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Extract from the Register of European Patents

EP About this file: EP1501861

EP1501861 - TARGETING PROTEINS TO DELIVER THERAPEUTIC OR DIAGNOSTIC REAGENTS [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  18.06.2010
Database last updated on 15.06.2024
Most recent event   Tooltip18.06.2010Refusal of applicationpublished on 21.07.2010  [2010/29]
Applicant(s)For all designated states
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
201 West Seventh Street
Austin, TX 78701 / US
[N/P]
Former [2005/05]For all designated states
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
201 West Seventh Street
Austin, TX 78701 / US
Inventor(s)01 / HUNG, Mien-Chie
5762 Birdwood Road
Houston, TX 77096 / US
02 / LAN, Keng-Li
7447 Cambridge Apt. 46
Houston, TX 77054 / US
03 / OU-YANG, Fu
7777 Greenbriar Drive
Houston, TX 77030 / US
04 / LIU, Jaw-Ching
7777 Greenbriar Drive
Houston, TX 77030 / US
05 / LAN, Keng-Hsin
6F-1, No. 3. Lane 151 Sec. Z, Fu-Hsing S. Rd
Taipei Taiwan 106 / TW
 [2005/05]
Representative(s)SONN Patentanwälte GmbH & Co KG
Riemergasse 14
1010 Wien / AT
[N/P]
Former [2005/05]Sonn & Partner Patentanwälte
Riemergasse 14
1010 Wien / AT
Application number, filing date03733952.006.05.2003
[2005/05]
WO2003US14243
Priority number, dateUS20020380063P06.05.2002         Original published format: US 380063 P
[2005/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03093303
Date:13.11.2003
Language:EN
[2003/46]
Type: A1 Application with search report 
No.:EP1501861
Date:02.02.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 13.11.2003 takes the place of the publication of the European patent application.
[2005/05]
Search report(s)International search report - published on:US13.11.2003
(Supplementary) European search report - dispatched on:EP23.05.2007
ClassificationIPC:C07K19/00, A61K38/00, C12N15/62, C07K14/78
[2007/24]
CPC:
C07K14/78 (EP,US); A61K47/66 (EP,US); A61P35/00 (EP);
A61P43/00 (EP); A61P9/00 (EP); B82Y5/00 (EP,US);
C07K14/5434 (EP,US); C12N9/78 (EP,US); A61K38/00 (EP,US);
C07K2319/32 (EP,US); C07K2319/60 (EP,US); C07K2319/74 (EP,US) (-)
Former IPC [2005/05]C07K1/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/05]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:GEZIELT BINDENDE PROTEINE ZUR VERABREICHUNG THERAPEUTISCHER ODER DIAGNOSTISCHER REAGENTIEN[2005/05]
English:TARGETING PROTEINS TO DELIVER THERAPEUTIC OR DIAGNOSTIC REAGENTS[2005/05]
French:CIBLAGE DE PROTEINES POUR L'APPORT DE REACTIFS THERAPEUTIQUES OU DE DIAGNOSTIC[2005/05]
Entry into regional phase26.11.2004National basic fee paid 
26.11.2004Search fee paid 
26.11.2004Designation fee(s) paid 
26.11.2004Examination fee paid 
Examination procedure05.12.2003Request for preliminary examination filed
International Preliminary Examining Authority: US
26.11.2004Amendment by applicant (claims and/or description)
26.11.2004Examination requested  [2005/05]
27.09.2007Despatch of a communication from the examining division (Time limit: M06)
04.04.2008Reply to a communication from the examining division
09.10.2008Despatch of a communication from the examining division (Time limit: M04)
09.02.2009Reply to a communication from the examining division
02.03.2010Cancellation of oral proceeding that was planned for 19.03.2010
05.03.2010Despatch of communication that the application is refused, reason: substantive examination [2010/29]
15.03.2010Application refused, date of legal effect [2010/29]
19.03.2010Date of oral proceedings (cancelled)
Fees paidRenewal fee
27.05.2005Renewal fee patent year 03
10.05.2006Renewal fee patent year 04
30.05.2007Renewal fee patent year 05
28.03.2008Renewal fee patent year 06
12.05.2009Renewal fee patent year 07
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[DX]WO9916889  (SEARLE & CO [US], et al) [DX] 1-3,6,7,10-12,16-19,23,24 * claim - *;
 [X]WO0011033  (LEXINGEN PHARMACEUTICALS CORP [US]) [X] 1-4,6,7 * claim - *;
 [X]WO0105826  (GPC BIOTECH INC [US]) [X] 1-4,6,7,10-12,16-19,23,24 * page 10, line 17 - line 30; claim - *;
 [X]WO0151523  (BETH ISRAEL HOSPITAL [US], et al) [X] 1-3,6,7,10-12,16-19,23,24 * page 53, line 22 - line 31; claim - *;
 [PX]WO0244328  (WAISMAN DAVID M [CA], et al) [PX] 1-4,6,7 * claim - *;
 [DX]  - SCAPPATICCI F A ET AL, "Statin-AE: a novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity.", ANGIOGENESIS 2001, (2001), vol. 4, no. 4, ISSN 0969-6970, pages 263 - 268, XP002431004 [DX] 1,2,5-7,10-12,14,18,19,22-24 * Statin-AE Statin-AE-IRES-GFP *

DOI:   http://dx.doi.org/10.1023/A:1016067717433
 [X]  - SAUTER B V ET AL, "Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, (20000425), vol. 97, no. 9, ISSN 0027-8424, pages 4802 - 4807, XP002145436 [X] 1-3,6,7 * GST-endostatin fusion protein. (cf. Materials and methods) *

DOI:   http://dx.doi.org/10.1073/pnas.090065597
 [DA]  - HALIN C ET AL, "Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (200203), vol. 20, no. 3, ISSN 1087-0156, pages 264 - 269, XP002256784

DOI:   http://dx.doi.org/10.1038/nbt0302-264
 [A]  - NICULESCU-DUVAZ I ET AL, "RECENT DEVELOPMENTS IN GENE-DIRECTED ENZYME PRODRUG THERAPY (GDEPT) FOR CANCER", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON,, GB, (199908), vol. 1, no. 4, ISSN 1464-8431, pages 480 - 486, XP009057173
 [A]  - AZAR Y ET AL, "GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells", APOPTOSIS, LONDON, GB, (200012), vol. 5, no. 6, ISSN 1360-8185, pages 531 - 542, XP002303415

DOI:   http://dx.doi.org/10.1023/A:1009689529756
International search[Y]US6413513  (HOLADAY JOHN W [US], et al);
 [Y]US6537554  (SHIMKETS RICHARD A [US], et al)
 [X]  - BOEHM ET AL., "Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance", NATURE, (19971127), vol. 390, pages 404 - 407, XP000857413

DOI:   http://dx.doi.org/10.1038/37126
Examination   - FU OU-YANG ET AL, "Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, (20060101), vol. 66, no. 1, ISSN 0008-5472, pages 378 - 384, XP009106294

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-05-1578
    - Helfrich et al. (2000) J. Immunol. Methods 237, 131-145.
by applicantWO9916889
 WO0011033
 US4797368
 US4879236
 WO0244328
 US5220007
 US6537554
 US4554101
 US4683202
 US5928906
 US2003228285
 US5925565
 US5935819
 US5871986
 US5670488
 US5641484
 US5139941
 US5284760
    - SAUTER ET AL., PNAS USA, (2000), vol. 97, pages 4802 - 4807
    - NICULESCU-DUVAZ ET AL., CURR OPIN MOL THER, (1999), vol. 1, pages 480 - 486
    - AZAR ET AL., APOPTOSIS, (2000), vol. 5, pages 531 - 542
    - HELFRICH ET AL., J IMMUNOL METHODS, (2000), vol. 237, pages 131 - 145
    - Remington's Pharmaceutical Sciences, MACK PRINTING COMPANY, (1990), pages 1289 - 1329
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.