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EP About this file: EP1413302

EP1413302 - Substituted guanidines for the treatment of pain [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 15.09.2006 Database last updated on 17.05.2024
Most recent event Tooltip	22.02.2013	Change - classification	published on 27.03.2013 [2013/13]
	22.02.2013	Change - classification	published on 27.03.2013 [2013/13]
Applicant(s)	For all designated states Kadmus Pharmaceuticals, Inc. Suite 200, 2730 Sand Hill Road Menlo Park, CA 94025-7067 / US
	[2004/18]
Inventor(s)	01 / Lipkowski, Andrzej W. Apartment 47, Symfonii Street 4 PL-02-786, Warsaw / PL
	02 / Gee, Kelvin 47 Urey Court Irvine, CA 92612 / US
	[2004/18]
Representative(s)	Adams, Harvey Vaughan John, et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	[N/P]
Former [2006/06]	Adams, Harvey Vaughan John, et al Mathys & Squire, 120 Holborn London EC1N 2SQ / GB
Former [2004/18]	Wong, Kit Yee, et al Mathys & Squire 100 Gray's Inn Road GB-London WC1X 8AL / GB
Application number, filing date	03015696.2	21.07.2000
	[2004/18]
Priority number, date	US19990144810P	21.07.1999 Original published format: US 144810 P
	[2004/18]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	EP1413302
	Date:	28.04.2004
	Language:	EN
	[2004/18]
	Type:	A3 Search report
	No.:	EP1413302
	Date:	12.05.2004
	[2004/20]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	25.03.2004
Classification	IPC:	A61K31/155, A61K31/222, A61K31/7008, A61K31/445, A61K31/495, A61K31/405, A61K31/40, A61P35/00	[2004/18]
	CPC:	C07D273/00 (EP); A61K31/395 (EP,US); A61K31/155 (EP); A61K31/216 (EP); A61K31/40 (EP); A61K31/4045 (EP); (+) A61K31/405 (EP); A61K31/428 (EP); A61K31/451 (EP); A61K31/495 (EP); A61P35/00 (EP); C07D209/16 (EP); C07D209/18 (EP); C07D209/20 (EP); C07D211/52 (EP); C07D211/64 (EP); C07D277/68 (EP); C07D277/82 (EP) (-)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2004/18]
Title	German:	Substitutierte Guanidinderivate zur Behandlung von Schmerz	[2004/18]
	English:	Substituted guanidines for the treatment of pain	[2004/18]
	French:	Guanidines substitutées et utilisation pour le traitement de douleurs	[2004/18]
Examination procedure	20.07.2004	Examination requested [2004/38]
	14.10.2005	Despatch of a communication from the examining division (Time limit: M06)
	25.04.2006	Application deemed to be withdrawn, date of legal effect [2006/42]
	02.06.2006	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2006/42]
Parent application(s) Tooltip	EP00948868.5 / EP1202718
Fees paid	Renewal fee
	21.07.2003	Renewal fee patent year 03
	21.07.2003	Renewal fee patent year 04
	22.07.2004	Renewal fee patent year 05
	20.07.2005	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	31.07.2006	07 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]JPS5724366 ;
		GB190618147 [ ] (HIRSCH JACOB GEORG [DE]);
		[X]DE355121 (GEORG HIRSCH DR) [X] 1-3,5,15 * page 1; claim 1 *;
		[X]US3961056 (DUCHARME DONALD W) [X] 3,5,15 * tables 1,2 *;
		[X]US4281004 (IVES JEFFREY L) [X] 3,5,15 * examples 1-3; claim - *;
		[A]EP0188333 (SYNTEX INC [US]) [A] 3 * page 22, line 10 - page 23, line 34; examples 2,5 * * claim - *;
		[X]US4686283 (NESTOR JR JOHN J [US], et al) [X] 3,5,6 * N,N' guanidino -diphenyl D -homoaraginine; (IUPAC NAME D-Lysine, N6-[bis(phenylamino)methylene] RN= 98500-90-4 ); column 17, lines 43,44 *;
		[E]WO0072800 (SMITHKLINE BEECHAM CORP [US], et al) [E] 3,5,6,15 * examples 1-13; claim - *;
		[E]WO0072840 (SMITHKLINE BEECHAM CORP [US], et al) [E] 3,5,6,15 * Page 19 compound k, page 20, Compound m;; claim - *;
		[X] - SIDDIQUI N ET AL, "Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, (1992), vol. 30, no. 9, ISSN 0019-5189, pages 811 - 813, XP000981381 [X] 1-3,5,15 * See table N. 2, results and discussion *
		[X] - ADLER, P. ET AL, "The effect of structurally different local anesthetics on the cholinesterase activity of human serum", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 44:57519, URL: STN, XP002272551 [X] 1-3,5,15 * abstract *
		[X] - LE BROCQ, C. N., "Local Anaesthetics Recommended as Substitutes for Cocaine", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 3:9616, URL: STN, XP002272552 [X] 1-3,5,15 * abstract *
		[X] - KISHORE V ET AL, "ANTI INFLAMMATORY AND ANTI PROTEOLYTIC PROPERTIES OF SUBSTITUTED GUANIDINES", PHARMACOLOGY (BASEL), (1977), vol. 15, no. 2, ISSN 0031-7012, pages 97 - 103, XP000981375 [X] 1-3,5,6,15 * See compounds in table 2, 3 * DOI: http://dx.doi.org/10.1159/000136668
		[X] - CHEMICAL ABSTRACTS, (19620305), vol. 56, no. 5, column 4592, XP002159408 [X] 3-6 * abstract *
		[X] - HIRSCH, JACOB G., "Clear, strong, aqueous solution of hydrargyrum oxycyanatum and acoine.", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 1:7530, URL: STN, XP002272553 [X] 3,5,15 * abstract *
		[X] - PATENT ABSTRACTS OF JAPAN, (19820602), vol. 006, no. 094, Database accession no. (C - 105), & JP57024366 A 19820208 (SHIONOGI & CO LTD) [X] 3,5,15 * abstract *
		[X] - HUMPHREY S J ET AL, "Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines.", METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, (1996), vol. 18, no. 4, ISSN 0379-0355, pages 247 - 260, XP000981378 [X] 3,5,15 * See table 2, compound U 39697e;; figure -; example - *
		[A] - KNIEPS S ET AL, "Omega-Phenyl-omega-(2-pyridyl)alkyl-substituted bisguanidines are moderate neuropeptide Y antagonists.", PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS, (1996), vol. 6, no. 1, ISSN 0939-9488, pages 27 - 30, XP000981419 [A] 3 * the whole document *
		[A] - M.B. DOUGHTY ET AL, "Non-peptide mimics of neuropeptide Y: A structure-activity study of benextramine analogs.", PEPT.: CHEM. STRUCT. BIOL., (1996), ISSN 0065-7727, pages 711 - 712, XP000979231 [A] 3 * the whole document *
		[ ] - ZEITSCHRIFT FUER VITAMIN-, HORMON- UND FERMENTFORSCHUNG (1950), 3, 236-43
		[ ] - PHARMACEUTICAL JOURNAL (1909), 82, 673-4
		[ ] - SZEKERTE M ET. AL., "Reaction Readiness of Carbodiimides with primary amines.", ANN. UNIV. SCI. BUDAPEST ROLANDO EOTOVOS NOMINATOE SECT. CHIM., (1959), vol. 1, pages 136 - 141

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