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Extract from the Register of European Patents

EP About this file: EP1573000

EP1573000 - CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.03.2009
Database last updated on 27.07.2024
Most recent event   Tooltip04.07.2014Lapse of the patent in a contracting state
New state(s): IT		published on 06.08.2014  [2014/32]
Applicant(s)For all designated states
AstraZeneca AB
151 85 Södertälje / SE
[2005/37]
Inventor(s)01 / ANDERSON, Marie
Styrsavägem 18
SE-437 93 Lindome / SE
02 / FISHER, Stewart, Lindsay
18 Harrington Road
Framingham, MA 01701 / US
03 / FOLMER, Rutger, Henk, Adriaan
Bräckavägen 45
437 42 Lindome / SE
04 / KERN, Gunther
71 Ravenswood Road
Waltham, MA 02453 / US
05 / LUNDQVIST, Rolf, Tomas
Övre Djupedalsgatan 9c
SE-413 07 Gothenburg / SE
06 / NEWTON, David, Trevor
696 Mathieu Way
Ottawa, Ontario K4A 2S4 / CA
07 / XUE, Yafeng
Askims svedjev. 24
SE-436 42 Askim / SE
 [2005/37]
Application number, filing date03810884.108.12.2003
[2005/37]
WO2003US38977
Priority number, dateUS20020435167P20.12.2002         Original published format: US 435167 P
US20020435272P20.12.2002         Original published format: US 435272 P
US20020435087P20.12.2002         Original published format: US 435087 P
US20020435527P20.12.2002         Original published format: US 435527 P
[2005/37]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004061097
Date:22.07.2004
Language:EN
[2004/30]
Type: A2 Application without search report 
No.:EP1573000
Date:14.09.2005
Language:EN
The application published by WIPO in one of the EPO official languages on 22.07.2004 takes the place of the publication of the European patent application.
[2005/37]
Type: B1 Patent specification 
No.:EP1573000
Date:07.05.2008
Language:EN
[2008/19]
Search report(s)International search report - published on:EP23.09.2004
ClassificationIPC:C12N9/90, C12N15/61, G01N33/573
[2005/37]
CPC:
C12N9/90 (EP,US); C07K2299/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2005/37]
Extension statesALNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:KRISTALLSTRUKTUR DER GLUTAMATRACEMASE (MURI)[2005/37]
English:CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI)[2005/37]
French:STRUCTURE CRISTALLINE DE GLUTAMATE RACEMASE (MURI)[2005/37]
Entry into regional phase21.06.2005National basic fee paid 
21.06.2005Designation fee(s) paid 
21.06.2005Examination fee paid 
Examination procedure22.06.2004Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.06.2005Examination requested  [2005/37]
11.01.2006Despatch of a communication from the examining division (Time limit: M06)
11.07.2006Reply to a communication from the examining division
25.08.2006Despatch of a communication from the examining division (Time limit: M04)
14.12.2006Reply to a communication from the examining division
30.01.2007Despatch of a communication from the examining division (Time limit: M04)
31.05.2007Reply to a communication from the examining division
22.11.2007Communication of intention to grant the patent
03.03.2008Fee for grant paid
03.03.2008Fee for publishing/printing paid
Opposition(s)10.02.2009No opposition filed within time limit [2009/16]
Fees paidRenewal fee
21.06.2005Renewal fee patent year 03
02.01.2007Renewal fee patent year 04
02.01.2008Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT07.05.2008
BE07.05.2008
CY07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
TR07.05.2008
BG07.08.2008
GR08.08.2008
PT07.10.2008
HU08.11.2008
GB08.12.2008
IE08.12.2008
IT08.12.2008
LU08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
[2014/32]
Former [2010/49]AT07.05.2008
BE07.05.2008
CY07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
TR07.05.2008
BG07.08.2008
GR08.08.2008
PT07.10.2008
HU08.11.2008
GB08.12.2008
IE08.12.2008
LU08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/37]AT07.05.2008
BE07.05.2008
CY07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
TR07.05.2008
BG07.08.2008
PT07.10.2008
HU08.11.2008
GB08.12.2008
IE08.12.2008
LU08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/34]AT07.05.2008
BE07.05.2008
CY07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
HU08.11.2008
GB08.12.2008
IE08.12.2008
LU08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/32]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
GB08.12.2008
IE08.12.2008
LU08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/31]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
GB08.12.2008
IE08.12.2008
ES09.12.2008
SE09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/21]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
GB08.12.2008
IE08.12.2008
ES09.12.2008
CH31.12.2008
FR31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/19]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
GB08.12.2008
IE08.12.2008
ES09.12.2008
CH31.12.2008
LI31.12.2008
MC31.12.2008
Former [2010/01]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
GB08.12.2008
IE08.12.2008
CH31.12.2008
LI31.12.2008
MC31.12.2008
Former [2009/47]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
IE08.12.2008
CH31.12.2008
LI31.12.2008
MC31.12.2008
Former [2009/35]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
MC31.12.2008
Former [2009/23]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
BG07.08.2008
PT07.10.2008
Former [2009/22]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
EE07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
PT07.10.2008
Former [2009/14]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
FI07.05.2008
NL07.05.2008
RO07.05.2008
SI07.05.2008
SK07.05.2008
PT07.10.2008
Former [2009/12]AT07.05.2008
BE07.05.2008
CZ07.05.2008
DK07.05.2008
FI07.05.2008
NL07.05.2008
SI07.05.2008
PT07.10.2008
Former [2009/09]AT07.05.2008
DK07.05.2008
FI07.05.2008
NL07.05.2008
SI07.05.2008
PT07.10.2008
Former [2008/49]AT07.05.2008
FI07.05.2008
NL07.05.2008
SI07.05.2008
Former [2008/44]SI07.05.2008
Cited inInternational search[X]WO0214261  (LILLY CO ELI [US], et al) [X] 36-40,45-47 * the whole document *;
 [DX]  - HWANG KWANG YEON ET AL, "Structure and mechanism of glutamate racemase from Aquifex pyrophilus", NATURE STRUCTURAL BIOLOGY, (199905), vol. 6, no. 5, ISSN 1072-8368, pages 422 - 426, XP002286544 [DX] 1-40,45-47 * the whole document *

DOI:   http://dx.doi.org/10.1038/8223
 [X]  - HWANG KWANG YEON ET AL, "Crystallization and preliminary X-ray analysis of glutamate racemase from Aquifex pyrophilus, a hyperthermophilic bacterium", ACTA CRYSTALLOGRAPHICA SECTION D BIOLOGICAL CRYSTALLOGRAPHY, (199904), vol. 55, no. 4, ISSN 0907-4449, pages 927 - 928, XP008031528 [X] 1-40,45-47 * the whole document *
 [X]  - DE DIOS ALFONSO ET AL, "4-substituted D-glutamic acid analogues: The first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activity", JOURNAL OF MEDICINAL CHEMISTRY, (20020926), vol. 45, no. 20, ISSN 0022-2623, pages 4559 - 4570, XP002286546 [X] 36-40,45-47 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm020901d
 [X]  - GLAVAS S ET AL, "The inhibition of glutamate racemase by d-N-hydroxyglutamate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19970909), vol. 7, no. 17, ISSN 0960-894X, pages 2265 - 2270, XP004136426 [X] 45-47 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(97)00413-7
 [X]  - KIM WOO-CHANG ET AL, "Isolation of peptide ligands that inhibit glutamate racemase activity from a random phage display library", JOURNAL OF BIOMOLECULAR SCREENING, (200012), vol. 5, no. 6, ISSN 1087-0571, pages 435 - 440, XP008032389 [X] 45-47 * the whole document *

DOI:   http://dx.doi.org/10.1177/108705710000500606
 [X]  - TANNER MARTIN E ET AL, "The synthesis and stability of aziridino-glutamate, an irreversible inhibitor of glutamate racemase", TETRAHEDRON LETTERS, (1994), vol. 35, no. 24, ISSN 0040-4039, pages 4073 - 4076, XP002286565 [X] 45-47 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)73115-7
 [A]  - GLAVAS SUZANA ET AL, "Active site residues of glutamate racemase", BIOCHEMISTRY, (20010529), vol. 40, no. 21, ISSN 0006-2960, pages 6199 - 6204, XP002286547 [A] 1-40,45-47 * the whole document *

DOI:   http://dx.doi.org/10.1021/bi002703z
 [A]  - PUCCI M J ET AL, "THE ESCHERICHIA COLI DGA (MURI) PROTEIN SHARES BIOLOGICAL ACTIVITY AND STRUCTURAL DOMAINS WITH THE PEDIOCOCCUS PENTOSACEUS GLUTAMATE RACEMASE", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, (199401), vol. 176, no. 2, ISSN 0021-9193, pages 528 - 530, XP001035226 [A] 1-40,45-47 * the whole document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.