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Extract from the Register of European Patents

EP About this file: EP1612224

EP1612224 - Novel monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.01.2013
Database last updated on 06.07.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
B.R.A.H.M.S GmbH
Neuendorfstrasse 25
16761 Hennigsdorf / DE
[2010/39]
Former [2006/01]For all designated states
B.R.A.H.M.S Aktiengesellschaft
Neuendorfstrasse 25
16761 Hennigsdorf / DE
Inventor(s)01 / Bergmann, Andreas, Dr.
Baumläuferweg 47
12351 Berlin / DE
02 / Morgenthaler, Nils, G.
Heiligenseestrasse 121 F
13503 Berlin / DE
03 / Vassart, Gilbert
113 avenue Lambeau
1200 Bruxelles / BE
04 / Costagliola, Sabine
31 rue de Menuet
1080 Bruxelles / BE
 [2006/01]
Representative(s)Andrae, Steffen, et al
Andrae l Westendorp
Patentanwälte Partnerschaft
Balanstrasse 55
81541 München / DE
[N/P]
Former [2006/01]Andrae, Steffen, et al
Andrae Flach Haug Balanstrasse 55
81541 München / DE
Application number, filing date04015239.929.06.2004
[2006/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1612224
Date:04.01.2006
Language:EN
[2006/01]
Type: B1 Patent specification 
No.:EP1612224
Date:07.03.2012
Language:EN
[2012/10]
Search report(s)(Supplementary) European search report - dispatched on:EP23.11.2004
ClassificationIPC:C07K16/28, A61K39/395
[2006/01]
CPC:
C07K16/2869 (EP,US); A61P27/02 (EP); A61P35/00 (EP);
A61P35/04 (EP); A61P43/00 (EP); A61P5/16 (EP);
G01N33/564 (EP,US); G01N33/76 (EP,US); A61K2039/505 (EP,US);
C07K2317/34 (EP,US); C07K2317/75 (EP,US); C07K2317/76 (EP,US);
C07K2317/92 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/01]
TitleGerman:Neue monoklonale Schilddrüsen-stimulierende oder -blockierende Antikörper, korrespondierende Peptidesquenzen ihrer variablen Regionen, und deren Verwendung in Diagnostik, präventiver und therapeutischer Medizin[2006/01]
English:Novel monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine[2006/01]
French:Nouvel anticorps monoclonal stimulant ou blocquant la thyroide, les séquences peptidiques correspondant à ses régions variables, et leur utilisation dans le diagnostic ou en médecine préventive et thérapeutique.[2006/01]
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure24.02.2006Examination requested  [2006/19]
28.04.2006Despatch of a communication from the examining division (Time limit: M06)
08.11.2006Reply to a communication from the examining division
25.07.2007Despatch of a communication from the examining division (Time limit: M06)
31.01.2008Reply to a communication from the examining division
16.02.2009Despatch of a communication from the examining division (Time limit: M06)
26.08.2009Reply to a communication from the examining division
18.05.2011Cancellation of oral proceeding that was planned for 20.05.2011
20.05.2011Date of oral proceedings (cancelled)
21.09.2011Communication of intention to grant the patent
23.01.2012Fee for grant paid
23.01.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.04.2006
Opposition(s)10.12.2012No opposition filed within time limit [2013/07]
Fees paidRenewal fee
30.06.2006Renewal fee patent year 03
29.06.2007Renewal fee patent year 04
27.06.2008Renewal fee patent year 05
29.06.2009Renewal fee patent year 06
28.06.2010Renewal fee patent year 07
28.06.2011Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.06.2004
CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
TR07.03.2012
BG07.06.2012
GR08.06.2012
IE29.06.2012
LU29.06.2012
MC30.06.2012
PT09.07.2012
[2014/34]
Former [2014/27]CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
TR07.03.2012
BG07.06.2012
GR08.06.2012
IE29.06.2012
LU29.06.2012
MC30.06.2012
PT09.07.2012
Former [2014/21]CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
TR07.03.2012
BG07.06.2012
GR08.06.2012
IE29.06.2012
MC30.06.2012
PT09.07.2012
Former [2013/33]CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
BG07.06.2012
GR08.06.2012
IE29.06.2012
MC30.06.2012
PT09.07.2012
Former [2013/20]CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
GR08.06.2012
IE29.06.2012
MC30.06.2012
PT09.07.2012
Former [2013/08]CY07.03.2012
CZ07.03.2012
DK07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
GR08.06.2012
MC30.06.2012
PT09.07.2012
Former [2013/01]CY07.03.2012
CZ07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
GR08.06.2012
PT09.07.2012
Former [2012/50]CY07.03.2012
CZ07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
SK07.03.2012
GR08.06.2012
Former [2012/49]CY07.03.2012
CZ07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
PL07.03.2012
RO07.03.2012
SE07.03.2012
SI07.03.2012
GR08.06.2012
Former [2012/48]CY07.03.2012
EE07.03.2012
FI07.03.2012
NL07.03.2012
SE07.03.2012
GR08.06.2012
Former [2012/41]CY07.03.2012
FI07.03.2012
NL07.03.2012
GR08.06.2012
Former [2012/37]FI07.03.2012
NL07.03.2012
GR08.06.2012
Former [2012/36]NL07.03.2012
GR08.06.2012
Former [2012/35]NL07.03.2012
Documents cited:Search[X]WO9523865  (GENENTECH INC [US], et al) [X] 19,20* the whole document *;
 [A]WO0049050  (BRAHMS DIAGNOSTICA GMBH [DE], et al) [A] 1-20 * the whole document *;
 [X]WO0061637  (SMITHKLINE BEECHAM CORP [US], et al) [X] 19,20 * the whole document *;
 [X]WO03018632  (RSR LTD [GB], et al) [X] 1,2,4,9-13,17,18 * page 64, paragraph 2 * * page 65, paragraph 3 * * page 95; example 2 * * page 95, paragraph 3 - page 96, paragraph 1 * * page 98; table 1 * * page 100; table 2 *;
 [X]WO2004050708  (RSR LTD [GB], et al) [X] 1,4,9-13,17,18 * page 4, paragraph 4 - page 5, paragraph 1 * * page 5, paragraph 7 * * page 37, paragraph 4 * * page 67, paragraph 2 * * page 60, paragraph 4 * * page 68, paragraph 2 * * page 71, paragraph 2 * * page 72, paragraph 6 * * page 33, paragraph 2 * * page 49, paragraph 2 - paragraph 3 * * page 52, paragraph 2 * * page 39, paragraph 2 * * claim 105 *;
 [X]  - SANDERS J ET AL, "THYROID-STIMULATING MONOCLONAL ANTIBODIES", THYROID, MARY ANN LIEBERT, NEW YORK, NY, US, (200212), vol. 12, no. 12, ISSN 1050-7256, pages 1043 - 1050, XP009015389 [X] 1,4,9-13,17,18 * abstract * * page 1045, column L, paragraph 4 - paragraph 5 * * page 1046, column R, paragraph 3 * * figures 2,3 * * page 1048, column L, paragraph 2 - paragraph 5 *

DOI:   http://dx.doi.org/10.1089/105072502321085135
 [A]  - SANDERS J ET AL, "Human monoclonal thyroid stimulating autoantibody.", LANCET (NORTH AMERICAN EDITION), (20030712), vol. 362, no. 9378, ISSN 0099-5355, pages 126 - 128, XP004438162 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0140-6736(03)13866-4
 [A]  - COSTAGLIOLA S ET AL, "Generation of a mouse monoclonal TSH receptor antibody with stimulating activity.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20021220), vol. 299, no. 5, ISSN 0006-291X, pages 891 - 896, XP002303966 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0006-291X(02)02762-6
 [A]  - ANDO TAKAO ET AL, "A monoclonal thyroid-stimulating antibody.", JOURNAL OF CLINICAL INVESTIGATION, (200212), vol. 110, no. 11, ISSN 0021-9738, pages 1667 - 1674, XP002303967 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1172/JCI200216991
 [A]  - KOSUGI SHINJI ET AL, "Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor", MOLECULAR ENDOCRINOLOGY, (1993), vol. 7, no. 1, ISSN 0888-8809, pages 114 - 130, XP002303968 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1210/me.7.1.114
Examination   - MORGENTHALER N G ET AL, "AFFINITY PURIFICATION AND DIAGNOSTIC USE OF TSH RECEPTOR AUTOANTIBODIES FROM HUMAN SERUM", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, (20030101), vol. 212, no. 1/02, doi:10.1016/J.MCE.2003.09.018, ISSN 0303-7207, pages 73 - 79, XP001188295

DOI:   http://dx.doi.org/10.1016/j.mce.2003.09.018
    - MINICH W B ET AL, "Antibodies to TSH-receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly distributed on the receptor.", CLINICAL AND EXPERIMENTAL IMMUNOLOGY APR 2004 LNKD- PUBMED:15030524, (200404), vol. 136, no. 1, ISSN 0009-9104, pages 129 - 136
    - SMITH B R ET AL, "TSH receptor antibodies", THYROID, MARY ANN LIEBERT, NEW YORK, NY, US, (20071001), vol. 17, no. 10, ISSN 1050-7256, pages 923 - 938, XP009111672
    - SANDERS JANE ET AL, "Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH", THYROID, MARY ANN LIEBERT, NEW YORK, NY, US, (20061201), vol. 16, no. 12, doi:10.1089/THY.2006.16.1195, ISSN 1050-7256, pages 1195 - 1206, XP009100831

DOI:   http://dx.doi.org/10.1089/thy.2006.16.1195
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.