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EP About this file: EP1361890

EP1361890 - INFLUENZA VACCINE FORMULATIONS FOR INTRADERMAL DELIVERY [Right-click to bookmark this link]
Status	Patent revoked Status updated on 15.03.2019 Database last updated on 03.04.2025
Most recent event Tooltip	18.10.2024	Lapse of the patent in a contracting state New state(s): FI, MC	published on 20.11.2024 [2024/47]
Applicant(s)	For all designated states GlaxoSmithKline Biologicals s.a. rue de l'Institut 89 1330 Rixensart / BE
	[2011/13]
Former [2003/47]	For all designated states GlaxoSmithKline Biologicals S.A. Rue de l'Institut 89 1330 Rixensart / BE
Inventor(s)	01 / GARCON, Nathalie GlaxoSmithKline Biologicals SA Rue de l'Institut 89 B-1330 Rixensart / BE
	02 / SLAOUI, Moncef, Mohamed GlaxoSmithKline Biologicals SA Rue de l'Institut 89 B-1330 Rixensart / BE
	03 / VAN HOECKE, Christian GlaxoSmithKline Biologicals SA Rue de l'Institut 89 B-1330 Rixensart / BE
	[2010/45]
Former [2003/47]	01 / GARCON, Nathalie GlaxoSmithKline Biologicals, Rue de l'Institut 89 B-1330 Rixensart / BE
	02 / SLAOUI, Moncef, Mohamed GlaxoSmithKline Biologicals, Rue de l'Institut 89 B-1330 Rixensart / BE
	03 / VAN HOECKE, Christian GlaxoSmithKline Biologicals, Rue de l'Institut 89 B-1330 Rixensart / BE
Representative(s)	Dalton, Marcus Jonathan William, et al GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	[N/P]
Former [2006/33]	Crepin, Carine Marie Blanche, et al Corporate Intellectual Property GlaxoSmithKline CN925.1 980 Great West Road Brentford, Middlesex TW8 9GS / GB
Former [2003/47]	Stephen, Robert John GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
Application number, filing date	02724176.9	21.02.2002
	[2003/47]
	WO2002EP01844
Priority number, date	GB20010004538	23.02.2001 Original published format: GB 0104538
	GB20010007511	26.03.2001 Original published format: GB 0107511
	GB20010008365	03.04.2001 Original published format: GB 0108365
	[2003/47]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO02074336
	Date:	26.09.2002
	Language:	EN
	[2002/39]
	Type:	A2 Application without search report
	No.:	EP1361890
	Date:	19.11.2003
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.09.2002 takes the place of the publication of the European patent application.
	[2003/47]
	Type:	B1 Patent specification
	No.:	EP1361890
	Date:	30.03.2011
	Language:	EN
	[2011/13]
Search report(s)	International search report - published on:	EP	14.08.2003
Classification	IPC:	A61K39/145, C12N7/04	[2003/47]
	CPC:	A61K39/145 (EP,US); A61K39/12 (EP,US); A61P31/16 (EP); A61P37/04 (EP); A61K2039/5252 (EP,US); A61K2039/54 (EP,US); (+) A61K2039/55572 (EP,US); A61K2039/55577 (EP,US); A61K2039/70 (EP,US); C12N2760/16134 (EP,US); C12N2760/16234 (EP,US) (-)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR [2011/13]
Former [2003/47]	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, TR
Extension states	AL	Not yet paid
	LT	Not yet paid
	LV	Not yet paid
	MK	Not yet paid
	RO	Not yet paid
	SI	Not yet paid
Title	German:	INFLUENZA VAKZINZUSAMMENSETZUNGEN ZUR INTRADERMALER VERABREICHUNG	[2003/47]
	English:	INFLUENZA VACCINE FORMULATIONS FOR INTRADERMAL DELIVERY	[2003/47]
	French:	FORMULATIONS DE VACCINS CONTRE LA GRIPPE DISPOSITIF POUR ADMINISTRATION INTRADERMIQUE	[2010/40]
	Former [2003/47]	VACCIN
Entry into regional phase	18.08.2003	National basic fee paid
	18.08.2003	Designation fee(s) paid
	18.08.2003	Examination fee paid
Examination procedure	09.09.2002	Request for preliminary examination filed International Preliminary Examining Authority: EP
	18.08.2003	Examination requested [2003/47]
	03.08.2005	Despatch of a communication from the examining division (Time limit: M06)
	20.01.2006	Reply to a communication from the examining division
	19.03.2008	Despatch of a communication from the examining division (Time limit: M04)
	25.07.2008	Reply to a communication from the examining division
	01.10.2009	Despatch of a communication from the examining division (Time limit: M04)
	01.02.2010	Reply to a communication from the examining division
	12.05.2010	Despatch of a communication from the examining division (Time limit: M02)
	21.06.2010	Reply to a communication from the examining division
	21.09.2010	Communication of intention to grant the patent
	31.01.2011	Fee for grant paid
	31.01.2011	Fee for publishing/printing paid
Divisional application(s)	EP10178402.3 / EP2269639
	EP10178427.0 / EP2281573
Opposition(s)	Opponent(s)	01 01.04.2011 31.01.2012 ADMISSIBLE Bock Wolfgang Stuntzstrasse 33 81677 München / DE Opponent's representative Samson & Partner Patentanwälte mbB Widenmayerstraße 6 80538 München / DE
		02 23.12.2011 24.09.2013 WITHDRAWN Merck Sharp & Dohme Corporation 126 East Lincoln Avenue Rahway, NJ 07065 / US Opponent's representative Böhles, Elena Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB
		03 27.12.2011 31.01.2012 WITHDRAWN SANOFI PASTEUR SA 2 Avenue Pont Pasteur 69007 Lyon / FR Opponent's representative Schaeffer, Nathalie Christiane Sanofi Pasteur Direction Propriété Intellectuelle 2, Avenue Pont Pasteur 69007 Lyon / FR
		[N/P]
	Former [2013/46]
	Opponent(s)	01 01.04.2011 31.01.2012 ADMISSIBLE Bock Wolfgang Stuntzstrasse 33 81677 München / DE Opponent's representative Samson & Partner Widenmayerstrasse 5 80538 München / DE
		02 23.12.2011 24.09.2013 WITHDRAWN Merck Sharp & Dohme Corporation 126 East Lincoln Avenue Rahway, NJ 07065 / US Opponent's representative Böhles, Elena Merck & Co., Inc. Hertford Road Hoddesdon, Hertfordshire EN11 9BU / GB
		03 27.12.2011 31.01.2012 WITHDRAWN SANOFI PASTEUR SA 2 Avenue Pont Pasteur 69007 Lyon / FR Opponent's representative Schaeffer, Nathalie Christiane Sanofi Pasteur Direction Propriété Intellectuelle 2, Avenue Pont Pasteur 69007 Lyon / FR
	Former [2013/37]
	Opponent(s)	01 01.04.2011 31.01.2012 ADMISSIBLE Bock Wolfgang Stuntzstrasse 33 81677 München / DE Opponent's representative Samson & Partner Widenmayerstrasse 5 80538 München / DE
		02 23.12.2011 31.01.2012 ADMISSIBLE Merck Sharp & Dohme Corporation 126 East Lincoln Avenue Rahway, NJ 07065 / US Opponent's representative Böhles, Elena Merck & Co., Inc. Hertford Road Hoddesdon, Hertfordshire EN11 9BU / GB
		03 27.12.2011 31.01.2012 WITHDRAWN SANOFI PASTEUR SA 2 Avenue Pont Pasteur 69007 Lyon / FR Opponent's representative Schaeffer, Nathalie Christiane Sanofi Pasteur Direction Propriété Intellectuelle 2, Avenue Pont Pasteur 69007 Lyon / FR
	Former [2012/05]
	Opponent(s)	01 01.04.2011 Bock Wolfgang Stuntzstrasse 33 81677 München / DE Opponent's representative Samson & Partner Widenmayerstrasse 5 80538 München / DE
		02 23.12.2011 Merck Sharp & Dohme Corporation 126 East Lincoln Avenue Rahway, NJ 07065 / US Opponent's representative Böhles, Elena Merck & Co., Inc. Hertford Road Hoddesdon, Hertfordshire EN11 9BU / GB
		03 27.12.2011 SANOFI PASTEUR SA 2 Avenue Pont Pasteur 69007 Lyon / FR Opponent's representative Schaeffer, Nathalie Christiane Sanofi Pasteur Direction Propriété Intellectuelle 2, Avenue Pont Pasteur 69007 Lyon / FR
	Former [2011/19]
	Opponent(s)	01 01.04.2011 ADMISSIBLE Bock Wolfgang Stuntzstrasse 33 81677 München / DE Opponent's representative Samson & Partner Widenmayerstrasse 5 80538 München / DE
	07.02.2012	Invitation to proprietor to file observations on the notice of opposition
	07.08.2012	Reply of patent proprietor to notice(s) of opposition
	11.11.2014	Date of oral proceedings
	23.12.2014	Despatch of interlocutory decision in opposition
	23.12.2014	Despatch of minutes of oral proceedings
	26.02.2019	Despatch of communication that the patent will be revoked
	08.03.2019	Legal effect of revocation of patent [2019/16]
Appeal following opposition	02.03.2015	Appeal received No. T0458/15
	04.05.2015	Statement of grounds filed
	21.12.2018	Invitation to file observations in an appeal (Time limit: M02) [2018/51]
	07.01.2019	Date of receipt of observations in an appeal [2019/02]
	05.02.2019	Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
Fees paid	Renewal fee
	04.02.2004	Renewal fee patent year 03
	04.02.2005	Renewal fee patent year 04
	06.02.2006	Renewal fee patent year 05
	05.02.2007	Renewal fee patent year 06
	08.02.2008	Renewal fee patent year 07
	09.02.2009	Renewal fee patent year 08
	08.02.2010	Renewal fee patent year 09
	08.02.2011	Renewal fee patent year 10
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	CY	21.02.2019
	IE	21.02.2019
	PT	21.02.2019
	ES	22.02.2019
	DK	28.02.2019
	FI	28.02.2019
	LU	28.02.2019
	MC	28.02.2019
	[2024/47]
Former [2024/41]	CY	21.02.2019
	IE	21.02.2019
	PT	21.02.2019
	ES	22.02.2019
	DK	28.02.2019
	LU	28.02.2019
Former [2024/30]	CY	21.02.2019
	IE	21.02.2019
	ES	22.02.2019
	LU	28.02.2019
Former [2024/28]	CY	21.02.2019
	IE	21.02.2019
	ES	22.02.2019
Former [2024/21]	CY	21.02.2019
	ES	22.02.2019
Former [2019/48]	CY	21.02.2019
Cited in	International search	[Y]US4724146 (KINO YOUICHIRO [JP], et al) [Y] 6 * column 6 *;
		[XY]WO9419013 (SMITHKLINE BEECHAM CORP [US], et al) [X] 1-3,5,7,13 * page 27; examples 25,26,30; claim 5 * [Y] 6,8,10,12,15,16;
		[YD]WO9633739 (SMITHKLINE BEECHAM BIOLOG [BE], et al) [YD] 10 * pages 1-3; claim 6 *;
		[PY]WO0121152 (SMITHKLINE BEECHAM BIOLOG [BE], et al) [PY] 6* example 2 *;
		[XY] - CHEN DEXIANG ET AL, "Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice.", NATURE MEDICINE, (200010), vol. 6, no. 10, ISSN 1078-8956, pages 1187 - 1190, XP002237943 [X] 1,2,4,9,11,14 * page 1188 - page 1189; figure 4 * [Y] 8,15,16 DOI: http://dx.doi.org/10.1038/80538
		[Y] - VASIL'EVA R I ET AL, "STUDY OF THE RESULTS OF USING NEW INACTIVATED WHOLE-VIRION INFLUENZA VACCINES IN THE USSR", ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII, (1987), no. 3, ISSN 0372-9311, pages 38 - 42, XP008005763 [Y] 8,12,15,16 * page 42, column 2, paragraph 3; tables 1,2 *
		[AD] - HALPERIN W ET AL, "A COMPARISON OF THE INTRADERMAL AND SUBCUTANEOUS ROUTES OF INFLUENZA VACCINATION WITH A/NEW JERSEY/76 (SWINE FLU) AND A/VICTORIA/75: REPORT OF A STUDY AND REVIEW OF THE LITERATURE", AMERICAN JOURNAL OF PUBLIC HEALTH, AMERICAN PUBLIC HEALTH ASSOCIATION, WASHINGTON, DC, US, (197912), vol. 12, no. 69, ISSN 0090-0036, pages 1247 - 1256, XP008003236 [AD] 1 * page 1251 *
	Examination	WO02087494
		- LAURENT P. ET AL, "Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system", VACCINE, (2007), vol. 25, doi:doi:10.1016/j.vaccine.2007.10.020, pages 8833 - 8842, XP022374866 DOI: http://dx.doi.org/10.1016/j.vaccine.2007.10.020
	by applicant	GB2122204
		GB2220211
		US4912094
		EP0109942
		WO9113281
		US5057540
		EP0311863
		WO9400153
		EP0516636
		WO9421292
		EP0362279
		WO9517210
		WO9611711
		WO9633739
		WO9843670
		EP0549074
		EP0822831
		EP1092444
		- J.M. WOOD ET AL., "An improved single radial immunodiffusion technique for the assay of influenza haemagglutinin antigen: adaptation for potency determination of inactivated whole virus and subunit vaccines", J. BIOL. STAND., (1977), vol. 5, pages 237 - 247
		- J. M. WOOD ET AL., "International collaborative study of single radial diffusion and immunoelectrophoresis techniques for the assay of haemagglutinin antigen of influenza virus", J. BIOL. STAND., (1981), vol. 9, pages 317 - 330
		- CROWE, AM J MEDICAL TECHNOLOGY, (1965), vol. 31, pages 387 - 396
		- MCELROY, NEW ENG J OF MEDICINE, (19691106), page 1076
		- TAURASO ET AL., BULL WLD HLTH ORG, (1969), vol. 41, pages 507 - 516
		- FOY, JAMA, (1970), vol. 213, page 130
		- THE BRITISH MEDICAL JOURNAL, (19771029), page 1152
		- BROOKS ET AL., ANNALS OF ALLERGY, (1977), vol. 39, pages 110 - 112
		- BROWN ET AL., J INFECTIOUS DISEASE, (1977), vol. 136, pages 466 - 471
		- HALPERIN ET AL., AJPH, (1979), vol. 89, pages 1247 - 1252
		- HERBERT; LARKE, J INFECTIOUS DISEASES, (1979), vol. 140, pages 234 - 238
		- BADER, AJPH, (1980), vol. 70, no. 5
		- NICULESCU ET AL., ARCH ROUM PATH EXP MICROBIOL, (1981), vol. 40, pages 67 - 70
		- WEBSTER R.G., CLIN INFECT DIS, (1999), vol. 28, pages 225 - 229
		- DEGANO ET AL., VACCINE, (1999), vol. 18, pages 623 - 32
		- HAENSLER ET AL., VACCINE, (1999), vol. 17, pages 628 - 638
		- DEGANO ET AL., VACCINE, (1998), vol. 16, pages 394 - 398
		- HILGERS ET AL., INT.ARCH.ALLERGY.IMMUNOL., (1986), vol. 79, no. 4, pages 392 - 6
		- HILGERS ET AL., IMMUNOLOGY, (1987), vol. 60, no. 1, pages 141 - 6
		- LACAILLE-DUBOIS, M; WAGNER H., "A review of the biological and pharmacological activities of saponins", PHYTOMEDICINE, (1996), vol. 2, pages 363 - 386, XP000993545
		- KENSIL, C. R., "Saponins as vaccine adjuvants", CRIT REV THER DRUG CARRIER SYST, (1996), vol. 12, no. 1-2, pages 1 - 55
		- BOMFORD ET AL., VACCINE, (1992), vol. 10, no. 9, pages 572 - 577
		- LINA ET AL., BIOLOGICALS, (2000), vol. 28, pages 95 - 103

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

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