blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1627924

EP1627924 - Method for the analysis of methylated DNA [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.02.2012
Database last updated on 20.03.2026
Most recent event   Tooltip04.07.2014Lapse of the patent in a contracting state
New state(s): IT		published on 06.08.2014  [2014/32]
Applicant(s)For all designated states
Epigenomics AG
Kleine Präsidentenstrasse 1
10178 Berlin / DE
[2011/14]
Former [2006/08]For all designated states
Epigenomics AG
Kleine Präsidentenstrasse 1
10178 Berlin / DE
Inventor(s)01 / Gütig, David
Grüntaler Strasse 18
13357 Berlin / DE
02 / Schuster, Matthias
Kastanienallee 107
13158 Berlin / DE
03 / Distler, Jürgen
Hewaldstrasse 2
10825 Berlin / DE
 [2006/08]
Representative(s)Schubert, Klemens, et al
Müller & Schubert Patentanwälte
Schlüterstrasse 37
10629 Berlin / DE
[N/P]
Former [2006/08]Schubert, Klemens, et al
Neue Promenade 5
10178 Berlin-Mitte / DE
Application number, filing date04090321.319.08.2004
[2006/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1627924
Date:22.02.2006
Language:EN
[2006/08]
Type: B1 Patent specification 
No.:EP1627924
Date:06.04.2011
Language:EN
[2011/14]
Search report(s)(Supplementary) European search report - dispatched on:EP08.08.2005
ClassificationIPC:C12Q1/68
[2006/08]
CPC:
C12Q1/6853 (EP,US); C12Q1/6858 (EP,US)
C-Set:
C12Q1/6853, C12Q2525/186, C12Q2523/125, C12Q2565/301 (EP,US);
C12Q1/6858, C12Q2525/186, C12Q2523/125, C12Q2535/125 (US,EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/08]
TitleGerman:Methode für die Analyse von methylierter DNA[2006/08]
English:Method for the analysis of methylated DNA[2006/08]
French:Méthode d'analyse de l'ADN méthylé[2006/08]
Examination procedure16.08.2006Examination requested  [2006/40]
03.11.2006Despatch of a communication from the examining division (Time limit: M04)
27.02.2007Reply to a communication from the examining division
10.05.2008Cancellation of oral proceeding that was planned for 02.06.2008
10.05.2008Minutes of oral proceedings despatched
02.06.2008Date of oral proceedings
02.06.2008Date of oral proceedings (cancelled)
10.06.2008Despatch of communication that the application is refused, reason: substantive examination {1}
14.12.2010Communication of intention to grant the patent
21.02.2011Fee for grant paid
21.02.2011Fee for publishing/printing paid
Appeal following examination07.08.2008Appeal received No.  T2355/08
02.10.2008Statement of grounds filed
15.09.2010Result of appeal procedure: remittal for grant
15.09.2010Date of oral proceedings
Opposition(s)10.01.2012No opposition filed within time limit [2012/11]
Fees paidRenewal fee
31.08.2006Renewal fee patent year 03
16.08.2007Renewal fee patent year 04
31.03.2008Renewal fee patent year 05
10.08.2009Renewal fee patent year 06
25.08.2010Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
HU06.04.2011
IT06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
LU19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
[2014/32]
Former [2013/45]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
HU06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
LU19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2013/44]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
TR06.04.2011
BG06.07.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
LU19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2013/29]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
BG06.07.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
LU19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2013/25]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
LU19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2012/35]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
IE19.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2012/20]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
CH31.08.2011
LI31.08.2011
MC31.08.2011
Former [2012/18]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
MC31.08.2011
Former [2012/11]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
PL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
Former [2012/10]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
DK06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
RO06.04.2011
SE06.04.2011
SI06.04.2011
SK06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
Former [2012/09]AT06.04.2011
BE06.04.2011
CY06.04.2011
CZ06.04.2011
EE06.04.2011
FI06.04.2011
NL06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
PL22.08.2011
Former [2012/02]AT06.04.2011
BE06.04.2011
CY06.04.2011
FI06.04.2011
NL06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
PL22.08.2011
Former [2012/01]AT06.04.2011
BE06.04.2011
CY06.04.2011
FI06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
PL22.08.2011
Former [2011/50]CY06.04.2011
FI06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
PL22.08.2011
Former [2011/49]CY06.04.2011
FI06.04.2011
SE06.04.2011
SI06.04.2011
GR07.07.2011
ES17.07.2011
PT08.08.2011
Former [2011/47]SI06.04.2011
PT08.08.2011
Former [2011/41]SI06.04.2011
Documents cited:Search[X] US2004009515  (LIU QIANG et al.) [X] 14 * table 6 *
 [A] US2003082600  (OLEK ALEXANDER et al.) [A] * the whole document *
 [A] US5786146  (HERMAN JAMES G et al.) [A] * the whole document *
 [X]   LIU QIANG ET AL: "Pyrophosphorolysis-activatable oligonucleotides may facilitate detection of rare alleles, mutation scanning and analysis of chromatin structures.", NUCLEIC ACIDS RESEARCH. 15 JAN 2002, vol. 30, no. 2, 15 January 2002 (2002-01-15), pages 598 - 604, XP002336292, ISSN: 1362-4962 [X] 14 * the whole document * * table 1 *

DOI:   http://dx.doi.org/10.1093/nar/30.2.598
 [A]   LIU QIANG ET AL: "Detection of extremely rare alleles by bidirectional pyrophosphorolysis-activated polymerization allele-specific amplification (Bi-PAP-A): measurement of mutation load in mammalian tissues.", BIOTECHNIQUES. JAN 2004, vol. 36, no. 1, January 2004 (2004-01-01), pages 156 - 166, XP001207019, ISSN: 0736-6205 [A] * the whole document *
 [A]   FRAGA M F ET AL: "DNA METHYLATION: A PROFILE OF METHODS AND APPLICATIONS", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 33, no. 3, September 2002 (2002-09-01), pages 632,634,636 - 649, XP001107174, ISSN: 0736-6205 [A] * the whole document *
 [A]   HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424 [A] * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.93.18.9821
Examination  XP002296074

DOI:   http://dx.doi.org/10.1016/S1046-2023(02)00062-2
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.