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EP1448762
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EP About this file: EP1448762
| EP1448762 - ANTISENSE MODULATION OF TOLL-LIKE RECEPTOR 4 EXPRESSION FIELD OF THE INVENTION [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 14.10.2005 Database last updated on 26.06.2024 | Most recent event Tooltip | 14.10.2005 | Application deemed to be withdrawn | published on 30.11.2005 [2005/48] | Applicant(s) | For all designated states Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad, CA 92010 / US | [N/P] |
| Former [2005/26] | For all designated states Isis Pharmaceuticals, Inc. 1896 Rutherford Road Carlsbad, CA 92008 / US | ||
| Former [2004/35] | For all designated states ISIS PHARMACEUTICALS, INC. 2292 Faraday Avenue Carlsbad, CA 92008 / US | Inventor(s) | 01 /
KARRAS, James, G. 1159 Montura Road San Marcos, CA 92069 / US | 02 /
KOLLER, Erich 2622 Lewis Lane Carlsbad, CA 92008 / US | [2004/35] | Representative(s) | Bassil, Nicholas Charles, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [N/P] |
| Former [2004/35] | Bassil, Nicholas Charles, et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ / GB | Application number, filing date | 02797100.1 | 14.11.2002 | [2004/35] | WO2002US36390 | Priority number, date | US20010001863 | 19.11.2001 Original published format: US 1863 | [2004/35] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO03044163 | Date: | 30.05.2003 | Language: | EN | [2003/22] | Type: | A2 Application without search report | No.: | EP1448762 | Date: | 25.08.2004 | Language: | EN | The application published by WIPO in one of the EPO official languages on 30.05.2003 takes the place of the publication of the European patent application. | [2004/35] | Search report(s) | International search report - published on: | US | 15.04.2004 | (Supplementary) European search report - dispatched on: | EP | 04.03.2005 | Classification | IPC: | C12N5/00, C12Q1/68, A61K31/70, C07H21/04 | [2005/15] | CPC: |
C12N15/1138 (EP,US);
A61K38/00 (EP,US);
C12N2310/315 (EP,US);
C12N2310/321 (EP,US);
C12N2310/3341 (EP,US);
C12N2310/341 (EP,US);
| C-Set: |
C12N2310/321, C12N2310/3525 (EP,US)
|
| Former IPC [2004/35] | C12N5/00, C12Q1/68, A61K31/70, A01N43/04, C07H21/04 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, SK, TR [2004/35] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | ANTISENSE-MODULATION DER EXPRESSION DES TOLL-ÄHNLICHEN REZEPTORS 4 ERFINDUNGSGEBIET | [2004/35] | English: | ANTISENSE MODULATION OF TOLL-LIKE RECEPTOR 4 EXPRESSION FIELD OF THE INVENTION | [2004/35] | French: | MODULATION ANTISENS DE L'EXPRESSION D'UN RECEPTEUR 4 DE TYPE TOLL | [2004/35] | Entry into regional phase | 28.05.2004 | National basic fee paid | 28.05.2004 | Search fee paid | 28.05.2004 | Designation fee(s) paid | 28.05.2004 | Examination fee paid | Examination procedure | 12.06.2003 | Request for preliminary examination filed International Preliminary Examining Authority: US | 28.05.2004 | Amendment by applicant (claims and/or description) | 28.05.2004 | Examination requested [2004/35] | 19.05.2005 | Application deemed to be withdrawn, date of legal effect [2005/48] | 30.06.2005 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2005/48] | Fees paid | Renewal fee | 28.05.2004 | Renewal fee patent year 03 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X]WO0172993 (MOCHIDA PHARM CO LTD [JP], et al) [X] 1-20 * SEQ ID NO.8 has 100% identity in a 20nt overlap to SEQ ID NO.11 of the present application *; | [E]WO03035110 (CEDARS SINAI MEDICAL CENTER [US]) [E] 1-20* Sequence 4 has 100% identity in a 16nt overlap to SEQ ID NO.23 of the present application *; | [Y] - SMITH P D ET AL, "Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 SEP 2001, (20010901), vol. 167, no. 5, ISSN 0022-1767, pages 2651 - 2656, XP002316199 [Y] 1-20 * page 2652, column L, paragraph 4 * | [Y] - KOLLER E ET AL, "Elucidating cell signaling mechanisms using antisense technology", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, (200004), vol. 21, no. 4, ISSN 0165-6147, pages 142 - 148, XP004196016 [Y] 1-20 * the whole document * DOI: http://dx.doi.org/10.1016/S0165-6147(00)01448-6 | [Y] - HEDLUND M ET AL, "Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells.", MOLECULAR MICROBIOLOGY. FEB 2001, (200102), vol. 39, no. 3, ISSN 0950-382X, pages 542 - 552, XP002316200 [Y] 1-20 * page 550, column R; table 2 * DOI: http://dx.doi.org/10.1046/j.1365-2958.2001.02205.x | [A] - BAKER B F ET AL, "Discovery and analysis of antisense oligonucleotide activity in cell culture.", METHODS (SAN DIEGO, CALIF.) FEB 2001, (200102), vol. 23, no. 2, ISSN 1046-2023, pages 191 - 198, XP002316201 DOI: http://dx.doi.org/10.1006/meth.2000.1120 | [A] - HAO H ET AL, "Human beta-defensin-2 production by lipopolysaccharide treated-astrocytes depends on toll-like receptor expression", SOCIETY FOR NEUROSCIENCE ABSTRACTS, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, (2001), vol. 27, no. 2, ISSN 0190-5295, page 1757, XP001205207 | [A] - HOSHINO K ET AL, "Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (19990401), vol. 162, no. 7, ISSN 0022-1767, pages 3749 - 3752, XP002221244 | International search | [X]WO0077204 (UNIV IOWA RES FOUND [US], et al); | [X] - QURESHI ET AL., "Endotoxin-tolerant mice have mutatons in toll-like receptor 4 (Tlr4)", JOURNAL OF EXPERIMENTAL MEDICINE, (19990215), vol. 189, no. 4, pages 615 - 625, XP000900609 DOI: http://dx.doi.org/10.1084/jem.189.4.615 |