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Extract from the Register of European Patents

EP About this file: EP1499731

EP1499731 - MODIFIED PITUITARY GLAND DEVELOPMENT IN OFFSPRING FROM EXPECTANT MOTHER ANIMALS TREATED WITH GROWTH HORMONE RELEASING HORMONE THERAPY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.03.2012
Database last updated on 03.09.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
BAYLOR COLLEGE OF MEDICINE
One Baylor Plaza
Houston, TX 77030 / US
[2005/04]
Inventor(s)01 / DRAGHIA-AKLI, Ruxandra
61 Avenue de l'Observatoire
B-1180 Brussels / BE
02 / KHAN, Amir
8787 Shenandoah Park Drive, apt. 1006
Conroe, TX 77385 / US
 [2011/12]
Former [2005/04]01 / DRAGHIA-AKLI, Ruxandra
5215 Starkridge Drive
Houston, TX 77035 / US
02 / KHAN, Amir
8787 Shenandoah Park Drive, apt. 1006
Conroe, TX 77385 / US
Representative(s)Bassil, Nicholas Charles
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [2010/02]Bassil, Nicholas Charles
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Former [2009/49]Bassil, Nicholas Charles
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Former [2005/04]Fisher, Adrian John, et al
CARPMAELS & RANSFORD 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date03710898.206.02.2003
[2005/04]
WO2003US03640
Priority number, dateUS20020355566P07.02.2002         Original published format: US 355566 P
[2005/04]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO03066825
Date:14.08.2003
Language:EN
[2003/33]
Type: A2 Application without search report 
No.:EP1499731
Date:26.01.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 14.08.2003 takes the place of the publication of the European patent application.
[2005/04]
Type: B1 Patent specification 
No.:EP1499731
Date:25.05.2011
Language:EN
[2011/21]
Search report(s)International search report - published on:US28.10.2004
(Supplementary) European search report - dispatched on:EP14.03.2006
ClassificationIPC:C12N15/63, C12N15/87, C12N5/00, A61K48/00
[2005/04]
CPC:
C07K14/60 (EP,US); A61K48/005 (EP,US); A61P5/02 (EP);
A61P5/06 (EP); A61K38/00 (EP,US); A61K48/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   SI,   SK,   TR [2005/04]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
RONot yet paid
TitleGerman:VERÄNDERTE HIRNANHANGSDRÜSENENTWICKLUNG IN NACHKOMMEN VON MIT EINER THERAPIE MIT WACHSTUMSHORMON FREISETZENDEM HORMON BEHANDELTEN TRÄCHTIGEN MUTTERTIEREN[2005/04]
English:MODIFIED PITUITARY GLAND DEVELOPMENT IN OFFSPRING FROM EXPECTANT MOTHER ANIMALS TREATED WITH GROWTH HORMONE RELEASING HORMONE THERAPY[2005/04]
French:DEVELOPPEMENT MODIFIE DE L'HYPOPHYSE CHEZ LA PROGENITURE DE FEMELLES ANIMALES PORTANTES TRAITEES PAR LA THERAPIE HORMONALE DE LIBERATION DE L'HORMONE DE CROISSANCE[2005/04]
Entry into regional phase07.09.2004National basic fee paid 
07.09.2004Search fee paid 
07.09.2004Designation fee(s) paid 
07.09.2004Examination fee paid 
Examination procedure04.09.2003Request for preliminary examination filed
International Preliminary Examining Authority: US
07.09.2004Examination requested  [2005/04]
16.12.2004Amendment by applicant (claims and/or description)
30.08.2006Despatch of a communication from the examining division (Time limit: M06)
05.02.2007Reply to a communication from the examining division
04.06.2007Despatch of a communication from the examining division (Time limit: M06)
13.12.2007Reply to a communication from the examining division
17.03.2008Despatch of a communication from the examining division (Time limit: M06)
19.09.2008Reply to a communication from the examining division
03.03.2009Despatch of a communication from the examining division (Time limit: M04)
09.07.2009Reply to a communication from the examining division
24.02.2010Despatch of a communication from the examining division (Time limit: M02)
15.04.2010Reply to a communication from the examining division
24.11.2010Communication of intention to grant the patent
28.02.2011Fee for grant paid
28.02.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.08.2006
Opposition(s)28.02.2012No opposition filed within time limit [2012/18]
Fees paidRenewal fee
07.09.2004Renewal fee patent year 03
14.02.2006Renewal fee patent year 04
14.02.2007Renewal fee patent year 05
14.03.2008Renewal fee patent year 06
26.02.2009Renewal fee patent year 07
24.02.2010Renewal fee patent year 08
23.02.2011Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
29.02.200806   M06   Fee paid on   14.03.2008
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.02.2003
AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
TR25.05.2011
BG25.08.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
IE06.02.2012
LU06.02.2012
[2014/34]
Former [2014/27]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
TR25.05.2011
BG25.08.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
IE06.02.2012
LU06.02.2012
Former [2014/21]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
TR25.05.2011
BG25.08.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
IE06.02.2012
Former [2013/29]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
BG25.08.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
IE06.02.2012
Former [2013/08]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
IE06.02.2012
Former [2012/23]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
IT25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2012/10]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
DK25.05.2011
EE25.05.2011
FI25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
SK25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2012/09]AT25.05.2011
BE25.05.2011
CY25.05.2011
CZ25.05.2011
EE25.05.2011
FI25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2012/01]AT25.05.2011
BE25.05.2011
CY25.05.2011
FI25.05.2011
NL25.05.2011
SE25.05.2011
SI25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2011/52]AT25.05.2011
CY25.05.2011
FI25.05.2011
SE25.05.2011
SI25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2011/50]CY25.05.2011
FI25.05.2011
SE25.05.2011
SI25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2011/49]CY25.05.2011
FI25.05.2011
SE25.05.2011
GR26.08.2011
ES05.09.2011
PT26.09.2011
Former [2011/47]PT26.09.2011
Documents cited:Search[Y]US5061690  (KANN GUY [FR], et al) [Y] 2,4-8,12,13,15-17,20-24 * column 2, line 38 - line 42 * * column 2, line 50 - line 55 * * column 2, line 67 - column 3, line 8 * * column 3, line 25 - line 32 *;
 [PX]WO02061037  (BAYLOR COLLEGE MEDICINE [US], et al) [PX] 1-26 * the whole document *;
 [DY]  - DRAGHIA-AKLI RUXANDRA ET AL, "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (199912), vol. 17, no. 12, ISSN 1087-0156, pages 1179 - 1183, XP002159711 [DY] 2,4-8,12,13,15-17,20-24 * abstract *

DOI:   http://dx.doi.org/10.1038/70718
 [A]  - CHEN DAIWEN, "Biotechnologies for improving animal metabolism and growth: A review", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, (200112), vol. 14, no. 12, ISSN 1011-2367, pages 1794 - 1802, XP008061093 [A] 1-26 * the whole document *
 [PX]  - KHAN A S ET AL, "GHRH GENE DELIVERY TO PREGNANT RATS INCREASES SOMATOTROPH POPULATION AND GROWTH OF PUPS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, (2002), vol. 2002, page ABSTRACT NO. 74.3, XP009053813 [PX] 1-18,20-24 * the whole document *
 [PX]  - KHAN AMIR S ET AL, "Nonhereditary enhancement of progeny growth", ENDOCRINOLOGY, (200209), vol. 143, no. 9, ISSN 0013-7227, pages 3561 - 3567, XP002370867 [PX] 1-18,20-24 * the whole document *

DOI:   http://dx.doi.org/10.1210/en.2002-220282
International search[Y]US5061690  (KANN GUY [FR], et al);
 [Y]US5846936  (FELIX ARTHUR MARTIN [US], et al);
 [Y]  - DRAGHIA-AKLI ET AL, "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, (199912), vol. 17, no. 12, pages 1179 - 1183, XP002159711

DOI:   http://dx.doi.org/10.1038/70718
 [Y]  - LI X. ET AL, "Synthetic muscle promoters: Activities exceeding naturally occurring regulatory sequences", NATURE BIOTECHNOLOGY, (199903), vol. 17, no. 3, pages 241 - 245, XP002209991

DOI:   http://dx.doi.org/10.1038/6981
Examination   - PURSEL V. ET AL., "Genetic Engineering of Livestock", SCIENCE, (19890616), vol. 244, pages 1281 - 1288
    - KIARIS H. ET AL., "Growth hormone-releasing hormone and extra-pituitary tumorigenesis: therapeutic and diagnositic applications of growth hormone-releasing hormone antagonists", EXPERT OPIN. INVESTIG. DRUGS, (2003), vol. 12, no. 8, pages 1385 - 1395
    - TÖRNELL J. ET AL., "High frequency of mammary adenocarcinomas in metallothionein promoter-human Growth Hormone transgenic mice created from two different strains", J. STEROID BIOCHEM MOLEC. BIOL., (1992), vol. 43, pages 237 - 242
    - KINEMAN R., ET AL., "The effect of GHRH on Somatotrope Hyperplasia and tumor formation in the Presence and Absence of GH Signaling", ENDOCRINOLOGY, (200109), vol. 142, pages 3764 - 3773
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.