EP1554016 - IN VITRO SYNCHRONISATION OF NUCLEAR AND CYTOPLASMATIC MATURATION OF OOCYTES INVOLVING ADDITION AND REMOVAL OF PHOSPHODIESTERASE TYPE 3 INHIBITOR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 20.03.2009 Database last updated on 09.09.2024 | Most recent event Tooltip | 29.10.2010 | Lapse of the patent in a contracting state New state(s): GR | published on 01.12.2010 [2010/48] | Applicant(s) | For all designated states NOVO NORDISK A/S Novo Allé 2880 Bagsværd / DK | For all designated states Bayer Schering Pharma Aktiengesellschaft Müllerstrasse 178 13353 Berlin / DE | [N/P] |
Former [2007/19] | For all designated states NOVO NORDISK A/S Novo Allé 2880 Bagsvaerd / DK | ||
For all designated states Bayer Schering Pharma Aktiengesellschaft Müllerstrasse 178 13353 Berlin / DE | |||
Former [2007/15] | For all designated states NOVO NORDISK A/S Novo Allé 2880 Bagsvaerd / DK | ||
For all designated states Bayer Schering Pharma AG Müllerstrasse 178 13353 Berlin / DE | |||
Former [2005/29] | For all designated states NOVO NORDISK A/S Novo Allé 2880 Bagsvaerd / DK | ||
For all designated states Schering AG Müllerstrasse 178 13353 Berlin-Wedding / DE | Inventor(s) | 01 /
SMITZ, Johan Laarbeeklaan 101 B-1090 Brussels / BE | 02 /
GRONDAHL, Christian Irisvej 19 DK-3500 Vaerlose / DK | [2005/29] | Application number, filing date | 03757724.4 | 15.10.2003 | [2005/29] | WO2003DK00703 | Priority number, date | DK20020001581 | 15.10.2002 Original published format: DK 200201581 | [2005/29] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2004035766 | Date: | 29.04.2004 | Language: | EN | [2004/18] | Type: | A2 Application without search report | No.: | EP1554016 | Date: | 20.07.2005 | Language: | EN | The application published by WIPO in one of the EPO official languages on 29.04.2004 takes the place of the publication of the European patent application. | [2005/29] | Type: | B1 Patent specification | No.: | EP1554016 | Date: | 14.05.2008 | Language: | EN | [2008/20] | Search report(s) | International search report - published on: | EP | 03.06.2004 | Classification | IPC: | A61P15/08, C12N5/00 | [2005/29] | CPC: |
C12N5/0609 (EP,US);
A61P15/08 (EP);
C12N2500/25 (EP,US);
C12N2501/01 (EP,US);
C12N2501/105 (EP,US);
C12N2501/31 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2005/29] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | Title | German: | IN-VITRO-SYNCHRONISATION DER KERN- UND ZYTOPLASMA-REIFUNG VON OOZYTEN MIT ADDITION UND ENTFERNUNG VON PHOSPHODIESTERASE-HEMMER TYP 3 | [2005/29] | English: | IN VITRO SYNCHRONISATION OF NUCLEAR AND CYTOPLASMATIC MATURATION OF OOCYTES INVOLVING ADDITION AND REMOVAL OF PHOSPHODIESTERASE TYPE 3 INHIBITOR | [2005/29] | French: | SYNCHRONISATION IN VITRO DE LA MATURATION NUCLEAIRE ET CYTOPLASMIQUE DES OOCYTES COMPRENANT L'AJOUT ET LE RETRAIT D'INHIBITEUR DE LA PHOSPHODIESTERASE DE TYPE 3 | [2005/29] | Entry into regional phase | 17.05.2005 | National basic fee paid | 17.05.2005 | Designation fee(s) paid | 17.05.2005 | Examination fee paid | Examination procedure | 15.04.2004 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 17.05.2005 | Examination requested [2005/29] | 01.09.2005 | Despatch of a communication from the examining division (Time limit: M08) | 20.06.2006 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 22.08.2006 | Reply to a communication from the examining division | 29.11.2007 | Communication of intention to grant the patent | 28.03.2008 | Fee for grant paid | 28.03.2008 | Fee for publishing/printing paid | Opposition(s) | 17.02.2009 | No opposition filed within time limit [2009/17] | Request for further processing for: | 22.08.2006 | Request for further processing filed | 22.08.2006 | Full payment received (date of receipt of payment) Request granted | 12.09.2006 | Decision despatched | Fees paid | Renewal fee | 31.10.2005 | Renewal fee patent year 03 | 31.10.2006 | Renewal fee patent year 04 | 31.10.2007 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AT | 14.05.2008 | BE | 14.05.2008 | CY | 14.05.2008 | CZ | 14.05.2008 | DK | 14.05.2008 | EE | 14.05.2008 | FI | 14.05.2008 | IT | 14.05.2008 | NL | 14.05.2008 | RO | 14.05.2008 | SI | 14.05.2008 | SK | 14.05.2008 | TR | 14.05.2008 | BG | 14.08.2008 | SE | 14.08.2008 | GR | 15.08.2008 | ES | 25.08.2008 | PT | 14.10.2008 | GB | 15.10.2008 | IE | 15.10.2008 | LU | 15.10.2008 | CH | 31.10.2008 | FR | 31.10.2008 | LI | 31.10.2008 | MC | 31.10.2008 | HU | 15.11.2008 | [2010/48] |
Former [2010/37] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CY | 14.05.2008 | ||
CZ | 14.05.2008 | ||
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EE | 14.05.2008 | ||
FI | 14.05.2008 | ||
IT | 14.05.2008 | ||
NL | 14.05.2008 | ||
RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
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TR | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
GB | 15.10.2008 | ||
IE | 15.10.2008 | ||
LU | 15.10.2008 | ||
CH | 31.10.2008 | ||
FR | 31.10.2008 | ||
LI | 31.10.2008 | ||
MC | 31.10.2008 | ||
HU | 15.11.2008 | ||
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CZ | 14.05.2008 | ||
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SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
GB | 15.10.2008 | ||
IE | 15.10.2008 | ||
LU | 15.10.2008 | ||
CH | 31.10.2008 | ||
FR | 31.10.2008 | ||
LI | 31.10.2008 | ||
MC | 31.10.2008 | ||
HU | 15.11.2008 | ||
Former [2010/32] | AT | 14.05.2008 | |
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CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
EE | 14.05.2008 | ||
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IT | 14.05.2008 | ||
NL | 14.05.2008 | ||
RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
GB | 15.10.2008 | ||
IE | 15.10.2008 | ||
LU | 15.10.2008 | ||
CH | 31.10.2008 | ||
FR | 31.10.2008 | ||
LI | 31.10.2008 | ||
MC | 31.10.2008 | ||
Former [2010/01] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
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EE | 14.05.2008 | ||
FI | 14.05.2008 | ||
IT | 14.05.2008 | ||
NL | 14.05.2008 | ||
RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
GB | 15.10.2008 | ||
IE | 15.10.2008 | ||
CH | 31.10.2008 | ||
FR | 31.10.2008 | ||
LI | 31.10.2008 | ||
MC | 31.10.2008 | ||
Former [2009/49] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
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EE | 14.05.2008 | ||
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RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
IE | 15.10.2008 | ||
CH | 31.10.2008 | ||
FR | 31.10.2008 | ||
LI | 31.10.2008 | ||
MC | 31.10.2008 | ||
Former [2009/47] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
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EE | 14.05.2008 | ||
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IT | 14.05.2008 | ||
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SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
IE | 15.10.2008 | ||
MC | 31.10.2008 | ||
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BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
EE | 14.05.2008 | ||
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BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
MC | 31.10.2008 | ||
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CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
EE | 14.05.2008 | ||
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RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
MC | 31.10.2008 | ||
Former [2009/23] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
EE | 14.05.2008 | ||
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RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
BG | 14.08.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
Former [2009/22] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
EE | 14.05.2008 | ||
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SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
Former [2009/14] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
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FI | 14.05.2008 | ||
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RO | 14.05.2008 | ||
SI | 14.05.2008 | ||
SK | 14.05.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
Former [2009/12] | AT | 14.05.2008 | |
BE | 14.05.2008 | ||
CZ | 14.05.2008 | ||
DK | 14.05.2008 | ||
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NL | 14.05.2008 | ||
SI | 14.05.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
Former [2009/09] | AT | 14.05.2008 | |
DK | 14.05.2008 | ||
FI | 14.05.2008 | ||
NL | 14.05.2008 | ||
SI | 14.05.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
PT | 14.10.2008 | ||
Former [2009/07] | AT | 14.05.2008 | |
FI | 14.05.2008 | ||
NL | 14.05.2008 | ||
SI | 14.05.2008 | ||
SE | 14.08.2008 | ||
ES | 25.08.2008 | ||
Former [2008/50] | AT | 14.05.2008 | |
FI | 14.05.2008 | ||
NL | 14.05.2008 | ||
SI | 14.05.2008 | ||
ES | 25.08.2008 | ||
Former [2008/47] | SI | 14.05.2008 | |
ES | 25.08.2008 | ||
Former [2008/44] | SI | 14.05.2008 | Cited in | International search | [A]WO9300863 (RANOUX CLAUDE [US]) [A] 3 * abstract *; | [A]WO0138493 (NOVO NORDISK AS [DK]) [A] 4,18-20 * examples 1,2 * * claim 1 *; | [A]WO0176360 (NOVO NORDISK AS [DK], et al) [A] 8,27 * claim - *; | [X] - REBECKA E. THOMAS ET AL, "Differential Effects of Specific Phosphodiesterase Isoenzyme Inhibitors on Bovine Oocyte Meiotic Maturation", DEVELOPMENTAL BIOLOGY, (2002), vol. 244, pages 215 - 225, XP002268443 [X] 1-30 * the whole document * * page 219, column 2; figure 3 * * page 222, column 1 * DOI: http://dx.doi.org/10.1006/dbio.2002.0609 | [A] - MIKKELSEN A L ET AL, "Possible factors affecting the development of oocytes in in-vitro maturation.", MEDLINE, (200012), Database accession no. NLM11263532, XP002268446 [A] 22,23,29 * abstract * | [ ] - HUMAN REPRODUCTION (OXFORD, ENGLAND) ENGLAND DEC 2000, (200012), vol. 15 Suppl 5, ISSN 0268-1161, pages 11 - 17 | [A] - A. WIERSMA ET AL, "Phosphodiesterase 3 Inhibitors Suppress Oocyte Maturation and Consequent Pregnance without Affecting Ovulation and Cyclicity in Rodents", J. CLIN. INVEST., (199808), vol. 102, no. 3, pages 532 - 537, XP002268444 [A] 9 * the whole document * DOI: http://dx.doi.org/10.1172/JCI2566 | [A] - A. TSAFRIRI ET AL, "Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors", DEVELOPMENTAL BIOLOGY, (1996), vol. 178, pages 393 - 402, XP002268445 [A] 1-30 * page 395, column 1, line 27 - line 33 * DOI: http://dx.doi.org/10.1006/dbio.1996.0226 | [PX] - NOGUEIRA D ET AL, "Effect of phosphodiesterase type 3 inhibitor on developmental competence of immature mouse oocytes in vitro.", MEDLINE, (200312), Database accession no. NLM12930710, XP002268447 [PX] 1-30 * abstract * | [ ] - BIOLOGY OF REPRODUCTION. UNITED STATES DEC 2003, (200312), vol. 69, no. 6, ISSN 0006-3363, pages 2045 - 2052 | [PX] - NOGUEIRA DANIELA ET AL, "Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro.", MEDLINE, (200309), Database accession no. NLM12773402, XP002268448 [PX] 1-30 * abstract * | [ ] - BIOLOGY OF REPRODUCTION. UNITED STATES SEP 2003, (200309), vol. 69, no. 3, ISSN 0006-3363, pages 1042 - 1052 |