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Extract from the Register of European Patents

EP About this file: EP1585972

EP1585972 - USE OF GENE EXPRESSION MARKERS FOR ASSESSING CARDIAC ALLOGRAFT REJECTION [Right-click to bookmark this link]
Former [2005/42]METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION
[2012/39]
StatusNo opposition filed within time limit
Status updated on  24.01.2014
Database last updated on 18.05.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
XDx, Inc.
750 Gateway Boulevard Suite H
San Francisco CA 94080 / US
[2007/52]
Former [2005/42]For all designated states
Expression Diagnostics, Inc.
750 Gateway Boulevard, Suite H
South San Francisco, CA 94080 / US
Inventor(s)01 / WOHLGEMUTH, Jay
1165 Monte Rosa Drive
Menlo Park, CA 94025 / US
02 / FRY, Kirk
2604 Ross Road
Palo Alto, CA 94303 / US
03 / WOODWARD, Robert
1828 Rheem Court
Pleasanton, CA 94558 / US
04 / LY, Ngoc
2000 Crystal Springs Road 15-14
San Bruno, CA 94066 / US
05 / PRENTICE, James
1414 Polk Street
San Francisco, California 94109 / US
06 / MORRIS, MacDonald
34 Lloyden Drive
Atherton, CA 94027 / US
07 / ROSENBERG, Steven
2323 Bywood Drive
Oakland, CA 94682 / US
 [2005/42]
Representative(s)Holmberg-Schwindt, Tor Martin, et al
Bergenstrahle & Lindvall AB
P.O. Box 17704
118 93 Stockholm / SE
[N/P]
Former [2013/12]Holmberg, Martin Tor, et al
Bergenstråhle & Lindvall AB P.O. Box 17704
118 93 Stockholm / SE
Former [2005/42]Holmberg, Martin Tor, et al
Bergenstrahle & Lindvall AB P.O. Box 17704
118 93 Stockholm / SE
Application number, filing date03799755.824.04.2003
[2005/42]
WO2003US12946
Priority number, dateUS2002013183124.04.2002         Original published format: US 131831
US2002032589920.12.2002         Original published format: US 325899
[2005/42]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004042346
Date:21.05.2004
Language:EN
[2004/21]
Type: A2 Application without search report 
No.:EP1585972
Date:19.10.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 21.05.2004 takes the place of the publication of the European patent application.
[2005/42]
Type: B1 Patent specification 
No.:EP1585972
Date:20.03.2013
Language:EN
[2013/12]
Search report(s)International search report - published on:US24.11.2005
(Supplementary) European search report - dispatched on:EP18.10.2007
ClassificationIPC:C12Q1/68, G01N33/564, G01N33/567, G01N33/68
[2012/39]
CPC:
C12Q1/6883 (EP,US); C12Q1/6881 (EP,US); C12Q1/6888 (EP,US);
G01N33/564 (EP,US); G01N33/6863 (EP,US); C12Q2600/158 (EP,US);
G01N2800/245 (EP,US) (-)
Former IPC [2006/04]C12Q1/68, G01N33/567, G01N33/53, G01N24/08, C12P19/34
Former IPC [2005/42]G01N1/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/42]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:VERWENDUNG VON GENEXPRESSIONMARKERN ZUR FESTSTELLUNG VON ALLOGRAFT-ABSTOSSUNG DES HERZENS[2012/39]
English:USE OF GENE EXPRESSION MARKERS FOR ASSESSING CARDIAC ALLOGRAFT REJECTION[2012/39]
French:UTILISATION DE MARQUEURS GENETIQUES D'EXPRESSION POUR L'EVALUATION DU REJET D'UNE ALLOGREFFE CARDIAQUE[2012/39]
Former [2005/42]VERFAHREN UND ZUSAMMENSETZUNGEN ZUR DIAGNOSE UND ÜBERWACHUNG VON TRANSPLANTATABSTOSSUNG
Former [2005/42]METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION
Former [2005/42]METHODES ET COMPOSITIONS PERMETTANT DE DIAGNOSTIQUER ET DE SURVEILLER LE REJET D'UN GREFFON
Entry into regional phase23.11.2004National basic fee paid 
23.11.2004Search fee paid 
23.11.2004Designation fee(s) paid 
23.11.2004Examination fee paid 
Examination procedure23.11.2004Examination requested  [2005/42]
21.01.2005Amendment by applicant (claims and/or description)
17.03.2008Despatch of a communication from the examining division (Time limit: M06)
16.09.2008Reply to a communication from the examining division
17.12.2009Despatch of a communication from the examining division (Time limit: M06)
14.06.2010Reply to a communication from the examining division
24.02.2011Despatch of a communication from the examining division (Time limit: M06)
13.10.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
13.12.2011Reply to a communication from the examining division
08.02.2012Despatch of a communication from the examining division (Time limit: M06)
20.08.2012Reply to a communication from the examining division
12.11.2012Communication of intention to grant the patent
07.02.2013Fee for grant paid
07.02.2013Fee for publishing/printing paid
Divisional application(s)EP08016970.9  / EP2194145
EP10157687.4  / EP2253719
EP10183179.0  / EP2292786
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.03.2008
Opposition(s)02.01.2014No opposition filed within time limit [2014/09]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
13.12.2011Request for further processing filed
13.12.2011Full payment received (date of receipt of payment)
Request granted
23.12.2011Decision despatched
Fees paidRenewal fee
13.04.2005Renewal fee patent year 03
17.03.2006Renewal fee patent year 04
12.04.2007Renewal fee patent year 05
28.03.2008Renewal fee patent year 06
16.04.2009Renewal fee patent year 07
25.03.2010Renewal fee patent year 08
12.04.2011Renewal fee patent year 09
28.03.2012Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU24.04.2003
AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
DK20.03.2013
EE20.03.2013
FI20.03.2013
IT20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
TR20.03.2013
IE24.04.2013
LU24.04.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
[2015/34]
Former [2015/32]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
DK20.03.2013
EE20.03.2013
FI20.03.2013
IT20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
TR20.03.2013
IE24.04.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2014/20]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
DK20.03.2013
EE20.03.2013
FI20.03.2013
IT20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
IE24.04.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2014/11]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
DK20.03.2013
EE20.03.2013
FI20.03.2013
IT20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2014/09]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
DK20.03.2013
EE20.03.2013
FI20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2014/08]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
EE20.03.2013
FI20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
CH30.04.2013
LI30.04.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2014/03]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
EE20.03.2013
FI20.03.2013
MC20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2013/52]AT20.03.2013
BE20.03.2013
CY20.03.2013
CZ20.03.2013
EE20.03.2013
FI20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2013/49]AT20.03.2013
BE20.03.2013
CZ20.03.2013
EE20.03.2013
FI20.03.2013
NL20.03.2013
RO20.03.2013
SE20.03.2013
SI20.03.2013
SK20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2013/48]AT20.03.2013
BE20.03.2013
EE20.03.2013
FI20.03.2013
NL20.03.2013
SE20.03.2013
SI20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2013/47]BE20.03.2013
FI20.03.2013
SE20.03.2013
SI20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
PT22.07.2013
Former [2013/44]BE20.03.2013
FI20.03.2013
SE20.03.2013
SI20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
Former [2013/37]FI20.03.2013
SE20.03.2013
SI20.03.2013
BG20.06.2013
GR21.06.2013
ES01.07.2013
Former [2013/36]SE20.03.2013
BG20.06.2013
ES01.07.2013
Former [2013/34]SE20.03.2013
BG20.06.2013
Documents cited:Search[X]WO9716568  (BOWIE LEMUEL J [US]) [X] 1-8 * sequences 8-10 * * SEQ ID NO: 86 *;
 [X]WO0058473  (CURAGEN CORP [US], et al) [X] 1-8 * SEQ ID NO: 94 *;
 [X]WO0157182  (HUMAN GENOME SCIENCES INC [US], et al) [X] 1-8 * sequence 35302 * * SEQ ID NO: 107 *;
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DOI:   http://dx.doi.org/10.1016/S0378-1119(97)00260-6
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DOI:   http://dx.doi.org/10.1074/jbc.273.22.13663
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DOI:   http://dx.doi.org/10.1074/jbc.M100156200
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DOI:   http://dx.doi.org/10.1073/pnas.96.6.2907
 [A]  - DIETZ ALLAN B ET AL, "Maturation of human monocyte-derived dendritic cells studied by microarray hybridization", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20000907), vol. 275, no. 3, ISSN 0006-291X, pages 731 - 738, XP002236579 [A] * the whole document * * table 1 *

DOI:   http://dx.doi.org/10.1006/bbrc.2000.3372
 [A]  - KRAUSE S W ET AL, "Carboxypeptidase M as marker of macrophage maturation", IMMUNOLOGICAL REVIEWS, MUNKSGAARD, (1998), vol. 161, ISSN 0105-2896, pages 119 - 127, XP002272949 [A] * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1600-065X.1998.tb01576.x
 [A]  - GORCZYNSKI R M ET AL, "CORRELATION OF PERIPHERAL BLOOD LYMPHOCYTE AND INTRAGRAFT CYTOKINE MRNA EXPRESSION WITH REJECTION IN ORTHOTOPIC LIVER TRANSPLANTATION", SURGERY, C.V. MOSBY CO., ST. LOUIS,, US, (199609), vol. 120, no. 3, ISSN 0039-6060, pages 496 - 502, XP008005398 [A] * the whole document *

DOI:   http://dx.doi.org/10.1016/S0039-6060(96)80069-9
 [A]  - DUGRE F J ET AL, "Cytokine and cytotoxic molecule gene expression determined in peripheral blood mononuclear cells in the diagnosis of acute renal rejection", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, (20001015), vol. 70, no. 7, ISSN 0041-1337, pages 1074 - 1080, XP002434104 [A] * the whole document *

DOI:   http://dx.doi.org/10.1097/00007890-200010150-00014
 [A]  - VASCONCELLOS L M ET AL, "CYTOTOXIC LYMPHOCYTE GENE EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES CORRELATES WITH REJECTING RENAL ALLOGRAFTS", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, (19980915), vol. 66, no. 5, ISSN 0041-1337, pages 562 - 566, XP009083920 [A] * the whole document *

DOI:   http://dx.doi.org/10.1097/00007890-199809150-00002
 [A]  - GRIFFITHS G M ET AL, "Granzyme A and perforin as markers for rejection in cardiac transplantation", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, (1991), vol. 21, ISSN 0014-2980, pages 687 - 692, XP002092298 [A] * the whole document *

DOI:   http://dx.doi.org/10.1002/eji.1830210322
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DOI:   http://dx.doi.org/10.1073/pnas.91.5.1805
 [X]  - "Homo sapiens cDNA clone:CBMAXF06, 5'end, expressed in human CD34+ hematopoietic stem/progenitor cells.", EMBL, (20001010), Database accession no. AV742425, URL: EBI, XP002452877 [X] 1-8 * abstract * * SEQ ID NO: 86 *
 [X]  - "Human messenger RNA for beta-globin.", EMBL, (19820609), Database accession no. V00497, URL: EBI, XP002452782 [X] 1-8 * SEQ ID NO: 86 *
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 [X]  - "human STS WI-6978.", EMBL, (19950615), Database accession no. G06338, URL: EBI, XP002452784 [X] 1-8 * abstract * * SEQ ID NO: 87 *
 [X]  - "EST381430 MAGE resequences, MAGK Homo sapiens cDNA, mRNA sequence.", EMBL, (20000608), Database accession no. AW969353, URL: EBI, XP002452785 [X] 1-8 * abstract * * SEQ ID NO: 94 *
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International search[A]US5120525  (GOLDENBERG MILTON D [US])
Examination   - MORGUN A ET AL, "CYTOKINE AND TLRC7 MRNA EXPRESSION DURING ACUTE REJECTION IN CARDIAC ALLOGRAFT RECIPIENTS", TRANSPLANTATION PROCEEDINGS, ELSEVIER INC, ORLANDO, FL; US, (20010201), vol. 1/02, no. 33, doi:10.1016/S0041-1345(00)02613-0, ISSN 0041-1345, page 1610/1611, XP001073543

DOI:   http://dx.doi.org/10.1016/S0041-1345(00)02613-0
    - LAGOO ANAND S ET AL, "Semiquantitative measurement of cytokine messenger RNA in endomyocardium and peripheral blood mononuclear cells from human heart transplant recipients", JOURNAL OF HEART AND LUNG TRANSPLANTATION, MOSBY-YEAR BOOK, INC., ST LOUIS, MO, US, (19960201), vol. 15, no. 2, ISSN 1053-2498, pages 206 - 217, XP009138751
by applicant   - NATURE, vol. 406, pages 747 - 752
    - MENDEL ET AL., ANTICANCER DRUG DES, (2000), vol. 15, pages 29 - 41
    - WILSON, CURR MED CHEM, (2000), vol. 7, pages 73 - 98
    - HAMBY; SHOWWALTER, PHARMACOL THER, (1999), vol. 82, pages 169 - 93
    - SHIMAZAWA, CURR OPIN STRUCT BIOL, (1998), vol. 8, pages 451 - 8
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.