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Extract from the Register of European Patents

EP About this file: EP1604970

EP1604970 - 2-(Biphenyl-3-yl)-carboxylic acids of gamma-secretase-modulating activity [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.01.2007
Database last updated on 30.09.2024
Most recent event   Tooltip26.01.2007Application deemed to be withdrawnpublished on 28.02.2007  [2007/09]
Applicant(s)For all designated states
CELLZOME AG
Meyerhofstrasse 1
69117 Heidelberg / DE
[2005/50]
Inventor(s)01 / Ramsden, Nigel
Sparrows Lodge, Green Lane
Fowlmere, Royston, Herts SG8 7QP / GB
02 / Wilson, Francis
71 Moorlands, Welwyn Garden City
Herts, AL7 4QJ / GB
03 / Reid, Alison
Marlborough House, 60 High Street
Cottenham, CB4 8SA / GB
04 / Reader, Valerie
5 Coles Lane
Linton, Cambridge CB1 6JS / GB
05 / Miller, Warren
5 Saffron Court, Station Rd
Saffron Walden, Essex, CB11 3HB / GB
06 / Harrison, Richard John
5 Saffron Court, Sation Rd
Saffron Walden, Essex, CB11 3HB / GB
07 / Sunose, Mihiro
33 Brewery Road
Pampisford, Cambridge, CB2 4EN / GB
08 / Hernandez-Perni, Remedios
1 Hulatt Rd
Cambridge CB1 8TH / GB
09 / Major, Jeremy
10 Chigwell Court
Cambridge CB5 8TY / GB
10 / Boussard, Cyrille
32 Hornbook, Saffron Place, Radwinter RD
Saffron Walden, Essex CB11 3JN / GB
11 / Smelt, Kathryn
25 Rosebery Court
Rosebery Avenue, London, EC1R 5HP / GB
12 / Taylor, Jess
12 The Coppens
Stotfold, Hitchin, Hertfordshire SG5 4PJ / GB
13 / LeFormal, Adeline
14 Ozier Court
Saffron Walden CB11 4BH / GB
14 / Cansfield, Andrew
4 The Limes, Harston
Cambridge CB2 5QT / GB
15 / Burckhardt, Svenja
2 Grapevine Cottages
Boxworth, Cambridge CB3 8NG / GB
 [2005/50]
Representative(s)Huhn, Michael, et al
Patentanwälte
Isenbruck Bösl Hörschler PartG mbB
Eastsite One
Seckenheimer Landstrasse 4
68163 Mannheim / DE
[N/P]
Former [2005/50]Huhn, Michael, et al
Isenbruck Bösl Hörschler Wichmann Huhn Patentanwälte Theodor-Heuss-Anlage 12
68165 Mannheim / DE
Application number, filing date04011851.519.05.2004
[2005/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1604970
Date:14.12.2005
Language:EN
[2005/50]
Search report(s)(Supplementary) European search report - dispatched on:EP04.01.2005
ClassificationIPC:C07C57/58, A61K31/192, A61P25/28
[2005/50]
CPC:
C07C57/58 (EP); A61P25/28 (EP); C07C59/64 (EP)
Designated contracting states[2006/34]
Former [2005/50]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:2-(Biphenyl-3-yl)-carbonsäuren mit gamma-Sekretase-modulierender Wirkung[2005/50]
English:2-(Biphenyl-3-yl)-carboxylic acids of gamma-secretase-modulating activity[2005/50]
French:Acides 2-(biphenyl-3-yl)-carboxyliques avec une activité modulante de gamma-secretase[2005/50]
Examination procedure15.06.2006Application deemed to be withdrawn, date of legal effect  [2007/09]
10.10.2006Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2007/09]
Fees paidPenalty fee
Penalty fee Rule 85a EPC 1973
21.07.2006AT   M01   Not yet paid
21.07.2006BE   M01   Not yet paid
21.07.2006BG   M01   Not yet paid
21.07.2006CH   M01   Not yet paid
21.07.2006CY   M01   Not yet paid
21.07.2006CZ   M01   Not yet paid
21.07.2006DE   M01   Not yet paid
21.07.2006DK   M01   Not yet paid
21.07.2006EE   M01   Not yet paid
21.07.2006ES   M01   Not yet paid
21.07.2006FI   M01   Not yet paid
21.07.2006FR   M01   Not yet paid
21.07.2006GB   M01   Not yet paid
21.07.2006GR   M01   Not yet paid
21.07.2006HU   M01   Not yet paid
21.07.2006IE   M01   Not yet paid
21.07.2006IT   M01   Not yet paid
21.07.2006LU   M01   Not yet paid
21.07.2006MC   M01   Not yet paid
21.07.2006NL   M01   Not yet paid
21.07.2006PL   M01   Not yet paid
21.07.2006PT   M01   Not yet paid
21.07.2006RO   M01   Not yet paid
21.07.2006SE   M01   Not yet paid
21.07.2006SI   M01   Not yet paid
21.07.2006SK   M01   Not yet paid
21.07.2006TR   M01   Not yet paid
Penalty fee Rule 85b EPC 1973
21.07.2006M01   Not yet paid
Additional fee for renewal fee
31.05.200603   M06   Not yet paid
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]JPS56123935  ;
 [X]WO0178721  (MAYO FOUNDATION [US], et al) [X] 1-11,13 * Abstract; page 2, line 26 to page 3, line 8; claims 1, 5, 6. *;
 [X]WO03055860  (RIBOTARGETS LTD [GB], et al) [X] 1,2,12 * Pages 131-132: 4'-fluoro-biphenyl-4-ylacetic acid. *;
 [E]WO2004073705  (CHIESI FARMA SPA [IT], et al) [E] 1-11,13* Abstract; claims; examples. *;
 [X]  - MAITRA, U.; BRESLOW, R., "Conversion of the Cholesterol Sidechain to a 17-Acetyl Group by Remote Chlorination Reactions", TETRAHEDRON LETT., (1986), vol. 27, no. 27, pages 3087 - 3090, XP002311404 [X] 1,2 * Page 3089, compounds 4, 6; and compounds occurring in the conversion from 4 to 5. *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)84722-X
 [X]  - BUCHECKER, RICHARD ET AL, "Some studies on liquid crystals incorporating three membered linking units combined with 1,3 linked rings", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 1996:338710, URL: STN, XP002311407 [X] 1,2 * Abstract and CAS-RN 178812-91-4. *
 [XY]  - TAMURA, Y. ET AL., "Nonsteroidal Antiinflammatory Agents. 2.", J. MED. CHEM., (1981), vol. 24, pages 43 - 47, XP002311405 [X] 1,2,4,5,11,13 * Compounds 4h, 4j, 4p, 4q, 5h, 5j, 5p, and 5q. * [Y] 6-10,12

DOI:   http://dx.doi.org/10.1021/jm00133a010
 [XY]  - PATENT ABSTRACTS OF JAPAN, (19811224), vol. 0052, no. 04, Database accession no. (C - 085), & JP56123935 A 19810929 (NIPPON SHINYAKU CO LTD) [X] 1,2,4,5,11,13 * Abstract. * [Y] 6-10,12
 [YD]  - ROGERS J ET AL, "CLINICAL TRIAL OF INDOMETHACIN IN ALZHEIMER'S DISEASE", NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, US, (199308), vol. 43, no. 8, ISSN 0028-3878, pages 1609 - 1611, XP002070235 [YD] 6-10,12 * Abstract; discussion. *
 [YD]  - ERIKSEN, J. L. ET AL., "NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower A-beta-42 in vivo", J. CLIN. INVEST., (2003), vol. 112, no. 3, pages 440 - 449, XP002311406 [YD] 6-10,12 * The whole document. *

DOI:   http://dx.doi.org/10.1172/JCI200318162
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.