EP1499731 - MODIFIED PITUITARY GLAND DEVELOPMENT IN OFFSPRING FROM EXPECTANT MOTHER ANIMALS TREATED WITH GROWTH HORMONE RELEASING HORMONE THERAPY [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 30.03.2012 Database last updated on 03.09.2024 | Most recent event Tooltip | 18.07.2014 | Lapse of the patent in a contracting state New state(s): HU | published on 20.08.2014 [2014/34] | Applicant(s) | For all designated states BAYLOR COLLEGE OF MEDICINE One Baylor Plaza Houston, TX 77030 / US | [2005/04] | Inventor(s) | 01 /
DRAGHIA-AKLI, Ruxandra 61 Avenue de l'Observatoire B-1180 Brussels / BE | 02 /
KHAN, Amir 8787 Shenandoah Park Drive, apt. 1006 Conroe, TX 77385 / US | [2011/12] |
Former [2005/04] | 01 /
DRAGHIA-AKLI, Ruxandra 5215 Starkridge Drive Houston, TX 77035 / US | ||
02 /
KHAN, Amir 8787 Shenandoah Park Drive, apt. 1006 Conroe, TX 77385 / US | Representative(s) | Bassil, Nicholas Charles Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | [N/P] |
Former [2010/02] | Bassil, Nicholas Charles Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | ||
Former [2009/49] | Bassil, Nicholas Charles Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | ||
Former [2005/04] | Fisher, Adrian John, et al CARPMAELS & RANSFORD 43-45 Bloomsbury Square London WC1A 2RA / GB | Application number, filing date | 03710898.2 | 06.02.2003 | [2005/04] | WO2003US03640 | Priority number, date | US20020355566P | 07.02.2002 Original published format: US 355566 P | [2005/04] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO03066825 | Date: | 14.08.2003 | Language: | EN | [2003/33] | Type: | A2 Application without search report | No.: | EP1499731 | Date: | 26.01.2005 | Language: | EN | The application published by WIPO in one of the EPO official languages on 14.08.2003 takes the place of the publication of the European patent application. | [2005/04] | Type: | B1 Patent specification | No.: | EP1499731 | Date: | 25.05.2011 | Language: | EN | [2011/21] | Search report(s) | International search report - published on: | US | 28.10.2004 | (Supplementary) European search report - dispatched on: | EP | 14.03.2006 | Classification | IPC: | C12N15/63, C12N15/87, C12N5/00, A61K48/00 | [2005/04] | CPC: |
C07K14/60 (EP,US);
A61K48/005 (EP,US);
A61P5/02 (EP);
A61P5/06 (EP);
A61K38/00 (EP,US);
A61K48/00 (EP,US)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR [2005/04] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | Title | German: | VERÄNDERTE HIRNANHANGSDRÜSENENTWICKLUNG IN NACHKOMMEN VON MIT EINER THERAPIE MIT WACHSTUMSHORMON FREISETZENDEM HORMON BEHANDELTEN TRÄCHTIGEN MUTTERTIEREN | [2005/04] | English: | MODIFIED PITUITARY GLAND DEVELOPMENT IN OFFSPRING FROM EXPECTANT MOTHER ANIMALS TREATED WITH GROWTH HORMONE RELEASING HORMONE THERAPY | [2005/04] | French: | DEVELOPPEMENT MODIFIE DE L'HYPOPHYSE CHEZ LA PROGENITURE DE FEMELLES ANIMALES PORTANTES TRAITEES PAR LA THERAPIE HORMONALE DE LIBERATION DE L'HORMONE DE CROISSANCE | [2005/04] | Entry into regional phase | 07.09.2004 | National basic fee paid | 07.09.2004 | Search fee paid | 07.09.2004 | Designation fee(s) paid | 07.09.2004 | Examination fee paid | Examination procedure | 04.09.2003 | Request for preliminary examination filed International Preliminary Examining Authority: US | 07.09.2004 | Examination requested [2005/04] | 16.12.2004 | Amendment by applicant (claims and/or description) | 30.08.2006 | Despatch of a communication from the examining division (Time limit: M06) | 05.02.2007 | Reply to a communication from the examining division | 04.06.2007 | Despatch of a communication from the examining division (Time limit: M06) | 13.12.2007 | Reply to a communication from the examining division | 17.03.2008 | Despatch of a communication from the examining division (Time limit: M06) | 19.09.2008 | Reply to a communication from the examining division | 03.03.2009 | Despatch of a communication from the examining division (Time limit: M04) | 09.07.2009 | Reply to a communication from the examining division | 24.02.2010 | Despatch of a communication from the examining division (Time limit: M02) | 15.04.2010 | Reply to a communication from the examining division | 24.11.2010 | Communication of intention to grant the patent | 28.02.2011 | Fee for grant paid | 28.02.2011 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 30.08.2006 | Opposition(s) | 28.02.2012 | No opposition filed within time limit [2012/18] | Fees paid | Renewal fee | 07.09.2004 | Renewal fee patent year 03 | 14.02.2006 | Renewal fee patent year 04 | 14.02.2007 | Renewal fee patent year 05 | 14.03.2008 | Renewal fee patent year 06 | 26.02.2009 | Renewal fee patent year 07 | 24.02.2010 | Renewal fee patent year 08 | 23.02.2011 | Renewal fee patent year 09 | Penalty fee | Additional fee for renewal fee | 29.02.2008 | 06   M06   Fee paid on   14.03.2008 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 06.02.2003 | AT | 25.05.2011 | BE | 25.05.2011 | CY | 25.05.2011 | CZ | 25.05.2011 | DK | 25.05.2011 | EE | 25.05.2011 | FI | 25.05.2011 | IT | 25.05.2011 | NL | 25.05.2011 | SE | 25.05.2011 | SI | 25.05.2011 | SK | 25.05.2011 | TR | 25.05.2011 | BG | 25.08.2011 | GR | 26.08.2011 | ES | 05.09.2011 | PT | 26.09.2011 | IE | 06.02.2012 | LU | 06.02.2012 | [2014/34] |
Former [2014/27] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
IT | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
TR | 25.05.2011 | ||
BG | 25.08.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
IE | 06.02.2012 | ||
LU | 06.02.2012 | ||
Former [2014/21] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
IT | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
TR | 25.05.2011 | ||
BG | 25.08.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
IE | 06.02.2012 | ||
Former [2013/29] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
IT | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
BG | 25.08.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
IE | 06.02.2012 | ||
Former [2013/08] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
IT | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
IE | 06.02.2012 | ||
Former [2012/23] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
IT | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2012/10] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
DK | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
SK | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2012/09] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
CZ | 25.05.2011 | ||
EE | 25.05.2011 | ||
FI | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2012/01] | AT | 25.05.2011 | |
BE | 25.05.2011 | ||
CY | 25.05.2011 | ||
FI | 25.05.2011 | ||
NL | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2011/52] | AT | 25.05.2011 | |
CY | 25.05.2011 | ||
FI | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2011/50] | CY | 25.05.2011 | |
FI | 25.05.2011 | ||
SE | 25.05.2011 | ||
SI | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2011/49] | CY | 25.05.2011 | |
FI | 25.05.2011 | ||
SE | 25.05.2011 | ||
GR | 26.08.2011 | ||
ES | 05.09.2011 | ||
PT | 26.09.2011 | ||
Former [2011/47] | PT | 26.09.2011 | Documents cited: | Search | [Y]US5061690 (KANN GUY [FR], et al) [Y] 2,4-8,12,13,15-17,20-24 * column 2, line 38 - line 42 * * column 2, line 50 - line 55 * * column 2, line 67 - column 3, line 8 * * column 3, line 25 - line 32 *; | [PX]WO02061037 (BAYLOR COLLEGE MEDICINE [US], et al) [PX] 1-26 * the whole document *; | [DY] - DRAGHIA-AKLI RUXANDRA ET AL, "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (199912), vol. 17, no. 12, ISSN 1087-0156, pages 1179 - 1183, XP002159711 [DY] 2,4-8,12,13,15-17,20-24 * abstract * DOI: http://dx.doi.org/10.1038/70718 | [A] - CHEN DAIWEN, "Biotechnologies for improving animal metabolism and growth: A review", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, (200112), vol. 14, no. 12, ISSN 1011-2367, pages 1794 - 1802, XP008061093 [A] 1-26 * the whole document * | [PX] - KHAN A S ET AL, "GHRH GENE DELIVERY TO PREGNANT RATS INCREASES SOMATOTROPH POPULATION AND GROWTH OF PUPS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, (2002), vol. 2002, page ABSTRACT NO. 74.3, XP009053813 [PX] 1-18,20-24 * the whole document * | [PX] - KHAN AMIR S ET AL, "Nonhereditary enhancement of progeny growth", ENDOCRINOLOGY, (200209), vol. 143, no. 9, ISSN 0013-7227, pages 3561 - 3567, XP002370867 [PX] 1-18,20-24 * the whole document * DOI: http://dx.doi.org/10.1210/en.2002-220282 | International search | [Y]US5061690 (KANN GUY [FR], et al); | [Y]US5846936 (FELIX ARTHUR MARTIN [US], et al); | [Y] - DRAGHIA-AKLI ET AL, "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, (199912), vol. 17, no. 12, pages 1179 - 1183, XP002159711 DOI: http://dx.doi.org/10.1038/70718 | [Y] - LI X. ET AL, "Synthetic muscle promoters: Activities exceeding naturally occurring regulatory sequences", NATURE BIOTECHNOLOGY, (199903), vol. 17, no. 3, pages 241 - 245, XP002209991 DOI: http://dx.doi.org/10.1038/6981 | Examination | - PURSEL V. ET AL., "Genetic Engineering of Livestock", SCIENCE, (19890616), vol. 244, pages 1281 - 1288 | - KIARIS H. ET AL., "Growth hormone-releasing hormone and extra-pituitary tumorigenesis: therapeutic and diagnositic applications of growth hormone-releasing hormone antagonists", EXPERT OPIN. INVESTIG. DRUGS, (2003), vol. 12, no. 8, pages 1385 - 1395 | - TÖRNELL J. ET AL., "High frequency of mammary adenocarcinomas in metallothionein promoter-human Growth Hormone transgenic mice created from two different strains", J. STEROID BIOCHEM MOLEC. BIOL., (1992), vol. 43, pages 237 - 242 | - KINEMAN R., ET AL., "The effect of GHRH on Somatotrope Hyperplasia and tumor formation in the Presence and Absence of GH Signaling", ENDOCRINOLOGY, (200109), vol. 142, pages 3764 - 3773 |