor Transcription in Brain Tumors in Vivo", CANCER RESEARCH, (200108), vol. 61, no. 16, pages 6020 - 6024, XP002977762
 [A]  - PACHECO T.R. ET AL, "Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line", GENE, (200001), vol. 242, no. 1-2, pages 249 - 256, XP004186907

DOI:   http://dx.doi.org/10.1016/S0378-1119(99)00514-4
 [A]  - D'ANGELO G. ET AL, "Cyclosporin A Prevents the Hypoxic Adaptation by Activating Hypoxia-inducible Factor-1 Pro-564 Hydroxylation", J. BIOL. CHEM., (200304), vol. 278, no. 17, pages 15406 - 15411, XP002977763

DOI:   http://dx.doi.org/10.1074/jbc.M211293200
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.