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Extract from the Register of European Patents

EP About this file: EP1532241

EP1532241 - RATIONALLY DESIGNED POLYSACCHARIDE LYASES DERIVED FROM CHONDROITINASE B [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.07.2011
Database last updated on 24.04.2024
Most recent event   Tooltip04.10.2013Lapse of the patent in a contracting state
New state(s): HU		published on 06.11.2013  [2013/45]
Applicant(s)For all designated states
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
77 Massachusetts Avenue
Cambridge, MA 02139 / US
[2010/37]
Former [2005/21]For all designated states
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
17 Massachusetts Avenue
Cambridge, Massachusetts 02139 / US
Inventor(s)01 / POJASEK, Kevin
294 Harvard Street, 2
Cambridge, MA 02139 / US
02 / RAMAN, Rahul
144 Pemberton Street
Cambridge, MA 02139 / US
03 / SASISEKHARAN, Ram
2130 Massachusetts Avenue 7B
Cambridge, MA 02140 / US
 [2007/03]
Former [2005/21]01 / POJASEK, Kevin
26 Inman Street, 3C
Cambridge, MA 02139 / US
02 / RAMAN, Rahul
144 Pemberton Street
Cambridge, MA 02139 / US
03 / SASISEKHARAN, Ram
2130 Massachusetts Avenue 7B
Cambridge, MA 02140 / US
Representative(s)Hutter, Anton, et al
Venner Shipley LLP
5 Stirling House
Stirling Road The Surrey Research Park
Guildford GU2 7RF / GB
[N/P]
Former [2009/38]Hutter, Anton, et al
Venner Shipley LLP 20 Little Britain London
EC1A 7DH / GB
Former [2005/21]Jump, Timothy John Simon, et al
Venner Shipley LLP 20 Little Britain
London EC1A 7DH / GB
Application number, filing date03756399.603.06.2003
[2005/21]
WO2003US17680
Priority number, dateUS20020385509P03.06.2002         Original published format: US 385509 P
[2005/21]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO03102160
Date:11.12.2003
Language:EN
[2003/50]
Type: A2 Application without search report 
No.:EP1532241
Date:25.05.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 11.12.2003 takes the place of the publication of the European patent application.
[2005/21]
Type: B1 Patent specification 
No.:EP1532241
Date:15.09.2010
Language:EN
[2010/37]
Search report(s)International search report - published on:US16.09.2004
(Supplementary) European search report - dispatched on:EP28.10.2005
ClassificationIPC:C12N9/88, C12N15/60, A61K38/51
[2005/21]
CPC:
C08B37/0069 (EP,US); C12N9/88 (EP,US); C12Q1/527 (EP,US);
A61K38/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/21]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:RATIONELL KONSTRUIERTE, VON CHONDROITINASE B ABGELEITETE LYASEN[2005/21]
English:RATIONALLY DESIGNED POLYSACCHARIDE LYASES DERIVED FROM CHONDROITINASE B[2005/21]
French:LYASES DE POLYSACCHARIDE DERIVEES DE CHONDROITINASE B, CONCUES DE FACON RATIONNELLE[2005/21]
Entry into regional phase31.12.2004National basic fee paid 
31.12.2004Search fee paid 
31.12.2004Designation fee(s) paid 
31.12.2004Examination fee paid 
Examination procedure31.12.2004Examination requested  [2005/21]
28.02.2005Amendment by applicant (claims and/or description)
26.01.2009Despatch of a communication from the examining division (Time limit: M06)
28.07.2009Reply to a communication from the examining division
04.11.2009Cancellation of oral proceeding that was planned for 19.11.2009
17.11.2009Date of oral proceedings
19.11.2009Date of oral proceedings
19.11.2009Date of oral proceedings (cancelled)
01.03.2010Communication of intention to grant the patent
12.07.2010Fee for grant paid
12.07.2010Fee for publishing/printing paid
Opposition(s)16.06.2011No opposition filed within time limit [2011/34]
Fees paidRenewal fee
21.06.2005Renewal fee patent year 03
28.06.2006Renewal fee patent year 04
27.06.2007Renewal fee patent year 05
25.06.2008Renewal fee patent year 06
26.06.2009Renewal fee patent year 07
25.06.2010Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
HU15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
TR15.09.2010
BG15.12.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
IE03.06.2011
LU03.06.2011
[2013/45]
Former [2013/44]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
TR15.09.2010
BG15.12.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
IE03.06.2011
LU03.06.2011
Former [2013/42]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
BG15.12.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
IE03.06.2011
LU03.06.2011
Former [2013/25]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
IE03.06.2011
LU03.06.2011
Former [2012/20]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
IE03.06.2011
Former [2011/40]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
DK15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
Former [2011/31]AT15.09.2010
BE15.09.2010
CY15.09.2010
CZ15.09.2010
EE15.09.2010
FI15.09.2010
IT15.09.2010
NL15.09.2010
RO15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
ES26.12.2010
PT17.01.2011
Former [2011/24]AT15.09.2010
CY15.09.2010
CZ15.09.2010
EE15.09.2010
FI15.09.2010
NL15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
PT17.01.2011
Former [2011/23]AT15.09.2010
CY15.09.2010
CZ15.09.2010
EE15.09.2010
FI15.09.2010
SE15.09.2010
SI15.09.2010
SK15.09.2010
GR16.12.2010
Former [2011/15]AT15.09.2010
CY15.09.2010
FI15.09.2010
SE15.09.2010
SI15.09.2010
GR16.12.2010
Former [2011/13]AT15.09.2010
CY15.09.2010
FI15.09.2010
SI15.09.2010
Former [2011/10]AT15.09.2010
FI15.09.2010
SI15.09.2010
Former [2011/08]AT15.09.2010
Documents cited:Search[X]  - POJASEK K ET AL, "Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 17 AUG 2001, (20010817), vol. 286, no. 2, ISSN 0006-291X, pages 343 - 351, XP002348572 [X] 16-27,16-21,22-27 * page 344, column R, paragraph 4 - page 345, column L, line 2 * * figures 3,4 *

DOI:   http://dx.doi.org/10.1006/bbrc.2001.5380
 [A]  - TKALEC ANA LYDIA ET AL, "Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium heparinum", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (200001), vol. 66, no. 1, ISSN 0099-2240, pages 29 - 35, XP002348550
 [A]  - GU KENAN ET AL, "Purification, characterization and specificity of chondroitin lyases and glucuronidase from Flavobacterium heparinum", BIOCHEMICAL JOURNAL, (1995), vol. 312, no. 2, ISSN 0264-6021, pages 569 - 577, XP002348573
 [A]  - MASCELLANI GIUSEPPE ET AL, "Structure and contribution to the heparin cofactor II-mediated inhibition of thrombin of naturally oversulphated sequences of dermatan sulphate", BIOCHEMICAL JOURNAL, (1993), vol. 296, no. 3, ISSN 0264-6021, pages 639 - 648, XP002348574
 [A]  - ACHUR RAJESHWARA N ET AL, "Characterization of proteoglycans of human placenta and identification of unique chondroitin sulfate proteoglycans of the intervillous spaces that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta", JOURNAL OF BIOLOGICAL CHEMISTRY, (20001222), vol. 275, no. 51, ISSN 0021-9258, pages 40344 - 40356, XP002348575

DOI:   http://dx.doi.org/10.1074/jbc.M006398200
 [A]  - PLAAS ANNA H K ET AL, Glycosaminoglycan sulfation in human osteoarthritis: Disease-related alterations at the non-reducing termini of chondroitin and dermatan sulfate, JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, PAGE(S) 12642-12649, (19980515), ISSN 0021-9258, XP002339999

DOI:   http://dx.doi.org/10.1074/jbc.273.20.12642
 [A]  - MONAGLE PAUL ET AL, "Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes: Characterization of novel anticoagulants", JOURNAL OF BIOLOGICAL CHEMISTRY, (19981211), vol. 273, no. 50, ISSN 0021-9258, pages 33566 - 33571, XP002348576

DOI:   http://dx.doi.org/10.1074/jbc.273.50.33566
 [A]  - DAIDOUJI KOUICHI ET AL, "Neoplastic changes in saccharide sequence of dermatan sulfate chains derived from human colon cancer", DIGESTIVE DISEASES AND SCIENCES, (200202), vol. 47, no. 2, ISSN 0163-2116, pages 331 - 337, XP002348577

DOI:   http://dx.doi.org/10.1023/A:1013718021713
    [ ] - "Pedobacter heparinus chondroitinase B precursor (cslB) gene, complete cds.", EMBL, (19951003), Database accession no. CH27584, URL: EBI, XP002348555
International search[A]US6093563  (BENNETT D CLARK [CA], et al);
 [XP]  - POJASEK ET AL, "Biochemical characterization of the chondroitinase B active site", J. BIOL. CHEM., (200208), vol. 277, no. 34, pages 31179 - 31186, XP002978617

DOI:   http://dx.doi.org/10.1074/jbc.M201552200
 [A]  - HAUNG ET AL, "Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis", BIOCHEMISTRY, (2001), vol. 40, no. 8, pages 2359 - 2372, XP002978618

DOI:   http://dx.doi.org/10.1021/bi0024254
 [A]  - HAUNG ET AL, "Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution", J. MOL. BIOL., (1999), vol. 294, pages 1257 - 1269, XP004461802

DOI:   http://dx.doi.org/10.1006/jmbi.1999.3292
by applicant   - POJASEK, K. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2001), vol. 286, pages 343 - 51
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.