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Extract from the Register of European Patents

EP About this file: EP1501848

EP1501848 - SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.06.2008
Database last updated on 07.10.2024
Most recent event   Tooltip13.08.2010Lapse of the patent in a contracting state
New state(s): TR		published on 15.09.2010  [2010/37]
Applicant(s)For all designated states
Santaris Pharma A/S
Bøge Allé 3
2970 Hørsholm / DK
[2007/32]
Former [2007/14]For all designated states
Santaris Pharma A/S
Boge Allé 3
2970 Horsholm / DK
Former [2005/05]For all designated states
Santaris Pharma A/S
Boge Allé 3
2970 Horsholm / DK
For all designated states
Exiqon A/S
Bygstubben 9
2950 Vedbaek / DK
Inventor(s)01 / SORENSEN, Mads, Detlef
Skotterupgade 2, 4 tv
DK-2200 Kobenhavn N / DK
02 / WENGEL, Jesper
Rugmarken 48
DK-5260 Odense S. / DK
03 / KOCH, Troels
Funkiavej 47
DK-2300 Copenhagen S / DK
04 / CHRISTENSEN, Signe, M.
Gammeltoftsgade 24, 3. tv.
DK-2200 Copenhagen N / DK
05 / Rosenbohm, Christoph
Kirsebaerlunden 25
3460 Birkerod / DK
06 / Pedersen, Daniel Sejer, Darwin College
Silver Street
Cambridge CB3 9EU / GB
 [2005/12]
Former [2005/05]01 / SORENSEN, Mads, Detlef
Humlebaeksgade 33, st. th.
DK-2200 Copenhagen N / DK
02 / WENGEL, Jesper
Rugmarken 48
DK-5260 Odense S. / DK
03 / KOCH, Troels
Funkiavej 47
DK-2300 Copenhagen S / DK
04 / CHRISTENSEN, Signe, M.
Gammeltoftsgade 24, 3. tv.
DK-2200 Copenhagen N / DK
05 / Rosenbohm, Christoph
Frederikssundsvej 55, 4. th.
DK-2400 Copenhagen NV / DK
06 / Pedersen, Daniel Sejer, Darwin College
Silver Street
Cambridge CB3 9EU / GB
Representative(s)Plougmann Vingtoft a/s
Strandvejen 70
2900 Hellerup / DK
[N/P]
Former [2008/31]Plougmann & Vingtoft A/S
Sundkrogsgade 9 P.O. Box 831
2100 Copenhagen Ø / DK
Former [2005/05]Plougmann & Vingtoft A/S
Sundkrogsgade 9 P.O. Box 831
2100 Copenhagen O / DK
Application number, filing date03718663.208.05.2003
[2005/05]
WO2003DK00305
Priority number, dateDK2002000071208.05.2002         Original published format: DK 200200712
DK2002000121416.08.2002         Original published format: DK 200201214
[2005/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03095467
Date:20.11.2003
Language:EN
[2003/47]
Type: A1 Application with search report 
No.:EP1501848
Date:02.02.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 20.11.2003 takes the place of the publication of the European patent application.
[2005/05]
Type: B1 Patent specification 
No.:EP1501848
Date:08.08.2007
Language:EN
[2007/32]
Search report(s)International search report - published on:EP20.11.2003
ClassificationIPC:C07H19/00
[2005/05]
CPC:
C07H19/06 (EP); C07H19/16 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/05]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:SYNTHESE VON LOCKED NUCLEIC ACID-DERIVATEN[2005/05]
English:SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES[2005/05]
French:SYNTHESE DE DERIVES D'ACIDES NUCLEIQUES LNA[2005/05]
Entry into regional phase16.11.2004National basic fee paid 
16.11.2004Designation fee(s) paid 
16.11.2004Examination fee paid 
Examination procedure22.11.2003Request for preliminary examination filed
International Preliminary Examining Authority: EP
16.11.2004Examination requested  [2005/05]
20.01.2005Despatch of a communication from the examining division (Time limit: M04)
13.05.2005Reply to a communication from the examining division
28.09.2005Communication of intention to grant the patent
07.02.2006Fee for grant paid
07.02.2006Fee for publishing/printing paid
Opposition(s)09.05.2008No opposition filed within time limit [2008/29]
Fees paidRenewal fee
13.05.2005Renewal fee patent year 03
12.05.2006Renewal fee patent year 04
14.05.2007Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.08.2007
BE08.08.2007
CY08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SI08.08.2007
SK08.08.2007
TR08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
HU09.02.2008
IE08.05.2008
LU08.05.2008
[2010/37]
Former [2010/34]AT08.08.2007
BE08.08.2007
CY08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SI08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
HU09.02.2008
IE08.05.2008
LU08.05.2008
Former [2010/32]AT08.08.2007
BE08.08.2007
CY08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SI08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
IE08.05.2008
LU08.05.2008
Former [2009/34]AT08.08.2007
BE08.08.2007
CY08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SI08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
IE08.05.2008
Former [2009/29]AT08.08.2007
BE08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SI08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
IE08.05.2008
Former [2009/23]AT08.08.2007
BE08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
IE08.05.2008
Former [2009/11]AT08.08.2007
BE08.08.2007
CZ08.08.2007
EE08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
Former [2008/28]AT08.08.2007
BE08.08.2007
CZ08.08.2007
FI08.08.2007
NL08.08.2007
RO08.08.2007
SK08.08.2007
BG08.11.2007
SE08.11.2007
GR09.11.2007
PT08.01.2008
Former [2008/25]AT08.08.2007
BE08.08.2007
CZ08.08.2007
FI08.08.2007
NL08.08.2007
SK08.08.2007
BG08.11.2007
GR09.11.2007
PT08.01.2008
Former [2008/21]AT08.08.2007
BE08.08.2007
FI08.08.2007
NL08.08.2007
BG08.11.2007
GR09.11.2007
Former [2008/13]AT08.08.2007
FI08.08.2007
NL08.08.2007
BG08.11.2007
Former [2008/10]FI08.08.2007
NL08.08.2007
BG08.11.2007
Former [2008/09]NL08.08.2007
BG08.11.2007
Cited inInternational search[AX]WO0066604  (EXIQON AS [DK], et al) [A] 1-32,44-52 * the whole document * [X] 33-43,53-55;
 [AX]WO0228875  (CUREON AS [DK], et al) [A] 1-32,44-52 * the whole document * [X] 33-43,53-55;
 [X]  - ULRICH JORDIS ET AL, "Synthesis of (1S,4S)-2-Thia-5-azabicyclo(2.2.1)heptane", INDIAN JOURNAL OF CHEMISTRY, (198904), vol. 28B, pages 294 - 296, XP002252478 [X] 1-55 * the whole document *
 [X]  - LISBET KVAERNO ET AL, "Synthesis of a Novel Bicyclic Nucleoside Restricted to an S-Type Conformation and Initial Evaluation of Its Hybridization Properties When Incorporated into Oligodeoxynucleotides", J. ORG. CHEM., (2001), vol. 66, pages 5106 - 5112, XP002252479 [X] 1-55 * the whole document *

DOI:   http://dx.doi.org/10.1021/jo015602v
 [X]  - VELIMIR POPSAVIN ET AL, "An alternative synthesis of (+)-epiallo-muscarine from D-glucose", CARBOHYDRATE RESEARCH, (1995), vol. 269, pages 343 - 347, XP002252480 [X] 1-55 * the whole document *

DOI:   http://dx.doi.org/10.1016/0008-6215(94)00363-K
 [AX]  - SANJAY K. SINGH ET AL, "Synthesis of 2'-Amino-LNA: A Novel Conformationally Restricted High-Affinity Oligonucleotide Analogue with a Handle", J. ORG. CHEM., (1998), vol. 63, pages 10035 - 10039, XP002252481 [A] 1-32,44-52 * the whole document * [X] 33-43,53-55

DOI:   http://dx.doi.org/10.1021/jo9814445
 [A]  - GEORGE W. J. FLEET ET AL, "The synthesis from D-xylose of the potent and specific enantiomeric glucosidase inhibitors, 1,4-dideoxy-1,4-imino-D-arabinitol and 1,4-dideoxy-1,4-imino-L-arabinitol", TETRAHEDRON, (1986), vol. 42, no. 20, pages 5685 - 5692, XP002252482 [A] 1-55 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0040-4020(01)88174-6
 [PX]  - CHRISTOPH ROSENBOHM ET AL, "Synthesis of 2'-amino-LNA: a new strategy", ORGANIC & BIOMOLECULAR CHEMISTRY, (2003), vol. 1, no. 4, pages 655 - 663, XP002252483 [PX] 1-55 * the whole document *

DOI:   http://dx.doi.org/10.1039/b208864a
 [PX]  - TORSTEN BRYLD ET AL, "Synthesis and antiviral evaluation of novel conformationally locked mucleosides and masked 5'-phosphate derivatives thereof", J. CHEM. SOC., PERKIN TRANS., (2002), vol. 1, pages 1655 - 1662, XP002252484 [PX] 1-43,53-55 * see compound 27 *

DOI:   http://dx.doi.org/10.1039/b203484k
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.