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Extract from the Register of European Patents

EP About this file: EP1554016

EP1554016 - IN VITRO SYNCHRONISATION OF NUCLEAR AND CYTOPLASMATIC MATURATION OF OOCYTES INVOLVING ADDITION AND REMOVAL OF PHOSPHODIESTERASE TYPE 3 INHIBITOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.03.2009
Database last updated on 09.09.2024
Most recent event   Tooltip29.10.2010Lapse of the patent in a contracting state
New state(s): GR		published on 01.12.2010  [2010/48]
Applicant(s)For all designated states
NOVO NORDISK A/S
Novo Allé
2880 Bagsværd / DK
For all designated states
Bayer Schering Pharma Aktiengesellschaft
Müllerstrasse 178
13353 Berlin / DE
[N/P]
Former [2007/19]For all designated states
NOVO NORDISK A/S
Novo Allé
2880 Bagsvaerd / DK
For all designated states
Bayer Schering Pharma Aktiengesellschaft
Müllerstrasse 178
13353 Berlin / DE
Former [2007/15]For all designated states
NOVO NORDISK A/S
Novo Allé
2880 Bagsvaerd / DK
For all designated states
Bayer Schering Pharma AG
Müllerstrasse 178
13353 Berlin / DE
Former [2005/29]For all designated states
NOVO NORDISK A/S
Novo Allé
2880 Bagsvaerd / DK
For all designated states
Schering AG
Müllerstrasse 178
13353 Berlin-Wedding / DE
Inventor(s)01 / SMITZ, Johan
Laarbeeklaan 101
B-1090 Brussels / BE
02 / GRONDAHL, Christian
Irisvej 19
DK-3500 Vaerlose / DK
 [2005/29]
Application number, filing date03757724.415.10.2003
[2005/29]
WO2003DK00703
Priority number, dateDK2002000158115.10.2002         Original published format: DK 200201581
[2005/29]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004035766
Date:29.04.2004
Language:EN
[2004/18]
Type: A2 Application without search report 
No.:EP1554016
Date:20.07.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 29.04.2004 takes the place of the publication of the European patent application.
[2005/29]
Type: B1 Patent specification 
No.:EP1554016
Date:14.05.2008
Language:EN
[2008/20]
Search report(s)International search report - published on:EP03.06.2004
ClassificationIPC:A61P15/08, C12N5/00
[2005/29]
CPC:
C12N5/0609 (EP,US); A61P15/08 (EP); C12N2500/25 (EP,US);
C12N2501/01 (EP,US); C12N2501/105 (EP,US); C12N2501/31 (EP,US);
C12N2501/392 (EP,US); C12N2501/70 (EP,US); C12N2517/10 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/29]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:IN-VITRO-SYNCHRONISATION DER KERN- UND ZYTOPLASMA-REIFUNG VON OOZYTEN MIT ADDITION UND ENTFERNUNG VON PHOSPHODIESTERASE-HEMMER TYP 3[2005/29]
English:IN VITRO SYNCHRONISATION OF NUCLEAR AND CYTOPLASMATIC MATURATION OF OOCYTES INVOLVING ADDITION AND REMOVAL OF PHOSPHODIESTERASE TYPE 3 INHIBITOR[2005/29]
French:SYNCHRONISATION IN VITRO DE LA MATURATION NUCLEAIRE ET CYTOPLASMIQUE DES OOCYTES COMPRENANT L'AJOUT ET LE RETRAIT D'INHIBITEUR DE LA PHOSPHODIESTERASE DE TYPE 3[2005/29]
Entry into regional phase17.05.2005National basic fee paid 
17.05.2005Designation fee(s) paid 
17.05.2005Examination fee paid 
Examination procedure15.04.2004Request for preliminary examination filed
International Preliminary Examining Authority: EP
17.05.2005Examination requested  [2005/29]
01.09.2005Despatch of a communication from the examining division (Time limit: M08)
20.06.2006Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
22.08.2006Reply to a communication from the examining division
29.11.2007Communication of intention to grant the patent
28.03.2008Fee for grant paid
28.03.2008Fee for publishing/printing paid
Opposition(s)17.02.2009No opposition filed within time limit [2009/17]
Request for further processing for:22.08.2006Request for further processing filed
22.08.2006Full payment received (date of receipt of payment)
Request granted
12.09.2006Decision despatched
Fees paidRenewal fee
31.10.2005Renewal fee patent year 03
31.10.2006Renewal fee patent year 04
31.10.2007Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT14.05.2008
BE14.05.2008
CY14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
TR14.05.2008
BG14.08.2008
SE14.08.2008
GR15.08.2008
ES25.08.2008
PT14.10.2008
GB15.10.2008
IE15.10.2008
LU15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
HU15.11.2008
[2010/48]
Former [2010/37]AT14.05.2008
BE14.05.2008
CY14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
TR14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
GB15.10.2008
IE15.10.2008
LU15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
HU15.11.2008
Former [2010/34]AT14.05.2008
BE14.05.2008
CY14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
GB15.10.2008
IE15.10.2008
LU15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
HU15.11.2008
Former [2010/32]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
GB15.10.2008
IE15.10.2008
LU15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
Former [2010/01]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
GB15.10.2008
IE15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
Former [2009/49]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
IE15.10.2008
CH31.10.2008
FR31.10.2008
LI31.10.2008
MC31.10.2008
Former [2009/47]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
IE15.10.2008
MC31.10.2008
Former [2009/39]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
IT14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
MC31.10.2008
Former [2009/26]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
MC31.10.2008
Former [2009/23]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
BG14.08.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
Former [2009/22]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
EE14.05.2008
FI14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
Former [2009/14]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
FI14.05.2008
NL14.05.2008
RO14.05.2008
SI14.05.2008
SK14.05.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
Former [2009/12]AT14.05.2008
BE14.05.2008
CZ14.05.2008
DK14.05.2008
FI14.05.2008
NL14.05.2008
SI14.05.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
Former [2009/09]AT14.05.2008
DK14.05.2008
FI14.05.2008
NL14.05.2008
SI14.05.2008
SE14.08.2008
ES25.08.2008
PT14.10.2008
Former [2009/07]AT14.05.2008
FI14.05.2008
NL14.05.2008
SI14.05.2008
SE14.08.2008
ES25.08.2008
Former [2008/50]AT14.05.2008
FI14.05.2008
NL14.05.2008
SI14.05.2008
ES25.08.2008
Former [2008/47]SI14.05.2008
ES25.08.2008
Former [2008/44]SI14.05.2008
Cited inInternational search[A]WO9300863  (RANOUX CLAUDE [US]) [A] 3 * abstract *;
 [A]WO0138493  (NOVO NORDISK AS [DK]) [A] 4,18-20 * examples 1,2 * * claim 1 *;
 [A]WO0176360  (NOVO NORDISK AS [DK], et al) [A] 8,27 * claim - *;
 [X]  - REBECKA E. THOMAS ET AL, "Differential Effects of Specific Phosphodiesterase Isoenzyme Inhibitors on Bovine Oocyte Meiotic Maturation", DEVELOPMENTAL BIOLOGY, (2002), vol. 244, pages 215 - 225, XP002268443 [X] 1-30 * the whole document * * page 219, column 2; figure 3 * * page 222, column 1 *

DOI:   http://dx.doi.org/10.1006/dbio.2002.0609
 [A]  - MIKKELSEN A L ET AL, "Possible factors affecting the development of oocytes in in-vitro maturation.", MEDLINE, (200012), Database accession no. NLM11263532, XP002268446 [A] 22,23,29 * abstract *
    [ ] - HUMAN REPRODUCTION (OXFORD, ENGLAND) ENGLAND DEC 2000, (200012), vol. 15 Suppl 5, ISSN 0268-1161, pages 11 - 17
 [A]  - A. WIERSMA ET AL, "Phosphodiesterase 3 Inhibitors Suppress Oocyte Maturation and Consequent Pregnance without Affecting Ovulation and Cyclicity in Rodents", J. CLIN. INVEST., (199808), vol. 102, no. 3, pages 532 - 537, XP002268444 [A] 9 * the whole document *

DOI:   http://dx.doi.org/10.1172/JCI2566
 [A]  - A. TSAFRIRI ET AL, "Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors", DEVELOPMENTAL BIOLOGY, (1996), vol. 178, pages 393 - 402, XP002268445 [A] 1-30 * page 395, column 1, line 27 - line 33 *

DOI:   http://dx.doi.org/10.1006/dbio.1996.0226
 [PX]  - NOGUEIRA D ET AL, "Effect of phosphodiesterase type 3 inhibitor on developmental competence of immature mouse oocytes in vitro.", MEDLINE, (200312), Database accession no. NLM12930710, XP002268447 [PX] 1-30 * abstract *
    [ ] - BIOLOGY OF REPRODUCTION. UNITED STATES DEC 2003, (200312), vol. 69, no. 6, ISSN 0006-3363, pages 2045 - 2052
 [PX]  - NOGUEIRA DANIELA ET AL, "Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro.", MEDLINE, (200309), Database accession no. NLM12773402, XP002268448 [PX] 1-30 * abstract *
    [ ] - BIOLOGY OF REPRODUCTION. UNITED STATES SEP 2003, (200309), vol. 69, no. 3, ISSN 0006-3363, pages 1042 - 1052
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.