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Extract from the Register of European Patents

EP About this file: EP1631661

EP1631661 - TRANSGENIC ANIMAL HAVING AN AMYLOID PRECURSOR PROTEIN WITH A MODIFIED BETA SECRETASE CLEAVAGE SITE [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.10.2009
Database last updated on 31.08.2024
Most recent event   Tooltip09.10.2009Application deemed to be withdrawnpublished on 11.11.2009  [2009/46]
Applicant(s)For all designated states
Merck & Co., Inc.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
[N/P]
Former [2006/10]For all designated states
Merck & Co., Inc.
126 East Lincoln Avenue Rahway
New Jersey 07065-0907 / US
Inventor(s)01 / CHEN, Richard, Z.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
02 / SIMON, Adam, J.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
03 / VOGT, Thomas, F.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
 [2006/10]
Representative(s)Man, Jocelyn, et al
Merck & Co., Inc.
European Patent Department
Merck Sharp & Dohme Limited
Hertford Road, Hoddesdon
Hertfordshire, EN11 9BU / GB
[N/P]
Former [2006/48]Man, Jocelyn, et al
Merck & Co., Inc. European Patent Department Merck Sharp & Dohme Limited, Hertford Road, Hoddesdon
Hertfordshire, EN11 9BU / GB
Former [2006/10]Man, Jocelyn
Merck & Co.,Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR / GB
Application number, filing date04753635.428.05.2004
[2006/10]
WO2004US16836
Priority number, dateUS20030474772P30.05.2003         Original published format: US 474772 P
US20030518591P07.11.2003         Original published format: US 518591 P
[2006/10]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2004111189
Date:23.12.2004
Language:EN
[2004/52]
Type: A2 Application without search report 
No.:EP1631661
Date:08.03.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 23.12.2004 takes the place of the publication of the European patent application.
[2006/10]
Search report(s)International search report - published on:US31.03.2005
(Supplementary) European search report - dispatched on:EP07.07.2008
ClassificationIPC:C12N5/00, C12N15/00, A01K67/00, G01N33/00
[2006/10]
CPC:
C07K14/4711 (EP,US); A01K67/0275 (EP,US); A01K67/0278 (EP,US);
C07K16/18 (EP,US); C12N15/8509 (EP,US); A01K2207/15 (EP,US);
A01K2217/00 (EP,US); A01K2217/072 (EP,US); A01K2227/105 (EP,US);
A01K2267/0312 (EP,US); C12N2800/30 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/10]
Extension statesALNot yet paid
HRNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:TRANSGENES TIER MIT EINEM AMYLOID-VORLÄUFERPROTEIN MIT EINER MODIFIZIERTEN BETA-SECRETASE-SCHNITTSTELLE[2006/10]
English:TRANSGENIC ANIMAL HAVING AN AMYLOID PRECURSOR PROTEIN WITH A MODIFIED BETA SECRETASE CLEAVAGE SITE[2006/10]
French:ANIMAL TRANSGENIQUE COMPRENANT UNE PROTEINE PRECURSEUR AMYLOIDE PRESENTANT UN SITE DE CLIVAGE PAR LA BETA-SECRETASE MODIFIE[2006/10]
Entry into regional phase30.12.2005National basic fee paid 
30.12.2005Search fee paid 
30.12.2005Designation fee(s) paid 
30.12.2005Examination fee paid 
Examination procedure18.11.2005Amendment by applicant (claims and/or description)
30.12.2005Examination requested  [2006/10]
08.10.2008Despatch of a communication from the examining division (Time limit: M06)
21.04.2009Application deemed to be withdrawn, date of legal effect  [2009/46]
28.05.2009Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2009/46]
Fees paidRenewal fee
27.03.2006Renewal fee patent year 03
07.05.2007Renewal fee patent year 04
18.03.2008Renewal fee patent year 05
12.05.2009Renewal fee patent year 06
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Documents cited:Search[A]WO9634097  (CEPHALON INC [US], et al);
 [PX]WO03072041  (MERCK & CO INC [US], et al) [PX] 1-3,6 * claims 1,8-11 *;
 [E]WO2004099376  (MERCK & CO INC [US], et al) [E] 1-10 * figures 4-8; claims 31-35 *
International search[X]WO02094985  (MERCK & CO INC [US], et al);
 [A]  - MALLENDER W.D. ET AL., "Characterization of recombinant, soluble beta secretase from an insect cell expression system", MOLECULAR PHARMACOLOGY, (2001), vol. 59, no. 3, pages 619 - 626, XP001037766
 [A]  - GAN L. ET AL., "The amyloid beta peptide primes the proapoptotic p53 patway and countreacts the antiapoptic function of its precursor protein", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (2000), vol. 26, no. 1-2, XP008043353
 [A]  - LI Y. ET AL., "Novel function assay for proteases and modulators: application in beta-secretase studies", MOLECULAR BIOTECHNOLOGY, (2001), vol. 18, pages 1 - 10, XP009024465

DOI:   http://dx.doi.org/10.1385/MB:18:1:01
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.