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Extract from the Register of European Patents

EP About this file: EP1506313

EP1506313 - Methods of screening for modulators of the mitochondrial NAD-dependent deacetylase SIRT3 [Right-click to bookmark this link]
Former [2005/07]METHODS OF MODULATING MITOCHONDRIAL NAD-DEPENDENT DEACETYLASE
[2010/22]
StatusNo opposition filed within time limit
Status updated on  02.12.2011
Database last updated on 06.07.2024
Most recent event   Tooltip04.10.2013Lapse of the patent in a contracting state
New state(s): HU		published on 06.11.2013  [2013/45]
Applicant(s)For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607 / US
[N/P]
Former [2011/04]For all designated states
The Regents of The University of California
12th Floor 1111 Franklin Street
Oakland, CA 94607-5200 / US
Former [2005/07]For all designated states
The Regents of the University of California
12th Floor, 1111 Franklin Street
Oakland, California 94607-5200 / US
Inventor(s)01 / VERDIN, Eric
J. David Gladstone Institutes, 365 Vermont Street
San Francisco, CA 94103 / US
02 / NORTH, Brian, J.
1021 Jones Street
San Francisco, CA 94109 / US
03 / SCHWER, Bjoern
3741 Market Street B
San Francisco, CA 94131 / US
 [2011/04]
Former [2005/07]01 / VERDIN, Eric c/o J. David Gladstone Institutes
365 Vermont Street
San Francisco, CA 94103 / US
02 / NORTH, Brian, J.
1021 Jones Street
San Francisco, CA 94109 / US
03 / SCHWER, Bjoern
3741 Market Street B
San Francisco, CA 94131 / US
Representative(s)Brasnett, Adrian Hugh, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2005/07]Brasnett, Adrian Hugh, et al
Mewburn Ellis LLP York House 23 Kingsway
London WC2B 6HP / GB
Application number, filing date03736714.122.05.2003
[2005/07]
WO2003US16499
Priority number, dateUS20020383069P23.05.2002         Original published format: US 383069 P
[2005/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO03100089
Date:04.12.2003
Language:EN
[2003/49]
Type: A1 Application with search report 
No.:EP1506313
Date:16.02.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 04.12.2003 takes the place of the publication of the European patent application.
[2005/07]
Type: B1 Patent specification 
No.:EP1506313
Date:26.01.2011
Language:EN
[2011/04]
Search report(s)International search report - published on:US04.12.2003
(Supplementary) European search report - dispatched on:EP13.02.2007
ClassificationIPC:C12Q1/34, C12Q1/48, C12Q1/68
[2007/10]
CPC:
C12Q1/48 (EP,US); A61P43/00 (EP); C12Q1/34 (EP,US);
G01N2500/00 (EP,US)
Former IPC [2005/07]C12Q1/37
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/07]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:Verfahren zum Auswählen von Modulatoren der mitochondrialen NAD-abhängigen Deacetylase, SIRT3[2010/22]
English:Methods of screening for modulators of the mitochondrial NAD-dependent deacetylase SIRT3[2010/22]
French:Méthodes de sélecter de modulateurs de la deacetylase mitochondriale NAD-dépendante SIRT3.[2010/22]
Former [2005/07]VERFAHREN ZUR MODULATION MITOCHONDRIALER NAD-ABHÄNGIGER DEACETYLASE
Former [2005/07]METHODS OF MODULATING MITOCHONDRIAL NAD-DEPENDENT DEACETYLASE
Former [2005/07]METHODES DE MODULATION DE LA DESACETYLASE MITOCHONDRIALE NAD-DEPENDANTE
Entry into regional phase13.12.2004National basic fee paid 
13.12.2004Search fee paid 
13.12.2004Designation fee(s) paid 
13.12.2004Examination fee paid 
Examination procedure16.10.2003Request for preliminary examination filed
International Preliminary Examining Authority: US
29.11.2004Amendment by applicant (claims and/or description)
13.12.2004Examination requested  [2005/07]
25.09.2007Despatch of a communication from the examining division (Time limit: M06)
05.03.2008Reply to a communication from the examining division
17.11.2009Despatch of a communication from the examining division (Time limit: M04)
25.03.2010Reply to a communication from the examining division
04.08.2010Communication of intention to grant the patent
08.12.2010Fee for grant paid
08.12.2010Fee for publishing/printing paid
Opposition(s)27.10.2011No opposition filed within time limit [2012/01]
Fees paidRenewal fee
19.05.2005Renewal fee patent year 03
30.05.2006Renewal fee patent year 04
30.05.2007Renewal fee patent year 05
28.05.2008Renewal fee patent year 06
27.05.2009Renewal fee patent year 07
25.05.2010Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
HU26.01.2011
IT26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
TR26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
LU22.05.2011
PT26.05.2011
MC31.05.2011
[2013/45]
Former [2013/44]AT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
IT26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
TR26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
LU22.05.2011
PT26.05.2011
MC31.05.2011
Former [2013/25]AT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
IT26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
LU22.05.2011
PT26.05.2011
MC31.05.2011
Former [2012/23]AT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
IT26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
MC31.05.2011
Former [2012/05]AT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
MC31.05.2011
Former [2011/49]AT26.01.2011
BE26.01.2011
CY26.01.2011
CZ26.01.2011
EE26.01.2011
FI26.01.2011
NL26.01.2011
RO26.01.2011
SI26.01.2011
SK26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
Former [2011/48]AT26.01.2011
BE26.01.2011
CY26.01.2011
EE26.01.2011
FI26.01.2011
NL26.01.2011
SI26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
Former [2011/39]AT26.01.2011
BE26.01.2011
CY26.01.2011
FI26.01.2011
NL26.01.2011
SI26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
Former [2011/37]BE26.01.2011
CY26.01.2011
FI26.01.2011
SI26.01.2011
BG26.04.2011
GR27.04.2011
ES07.05.2011
PT26.05.2011
Former [2011/36]GR27.04.2011
ES07.05.2011
PT26.05.2011
Documents cited:Search[Y]WO0140506  ;
 EP1243658  [ ] (CYCLEX CO LTD [JP]);
 [PX]WO02102981  (UNIV COLUMBIA [US], et al) [PX] 1-13 * pages 32,34 *;
 [PX]WO03004621  (ELIXIR PHARMACEUTICALS INC [US], et al) [PX] 1-13 * figure 19; claim 15 *;
 [E]WO03099210  (UNIV CALIFORNIA [US], et al) [E] 1-13 * example 2; claim 1 *;
 [E]WO2004055169  (ELIXIR PHARMACEUTICALS INC [US], et al) [E] 1-13 * example 2; claims 6,8,13 *;
 [Y]  - FRYE ROY A, "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir-2-like proteins (Sirtuins) metabolized NAD and may have protein ADP-ribosyltransferase activity", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (1999), vol. 260, no. 1, ISSN 0006-291X, pages 273 - 279, XP002963940 [Y] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1006/bbrc.1999.0897
 [Y]  - GROZINGER C M ET AL, "Indentification of a Class of Small molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotype Screening", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, (20010801), vol. 276, no. 42, ISSN 0021-9258, pages 38837 - 38843, XP002392947 [Y] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.M106779200
 [Y]  - "Method for detecting the level of acetylation of a peptide by using peptidase activity as a marker", DATABASE WPI, 0, Derwent World Patents Index, Database accession no. 2001-374853, XP002417122 & WO0140506 A 20010607 (CYCLEX CO LTD [JP];) [Y] 1-13 * column A *
 [Y]  - LANDRY J ET AL, "Role of NAD+ in the deacetylase activity of the SIR2-like proteins", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20001130), vol. 278, no. 3, ISSN 0006-291X, pages 685 - 690, XP002963942 [Y] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1006/bbrc.2000.3854
 [PX]  - ONYANGO PATRICK ET AL, "SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20021015), vol. 99, no. 21, ISSN 0027-8424, pages 13653 - 13658, XP002417107 [PX] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.222538099
 [PX]  - SCHWER BJOERN ET AL, "The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase", JOURNAL OF CELL BIOLOGY, (20020819), vol. 158, no. 4, ISSN 0021-9525, pages 647 - 657, XP002417108 [PX] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1083/jcb.200205057
International search[XP]US2002120008  (BENZER SEYMOUR [US], et al);
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by applicant   - YANG, Y. H.; CHEN, Y. H.; ZHANG, C. Y.; NIMMAKAYALU, M. A.; WARD, D. C.; WEISSMAN, S., GENOMICS, (2000), vol. 69, no. 3, pages 355 - 69
    - ZEMZOUMI, K.; SERENO, D.; FRANCOIS, C.; GUILVARD, E.; LEMESRE, J. L.; OUAISSI, A., BIOL CELL, (1998), vol. 90, no. 3, pages 239 - 45
    - TISCHLER, M. E.; FRIEDRICHS, D.; COLL, K.; WILLIAMSON, J. R., ARCH BIOCHEM BIOPHYS, (1977), vol. 184, no. 1, pages 222 - 36
    - DI LISA, F.; MENABO, R.; CANTON, M.; BARILE, M.; BERNARDI, P., JBIOL CHEM, (2001), vol. 276, no. 4, pages 2571 - 5
    - DEVIN, A.; GUERIN, B.; RIGOULET, M., FEBS LETT, (1997), vol. 410, no. 2-3, pages 329 - 32
    - VINOGRADOV, A.; SCARPA, A.; CHANCE, B., ARCH BIOCHEM BIOPHYS, (1972), vol. 152, no. 2, pages 646 - 54
    - BERNARDI, P., PHYSIOL REV, (1999), vol. 79, no. 4, pages 1127 - 55
    - BERNARDI, P.; SCORRANO, L.; COLONNA, R.; PETRONILLI, V.; DI LISA, F., EUR J BIOCHEM, (1999), vol. 264, no. 3, pages 687 - 701
    - ZIEGLER, M.; JORCKE, D.; SCHWEIGER, M., BIOCHEM J, (1997), vol. 326, pages 401 - 5
    - LENAZ, G., BIOCHIM BIOPHYS ACTA, (1998), vol. 1366, no. 1-2, pages 53 - 67
    - JACKSON, M. D.; DENU, J. M., PERSONAL COMMUNICATION
    - WEKSBERG, R.; TESHIMA, I.; WILLIAMS, B. R.; GREENBERG, C. R.; PUESCHEL, S. M.; CHERNOS, J. E.; FOWLOW, S. B.; HOYME, E.; ANDERSON,, HUM MOL GENET, (1993), vol. 2, no. 5, pages 549 - 56
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    - FEINBERG, A. P., CURR TOP MICROBIOL IMMUNOL, (2000), vol. 249, pages 87 - 99
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