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EP About this file: EP1456230

EP1456230 - FLAVIVIRUS NS1 SUBUNIT VACCINE [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  26.07.2019
Database last updated on 09.09.2024
Most recent event   Tooltip26.07.2019Withdrawal of applicationpublished on 28.08.2019  [2019/35]
Applicant(s)For all designated states
Bavarian Nordic A/S
Boegeskovvej 9
3490 Kvistgaard / DK
For all designated states
Venture Technologies Sdn Bhd
Unimas Research Park MY-94300 Kota Samarahan
Sarawak / MY
[N/P]
Former [2005/14]For all designated states
Bavarian Nordic A/S
Boegeskovvej 9
3490 Kvistgaard / DK
For all designated states
Venture Technologies Sdn Bhd
Unimas Research Park
MY-94300 Kota Samarahan, Sarawak / MY
Former [2004/38]For all designated states
Bavarian Nordic A/S
Ved Amagerbanen 23
2300 Copenhagen S / DK
For all designated states
Venture Technologies Sdn Bhd
Unimas Research Park
MY-94300 Kota Samarahan, Sarawak / MY
Inventor(s)01 / HOWLEY, Paul
60 Rose Avenue
Glen Waverly, VIC 3140 / AU
02 / LEYRER, Sonja
Fürstenriederstrasse 272
81377 München / DE
03 / CARDOSA, Mary Jane
96 Jalan Wan Abbul Rahman 4
MY-93300 Kuching, Sarawak / MY
04 / HENRY SUM, Magdeline Sia
Lot 43 Lorong A5, Taman BDC
MY-94300 Kuching / MY
 [2004/38]
Representative(s)Bendiksen, Henrik
Bavarian Nordic GmbH
Patent Department
Fraunhoferstraße 13
82152 Martinsried / DE
[N/P]
Former [2013/12]Schiweck, Weinzierl & Koch
European Patent Attorneys Landsberger Straße 98
80339 München / DE
Former [2011/10]Pielken, Petra, et al
Bavarian Nordic GmbH Fraunhoferstrasse 13
82152 Martinsried / DE
Former [2006/23]Lenkkeri-Schütz, Ulla, et al
Bavarian Nordic GmbH Fraunhoferstraße 13
82152 Martinsried / DE
Former [2005/51]Alt, Michael
Bavarian Nordic GmbH, Fraunhoferstrasse 13
82152 Martinsried / DE
Former [2004/38]Alt, Michael, Dr.
Bavarian Nordic GmbH, Fraunhoferstrasse 18b
82152 Martinsried / DE
Application number, filing date02804184.620.11.2002
[2004/38]
WO2002EP12991
Priority number, dateDK2001000180404.12.2001         Original published format: DK 200101804
[2004/38]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO03048184
Date:12.06.2003
Language:EN
[2003/24]
Type: A2 Application without search report 
No.:EP1456230
Date:15.09.2004
Language:EN
The application published by WIPO in one of the EPO official languages on 12.06.2003 takes the place of the publication of the European patent application.
[2004/38]
Search report(s)International search report - published on:EP29.01.2004
ClassificationIPC:A61K38/16
[2012/18]
CPC:
C07K14/005 (EP,US); C07K14/18 (KR); A61P31/12 (EP);
A61P31/14 (EP); A61P37/04 (EP); A61P37/06 (EP);
C12N15/11 (KR); C12N15/63 (KR); A61K2039/5256 (EP,US);
A61K2039/545 (EP,US); C12N2710/24143 (EP,US); C12N2770/24022 (EP,US);
C12N2770/24122 (EP,US); Y02A50/30 (EP,US) (-)
Former IPC [2011/20]C07K14/18, C12N15/863
Former IPC [2004/38]C07K14/18
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   SK,   TR [2004/38]
Extension statesAL29.07.2004
LT29.07.2004
LV29.07.2004
MK29.07.2004
RO29.07.2004
SI29.07.2004
TitleGerman:IMPFSTOFF AUS DER NS1-UNTEREINHEIT EINES FLAVIVIRUS[2004/38]
English:FLAVIVIRUS NS1 SUBUNIT VACCINE[2004/38]
French:VACCIN A SOUS-UNITE DE NS1 DE FLAVIVIRUS[2004/38]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase05.07.2004National basic fee paid 
29.07.2004Designation fee(s) paid 
29.07.2004Examination fee paid 
Examination proceduredeletedCommunication of intention to grant the patent
27.06.2003Request for preliminary examination filed
International Preliminary Examining Authority: EP
29.07.2004Examination requested  [2004/40]
06.02.2009Despatch of a communication from the examining division (Time limit: M04)
12.05.2009Reply to a communication from the examining division
04.12.2009Despatch of a communication from the examining division (Time limit: M04)
12.04.2010Reply to a communication from the examining division
16.06.2010Despatch of a communication from the examining division (Time limit: M04)
02.10.2010Reply to a communication from the examining division
15.11.2010Despatch of a communication from the examining division (Time limit: M04)
09.02.2011Reply to a communication from the examining division
13.07.2011Despatch of a communication from the examining division (Time limit: M04)
19.10.2011Reply to a communication from the examining division
16.12.2011Despatch of a communication from the examining division (Time limit: M02)
26.01.2012Reply to a communication from the examining division
09.05.2012Communication of intention to grant the patent
02.08.2012Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
09.10.2012Despatch of communication that the application is refused, reason: substantive examination {1}
16.07.2019Application withdrawn by applicant  [2019/35]
Appeal following examination27.11.2012Appeal received No.  T0588/13
13.02.2013Statement of grounds filed
16.07.2019Result of appeal procedure: the application was withdrawn
21.11.2018Date of oral proceedings
28.11.2018Minutes of oral proceedings despatched
Divisional application(s)EP11000882.8  / EP2345665
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.02.2009
Fees paidRenewal fee
30.11.2004Renewal fee patent year 03
30.11.2005Renewal fee patent year 04
30.11.2006Renewal fee patent year 05
30.11.2007Renewal fee patent year 06
01.12.2008Renewal fee patent year 07
30.11.2009Renewal fee patent year 08
30.11.2010Renewal fee patent year 09
23.11.2011Renewal fee patent year 10
13.11.2012Renewal fee patent year 11
18.11.2013Renewal fee patent year 12
10.11.2014Renewal fee patent year 13
10.11.2015Renewal fee patent year 14
10.11.2016Renewal fee patent year 15
10.11.2017Renewal fee patent year 16
14.11.2018Renewal fee patent year 17
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Cited inInternational search[X]WO9001946  (US HEALTH [US]) [X] 23-35 * page 7, line 3 - page 10, line 30 *;
 [Y]WO9813500  (BAVARIAN NORDIC RES INST AS [DK], et al) [Y] 1-35 * page 5, paragraph 2 - page 9, paragraph 4; examples 5,6; claim - *;
 [X]US5824506  (CHAN LILY [SG], et al) [X] 1-4,6,12-15 * column 8, line 56 - column 15, line 48; claim - *;
 [XY]WO0160847  (US HEALTH [US], et al) [X] 1-6,12-16 * page 5, line 1 - page 8, line 25 * * page 11, line 6 - page 25, line 6 * * example -; claim - * [Y] 1-35;
 [PY]WO0242480  (BAVARIAN NORDIC RES INST AS [DK], et al) [PY] 1-35 * page 17, paragraph 3 - page 20, paragraph 2; claim - *;
 [X]  - SCHLESINGER JJ ET AL, "Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1", JOURNAL OF GENERAL VIROLOGY, (1987), vol. 68, no. 3, ISSN 0022-1317, pages 853 - 858, XP009015072 [X] 1-4,12-15 * abstract * * page 855, paragraph 2 - page 856, paragraph 3 *
 [X]  - CHAMBERS TJ ET AL, "Vaccine development against dengue and Japanese encephalitis: report of a World Health Organization meeting", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, (19971001), vol. 15, no. 14, ISSN 0264-410X, pages 1494 - 1502, XP004090331 [X] 1-4,12-15 * page 1499, column R, paragraph 1 - page 1500, column L, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0264-410X(97)00195-3
 [X]  - BRAY M ET AL, "Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge.", JOURNAL OF VIROLOGY, (1996), vol. 70, no. 6, ISSN 0022-538X, pages 4162 - 4166, XP002250234 [X] 1-3,12-14 * abstract *
 [Y]  - FALCONAR AK ET AL, "Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1", JOURNAL OF GENERAL VIROLOGY, READING, BERKS, GB, (199104), vol. 72, no. 4, ISSN 0022-1317, pages 961 - 965, XP000890192 [Y] 1-35 * abstract * * page 963, column R, paragraph 2 - page 965, column L, paragraph 1 *
Examination   - SHU P-Y ET AL, "Dengue NS1-specific antibody responses: Isotype distribution and serotyping in patients with dengue fever and dengue hemorrhagic fever", JOURNAL OF MEDICAL VIROLOGY, ALAN R. LISS, NEW YORK, NY LNKD- DOI:10.1002/1096-9071(200010)62:2<224::AID-JMV14>3.0.CO;2-C, vol. 62, no. 2, ISSN 0146-6615, (20001001), pages 224 - 232, (20000920), XP008102463

DOI:   http://dx.doi.org/10.1002/1096-9071(200010)62:2<224::AID-JMV14>3.0.CO;2-C
    - FALCONAR A ET AL, "Precise location of sequential dengue virus subcomplex and complex B cell epitopes on the nonstructural-1 glycoprotein", ARCHIVES OF VIROLOGY, SPRINGER WIEN, AT LNKD- DOI:10.1007/BF01309478, (19940101), vol. 137, no. 3/04, ISSN 0304-8608, pages 315 - 326, XP002101238

DOI:   http://dx.doi.org/10.1007/BF01309478
    - FALCONAR A K, "The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (1997), Database accession no. NLM9191856
    - ARCHIVES OF VIROLOGY 1997 LNKD- PUBMED:9191856, (1997), vol. 142, no. 5, ISSN 0304-8608, pages 897 - 916
    - FALCONAR A K, "The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis.", ARCHIVES OF VIROLOGY 1997 LNKD- PUBMED:9191856, (1997), vol. 142, no. 5, doi:doi:10.1007/s007050050127, ISSN 0304-8608, pages 897 - 916, XP002660273

DOI:   http://dx.doi.org/10.1007/s007050050127
    - YOUNG P R ET AL, "An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients.", JOURNAL OF CLINICAL MICROBIOLOGY MAR 2000 LNKD- PUBMED:10698995, (200003), vol. 38, no. 3, ISSN 0095-1137, pages 1053 - 1057, XP002660274
    - ROTHMAN A L ET AL, "Multiple specificities in the murine CD4+ and CD8+ T-cell response to dengue virus.", JOURNAL OF VIROLOGY OCT 1996 LNKD- PUBMED:8794288, (199610), vol. 70, no. 10, ISSN 0022-538X, pages 6540 - 6546, XP002660275
    - Accession :AY603355 Esposito et al. Vaccinia virus strain Acambis 3000 Modified Virus Ankara (MVA), complete genome
    - CHUNG KYUNG MIN ET AL, "Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms.", JOURNAL OF VIROLOGY FEB 2006 LNKD- PUBMED:16415011, (200602), vol. 80, no. 3, doi:doi:10.1128/JVI.80.3.1340-1351.2006, ISSN 0022-538X, pages 1340 - 1351, XP002570237

DOI:   http://dx.doi.org/10.1128/JVI.80.3.1340-1351.2006
    - LEE TAE HEE ET AL, "A cross-protective mAb recognizes a novel epitope within the flavivirus NS1 protein.", THE JOURNAL OF GENERAL VIROLOGY JAN 2012 LNKD- PUBMED:21918007, (201201), vol. 93, no. Pt 1, ISSN 1465-2099, pages 20 - 26
    - GAO GUANGPING ET AL, "Adenovirus-based vaccines generate cytotoxic T lymphocytes to epitopes of NS1 from dengue virus that are present in all major serotypes.", HUMAN GENE THERAPY SEP 2008 LNKD- PUBMED:18788905, (200809), vol. 19, no. 9, ISSN 1557-7422, pages 927 - 936
    - SWISS PROT, Database accession no. P09866
    - SWISS PROT, Database accession no. P27915
    - GENBANK, Database accession no. AAD11533
    - GENBANK, Database accession no. AAB70694
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.