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Extract from the Register of European Patents

EP About this file: EP1421187

EP1421187 - SYSTEMS FOR IN VIVO SITE-DIRECTED MUTAGENESIS USING OLIGONUCLEOTIDES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.08.2008
Database last updated on 08.06.2024
Most recent event   Tooltip13.08.2010Lapse of the patent in a contracting state
New state(s): TR		published on 15.09.2010  [2010/37]
Applicant(s)For all designated states
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325
Rockville, MD 20852 / US
[2007/41]
Former [2004/22]For all designated states
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325
Rockville, MD 20852 / US
Inventor(s)01 / STORICI, Francesca
5639 Chapel Hill Road Apartment 813
Durham, NC 27707 / US
02 / RESNICK, Michael, A.
102 Gurnsey Trail
Chapel Hill, NC 27517 / US
03 / LEWIS, Lysle, Kevin
1001 Leah Drive Apartment 133
San Marcos, TX 78666 / US
 [2004/22]
Representative(s)Walker, Ross Thomson
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
[N/P]
Former [2007/41]Walker, Ross Thomson
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Former [2004/22]Gowshall, Jonathan Vallance
FORRESTER & BOEHMERT Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date02750301.026.07.2002
[2004/22]
WO2002US23634
Priority number, dateUS20010308426P27.07.2001         Original published format: US 308426 P
[2004/22]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO03012036
Date:13.02.2003
Language:EN
[2003/07]
Type: A2 Application without search report 
No.:EP1421187
Date:26.05.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 13.02.2003 takes the place of the publication of the European patent application.
[2004/22]
Type: B1 Patent specification 
No.:EP1421187
Date:10.10.2007
Language:EN
[2007/41]
Search report(s)International search report - published on:US12.02.2004
(Supplementary) European search report - dispatched on:EP28.04.2005
ClassificationIPC:C12N15/10, C12N15/90
[2005/23]
CPC:
C12N15/102 (EP,US); C12N15/65 (EP,US); C12N15/902 (EP,US)
Former IPC [2004/22]C12N15/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   SK,   TR [2004/22]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
SINot yet paid
TitleGerman:SYSTEME ZUR STELLENGERICHTETEN IN-VIVO-MUTAGENESE MIT OLIGONUKLEOTIDEN[2004/22]
English:SYSTEMS FOR IN VIVO SITE-DIRECTED MUTAGENESIS USING OLIGONUCLEOTIDES[2004/22]
French:SYSTEMES UTILISANT DES OLIGONUCLEOTIDES POUR UNE MUTAGENESE DIRIGEE IN VIVO[2004/22]
Entry into regional phase25.02.2004National basic fee paid 
25.02.2004Search fee paid 
25.02.2004Designation fee(s) paid 
25.02.2004Examination fee paid 
Examination procedure07.02.2003Request for preliminary examination filed
International Preliminary Examining Authority: US
25.02.2004Examination requested  [2004/22]
29.04.2004Amendment by applicant (claims and/or description)
20.02.2006Despatch of a communication from the examining division (Time limit: M04)
03.07.2006Reply to a communication from the examining division
28.07.2006Despatch of a communication from the examining division (Time limit: M04)
07.12.2006Reply to a communication from the examining division
14.02.2007Communication of intention to grant the patent
12.06.2007Fee for grant paid
12.06.2007Fee for publishing/printing paid
Opposition(s)11.07.2008No opposition filed within time limit [2008/38]
Fees paidRenewal fee
22.07.2004Renewal fee patent year 03
20.07.2005Renewal fee patent year 04
27.07.2006Renewal fee patent year 05
27.07.2007Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT10.10.2007
BE10.10.2007
CY10.10.2007
CZ10.10.2007
DK10.10.2007
EE10.10.2007
FI10.10.2007
NL10.10.2007
SK10.10.2007
TR10.10.2007
BG10.01.2008
SE10.01.2008
GR11.01.2008
ES21.01.2008
PT10.03.2008
[2010/37]
Former [2009/34]AT10.10.2007
BE10.10.2007
CY10.10.2007
CZ10.10.2007
DK10.10.2007
EE10.10.2007
FI10.10.2007
NL10.10.2007
SK10.10.2007
BG10.01.2008
SE10.01.2008
GR11.01.2008
ES21.01.2008
PT10.03.2008
Former [2009/22]AT10.10.2007
BE10.10.2007
CZ10.10.2007
DK10.10.2007
EE10.10.2007
FI10.10.2007
NL10.10.2007
SK10.10.2007
BG10.01.2008
SE10.01.2008
GR11.01.2008
ES21.01.2008
PT10.03.2008
Former [2009/15]AT10.10.2007
BE10.10.2007
CZ10.10.2007
DK10.10.2007
FI10.10.2007
NL10.10.2007
SK10.10.2007
BG10.01.2008
SE10.01.2008
GR11.01.2008
ES21.01.2008
PT10.03.2008
Former [2009/13]AT10.10.2007
BE10.10.2007
CZ10.10.2007
DK10.10.2007
FI10.10.2007
NL10.10.2007
SK10.10.2007
BG10.01.2008
SE10.01.2008
GR11.01.2008
ES21.01.2008
PT10.03.2008
Former [2008/39]AT10.10.2007
BE10.10.2007
CZ10.10.2007
DK10.10.2007
NL10.10.2007
SK10.10.2007
BG10.01.2008
SE10.01.2008
ES21.01.2008
PT10.03.2008
Former [2008/35]AT10.10.2007
CZ10.10.2007
DK10.10.2007
NL10.10.2007
BG10.01.2008
SE10.01.2008
ES21.01.2008
PT10.03.2008
Former [2008/29]AT10.10.2007
NL10.10.2007
BG10.01.2008
SE10.01.2008
ES21.01.2008
PT10.03.2008
Former [2008/24]NL10.10.2007
BG10.01.2008
SE10.01.2008
ES21.01.2008
PT10.03.2008
Documents cited:Search[A]WO9014092  (CELL GENESYS INC [US]) [A] * the whole document *;
 [A]WO9641008  (UNIV YALE [US], et al) [A] * the whole document *;
 [X]EP0919619  (ROCHE DIAGNOSTICS GMBH [DE]) [X] 60 * claim 14 *;
 [DX]  - M. DUNO ET AL., "Targeted deletions created in yeast vectors by recombinational excision", NUCLEIC ACIDS RESEARCH, OXFORD, UK, (1999), vol. 27, no. 8, pages E1 - E5, XP002324348 [DX] 61 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/27.8.e1
 [X]  - Z-W LI ET AL, "Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site specific recombination in embryonic stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, (199606), vol. 93, ISSN 0027-8424, pages 6158 - 6162, XP002095251 [X] 60 * figure 1 *

DOI:   http://dx.doi.org/10.1073/pnas.93.12.6158
 [A]  - BIET ELODIE ET AL, "Stimulation of RecA-mediated D-loop formation by oligonucleotide-directed triple-helix formation: Guided homologous recombination (GOREC)", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, (20010213), vol. 40, no. 6, ISSN 0006-2960, pages 1779 - 1786, XP002175996 [A] * the whole document *

DOI:   http://dx.doi.org/10.1021/bi001605a
 [DA]  - INGA A ET AL, "Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants.", ONCOGENE. 7 JUN 2001, (20010607), vol. 20, no. 26, ISSN 0950-9232, pages 3409 - 3419, XP002324349 [DA] * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.onc.1204457
International search[Y]US4626504  (PUHLER ALFRED [DE], et al);
 [XP]  - STORICI ET AL., "In vivo site-directed mutagenesis using oligonucleotides", NATURE BIOTECHNOLOGY, (200108), vol. 19, pages 773 - 776, XP002963023

DOI:   http://dx.doi.org/10.1038/90837
 [Y]  - MOERSCHELL ET AL., "Transformation of yeast with synthetic oligonucleotides", PROC. NATL. ACAD. SCI. USA, (199801), vol. 85, pages 524 - 528, XP002933044

DOI:   http://dx.doi.org/10.1073/pnas.85.2.524
 [Y]  - YAMAMOTO ET AL., "Parameters affecting the frequencies of transformation and co-transformation with synthetic oligonucleotides in yeast", YEAST, (199211), vol. 8, pages 935 - 948, XP002963024

DOI:   http://dx.doi.org/10.1002/yea.320081104
ExaminationWO0234881
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.