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EP1594883
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EP About this file: EP1594883
| EP1594883 - COVALENT MODIFICATION OF RNA FOR IN VITRO AND IN VIVO DELIVERY [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 17.06.2016 Database last updated on 21.05.2024 | Most recent event Tooltip | 17.06.2016 | Application deemed to be withdrawn | published on 20.07.2016 [2016/29] | Applicant(s) | For all designated states Mirus Bio Corporation 505 S. Rosa Rd. Madison, WI 53719 / US | [2006/24] |
| Former [2005/46] | For all designated states Mirus Corporation 505 South Rosa Road Madison, WI 53719 / US | Inventor(s) | 01 /
MONAHAN, Sean, D. 5610 Tolman Terrace Madison, WI 53711 / US | 02 /
BUDKER, Vladimir, G. 5141 Sunrise Ridge Tr. Middleton, WI 53562 / US | 03 /
NADER, Lisa 12050 15th Avenue NE , nr 303 Seattle, WA 98125 / US | 04 /
SUBBOTIN, Vladimir 602 Samuel Drive Madison, WI 53717 / US | 05 /
WOLFF, Jon, A. 1122 University Bay Drive Madison, WI 53705 / US | [2007/13] |
| Former [2005/46] | 01 /
MONAHAN, Sean, D. 5610 Tolman Terrace Madison, WI 53711 / US | ||
| 02 /
BUDKER, Vladimir, G. 5141 Sunrise Ridge Tr. Middleton, WI 53562 / US | |||
| 03 /
NADER, Lisa 2411 Tawhee Dr. 212 Madison, WI 53711 / US | |||
| 04 /
SUBBOTIN, Vladimir 602 Samuel Drive Madison, WI 53717 / US | |||
| 05 /
WOLFF, Jon, A. 1122 University Bay Drive Madison, WI 53705 / US | Representative(s) | van Someren, Petronella F. H. M., et al Arnold & Siedsma Bezuidenhoutseweg 57 2594 AC The Hague / NL | [N/P] |
| Former [2008/34] | Van Someren, Petronella F. H. M., et al Arnold & Siedsma, Sweelinkplein 1 2517 GK The Hague / NL | ||
| Former [2005/46] | Van Someren, Petronella F. H. M., et al Arnold & Siedsma, Advocaten en Octrooigemachtigden, Sweelinckplein 1 2517 GK Den Haag / NL | Application number, filing date | 04713338.4 | 20.02.2004 | [2005/46] | WO2004US05096 | Priority number, date | US20030448789P | 21.02.2003 Original published format: US 448789 P | US20030455724P | 18.03.2003 Original published format: US 455724 P | US20040782075 | 19.02.2004 Original published format: US 782075 | [2005/46] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2004076630 | Date: | 10.09.2004 | Language: | EN | [2004/37] | Type: | A2 Application without search report | No.: | EP1594883 | Date: | 16.11.2005 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.09.2004 takes the place of the publication of the European patent application. | [2005/46] | Search report(s) | International search report - published on: | US | 09.06.2005 | (Supplementary) European search report - dispatched on: | EP | 02.02.2010 | Classification | IPC: | C07H21/04, A61K48/00 | [2005/46] | CPC: |
C12N15/111 (EP,US);
C12N2310/14 (EP,US);
C12N2310/321 (EP,US);
C12N2310/351 (EP,US);
C12N2310/53 (EP,US);
C12N2320/51 (EP,US)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2005/46] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | Title | German: | KOVALENTE MODIFIKATION VON RNA F R DIE IN-VITRO- UND IN-VIVO-ZUF HRUNG | [2005/46] | English: | COVALENT MODIFICATION OF RNA FOR IN VITRO AND IN VIVO DELIVERY | [2005/46] | French: | MODIFICATION COVALENTE DE L'ARN POUR DISTRIBUTION I IN VITRO /I ET I IN VIVO /I | [2005/46] | Entry into regional phase | 20.07.2004 | National basic fee paid | 20.07.2004 | Search fee paid | 20.07.2004 | Designation fee(s) paid | 20.07.2004 | Examination fee paid | Examination procedure | 20.07.2004 | Examination requested [2005/46] | 16.09.2010 | Despatch of a communication from the examining division (Time limit: M06) | 11.02.2011 | Reply to a communication from the examining division | 13.02.2012 | Despatch of a communication from the examining division (Time limit: M04) | 04.06.2012 | Reply to a communication from the examining division | 06.05.2014 | Despatch of a communication from the examining division (Time limit: M04) | 20.10.2014 | Reply to a communication from the examining division | 05.10.2015 | Despatch of a communication from the examining division (Time limit: M04) | 16.02.2016 | Application deemed to be withdrawn, date of legal effect [2016/29] | 15.03.2016 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2016/29] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 16.09.2010 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 20.10.2014 | Request for further processing filed | 20.10.2014 | Full payment received (date of receipt of payment) Request granted | 29.10.2014 | Decision despatched | Fees paid | Renewal fee | 23.02.2006 | Renewal fee patent year 03 | 27.02.2007 | Renewal fee patent year 04 | 25.02.2008 | Renewal fee patent year 05 | 24.02.2009 | Renewal fee patent year 06 | 26.02.2010 | Renewal fee patent year 07 | 23.02.2011 | Renewal fee patent year 08 | 28.02.2012 | Renewal fee patent year 09 | 21.02.2013 | Renewal fee patent year 10 | 20.02.2014 | Renewal fee patent year 11 | 23.02.2015 | Renewal fee patent year 12 | 22.02.2016 | Renewal fee patent year 13 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XD]US6262252 (WOLFF JON A [US], et al) [XD] 1-3,5,9,12,14 * example -; claim - *; | [XY]WO02094185 (RIBOZYME PHARM INC [US], et al) [X] 1-3,5,8-14,17-20 * the whole document * [Y] 1-20; | [XP]WO03070910 (RIBOZYME PHARM INC [US], et al) [XP] 1-6,8-20 * page 14, line 6 - line 17 * * page 21, line 6 - page 22, line 13 * * page 43, line 4 - line 30 * * page 63 - page 64 *; | [E]WO2004090105 (DHARMACON INC [US], et al) [E] 1-20* the whole document *; | [Y] - AMARZGUIOUI M ET AL, "Tolerance for mutations and chemical modifications in a siRNA", NUCLEIC ACIDS RESEARCH, (20030115), vol. 31, no. 2, ISSN 0305-1048, pages 589 - 595, XP002270887 [Y] 1-20 * the whole document * DOI: http://dx.doi.org/10.1093/nar/gkg147 | [XP] - CZAUDERNA F ET AL, "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells", NUCLEIC ACIDS RESEARCH, (20030601), vol. 31, no. 11, ISSN 0305-1048, pages 2705 - 2716, XP002270732 [XP] 1-6,9,11-16,19-20 * the whole document * DOI: http://dx.doi.org/10.1093/nar/gkg393 | International search | [Y] - CHAMBERLIN ET AL, "Catalysis of Amide Synthesis by RNA Phosphodiester and Hydroxyl Groups", PNAS, (20021112), vol. 99, pages 14688 - 14692, XP002986028 DOI: http://dx.doi.org/10.1073/pnas.212527799 | [X] - TANG X-Q. ET AL, "2'-C-Branched ribonucleosides: Synthesis of the Phosphoramidite Derivatives of 2'-C-beta-methylcytidine and Their Incorporation into Oligonucleotides", J ORG CHEM, (19990109), vol. 64, pages 747 - 754, XP002156891 DOI: http://dx.doi.org/10.1021/jo981329u | [Y] - SINGER ET AL, "Targeted mutagenesis of DNA with Alkylating RecA assisted oligonucleotides", NUCLEIC ACIDS RESEARCH, (19990915), vol. 27, page E38, XP002986029 DOI: http://dx.doi.org/10.1093/nar/27.24.e38 | [X] - MASTA ET AL, "Nitrogen Mustard Inhibits Transcription and Translation in a Cell Free System", NUCLEIC ACIDS RESEARCH, (19950806), vol. 23, pages 3508 - 3510, XP002986030 | Examination | - MANOHARAN M, "Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, (20020101), vol. 12, doi:10.1089/108729002760070849, ISSN 1087-2906, pages 103 - 128, XP002294027 DOI: http://dx.doi.org/10.1089/108729002760070849 |