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Extract from the Register of European Patents

EP About this file: EP1498421

EP1498421 - GAMMA-SECRETASE INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.09.2010
Database last updated on 02.09.2024
Most recent event   Tooltip19.10.2012Lapse of the patent in a contracting state
New state(s): TR		published on 21.11.2012  [2012/47]
Applicant(s)For all designated states
Mori, Hiroshi
Room 301, Haitsu-kosumo-21, 3-45, Nakamichi 1-chome, Higashinari-ku Osaka-shi
Osaka 537-0025 / JP
[2009/46]
Former [2005/03]For all designated states
Mori, Hiroshi
Room 301, Haitsu-kosumo-21, 3-45, Nakamichi 1-chome, Higashinari-ku
Osaka-shi, Osaka 537-0025 / JP
Inventor(s)01 / see applicant
...
 [2005/03]
Representative(s)Hartz, Nikolai, et al
Wächtershäuser & Hartz
Patentanwaltspartnerschaft mbB
Weinstrasse 8
80333 München / DE
[N/P]
Former [2005/03]Hartz, Nikolai F., Dr., et al
Wächtershäuser & Hartz Patentanwälte Weinstrasse 8
80333 München / DE
Application number, filing date03720938.418.04.2003
[2005/03]
WO2003JP05017
Priority number, dateJP2002012198324.04.2002         Original published format: JP 2002121983
[2005/03]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03091278
Date:06.11.2003
Language:EN
[2003/45]
Type: A1 Application with search report 
No.:EP1498421
Date:19.01.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 06.11.2003 takes the place of the publication of the European patent application.
[2005/03]
Type: B1 Patent specification 
No.:EP1498421
Date:11.11.2009
Language:EN
[2009/46]
Search report(s)International search report - published on:JP06.11.2003
(Supplementary) European search report - dispatched on:EP04.04.2006
ClassificationIPC:C07K5/00, C07K7/00, C07K16/44, C12N9/99
[2005/03]
CPC:
C07K5/0207 (EP,US); C07K5/00 (KR); A61P25/00 (EP);
A61P25/28 (EP); A61P43/00 (EP); C07K14/4711 (EP,US);
C07K14/8114 (EP,US); C07K16/44 (KR); C07K7/00 (KR);
A61K38/00 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/03]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:GAMMA-SEKRETASE-INHIBITOREN[2005/03]
English:GAMMA-SECRETASE INHIBITORS[2005/03]
French:INHIBITEURS DE GAMMA SECRETASE[2005/03]
Entry into regional phase18.10.2004Translation filed 
18.10.2004National basic fee paid 
18.10.2004Search fee paid 
18.10.2004Designation fee(s) paid 
18.10.2004Examination fee paid 
Examination procedure18.10.2004Examination requested  [2005/03]
04.04.2007Despatch of a communication from the examining division (Time limit: M06)
04.10.2007Reply to a communication from the examining division
10.06.2008Despatch of a communication from the examining division (Time limit: M06)
17.12.2008Reply to a communication from the examining division
22.06.2009Communication of intention to grant the patent
28.09.2009Fee for grant paid
28.09.2009Fee for publishing/printing paid
Opposition(s)12.08.2010No opposition filed within time limit [2010/42]
Fees paidRenewal fee
20.04.2005Renewal fee patent year 03
21.03.2006Renewal fee patent year 04
20.04.2007Renewal fee patent year 05
24.04.2008Renewal fee patent year 06
24.04.2009Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
TR11.11.2009
BG11.02.2010
GR12.02.2010
ES22.02.2010
PT11.03.2010
IE18.04.2010
MC30.04.2010
HU12.05.2010
[2012/47]
Former [2012/42]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
BG11.02.2010
GR12.02.2010
ES22.02.2010
PT11.03.2010
IE18.04.2010
MC30.04.2010
HU12.05.2010
Former [2011/07]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
BG11.02.2010
GR12.02.2010
ES22.02.2010
PT11.03.2010
IE18.04.2010
MC30.04.2010
Former [2010/50]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
BG11.02.2010
GR12.02.2010
ES22.02.2010
PT11.03.2010
MC30.04.2010
Former [2010/48]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
BG11.02.2010
GR12.02.2010
ES22.02.2010
PT11.03.2010
Former [2010/39]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
SK11.11.2009
BG11.02.2010
ES22.02.2010
PT11.03.2010
Former [2010/36]AT11.11.2009
BE11.11.2009
CY11.11.2009
CZ11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
BG11.02.2010
ES22.02.2010
PT11.03.2010
Former [2010/35]AT11.11.2009
BE11.11.2009
CY11.11.2009
DK11.11.2009
EE11.11.2009
FI11.11.2009
RO11.11.2009
SE11.11.2009
SI11.11.2009
BG11.02.2010
ES22.02.2010
PT11.03.2010
Former [2010/31]AT11.11.2009
BE11.11.2009
CY11.11.2009
FI11.11.2009
SE11.11.2009
SI11.11.2009
ES22.02.2010
PT11.03.2010
Former [2010/30]AT11.11.2009
CY11.11.2009
FI11.11.2009
SE11.11.2009
SI11.11.2009
ES22.02.2010
PT11.03.2010
Former [2010/25]CY11.11.2009
FI11.11.2009
SE11.11.2009
SI11.11.2009
ES22.02.2010
PT11.03.2010
Former [2010/23]FI11.11.2009
SE11.11.2009
SI11.11.2009
ES22.02.2010
PT11.03.2010
Former [2010/22]FI11.11.2009
SE11.11.2009
ES22.02.2010
PT11.03.2010
Former [2010/19]ES22.02.2010
Documents cited:Search[Y]WO0153255  (MERCK SHARP & DOHME [GB], et al) [Y] 1-16 * the whole document *;
 [Y]US2002013276  (NADIN ALAN JOHN [GB], et al) [Y] 1-16 * the whole document *;
 [Y]  - SASTRE M ET AL, "Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.", EMBO REPORTS. SEP 2001, (200109), vol. 2, no. 9, ISSN 1469-221X, pages 835 - 841, XP002373229 [Y] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1093/embo-reports/kve180
 [Y]  - YU C ET AL, "Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 23 NOV 2001, (20011123), vol. 276, no. 47, ISSN 0021-9258, pages 43756 - 43760, XP002373230 [Y] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.C100410200
International search[A]EP0236734  (CIBA GEIGY AG [CH]);
 [X]  - GU Y. ET AL., "Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch", J. BIOL. CHEM., (20010921), pages 35235 - 35238, XP002970044

DOI:   http://dx.doi.org/10.1074/jbc.C100357200
 [Y]  - SHEARMAN M.S. ET AL., "L-685, 458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity", BIOCHEMISTRY, (20000801), vol. 39, no. 30, pages 8698 - 8704, XP002164178

DOI:   http://dx.doi.org/10.1021/bi0005456
 [Y]  - WOLFE M.S. ET AL., "A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity", J. MED. CHEM., (19980101), vol. 41, no. 1, pages 6 - 9, XP000938942

DOI:   http://dx.doi.org/10.1021/jm970621b
 [Y]  - SCHWARZE S.R. ET AL., "In vivo protein transduction: delivery of a biologically active protein into the mouse", SCIENCE, (1999), vol. 285, pages 1569 - 1572, XP002140133

DOI:   http://dx.doi.org/10.1126/science.285.5433.1569
 [Y]  - WEIDEMANN A. ET AL., "A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrated homology with Notch processing", BIOCHEMISTRY, (20020226), vol. 41, no. 8, pages 2825 - 2835, XP002970045

DOI:   http://dx.doi.org/10.1021/bi015794o
 [A]  - PINNIX I. ET AL., "A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor", J. BIOL. CHEM., (20010105), vol. 276, no. 1, pages 481 - 487, XP002217635

DOI:   http://dx.doi.org/10.1074/jbc.M005968200
 [A]  - FIGUEIREDO-PEREIRA M.E. ET AL., "Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively", J. NEUROCHEM., (199904), vol. 72, no. 4, pages 1417 - 1422, XP002970046

DOI:   http://dx.doi.org/10.1046/j.1471-4159.1999.721417.x
 [A]  - GHOSH A.K. ET AL., "Structure-based design: potent inhibitoirs of human brain memapsin 2. (beta-secretase)", JOURNAL OF MEDICINAL CHEMISTRY, (2001), vol. 44, no. 18, pages 2865 - 2868, XP002213861

DOI:   http://dx.doi.org/10.1021/jm0101803
 [A]  - CHONG K.T. ET AL., "Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities", JOURNAL OF MEDICINAL CHEMISTRY, (1993), vol. 36, no. 17, pages 2575 - 2577, XP002007120

DOI:   http://dx.doi.org/10.1021/jm00069a018
 [A]  - TIAN G. ET AL., "Linear non-competitive inhibition of solubilized human gamma-secretase by peptide A methylaster, L685458, sulfonamides and benzodiazepines", J. BIOL. CHEM., (20020830), vol. 277, no. 35, pages 31499 - 31505, XP002970047

DOI:   http://dx.doi.org/10.1074/jbc.M112328200
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.